| Type |
Details |
Score |
| UniProt Feature |
| Begin: |
1 |
| Description: |
E3 ubiquitin-protein ligase TRIM33 |
| Type: |
chain |
| End: |
1142 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE68617 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
402
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
291
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1123
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
193
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1140
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He W |
| Year: |
2006 |
| Journal: |
Cell |
| Title: |
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. |
| Volume: |
125 |
| Issue: |
5 |
| Pages: |
929-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou DB |
| Year: |
2021 |
| Journal: |
Aging Cell |
| Title: |
TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation. |
| Volume: |
20 |
| Issue: |
7 |
| Pages: |
e13367 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rousseau V |
| Year: |
2023 |
| Journal: |
Nat Commun |
| Title: |
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
5143 |
|
•
•
•
•
•
|
| Allele |
| Name: |
collagen, type I, alpha 1; targeted mutation 16, Scott Lowe |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Knockdown, Reporter, RMCE-ready |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Sana Yokoi |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 5, Sana Yokoi |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 9, Sana Yokoi |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 13, Sana Yokoi |
| Allele Type: |
Transgenic |
| Attribute String: |
Epitope tag, Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tirard M |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. |
| Volume: |
109 |
| Issue: |
51 |
| Pages: |
21122-7 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE39851 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Homan CC |
| Year: |
2014 |
| Journal: |
Am J Hum Genet |
| Title: |
Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. |
| Volume: |
94 |
| Issue: |
3 |
| Pages: |
470-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dupont S |
| Year: |
2009 |
| Journal: |
Cell |
| Title: |
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. |
| Volume: |
136 |
| Issue: |
1 |
| Pages: |
123-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stegeman S |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
e68287 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Ubiquitin-specific protease 9x (Usp9x), also known as ubiquitin carboxyl-terminal hydrolase FAF-X or FAM, is a deubiquitinase that acts as an important component in TGF-beta and bone morphogenetic protein signalling. It specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 []. It is involved in axonal growth and neuronal cell migration []. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
345
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo A |
| Year: |
2014 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
372-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park J |
| Year: |
2013 |
| Journal: |
Mol Cell |
| Title: |
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. |
| Volume: |
50 |
| Issue: |
6 |
| Pages: |
919-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The RIKEN BioResource Center |
| Year: |
2006 |
| Journal: |
Unpublished |
| Title: |
Information obtained from The RIKEN BioResource Center |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huttlin EL |
| Year: |
2010 |
| Journal: |
Cell |
| Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
| Volume: |
143 |
| Issue: |
7 |
| Pages: |
1174-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|