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Search results 201 to 300 out of 721 for Tsc1

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Type Details Score
Publication
First Author: Chen H
Year: 2013
Journal: FASEB J
Title: Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice.
Volume: 27
Issue: 10
Pages: 3979-90
Publication
First Author: Jiang M
Year: 2018
Journal: Glia
Title: The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner.
Volume: 66
Issue: 9
Pages: 1947-1959
Publication  
First Author: Wang Y
Year: 2016
Journal: Sci Rep
Title: Nesfatin-1 promotes brown adipocyte phenotype.
Volume: 6
Pages: 34747
Publication
First Author: Wang H
Year: 2019
Journal: Virulence
Title: T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.
Volume: 10
Issue: 1
Pages: 892-901
Publication
First Author: Armour EA
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.
Volume: 303
Issue: 4
Pages: F584-92
Publication
First Author: Xie Y
Year: 2020
Journal: J Clin Invest
Title: Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer.
Volume: 130
Issue: 4
Pages: 2111-2128
Publication
First Author: Wilson C
Year: 2005
Journal: Cancer Res
Title: Induction of renal tumorigenesis with elevated levels of somatic loss of heterozygosity in Tsc1+/- mice on a Blm-deficient background.
Volume: 65
Issue: 22
Pages: 10179-82
Publication  
First Author: Guridi M
Year: 2016
Journal: Skelet Muscle
Title: Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.
Volume: 6
Pages: 13
Publication
First Author: Qi S
Year: 2022
Journal: Transgenic Res
Title: Expression of Cre recombinase in chondrocytes causes abnormal craniofacial and skeletal development.
Volume: 31
Issue: 3
Pages: 399-411
Publication
First Author: Tanaka Y
Year: 2012
Journal: Endocrinology
Title: Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Volume: 153
Issue: 1
Pages: 404-16
Publication
First Author: Xu G
Year: 2015
Journal: Diabetologia
Title: Intestinal mTOR regulates GLP-1 production in mouse L cells.
Volume: 58
Issue: 8
Pages: 1887-97
Publication
First Author: Miceli AP
Year: 2012
Journal: Mol Cell Biol
Title: Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.
Volume: 32
Issue: 2
Pages: 348-64
Publication
First Author: Uhlmann EJ
Year: 2002
Journal: Oncogene
Title: Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
Volume: 21
Issue: 25
Pages: 4050-9
Publication
First Author: Bonnet CS
Year: 2009
Journal: Hum Mol Genet
Title: Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis.
Volume: 18
Issue: 12
Pages: 2166-76
Publication
First Author: Ehninger D
Year: 2008
Journal: Nat Med
Title: Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.
Volume: 14
Issue: 8
Pages: 843-8
Publication
First Author: Zhou J
Year: 2009
Journal: Hum Mol Genet
Title: Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.
Volume: 18
Issue: 22
Pages: 4428-41
Publication
First Author: Meena NK
Year: 2018
Journal: Immunology
Title: mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity.
Volume: 155
Issue: 4
Pages: 505-518
Publication  
First Author: Hiraiwa M
Year: 2019
Journal: Front Pharmacol
Title: mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.
Volume: 10
Pages: 684
Publication
First Author: Shi L
Year: 2019
Journal: PLoS Biol
Title: TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.
Volume: 17
Issue: 8
Pages: e3000420
Publication
First Author: Zhang Y
Year: 2017
Journal: J Bone Miner Res
Title: mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice.
Volume: 32
Issue: 9
Pages: 1829-1840
Publication
First Author: Adhikari D
Year: 2010
Journal: Hum Mol Genet
Title: Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.
Volume: 19
Issue: 3
Pages: 397-410
Publication
First Author: McMahon J
Year: 2012
Journal: J Neurosci
Title: Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis.
Volume: 32
Issue: 45
Pages: 15704-14
Publication
First Author: Hu Z
Year: 2015
Journal: J Biol Chem
Title: Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.
Volume: 290
Issue: 42
Pages: 25756-65
Publication
First Author: Cornu M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21.
Volume: 111
Issue: 32
Pages: 11592-9
Publication
First Author: Wang H
Year: 2019
Journal: J Cell Physiol
Title: Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression.
Volume: 234
Issue: 3
Pages: 2730-2740
Publication
First Author: Wang Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.
Volume: 110
Issue: 50
Pages: E4894-903
Publication  
First Author: Yin N
Year: 2022
Journal: J Clin Invest
Title: SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation.
