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Search results 201 to 244 out of 244 for Trim21

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Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase TRIM21
Type: chain
End: 470
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Publication
32312982 | J:289154
First Author: Cheng J
Year: 2020
Journal: Nat Commun
Title: TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism.
Volume: 11
Issue: 1
Pages: 1880
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Publication
26506431 | J:248342
First Author: Watkinson RE
Year: 2015
Journal: PLoS Pathog
Title: TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
Volume: 11
Issue: 10
Pages: e1005253
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Publication
36749630 | J:334071
 
First Author: Liu J
Year: 2023
Journal: J Clin Invest
Title: The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
Volume: 133
Issue: 6
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Interaction Experiment
Keeble AH (2008)
Description: TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
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Interaction Experiment
Zhang Z (2012)
Description: The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.
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Publication
18420815 | -
First Author: Keeble AH
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
Volume: 105
Issue: 16
Pages: 6045-50
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Publication
19265157 | -
First Author: Yang K
Year: 2009
Journal: J Immunol
Title: TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response.
Volume: 182
Issue: 6
Pages: 3782-92
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Allele
Trim21<em1Smoc> | MGI:7292968
Name: tripartite motif-containing 21; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355306 | C57BL/6JSmoc-Trim21<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
30367038 | J:267718
First Author: Wei Z
Year: 2018
Journal: Nat Commun
Title: Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Volume: 9
Issue: 1
Pages: 4468
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Publication
32796032 | J:298721
First Author: Xie S
Year: 2020
Journal: J Biol Chem
Title: HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21.
Volume: 295
Issue: 42
Pages: 14343-14351
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Publication
38591006 | J:347630
First Author: Deng R
Year: 2024
Journal: iScience
Title: ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-catenin/PD-L1 axis.
Volume: 27
Issue: 4
Pages: 109533
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Publication
23091005 | J:191235
First Author: Hauler F
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Volume: 109
Issue: 48
Pages: 19733-8
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Publication
26442586 | J:251755
First Author: Shibata N
Year: 2015
Journal: J Biol Chem
Title: Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Volume: 290
Issue: 47
Pages: 28428-37
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Publication
36662617 | J:342798
First Author: Kong X
Year: 2023
Journal: Cell Rep
Title: Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner.
Volume: 42
Issue: 1
Pages: 112002
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Publication
17400754 | -
First Author: James LC
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.
Volume: 104
Issue: 15
Pages: 6200-5
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Publication
22402340 | -
First Author: Oke V
Year: 2012
Journal: J Autoimmun
Title: The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review.
Volume: 39
Issue: 1-2
Pages: 77-82
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Publication
16670339 | -
First Author: Espinosa A
Year: 2006
Journal: J Immunol
Title: The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
Volume: 176
Issue: 10
Pages: 6277-85
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Protein Domain
IPR035831 | PRY/SPRY_TRIM21
Type: Domain
Description: This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM21, which is also known as Sjogren Syndrome Antigen A (SSA), SSA1, 52kDa Ribonucleoprotein Autoantigen (Ro52, Ro/SSA, SS-A/Ro) or RING finger protein 81 (RNF81). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and also known as RBCC proteins []. As an E3 ligase, TRIM21 mediates target specificity in ubiquitination; it regulates type 1 interferon and proinflammatory cytokines via ubiquitination of interferon regulatory factors (IRFs) [, ]. It is up-regulated at the site of autoimmune inflammation, such as cutaneous lupus lesions, indicating a central role in the tissue destructive inflammatory process []. It interacts with auto-antigens in patients with Sjogren syndrome and systemic lupus erythematosus, a chronic systemic autoimmune disease characterized by the presence of autoantibodies against the protein component of the human intracellular ribonucleoprotein-RNA complexes and more specifically TRIM21, Ro60/TROVE2 and La/SSB proteins []. It binds the Fc part of IgG molecules via its PRY-SPRY domain with unexpectedly high affinity [, ].
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Publication
23975864 | J:205843
First Author: Sjöstrand M
Year: 2013
Journal: J Immunol
Title: Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
Volume: 191
Issue: 7
Pages: 3753-63
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Publication
31638890 | J:281684
First Author: Israel S
Year: 2019
Journal: BMC Genomics
Title: A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days.
Volume: 20
Issue: 1
Pages: 755
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Publication
16237670 | J:102328
First Author: Meroni G
Year: 2005
Journal: Bioessays
Title: TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.
Volume: 27
Issue: 11
Pages: 1147-57
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Protein
Q921V6
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
Q3U7K7
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q3UCL2
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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