|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 482 for Ubc

<< First    < Previous  |  Next >    Last >>
0.031s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
8631027 | J:31358
First Author: Ishiguro T
Year: 1996
Journal: Cancer Res
Title: Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials.
Volume: 56
Issue: 4
Pages: 875-9
•
•
•
•
•
Publication
22878500 | J:187380
First Author: Dey A
Year: 2012
Journal: Science
Title: Loss of the tumor suppressor BAP1 causes myeloid transformation.
Volume: 337
Issue: 6101
Pages: 1541-6
•
•
•
•
•
Publication
39461968 | J:357839
First Author: Nasim S
Year: 2024
Journal: Sci Rep
Title: Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve.
Volume: 14
Issue: 1
Pages: 25481
•
•
•
•
•
Publication
21903422 | J:176666
First Author: Li S
Year: 2011
Journal: Immunity
Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Volume: 35
Issue: 3
Pages: 426-40
•
•
•
•
•
Publication
22734001 | J:185347
First Author: Lim ST
Year: 2012
Journal: J Cell Biol
Title: Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Volume: 197
Issue: 7
Pages: 907-19
•
•
•
•
•
Publication
16717086 | J:116445
First Author: Lin SS
Year: 2006
Journal: J Biol Chem
Title: PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.
Volume: 281
Issue: 32
Pages: 23003-12
•
•
•
•
•
Publication
26811477 | J:230444
First Author: Jahan AS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Volume: 113
Issue: 6
Pages: E705-14
•
•
•
•
•
Publication
21151134 | J:169031
First Author: Sharma M
Year: 2011
Journal: Nat Cell Biol
Title: CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Volume: 13
Issue: 1
Pages: 30-9
•
•
•
•
•
Publication
36069228 | J:330439
 
First Author: Liu H
Year: 2022
Journal: Int J Mol Med
Title: Validation of superior reference genes in mouse submandibular glands under developmental and functional regeneration states.
Volume: 50
Issue: 5
•
•
•
•
•
Publication
20463034 | J:161408
First Author: Wang C
Year: 2010
Journal: Development
Title: Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
Volume: 137
Issue: 12
Pages: 2001-9
•
•
•
•
•
Publication
21765415 | J:176472
First Author: Shembade N
Year: 2011
Journal: Nat Immunol
Title: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Volume: 12
Issue: 9
Pages: 834-43
•
•
•
•
•
Publication
21690297 | J:175085
First Author: Le Masson F
Year: 2011
Journal: Mol Cell Biol
Title: Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Volume: 31
Issue: 16
Pages: 3410-23
•
•
•
•
•
Publication
9321482 | J:36975
First Author: Klingenspor M
Year: 1997
Journal: Mamm Genome
Title: Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18.
Volume: 8
Issue: 10
Pages: 789-90
•
•
•
•
•
Publication
28413018 | J:240526
First Author: Hall EA
Year: 2017
Journal: Am J Hum Genet
Title: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Volume: 100
Issue: 5
Pages: 706-724
•
•
•
•
•
Publication
10438476 | J:42314
First Author: Klingenspor M
Year: 1999
Journal: J Biol Chem
Title: Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.
Volume: 274
Issue: 33
Pages: 23078-84
•
•
•
•
•
Publication
28262664 | J:245009
 