Volume: 132
Issue: 20
Publication
First Author: Jansen LA
Year: 2005
Journal: Epilepsia
Title: Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.
Volume: 46
Issue: 12
Pages: 1871-80
Publication
First Author: Lim J
Year: 2017
Journal: Sci Rep
Title: mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.
Volume: 7
Issue: 1
Pages: 17175
Publication
First Author: Chen Y
Year: 2014
Journal: J Biol Chem
Title: Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
Volume: 289
Issue: 2
Pages: 1164-73
Publication
First Author: Guridi M
Year: 2015
Journal: Sci Signal
Title: Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Volume: 8
Issue: 402
Pages: ra113
Publication
First Author: Miyazaki M
Year: 2010
Journal: FEBS J
Title: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
Volume: 277
Issue: 9
Pages: 2180-91
Publication
First Author: Bilanges B
Year: 2007
Journal: Mol Cell Biol
Title: Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
Volume: 27
Issue: 16
Pages: 5746-64
Publication
First Author: Mejia LA
Year: 2013
Journal: J Neurosci
Title: A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.
Volume: 33
Issue: 46
Pages: 18015-21
Publication
First Author: Zhang Y
Year: 2014
Journal: Nature
Title: Coordinated regulation of protein synthesis and degradation by mTORC1.
Volume: 513
Issue: 7518
Pages: 440-3
Publication    
First Author: Chao X
Year: 2021
Journal: Autophagy
Title: An unexpected tumor suppressor role of SQSTM1/p62 in liver tumorigenesis.
Pages: 1-3
Publication
First Author: Nie D
Year: 2015
Journal: J Neurosci
Title: The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
Volume: 35
Issue: 30
Pages: 10762-72
Publication
First Author: Klibaite U
Year: 2022
Journal: Mol Autism
Title: Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models.
Volume: 13
Issue: 1
Pages: 12
Publication    
First Author: Figlia G
Year: 2017
Journal: Elife
Title: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Volume: 6
Publication  
First Author: Jiang M
Year: 2016
Journal: Nat Commun
Title: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.
Volume: 7
Pages: 12185
Publication
First Author: Magri L
Year: 2011
Journal: Cell Stem Cell
Title: Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.
Volume: 9
Issue: 5
Pages: 447-62
Publication
First Author: Banerjee S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
Volume: 108
Issue: 38
Pages: 15996-6001
Publication
First Author: Zhang H
Year: 2003
Journal: J Clin Invest
Title: Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Volume: 112
Issue: 8
Pages: 1223-33
Publication
First Author: Hartman TR
Year: 2009
Journal: Hum Mol Genet
Title: The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Volume: 18
Issue: 1
Pages: 151-63
Publication  
First Author: Kong B
Year: 2015
Journal: Mol Cancer
Title: Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.
Volume: 14
Pages: 212
Publication
First Author: Benhamron S
Year: 2015
Journal: Mol Cell Biol
Title: mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion.
Volume: 35
Issue: 1
Pages: 153-66
Publication
First Author: Fu X
Year: 2018
Journal: J Clin Invest
Title: Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.
Volume: 128
Issue: 11
Pages: 4938-4955
Publication
First Author: Baskaran P
Year: 2023
Journal: J Biol Chem
Title: Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.
Volume: 299
Issue: 1
Pages: 102788
Publication
First Author: Copps KD
Year: 2016
Journal: J Biol Chem
Title: Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
Volume: 291
Issue: 16
Pages: 8602-17
Publication
First Author: Tang H
Year: 2014
Journal: Sci Signal
Title: mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Volume: 7
Issue: 314
Pages: ra18
Publication
First Author: Asrani K
Year: 2019
Journal: J Clin Invest
Title: mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Volume: 129
Issue: 12
Pages: 5584-5599
Publication
First Author: Patursky-Polischuk I
Year: 2009
Journal: Mol Cell Biol
Title: The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Volume: 29
Issue: 3
Pages: 640-9
Publication
First Author: Wu X
Year: 2022
Journal: Cell Rep
Title: Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.
Volume: 40
Issue: 3
Pages: 111085
Publication
First Author: Sengupta S
Year: 2010
Journal: Nature
Title: mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
Volume: 468
Issue: 7327
Pages: 1100-4
Publication
First Author: Tanwar PS
Year: 2012
Journal: Hum Mol Genet
Title: Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
Volume: 21
Issue: 20
Pages: 4394-405
Publication
First Author: Tran Nguyen Truc L
Year: 2023
Journal: Sci Rep
Title: Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons.
