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Search results 201 to 300 out of 753 for Traf2

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Type Details Score
Publication
17360936 | J:145415
First Author: Lu LF
Year: 2007
Journal: Blood
Title: The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation.
Volume: 110
Issue: 1
Pages: 193-200
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Publication
21331077 | J:203399
First Author: Darding M
Year: 2011
Journal: Cell Death Differ
Title: Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
Volume: 18
Issue: 8
Pages: 1376-86
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Publication
9104814 | J:39510
First Author: Lee SY
Year: 1997
Journal: J Exp Med
Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.
Volume: 185
Issue: 7
Pages: 1275-85
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Publication
21658601 | J:173568
First Author: Choksi S
Year: 2011
Journal: Mol Cell
Title: A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2.
Volume: 42
Issue: 5
Pages: 597-609
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Publication
24633224 | J:215110
First Author: Guicciardi ME
Year: 2014
Journal: PLoS One
Title: Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
Volume: 9
Issue: 3
Pages: e92124
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Publication
9692890 | J:113841
First Author: Gravestein LA
Year: 1998
Journal: Eur J Immunol
Title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.
Volume: 28
Issue: 7
Pages: 2208-16
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Publication
12050113 | J:218004
First Author: Nishitoh H
Year: 2002
Journal: Genes Dev
Title: ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Volume: 16
Issue: 11
Pages: 1345-55
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Publication
17572386 | J:122774
First Author: Lamothe B
Year: 2007
Journal: Biochem Biophys Res Commun
Title: TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.
Volume: 359
Issue: 4
Pages: 1044-9
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Publication
25766329 | J:319105
 
First Author: Elbaz M
Year: 2015
Journal: Cell Death Dis
Title: Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A.
Volume: 6
Pages: e1690
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
18281285 | J:136554
First Author: Luo D
Year: 2008
Journal: J Biol Chem
Title: AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.
Volume: 283
Issue: 18
Pages: 11905-12
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Publication
10809768 | J:62270
First Author: Eby MT
Year: 2000
Journal: J Biol Chem
Title: TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death.
Volume: 275
Issue: 20
Pages: 15336-42
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Publication
9507120 | J:46644
First Author: Masson R
Year: 1998
Journal: Mech Dev
Title: Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.
Volume: 71
Issue: 1-2
Pages: 187-91
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Publication
21071692 | J:183202
First Author: Yacoub D
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway.
Volume: 30
Issue: 12
Pages: 2424-33
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Publication
32591397 | J:300403
First Author: Chen Z
Year: 2020
Journal: J Immunol
Title: TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy.
Volume: 205
Issue: 3
Pages: 830-841
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Publication
23603814 | J:198506
First Author: Xiao Y
Year: 2013
Journal: Nat Med
Title: Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation.
Volume: 19
Issue: 5
Pages: 595-602
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Publication
26122662 | J:226450
First Author: Malle EK
Year: 2015
Journal: J Exp Med
Title: Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.
Volume: 212
Issue: 8
Pages: 1239-54
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37566034 | J:338896
 
First Author: Paluschinski M
Year: 2023
Journal: Cells
Title: Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis.
Volume: 12
Issue: 15
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Publication
16184196 | J:101528
First Author: Bai S
Year: 2005
Journal: J Clin Invest
Title: FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Volume: 115
Issue: 10
Pages: 2742-51
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17053834 | J:114972
First Author: Zhang J
Year: 2006
Journal: J Clin Invest
Title: Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.
Volume: 116
Issue: 11
Pages: 3042-9
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Publication
20818435 | J:173147
First Author: Neely RJ
Year: 2011
Journal: Oncogene
Title: The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK.
Volume: 30
Issue: 1
Pages: 87-96
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12529173 | J:83031
First Author: Brown SA
Year: 2003
Journal: Biochem J
Title: The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.
Volume: 371
Issue: Pt 2
Pages: 395-403
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Publication
23334419 | J:194553
First Author: Hu H
Year: 2013
Journal: Nature
Title: OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3.
Volume: 494
Issue: 7437
Pages: 371-4
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21115689 | J:176866
First Author: Liang J
Year: 2010
Journal: J Exp Med
Title: MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling.
Volume: 207
Issue: 13
Pages: 2959-73
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Publication
20005846 | J:155446
First Author: Haas TL
Year: 2009
Journal: Mol Cell
Title: Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
Volume: 36
Issue: 5
Pages: 831-44
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22057290 | J:179005
First Author: Ahmed N
Year: 2011
Journal: Nat Immunol
Title: The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
Volume: 12
Issue: 12
Pages: 1176-83
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Publication
24706909 | J:208867
First Author: Inoue M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.
Volume: 111
Issue: 14
Pages: 5295-300
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18079694 | J:130530
First Author: Hasegawa M
Year: 2008
Journal: EMBO J
Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
Volume: 27
Issue: 2
Pages: 373-83
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Publication
16147974 | J:100699
First Author: Kim N
Year: 2005
Journal: J Exp Med
Title: Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis.
Volume: 202
Issue: 5
Pages: 589-95
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Publication
26755589 | J:229924
First Author: Mambetsariev N
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Nuclear TRAF3 is a negative regulator of CREB in B cells.
Volume: 113
Issue: 4
Pages: 1032-7
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Publication
35411325 | J:351587
First Author: Ma X
Year: 2022
Journal: JACC Basic Transl Sci
Title: TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis.
Volume: 7
Issue: 3
Pages: 223-243
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Publication
10097072 | J:54076
First Author: Hsu H
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
Volume: 96
Issue: 7
Pages: 3540-5
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Publication
9177772 | J:40730
First Author: Nakano H
Year: 1997
Journal: Genomics
Title: Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32.
Volume: 42
Issue: 1
Pages: 26-32
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9916988 | J:52201
First Author: Baker SJ
Year: 1998
Journal: Oncogene
Title: Modulation of life and death by the TNF receptor superfamily.
Volume: 17
Issue: 25
Pages: 3261-70
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Publication
23815148 | J:216562
First Author: Etemadi N
Year: 2013
Journal: FEBS J
Title: Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.
Volume: 280
Issue: 21
Pages: 5283-97
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Publication
18849341 | J:144594
First Author: Sanada T
Year: 2008
Journal: J Biol Chem
Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
Volume: 283
Issue: 49
Pages: 33858-64
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Publication
23951545 | J:207797
 
