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Search results 201 to 300 out of 311 for Traf4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5435201
Age: postnatal adult
Image: 4E
Specimen Label: 4E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1833322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:2664384
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1792222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:2664393
Age: embryonic day 14.5
Image: 2N
Specimen Label: 2N
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3557722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10282
Specimen Label: GUDMAP:10282
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10283
Specimen Label: GUDMAP:10283
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10283
Specimen Label: GUDMAP:10283
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5435205
Age: embryonic day 12.5
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5435205
Age: embryonic day 14.5
Image: 3F
Specimen Label: 3F
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10282
Specimen Label: GUDMAP:10282
Detected: false
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10283
Specimen Label: GUDMAP:10283
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Specimen Label: DA122; Specimen C1491
Detected: false
Specimen Num: 1
•
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•
GXD Expression
GXD Expression
     
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Specimen Label: DA122; Specimen C1491
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5435205
Age: embryonic day 12.5
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5435201
Age: embryonic day 10.5
Image: 3C
Specimen Label: 3C
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:5001971
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542525
Age: embryonic day 15.5
Image: GUDMAP:10283
Specimen Label: GUDMAP:10283
Detected: true
Specimen Num: 2
•
•
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•
GXD Expression
GXD Expression
   
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: DA122; Specimen C1491
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5309181
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422770
Age: embryonic day 14.5
Image: DA122; Specimen C1491
Note: Expression was weak in whisker follicle.
Specimen Label: DA122; Specimen C1491
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5435199
Assay Type: RNA in situ
Annotation Date: 2012-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5435205
Age: embryonic day 12.5
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 1
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Publication
16184196 | J:101528
First Author: Bai S
Year: 2005
Journal: J Clin Invest
Title: FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Volume: 115
Issue: 10
Pages: 2742-51
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Publication
30578323 | J:273043
First Author: Chen X
Year: 2019
Journal: J Exp Med
Title: IL-17R-EGFR axis links wound healing to tumorigenesis in Lrig1+ stem cells.
Volume: 216
Issue: 1
Pages: 195-214
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Publication
36459087 | J:331692
   
First Author: Xin Y
Year: 2022
Journal: Elife
Title: m(6)A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.
Volume: 11
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Interaction Experiment
Zhang L (2013)
Description: TRAF4 promotes TGF- receptor signaling and drives breast cancer metastasis.
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Interaction Experiment
Abell AN (2005)
Description: MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
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Allele
Traf4<em1Smoc> | MGI:7292946
Name: TNF receptor associated factor 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Traf4<m1Pav> | MGI:3807561
 
Name: TNF receptor associated factor 4; mutation 1, William J Pavan
Allele Type: Chemically induced (ENU)
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Allele
Tg(Traf4-EGFP)KR254Gsat | MGI:4847504
Name: transgene insertion KR254, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:6771232 | C57BL/6JSmoc-Traf4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:4843179 | B6.C(129)-Traf4<m1Pav>/Mmmh
Attribute String: congenic, mutant strain, chemically induced mutation
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Strain
MGI:5004193 | STOCK Tg(Traf4-EGFP)KR254Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Protein Domain
IPR037307 | TRAF4_MATH
Type: Domain
Description: TNF receptor-associated factor 4 (TRAF4) is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. TRAF4 plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. It regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. TRAF4 modulates TRAF6 functions [, , , , , ]. In mouse, it has been shown to be required for normal skeleton development, and for normal development of the respiratory tract []. TRAF4 contains a RING finger domain, seven zinc finger domains, and a TRAF domain.The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded β-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors [, ].
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Genotype
Genotype
Symbol: Traf4/Traf4 Sox10/Sox10<+>
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
9488716 | J:46205
First Author: Kawamata S
Year: 1998
Journal: J Biol Chem
Title: Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
Volume: 273
Issue: 10
Pages: 5808-14
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Publication
17726008 | J:126840
First Author: Abell AN
Year: 2007
Journal: J Biol Chem
Title: MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
Volume: 282
Issue: 42
Pages: 30476-84
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Publication
29715200 | J:265481
First Author: Singh R
Year: 2018
Journal: J Clin Invest
Title: TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.
