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Search results 201 to 268 out of 268 for Txk

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: Tyrosine-protein kinase TXK
Type: chain
End: 527
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Strain
MGI:6476567 | C57BL/6JSmoc-Txk<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein
P42682
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 201
Description: Phosphotyrosine; by TXK and JAK2
Type: modified residue
End: 201
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Protein
P42682-2
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Publication
21362139 | J:190803
First Author: Gomez-Rodriguez J
Year: 2011
Journal: FEBS J
Title: Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.
Volume: 278
Issue: 12
Pages: 1980-9
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UniProt Feature
UniProt Feature
Begin: 783
Description: Phosphotyrosine; by ITK, SYK and TXK
Type: modified residue
End: 783
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Allele
Txk<+> | MGI:2440205
   
Name: TXK tyrosine kinase; wild type
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Publication
9891083 | -
First Author: Debnath J
Year: 1999
Journal: Mol Cell Biol
Title: rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.
Volume: 19
Issue: 2
Pages: 1498-507
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Publication
11353545 | -
 
First Author: Chamorro M
Year: 2001
Journal: BMC Immunol
Title: Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
Volume: 2
Pages: 3
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Publication
19290923 | -
First Author: Readinger JA
Year: 2009
Journal: Immunol Rev
Title: Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
Volume: 228
Issue: 1
Pages: 93-114
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Allele
Txk<tm1(KOMP)Vlcg> | MGI:4881281
Name: TXK tyrosine kinase; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Txk<tm1Pls> | MGI:2652126
Name: TXK tyrosine kinase; targeted mutation 1, Pamela L Schwartzberg
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Txk<tm2a(EUCOMM)Wtsi> | MGI:5050919
Name: TXK tyrosine kinase; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Txk<tm2b(EUCOMM)Wtsi> | MGI:5696876
Name: TXK tyrosine kinase; targeted mutation 2b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Txk<em14Gpt> | MGI:7308125
Name: TXK tyrosine kinase; endonuclease-mediated mutation 14, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Txk<em1Gpt> | MGI:7377455
Name: TXK tyrosine kinase; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
10660534 | -
First Author: Schneider H
Year: 2000
Journal: J Biol Chem
Title: Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.
Volume: 275
Issue: 6
Pages: 3835-40
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Strain
MGI:6334761 | C57BL/6N-Txk<tm2a(EUCOMM)Wtsi>/Tcp
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6260888 | C57BL/6N-Txk<tm2b(EUCOMM)Wtsi>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:7382488 | C57BL/6JGpt-Txk<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Txk/Txk
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Txk/Txk
Background: C57BL/6N-Txk/Tcp
Zygosity: hm
Has Mutant Allele: true
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Publication
11340625 | -
First Author: Smith CI
Year: 2001
Journal: Bioessays
Title: The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.
Volume: 23
Issue: 5
Pages: 436-46
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Publication
10587356 | J:64938
First Author: Rajagopal K
Year: 1999
Journal: J Exp Med
Title: RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
Volume: 190
Issue: 11
Pages: 1657-68
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Strain
MGI:6348249 | C57BL/6N-A<tm1Brd> Txk<tm2b(EUCOMM)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6348248 | C57BL/6N-A<tm1Brd> Txk<tm2a(EUCOMM)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Txk/Txk<+>
Background: C57BL/6N-Txk/Tcp
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:4356477 | B6.129-Txk<tm1Pls> Itk<tm1Ljb>
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Itk/Itk Txk/Txk
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itk/Itk Txk/Txk
Background: B6.129-Txk Itk
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR035579 | TXK_SH3
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
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Publication
17177976 | -
First Author: Maruyama T
Year: 2007
Journal: Clin Exp Immunol
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Volume: 147
Issue: 1
Pages: 164-75
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Publication
14993283 | J:89059
First Author: Tomlinson MG
Year: 2004
Journal: Mol Cell Biol
Title: Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
Volume: 24
Issue: 6
Pages: 2455-66
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Publication
11859127 | -
First Author: Takeba Y
Year: 2002
Journal: J Immunol
Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Volume: 168
Issue: 5
Pages: 2365-70
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Protein Domain
IPR035870 | Txk_SH2
Type: Domain
Description: Txk is a member of the Tec protein tyrosine kinase family. It plays a role in TCR signal transduction, T cell development, and selection which is analogous to the function of Itk. Txk has been shown to interact with IFN-gamma [, ]. Unlike most of the Tec family members Txk lacks a PH domain. Instead Txk has a unique region containing a palmitoylated cysteine string which has a similar membrane tethering function as the PH domain []. This entry includes the SH2 domain of Txk.The Tec protein tyrosine kinase family includes Tec,Btk, Itk, Bmx, and Txk. They contain an NH2-terminal pleckstrin homology (PH) domain (absent in Txk), a proline-rich region, Src-homology 3 (SH3) and SH2 domains, and a COOH-terminal PTK domain. The TH domain consists of a Zn2+-binding Btk motif and a proline-rich region. The Btk motif is found in Tec kinases, Ras GAP, and IGBP and crucial to the function of the PH domain. It is not present in Txk which is not surprising since it lacks a PH domain. The type 1 splice form of the Drosophila homologue also lacks both the PH domain and the Btk motif. The proline-rich regions are highly conserved for the most part with the exception of Bmx whose residues surrounding the PXXP motif are not conserved (TH-like) and Btk29A which is entirely unique with large numbers of glycine residues (TH-extended). Tec family members all lack a C-terminal tyrosine having an autoinhibitory function in its phosphorylated state [, ].
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Publication
20206686 | -
First Author: Bradshaw JM
Year: 2010
Journal: Cell Signal
Title: The Src, Syk, and Tec family kinases: distinct types of molecular switches.
Volume: 22
Issue: 8
Pages: 1175-84
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Publication
9761724 | J:50458
 
First Author: Ellis JH
Year: 1998
Journal: Biochem J
Title: Functional analysis of the T-cell-restricted protein tyrosine kinase Txk.
Volume: 335 ( Pt 2)
Pages: 277-84
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Publication
22527282 | J:185810
First Author: Gustafsson MO
Year: 2012
Journal: Mol Cell Biol
Title: Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
Volume: 32
Issue: 13
Pages: 2440-53
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Protein
Q0VBP6
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
B2RQ20
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Publication
17947660 | -
First Author: Cao L
Year: 2007
Journal: J Immunol
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Volume: 179
Issue: 9
Pages: 5864-76
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