Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
611
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Demonacos C |
Year: |
2001 |
Journal: |
Mol Cell |
Title: |
A TPR motif cofactor contributes to p300 activity in the p53 response. |
Volume: |
8 |
Issue: |
1 |
Pages: |
71-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lapouge K |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
Structure of the TPR domain of p67phox in complex with Rac.GTP. |
Volume: |
6 |
Issue: |
4 |
Pages: |
899-907 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Malik SC |
Year: |
2023 |
Journal: |
Cells |
Title: |
Tpr Misregulation in Hippocampal Neural Stem Cells in Mouse Models of Alzheimer's Disease. |
Volume: |
12 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The proteins in this family contain a divergent form of TPR repeats. Their function is unknown. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The function of TPR and ankyrin repeat-containing protein 1 (TRANK1) is not known. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lakhssassi N |
Year: |
2012 |
Journal: |
Plant Physiol |
Title: |
The Arabidopsis tetratricopeptide thioredoxin-like gene family is required for osmotic stress tolerance and male sporogenesis. |
Volume: |
158 |
Issue: |
3 |
Pages: |
1252-66 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of tetratricopeptide thioredoxin-like proteins (TTLs), including TTL1-4 from Arabidopsis. They are characterised by the presence of six tetratricopeptide repeats in conserved positions and a C-terminal region known as the thioredoxin-like domain with homology to thioredoxins. TTL2 is specific to pollen grains, while TTL1/3/4 display ubiquitous expression in normal growing conditions but differential expression patterns in response to osmotic and NaCl stresses. TTL1, TTL3, and TTL4 have partially overlapping yet specific functions in abiotic stress tolerance while TTL2 is involved in male gametophytic transmission []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This is a family of uncharacterised tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan Z |
Year: |
2013 |
Journal: |
Structure |
Title: |
An autoinhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs. |
Volume: |
21 |
Issue: |
6 |
Pages: |
1007-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blatch GL |
Year: |
1997 |
Journal: |
Gene |
Title: |
Isolation of a mouse cDNA encoding mSTI1, a stress-inducible protein containing the TPR motif. |
Volume: |
194 |
Issue: |
2 |
Pages: |
277-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'Andrea LD |
Year: |
2003 |
Journal: |
Trends Biochem Sci |
Title: |
TPR proteins: the versatile helix. |
Volume: |
28 |
Issue: |
12 |
Pages: |
655-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams CJ |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. |
Volume: |
109 |
Issue: |
10 |
Pages: |
3778-83 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
767
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
568
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
186
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
704
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
843
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
386
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Izumiyama T |
Year: |
2012 |
Journal: |
Gene |
Title: |
A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. |
Volume: |
511 |
Issue: |
2 |
Pages: |
202-17 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
TPR and ankyrin repeat-containing protein 1 |
Type: |
chain |
End: |
2999 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is one of two constant domains forming the CATRA module which is in turn C-terminally fused to a diverse range of conflict effector domains. This gene, along with a gene encoding the CATASP domain and a gene encoding a TPR repeat region fused to a CASPASE domain, forms the three gene island making up the CATRA conflict systems. This all α-helical domain is predicted to be involved in recognition of invasive molecules or in the transmitting of a signal through conformational change, enabling CASPASE-mediated proteolysis to free the fused effector domains []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is one of two constant domains forming the CATRA module which is in turn C-terminally fused to a diverse range of conflict effector domains. This gene, along with a gene encoding the CATASP domain and a gene encoding a TPR repeat region fused to a CASPASE domain, forms the three gene island making up the CATRA conflict systems. This α/β domain is predicted to be involved in recognition of invasive molecules or in the transmitting of a signal through conformational change, enabling CASPASE-mediated proteolysis to free the fused effector domains []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
664
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
664
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
292
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
664
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
239
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
580
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamb JR |
Year: |
1995 |
Journal: |
Trends Biochem Sci |
Title: |
Tetratrico peptide repeat interactions: to TPR or not to TPR? |
Volume: |
20 |
Issue: |
7 |
Pages: |
257-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
262
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
471
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1198
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
334
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
488
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
363
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
858
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1300
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
228
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
365
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
847
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Goebl M |
Year: |
1991 |
Journal: |
Trends Biochem Sci |
Title: |
The TPR snap helix: a novel protein repeat motif from mitosis to transcription. |
Volume: |
16 |
Issue: |
5 |
Pages: |
173-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
920
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
836
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
465
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
942
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
617
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ordway RW |
Year: |
1994 |
Journal: |
Trends Biochem Sci |
Title: |
A TPR domain in the SNAP secretory proteins. |
Volume: |
19 |
Issue: |
12 |
Pages: |
530-1 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
59
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1141
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
136
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
277
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1314
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1141
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
624
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2450
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
797
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
440
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Crevel G |
Year: |
2008 |
Journal: |
PLoS One |
Title: |
The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. |
Volume: |
3 |
Issue: |
3 |
Pages: |
e0001737 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
554
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
578
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
515
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
761
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Prince C |
Year: |
2015 |
Journal: |
Structure |
Title: |
An Unexpected Duo: Rubredoxin Binds Nine TPR Motifs to Form LapB, an Essential Regulator of Lipopolysaccharide Synthesis. |
Volume: |
23 |
Issue: |
8 |
Pages: |
1500-1506 |
|
•
•
•
•
•
|
Allele |
Name: |
translocated promoter region, nuclear basket protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
152
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1315
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
352
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
658
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
904
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
846
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
279
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
721
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1318
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Tao J |
Year: |
2010 |
Journal: |
J Mol Biol |
Title: |
Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPR. |
Volume: |
397 |
Issue: |
5 |
Pages: |
1307-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen TQ |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0186354 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dohm JA |
Year: |
2004 |
Journal: |
Proteins |
Title: |
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold. |
Volume: |
54 |
Issue: |
1 |
Pages: |
153-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
412
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore PM |
Year: |
1998 |
Journal: |
J Neuroimmunol |
Title: |
Identification and cloning of a brain autoantigen in neuro-behavioral SLE. |
Volume: |
82 |
Issue: |
2 |
Pages: |
116-25 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
824
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1401
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1212
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Han D |
Year: |
2008 |
Journal: |
Proteins |
Title: |
TPR domain of NrfG mediates complex formation between heme lyase and formate-dependent nitrite reductase in Escherichia coli O157:H7. |
Volume: |
70 |
Issue: |
3 |
Pages: |
900-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin Z |
Year: |
2009 |
Journal: |
J Exp Bot |
Title: |
AtTRP1 encodes a novel TPR protein that interacts with the ethylene receptor ERS1 and modulates development in Arabidopsis. |
Volume: |
60 |
Issue: |
13 |
Pages: |
3697-714 |
|
•
•
•
•
•
|
Allele |
Name: |
WD repeat domain 19; diamondhead |
Allele Type: |
Chemically induced (ENU) |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1233
 |
Fragment?: |
false |
|
•
•
•
•
•
|