Volume: 13
Issue: 1
Pages: 508
Publication
First Author: Kenerson HL
Year: 2015
Journal: PLoS One
Title: Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.
Volume: 10
Issue: 2
Pages: e0117000
Publication
First Author: Kenerson HL
Year: 2013
Journal: Gastroenterology
Title: Akt and mTORC1 have different roles during liver tumorigenesis in mice.
Volume: 144
Issue: 5
Pages: 1055-65
Publication
First Author: Shi Q
Year: 2022
Journal: J Neurosci
Title: Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model.
Volume: 42
Issue: 27
Pages: 5294-5313
Publication
First Author: Pollizzi K
Year: 2009
Journal: Hum Mol Genet
Title: A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Volume: 18
Issue: 13
Pages: 2378-87
Publication
First Author: Magri L
Year: 2013
Journal: Dis Model Mech
Title: Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.
Volume: 6
Issue: 5
Pages: 1185-97
Publication
First Author: Jones I
Year: 2015
Journal: Dis Model Mech
Title: A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development.
Volume: 8
Issue: 12
Pages: 1517-29
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Cheadle JP
Year: 2000
Journal: Mamm Genome
Title: Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus.
Volume: 11
Issue: 12
Pages: 1135-8
Publication
First Author: Traykova-Brauch M
Year: 2008
Journal: Nat Med
Title: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.
Volume: 14
Issue: 9
Pages: 979-84
Publication
First Author: Kelly E
Year: 2020
Journal: Nat Neurosci
Title: Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits.
Volume: 23
Issue: 9
Pages: 1102-1110
Publication
First Author: Gibson JM
Year: 2022
Journal: J Neurosci
Title: A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior.
Volume: 42
Issue: 13
Pages: 2804-2823
Publication
First Author: Tsai PT
Year: 2018
Journal: Cell Rep
Title: Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors.
Volume: 25
Issue: 2
Pages: 357-367.e4
Publication
First Author: Stoodley CJ
Year: 2017
Journal: Nat Neurosci
Title: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.
Volume: 20
Issue: 12
Pages: 1744-1751
Publication
First Author: Pak HH
Year: 2024
Journal: Cell Rep
Title: Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions.
Volume: 43
Issue: 9
Pages: 114663
Publication
First Author: Yu D
Year: 2018
Journal: FASEB J
Title: Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.
Volume: 32
Issue: 6
Pages: 3471-3482
Publication
First Author: Yun YS
Year: 2016
Journal: Mol Cell
Title: mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress.
Volume: 61
Issue: 4
Pages: 625-639
Publication
First Author: Sha L
Year: 2017
Journal: J Exp Med
Title: Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy.
Volume: 214
Issue: 2
Pages: 547-563
Publication  
First Author: Zhang B
Year: 2015
Journal: Neurobiol Dis
Title: Inflammatory mechanisms contribute to the neurological manifestations of tuberous sclerosis complex.
Volume: 80
Pages: 70-9
Publication  
First Author: Bateup HS
Year: 2013
Journal: Front Mol Neurosci
Title: Temporal dynamics of a homeostatic pathway controlling neural network activity.
Volume: 6
Pages: 28
Publication
First Author: Zhang B
Year: 2013
Journal: PLoS One
Title: Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.
Volume: 8
Issue: 2
Pages: e57445
Publication
First Author: Suzuki T
Year: 2013
Journal: Mol Cell
Title: Inhibition of AMPK catabolic action by GSK3.
Volume: 50
Issue: 3
Pages: 407-19
Publication
First Author: Ham DJ
Year: 2022
Journal: Nat Commun
Title: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.
Volume: 13
Issue: 1
Pages: 2025
Publication
First Author: Luo X
Year: 2021
Journal: FASEB J
Title: mTORC1 promotes mineralization via p53 pathway.
Volume: 35
Issue: 2
Pages: e21325
Publication
First Author: Vangoor VR
Year: 2024
Journal: Acta Neuropathol
Title: Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy.
Volume: 148
Issue: 1
Pages: 61
Publication
First Author: Ham DJ
Year: 2020
Journal: Nat Commun
Title: The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia.
Volume: 11
Issue: 1
Pages: 4510
Publication
First Author: Go YM
Year: 2020
Journal: FASEB J
Title: MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
Volume: 34
Issue: 9
Pages: 12502-12520