Type |
Details |
Score |
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14287H4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14384F8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14438F3, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14423G8, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14603F10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14755F11, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14761E1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14890C2, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14938G1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14938G4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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|
•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14970C6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14992E4, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST14995B10, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST15009A6, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Allele |
Name: |
TSSK6 activating co-chaperone; gene trap IST15113D1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK (testis-specific serine kinase) proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression []. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates [, ]. |
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•
•
•
•
•
|
Publication |
First Author: |
Kavarthapu R |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
Targeted Knock-In Mice with a Human Mutation in GRTH/DDX25 Reveals the Essential Role of Phosphorylated GRTH in Spermatid Development during Spermatogenesis. |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Nayyab S |
Year: |
2021 |
Journal: |
Mol Reprod Dev |
Title: |
TSSK3, a novel target for male contraception, is required for spermiogenesis. |
Volume: |
88 |
Issue: |
11 |
Pages: |
718-730 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salicioni AM |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†. |
Volume: |
103 |
Issue: |
2 |
Pages: |
264-274 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anbazhagan R |
Year: |
2020 |
Journal: |
Front Cell Dev Biol |
Title: |
Role of Phosphorylated Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in the Regulation of Germ Cell Specific mRNAs in Chromatoid Bodies During Spermatogenesis. |
Volume: |
8 |
|
Pages: |
580019 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
273
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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|
|
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•
•
•
•
•
|