| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
E3 ubiquitin-protein ligase TRIM39 |
| Type: |
chain |
| End: |
488 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
496
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
488
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
60
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang L |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. |
| Volume: |
109 |
| Issue: |
51 |
| Pages: |
20937-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SS |
| Year: |
2009 |
| Journal: |
Exp Cell Res |
| Title: |
TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process. |
| Volume: |
315 |
| Issue: |
7 |
| Pages: |
1313-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang NJ |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. |
| Volume: |
197 |
| Issue: |
3 |
| Pages: |
361-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grütter C |
| Year: |
2006 |
| Journal: |
FEBS Lett |
| Title: |
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. |
| Volume: |
580 |
| Issue: |
1 |
| Pages: |
99-106 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM39, an E3 ubiquitin-protein ligase [].Tripartite motif 39 (TRIM39), also known as Ring finger protein 23 (RNF23), has been shown to stabilize modulator of apoptosis 1 (MOAP-1) by suppressing its polyubiquitylation by the anaphase promoting complex []. It also stabilizes p21, thus regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage. TRIM39 interacts with p21, preventing binding to Cdt2, ubiquitylation by Cdt2 E3 ligase, and degradation []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
388
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
500
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|