Volume: 128
Issue: 7
Pages: 3129-3143
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Publication
15743827 | J:97513
First Author: Li JM
Year: 2005
Journal: Mol Cell Biol
Title: Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.
Volume: 25
Issue: 6
Pages: 2320-30
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Publication
10518213 | J:57751
First Author: Ye H
Year: 1999
Journal: Mol Cell
Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.
Volume: 4
Issue: 3
Pages: 321-30
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Publication
11098060 | -
First Author: Leo E
Year: 2001
Journal: J Biol Chem
Title: TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
Volume: 276
Issue: 11
Pages: 8087-93
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Publication
9847406 | -
First Author: Wajant H
Year: 1998
Journal: J Mol Evol
Title: Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans.
Volume: 47
Issue: 6
Pages: 656-62
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Publication
9744859 | -
First Author: Arch RH
Year: 1998
Journal: Genes Dev
Title: Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.
Volume: 12
Issue: 18
Pages: 2821-30
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Publication
10021364 | -
First Author: Liu H
Year: 1999
Journal: Curr Biol
Title: A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase.
Volume: 9
Issue: 2
Pages: 101-4
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Publication
10206649 | -
First Author: Park YC
Year: 1999
Journal: Nature
Title: Structural basis for self-association and receptor recognition of human TRAF2.
Volume: 398
Issue: 6727
Pages: 533-8
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Protein
Q8C245
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein Domain
IPR012227 | TNF_rcpt-assoc_TRAF_met
Type: Family
Description: The tumour necrosis factor (TNF) receptor associated factors (TRAFs) are major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily in mammals []. TRAFs constitute a family of genetically conserved adapter proteins found in mammals (TRAF1-6) as well as in other multicellular organisms such as Drosophila [], Caenorhabditis elegans []. TRAF2 is the prototypical member of the family. Mammalian TRAF1 and TRAF2 were the first members initially identified by their association with TNFR2. The TRAF1/TRAF2 and TRAF3/TRAF5 gene pairs may have arisen from recent independent gene duplications and to share a common ancestral gene. TRAF4 and TRAF6 precursor genes may have arisen earlier during evolution, with the divergence of the TRAF6 precursor occurring earliest of all. Except TRAF1, this PIRSF has a general domain architecture containing one N-terminal RING finger, a variable number of middle region of TRAF-type zinc finger and C2H2 type of zinc finger, and one C-terminal MATH domain. TRAF1 is unique in the family in that it lacks the N-terminal RING and zinc-finger domains []. This has rendered TRAF1 unable to promote TNF receptor signalling and act as a "dominant negative"TRAF []. Also TRAF1 is a substrate for caspases activated by TNF family death receptors []. The larger C-terminal cleaved fragment can bind to and sequester TRAF2 from TNFR1 complex, therefore modulating TNF induced NFkB activation []. A wide range of biological functions, such as adaptive and innate immunity, embryonic development, stress response and bone metabolism, are mediated by TRAFs through the induction of cell survival, proliferation, differentiation and death. TRAFs are functionally divergent from a perspective of both upstream and downstream TRAF signal transduction pathways and of signalling-dependent regulation of TRAF trafficking. Each TRAF protein interacts with and mediates the signal transduction of multiple receptors, and in turn each receptor utilises multiple TRAFs for specific functions []. About 40 interaction partners of TRAF have been described thus far, including receptors, kinases, regulators and adaptor proteins.TRAF proteins can be recruited to and activated by ligand-engaged receptors in least three distinct ways []. 1) Members of the TNFR superfamily that do not contain intracellular death domains, such as TNFR2 and CD40, recruit TRAFs directly via short sequences in their intracellular tails []. 2) Those that contain an intracellular death domain, such as TNFR1, first recruit an adapter protein, TRADD, via a death-domain-death-domain interaction, which then serves as a central platform of the TNFR1 signalling complex, which assembles TRAF2 and RIP for survival signalling, and FADD and caspase-8 for the induction of apoptosis. 3) Members of the IL-1R/TLR superfamily contain a protein interaction module known as the TIR domain, which recruits, sequentially, MyD88, a TIR domain and death domain containing protein, and IRAKs, adapter Ser/Thr kinases with death domains. IRAKs in turn associate with TRAF6 to elicit signalling by IL-1 and pathogenic components such as LPS. A common mechanism for the membrane-proximal event in TRAF signalling has been revealed by the conserved trimeric association in the crystal structure of the TRAF domain of TRAF2 [].This entry represents the TNF receptor associated factors found in metazoa.
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Protein Domain
IPR043211 | TNF_rcpt-assoc_TRAF
Type: Family
Description: The tumour necrosis factor (TNF) receptor associated factors (TRAFs) are major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily in mammals []. TRAFs constitute a family of genetically conserved adapter proteinsfound in mammals (TRAF1-6) as well as in other multicellular organisms such as Drosophila [], Caenorhabditis elegans []. TRAF2 is the prototypical member of the family. Mammalian TRAF1 and TRAF2 were the first members initially identified by their association with TNFR2. The TRAF1/TRAF2 and TRAF3/TRAF5 gene pairs may have arisen from recent independent gene duplications and to share a common ancestral gene. TRAF4 and TRAF6 precursor genes may have arisen earlier during evolution, with the divergence of the TRAF6 precursor occurring earliest of all. Except TRAF1, this PIRSF has a general domain architecture containing one N-terminal RING finger, a variable number of middle region of TRAF-type zinc finger and C2H2 type of zinc finger, and one C-terminal MATH domain. TRAF1 is unique in the family in that it lacks the N-terminal RING and zinc-finger domains []. This has rendered TRAF1 unable to promote TNF receptor signalling and act as a "dominant negative"TRAF []. Also TRAF1 is a substrate for caspases activated by TNF family death receptors []. The larger C-terminal cleaved fragment can bind to and sequester TRAF2 from TNFR1 complex, therefore modulating TNF induced NFkB activation []. A wide range of biological functions, such as adaptive and innate immunity, embryonic development, stress response and bone metabolism, are mediated by TRAFs through the induction of cell survival, proliferation, differentiation and death. TRAFs are functionally divergent from a perspective of both upstream and downstream TRAF signal transduction pathways and of signalling-dependent regulation of TRAF trafficking. Each TRAF protein interacts with and mediates the signal transduction of multiple receptors, and in turn each receptor utilises multiple TRAFs for specific functions []. About 40 interaction partners of TRAF have been described thus far, including receptors, kinases, regulators and adaptor proteins.TRAF proteins can be recruited to and activated by ligand-engaged receptors in least three distinct ways []. 1) Members of the TNFR superfamily that do not contain intracellular death domains, such as TNFR2 and CD40, recruit TRAFs directly via short sequences in their intracellular tails []. 2) Those that contain an intracellular death domain, such as TNFR1, first recruit an adapter protein, TRADD, via a death-domain-death-domain interaction, which then serves as a central platform of the TNFR1 signalling complex, which assembles TRAF2 and RIP for survival signalling, and FADD and caspase-8 for the induction of apoptosis. 3) Members of the IL-1R/TLR superfamily contain a protein interaction module known as the TIR domain, which recruits, sequentially, MyD88, a TIR domain and death domain containing protein, and IRAKs, adapter Ser/Thr kinases with death domains. IRAKs in turn associate with TRAF6 to elicit signalling by IL-1 and pathogenic components such as LPS. A common mechanism for the membrane-proximal event in TRAF signalling has been revealed by the conserved trimeric association in the crystal structure of the TRAF domain of TRAF2 [].
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Publication
8069916 | J:19898
First Author: Rothe M
Year: 1994
Journal: Cell
Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
Volume: 78
Issue: 4
Pages: 681-92
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Publication
11865024 | -
First Author: Chung JY
Year: 2002
Journal: J Cell Sci
Title: All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.
Volume: 115
Issue: Pt 4
Pages: 679-88
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Protein
P39428
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q3UM74
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q4VA12
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Publication
11607847 | -
First Author: Bradley JR
Year: 2001
Journal: Oncogene
Title: Tumor necrosis factor receptor-associated factors (TRAFs).
Volume: 20
Issue: 44
Pages: 6482-91
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Protein
A0A0A6YXC4
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
P70191
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
Q60803
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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