First Author: Himmels P
Year: 2017
Journal: Nat Commun
Title: Motor neurons control blood vessel patterning in the developing spinal cord.
Volume: 8
Pages: 14583
•
•
•
•
•
Publication
17095659 | J:116164
First Author: Dequéant ML
Year: 2006
Journal: Science
Title: A complex oscillating network of signaling genes underlies the mouse segmentation clock.
Volume: 314
Issue: 5805
Pages: 1595-8
•
•
•
•
•
Publication
22001906 | J:178114
First Author: Pei L
Year: 2011
Journal: Nat Med
Title: Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Volume: 17
Issue: 11
Pages: 1466-72
•
•
•
•
•
Publication
17634366 | J:145263
First Author: Werner HB
Year: 2007
Journal: J Neurosci
Title: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Volume: 27
Issue: 29
Pages: 7717-30
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Protein
Q8R0Z9
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
•
•
•
•
•
Protein
Q922Z8
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
Q922B0
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
•
•
•
•
•
Protein
Q8VC46
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
•
•
•
•
•
Protein
Q541Z5
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
•
•
•
•
•
Protein
Q3TL77
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
•
•
•
•
•
Protein
Q5F239
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
•
•
•
•
•
Protein
Q3TIH9
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
•
•
•
•
•
Protein
Q9D7F5
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
•
•
•
•
•
Protein
Q9D1S1
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
•
•
•
•
•
Protein
Q3V2N4
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: false
•
•
•
•
•
Protein
Q3UWQ1
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
•
•
•
•
•
Protein
Q3TUV9
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
•
•
•
•
•
Protein
Q3UWG7
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
•
•
•
•
•
Protein
Q3UT95
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
•
•
•
•
•
Protein
Q3UCS1
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
•
•
•
•
•
Protein
Q3UFQ4
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
•
•
•
•
•
Protein
Q3U5V6
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
•
•
•
•
•
Protein
Q3U431
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
•
•
•
•
•
Protein
Q3TS71
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
•
•
•
•
•
Protein
Q3UDP8
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
•
•
•
•
•
Protein
Q3TV38
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
•
•
•
•
•
Protein
Q3TTE3
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
•
•
•
•
•
Publication
11406273 | J:70056
First Author: Franko J
Year: 2001
Journal: Biochim Biophys Acta
Title: Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis.
Volume: 1519
Issue: 1-2
Pages: 70-7
•
•
•
•
•
Protein
A0A1S6GWH6
Organism: Mus musculus/domesticus
Length: 4939  
Fragment?: false
•
•
•
•
•
Protein
A0A1S6GWH3
Organism: Mus musculus/domesticus
Length: 4882  
Fragment?: false
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7327559
Assay Type: RNA in situ
Annotation Date: 2022-08-08
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1824922
Pattern: Punctate
Stage: TS22
Assay Id: MGI:7327633
Age: embryonic day 14.5
Image: 1F
Note: High level of expression in puncta, equivalent to Ubc positive control.
Specimen Label: 1F
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7327559
Assay Type: RNA in situ
Annotation Date: 2022-08-08
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1824922
Pattern: Punctate
Stage: TS22
Assay Id: MGI:7327633
Age: embryonic day 14.5
Image: 1F
Note: High level of expression in puncta, equivalent to Ubc positive control.
Specimen Label: 1F
Detected: true
Specimen Num: 1
•
•
•
•
•
Interaction Experiment
Franko J (2001)
Description: Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis.
•
•
•
•
•
Allele
Tg(UBC-Mtf1)1Wsc | MGI:3046547
Name: transgene insertion 1, Walter Schaffner
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(UBC-DsRed,-emGFP)22Narl | MGI:7434304
Name: transgene insertion 22, National Applied Research Laboratories
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
Allele
Hprt1<tm1(UBC-UBB)Rrk> | MGI:3715138
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Ron R Kopito
Allele Type: Targeted
Attribute String: Inserted expressed sequence
•
•
•
•
•
Publication
35408794 | J:337125
 