First Author: Liu S
Year: 2013
Journal: Elife
Title: MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
Volume: 2
Pages: e00785
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Publication
10702415 | J:60742
First Author: Rosenfeld ME
Year: 2000
Journal: Am J Pathol
Title: Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice.
Volume: 156
Issue: 3
Pages: 997-1007
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Publication
37329888 | J:338216
First Author: Vucur M
Year: 2023
Journal: Immunity
Title: Sublethal necroptosis signaling promotes inflammation and liver cancer.
Volume: 56
Issue: 7
Pages: 1578-1595.e8
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Publication
25260751 | J:215973
First Author: Charlaftis N
Year: 2014
Journal: EMBO J
Title: The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
Volume: 33
Issue: 21
Pages: 2581-96
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Publication
17462996 | J:123526
First Author: Misra RS
Year: 2007
Journal: J Biol Chem
Title: Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.
Volume: 282
Issue: 27
Pages: 19365-74
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Publication
24275659 | J:319042
First Author: Koenig A
Year: 2014
Journal: J Biol Chem
Title: The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
Volume: 289
Issue: 2
Pages: 1183-91
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Publication
10748240 | J:120542
First Author: Schwandner R
Year: 2000
Journal: J Exp Med
Title: Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction.
Volume: 191
Issue: 7
Pages: 1233-40
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Publication
17015619 | J:114498
First Author: Gan B
Year: 2006
Journal: J Cell Biol
Title: Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.
Volume: 175
Issue: 1
Pages: 121-33
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Publication
30755793 | J:341418
   
First Author: Holbrook J
Year: 2019
Journal: F1000Res
Title: Tumour necrosis factor signalling in health and disease.
Volume: 8
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Publication
20614026 | J:161997
First Author: Hostager BS
Year: 2010
Journal: PLoS One
Title: HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Volume: 5
Issue: 6
Pages: e11380
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Publication
30185824 | J:281201
First Author: Anderton H
Year: 2019
Journal: Cell Death Differ
Title: RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development.
Volume: 26
Issue: 5
Pages: 877-889
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Publication
21765415 | J:176472
First Author: Shembade N
Year: 2011
Journal: Nat Immunol
Title: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Volume: 12
Issue: 9
Pages: 834-43
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Publication
28723569 | J:254238
First Author: Lawlor KE
Year: 2017
Journal: Cell Rep
Title: XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
Volume: 20
Issue: 3
Pages: 668-682
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Publication
22365665 | J:181625
First Author: Vince JE
Year: 2012
Journal: Immunity
Title: Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
Volume: 36
Issue: 2
Pages: 215-27
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Publication
25401743 | J:225134
First Author: Ren K
Year: 2014
Journal: PLoS One
Title: KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
Volume: 9
Issue: 11
Pages: e112275
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
19500387 | J:152818
 
First Author: Melnick M
Year: 2009
Journal: BMC Dev Biol
Title: Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Volume: 9
Pages: 32
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- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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37813816 | J:358134
First Author: Soma S
Year: 2024
Journal: Stem Cells
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Volume: 42
Issue: 1
Pages: 55-63
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29539633 | J:261316
First Author: Perez-Garcia V
Year: 2018
Journal: Nature
Title: Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Volume: 555
Issue: 7697
Pages: 463-468
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21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
25753355 | J:238171
First Author: Burette AC
Year: 2015
Journal: J Comp Neurol
Title: Organization of TNIK in dendritic spines.
Volume: 523
Issue: 13
Pages: 1913-24
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UniProt Feature
UniProt Feature
Begin: 1
Description: Traf2 and NCK-interacting protein kinase
Type: chain
End: 1323
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Protein Coding Gene
MGI:1916264 | Tnik
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
37556547 | J:358035
First Author: Pham TCP
Year: 2023
Journal: Sci Adv
Title: TNIK is a conserved regulator of glucose and lipid metabolism in obesity.
Volume: 9
Issue: 32
Pages: eadf7119
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Publication
23035106 | J:190924
First Author: Coba MP
Year: 2012
Journal: J Neurosci
Title: TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function.
Volume: 32
Issue: 40
Pages: 13987-99
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Gene
294917 | Tnik
Type: gene
Organism: rat
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Gene
460849 | TNIK
Type: gene
Organism: chimpanzee
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Gene
488166 | TNIK
Type: gene
Organism: dog, domestic
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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