| Type |
Details |
Score |
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
913
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
913
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, coisogenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain, coisogenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Cck-EGFP/RNAi:Gad1)2Mirn/? |
| Background: |
C57BL/6NHsd-Tg(Cck-EGFP/RNAi:Gad1)2Mirn |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bertaux F |
| Year: |
1998 |
| Journal: |
FEBS Lett |
| Title: |
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice. |
| Volume: |
426 |
| Issue: |
2 |
| Pages: |
229-32 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
628
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
326
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
181
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
304
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
24
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li XJ |
| Year: |
1995 |
| Journal: |
Nature |
| Title: |
A huntingtin-associated protein enriched in brain with implications for pathology. |
| Volume: |
378 |
| Issue: |
6555 |
| Pages: |
398-402 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang GZ |
| Year: |
2012 |
| Journal: |
J Neurochem |
| Title: |
Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. |
| Volume: |
122 |
| Issue: |
5 |
| Pages: |
1010-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu LL |
| Year: |
2009 |
| Journal: |
Cell Adh Migr |
| Title: |
Huntingtin associated protein 1 and its functions. |
| Volume: |
3 |
| Issue: |
1 |
| Pages: |
71-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lumsden AL |
| Year: |
2016 |
| Journal: |
BMC Evol Biol |
| Title: |
Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
214 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents a N-terminal conserved region found in huntingtin-associated protein 1 (HAP1), trafficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and T27A3.1 (C. elegans) []. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner [, , ]. It is involved in intracellular trafficking []. HAP1 is also linked to Alzheimer's disease. It regulates amyloid precursor protein subcellular trafficking to the non-amyloidogenic pathway and may negatively regulate Abeta production in neurons [].TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth, whereas TRAK2 predominantly interacts with dynein/dynactin, is more abundantly present in dendrites, and is required for dendritic development []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
López-Doménech G |
| Year: |
2018 |
| Journal: |
EMBO J |
| Title: |
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution. |
| Volume: |
37 |
| Issue: |
3 |
| Pages: |
321-336 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmidt MJ |
| Year: |
2014 |
| Journal: |
Mol Psychiatry |
| Title: |
Modulation of behavioral networks by selective interneuronal inactivation. |
| Volume: |
19 |
| Issue: |
5 |
| Pages: |
580-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Colomer V |
| Year: |
1997 |
| Journal: |
Hum Mol Genet |
| Title: |
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. |
| Volume: |
6 |
| Issue: |
9 |
| Pages: |
1519-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|