First Author: Lee CM
Year: 2022
Journal: Int J Mol Sci
Title: Thrombin-Activated Platelets Protect Vascular Endothelium against Tumor Cell Extravasation by Targeting Endothelial VCAM-1.
Volume: 23
Issue: 7
•
•
•
•
•
Allele
Tn(pb-UBC-Trim24)1Mcba | MGI:7398503
Name: transposon insertion 1, Michelle Craig Barton
Allele Type: Transposon induced
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
•
•
•
•
•
Allele
Tg(UBC-CGB)1Hht | MGI:2445958
Name: transgene insertion 1, Ilpo Huhtaniemi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Arsb<tm1.1Anec> | MGI:7569014
Name: arylsulfatase B; targeted mutation 1.1, Aris Economides
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
•
•
•
•
•
Allele
Adgrf5<tm1Vlcg> | MGI:5924942
Name: adhesion G protein-coupled receptor F5; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(UBC-EGFP)Fcam> | MGI:7526265
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Fernando Camargo
Allele Type: Targeted
Attribute String: Lineage barcode, Reporter
•
•
•
•
•
Genotype
Genotype
Symbol: Hprt1/? Ubc/Ubc
Background: involves: 129 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Hprt1/Hprt1 Ubc/Ubc
Background: involves: 129 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gpr52-cre)116FKohi/?
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gpr52-cre)116FKohi/?
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
20211139 | J:167955
First Author: Greer PL
Year: 2010
Journal: Cell
Title: The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
Volume: 140
Issue: 5
Pages: 704-16
•
•
•
•
•
Publication
12239120 | J:79060
First Author: Rulli SB
Year: 2002
Journal: Endocrinology
Title: Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin.
Volume: 143
Issue: 10
Pages: 4084-95
•
•
•
•
•
Publication
12960071 | J:87234
First Author: Rulli SB
Year: 2003
Journal: Endocrinology
Title: Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin.
Volume: 144
Issue: 11
Pages: 4980-90
•
•
•
•
•
Publication
30410667 | J:298065
First Author: Singh P
Year: 2018
Journal: Oncotarget
Title: The transgenic expression of the β-subunit of human chorionic gonadotropin influences the growth of implanted tumor cells.
Volume: 9
Issue: 78
Pages: 34670-34680
•
•
•
•
•
Publication
23593454 | J:200025
First Author: Bose A
Year: 2013
Journal: PLoS One
Title: Synergistic activation of innate and adaptive immune mechanisms in the treatment of gonadotropin-sensitive tumors.
Volume: 8
Issue: 4
Pages: e61288
•
•
•
•
•
Publication
23117930 | J:192840
First Author: Ratner LD
Year: 2012
Journal: Endocrinology
Title: Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility.
Volume: 153
Issue: 12
Pages: 5980-92
•
•
•
•
•
Publication
23226476 | J:194993
First Author: Sachdeva R
Year: 2012
Journal: PLoS One
Title: Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.
Volume: 7
Issue: 11
Pages: e51125
•
•
•
•
•
Publication
24755422 | J:212323
First Author: Gonzalez B
Year: 2014
Journal: Mol Cell Endocrinol
Title: Elevated hypothalamic aromatization at the onset of precocious puberty in transgenic female mice hypersecreting human chorionic gonadotropin: effect of androgens.
Volume: 390
Issue: 1-2
Pages: 102-11
•
•
•
•
•
Publication
17510243 | J:123842
First Author: Kuorelahti A
Year: 2007
Journal: Endocrinology
Title: Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.
Volume: 148
Issue: 8
Pages: 3694-703
•
•
•
•
•
Publication
16007123 | J:102880
First Author: Ahtiainen P
Year: 2005
Journal: Oncogene
Title: Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.
Volume: 24
Issue: 49
Pages: 7301-9
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(UBC-HEL3x,-HEL4x)Rbr> | MGI:5467327
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Robert Brink
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
Publication
37751300 | J:343559
 
First Author: Hwang-Wong E
Year: 2023
Journal: JCI Insight
Title: Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development.
Volume: 8
Issue: 21
•
•
•
•
•
Genotype
Genotype
Symbol: Mtf1/Mtf1 Tg(UBC-Mtf1)1Wsc/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
10350465 | -
First Author: Jiang F
Year: 1999
Journal: Biochemistry
Title: Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution.
Volume: 38
Issue: 20
Pages: 6471-8
•
•
•
•
•
Protein Domain
IPR023313 | UBQ-conjugating_AS
Type: Active_site
Description: Ubiquitin-conjugating enzymes (, UBC or E2 enzymes) catalyse the covalent attachment of ubiquitin to target proteins. Ubiquitin is conjugated to the target protein through the coordinated action of three enzyme activities designated E1, E2, and E3. The E1 or ubiquitin-activating enzyme forms, in an ATP-dependent manner, a thioester linkage between its active site cysteine and the carboxy terminus of ubiquitin. The activated ubiquitin moiety is then transferred from E1 to the active site cysteine in E2 through a trans-thiol esterification reaction. The UBC enzyme later ligates ubiquitin directly to substrate proteins with or without the assistance of 'N-end' recognizing proteins (E3) [, , ]. In most species there are many forms of UBC (at least 9 in yeast) which are implicated in diverse cellular functions. A cysteine residue is required for ubiquitin-thiolester formation. There is a single conserved cysteine in UBC's and the region around that residue is conserved in the sequence of known UBC isozymes. The UBC core is an alpha/beta domain containing one four-stranded antiparallel β-sheet and four α-helices (). Three of these helices flank two opposite edges of the sheet, and one helix lays diagonally across one broad face of the sheet. The other face of the sheet is exposed to solvent. One turn of a 3(10)-helix is located between the fourth strand of the sheet and the second α-helix. The active site cysteine is situated in a segment between the fourth strand of the sheet and the 3(10)-helix []. The signature pattern, of this entry, contains the active-site cysteine and spans the complete catalytic domain.
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom