Type |
Details |
Score |
Publication |
First Author: |
Miletic AV |
Year: |
2007 |
Journal: |
Blood |
Title: |
Vav proteins control MyD88-dependent oxidative burst. |
Volume: |
109 |
Issue: |
8 |
Pages: |
3360-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham DB |
Year: |
2007 |
Journal: |
J Clin Invest |
Title: |
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. |
Volume: |
117 |
Issue: |
11 |
Pages: |
3445-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu JY |
Year: |
2009 |
Journal: |
J Cell Sci |
Title: |
Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. |
Volume: |
122 |
Issue: |
Pt 3 |
Pages: |
324-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acton SE |
Year: |
2012 |
Journal: |
Immunity |
Title: |
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. |
Volume: |
37 |
Issue: |
2 |
Pages: |
276-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stephenson LM |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Vav proteins regulate the plasma cell program and secretory Ig production. |
Volume: |
177 |
Issue: |
12 |
Pages: |
8620-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhavsar PJ |
Year: |
2009 |
Journal: |
Exp Cell Res |
Title: |
Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. |
Volume: |
315 |
Issue: |
19 |
Pages: |
3345-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mattila PK |
Year: |
2013 |
Journal: |
Immunity |
Title: |
The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. |
Volume: |
38 |
Issue: |
3 |
Pages: |
461-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahaman SO |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. |
Volume: |
286 |
Issue: |
9 |
Pages: |
7010-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Graham DB |
Year: |
2007 |
Journal: |
J Exp Med |
Title: |
An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. |
Volume: |
204 |
Issue: |
12 |
Pages: |
2889-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gmyrek GB |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e76145 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dumont C |
Year: |
2009 |
Journal: |
Blood |
Title: |
Rac GTPases play critical roles in early T-cell development. |
Volume: |
113 |
Issue: |
17 |
Pages: |
3990-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henderson RB |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. |
Volume: |
207 |
Issue: |
4 |
Pages: |
837-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arana E |
Year: |
2008 |
Journal: |
Immunity |
Title: |
Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. |
Volume: |
28 |
Issue: |
1 |
Pages: |
88-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan D |
Year: |
2015 |
Journal: |
Blood |
Title: |
P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. |
Volume: |
125 |
Issue: |
7 |
Pages: |
1146-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin H |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. |
Volume: |
123 |
Issue: |
10 |
Pages: |
4449-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hall AB |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. |
Volume: |
24 |
Issue: |
3 |
Pages: |
305-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lawson CD |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. |
Volume: |
186 |
Issue: |
3 |
Pages: |
1467-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Damoulakis G |
Year: |
2014 |
Journal: |
J Cell Sci |
Title: |
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. |
Volume: |
127 |
Issue: |
Pt 11 |
Pages: |
2589-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Janas ML |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Interaction of Ras with p110γ is required for thymic β-selection in the mouse. |
Volume: |
187 |
Issue: |
9 |
Pages: |
4667-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vigorito E |
Year: |
2005 |
Journal: |
Blood |
Title: |
Vav proteins regulate peripheral B-cell survival. |
Volume: |
106 |
Issue: |
7 |
Pages: |
2391-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kant S |
Year: |
2011 |
Journal: |
Genes Dev |
Title: |
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. |
Volume: |
25 |
Issue: |
19 |
Pages: |
2069-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Treanor B |
Year: |
2010 |
Journal: |
Immunity |
Title: |
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor. |
Volume: |
32 |
Issue: |
2 |
Pages: |
187-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roth S |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity. |
Volume: |
17 |
Issue: |
10 |
Pages: |
2572-2583 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kant S |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. |
Volume: |
20 |
Issue: |
12 |
Pages: |
2775-2783 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nordstrand LM |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. |
Volume: |
5 |
Issue: |
11 |
Pages: |
e13827 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong Z |
Year: |
2012 |
Journal: |
Immunity |
Title: |
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. |
Volume: |
36 |
Issue: |
6 |
Pages: |
974-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johansson MH |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice. |
Volume: |
177 |
Issue: |
11 |
Pages: |
7923-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glassmann A |
Year: |
2009 |
Journal: |
Neuroscience |
Title: |
Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors. |
Volume: |
159 |
Issue: |
1 |
Pages: |
69-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spies T |
Year: |
1991 |
Journal: |
Nature |
Title: |
Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. |
Volume: |
351 |
Issue: |
6324 |
Pages: |
323-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyle KB |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. |
Volume: |
186 |
Issue: |
5 |
Pages: |
2978-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quesnel-Vallières M |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. |
Volume: |
64 |
Issue: |
6 |
Pages: |
1023-1034 |
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•
•
•
•
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Publication |
First Author: |
Quesnel-Vallières M |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. |
Volume: |
29 |
Issue: |
7 |
Pages: |
746-59 |
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•
•
•
•
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Publication |
First Author: |
Lee CG |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Genetic mapping of eight SH3 domain genes on seven mouse chromosomes. |
Volume: |
10 |
Issue: |
4 |
Pages: |
402-4 |
|
•
•
•
•
•
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Publication |
First Author: |
Pilz A |
Year: |
1995 |
Journal: |
Genomics |
Title: |
Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse. |
Volume: |
25 |
Issue: |
1 |
Pages: |
139-49 |
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•
•
•
•
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Publication |
First Author: |
Quina LA |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. |
Volume: |
29 |
Issue: |
45 |
Pages: |
14309-22 |
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•
•
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•
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Publication |
First Author: |
Miller JA |
Year: |
2013 |
Journal: |
Development |
Title: |
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. |
Volume: |
140 |
Issue: |
22 |
Pages: |
4633-44 |
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•
•
•
•
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Publication |
First Author: |
Freeman TC |
Year: |
1998 |
Journal: |
MGI Direct Data Submission |
Title: |
Expression Mapping of Mouse Genes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
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•
•
•
•
•
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Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
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Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
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Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
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Pages: |
686034 |
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
GOA curators |
Year: |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
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Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
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Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
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Journal: |
Database Release |
Title: |
Entrez Gene Load |
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First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
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Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Journal: |
Database Download |
Title: |
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Mouse Genome Informatics Group |
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Database Procedure |
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Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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•
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Publication |
First Author: |
Moon MS |
Year: |
2010 |
Journal: |
Mol Cell Neurosci |
Title: |
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. |
Volume: |
44 |
Issue: |
2 |
Pages: |
118-28 |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
868
 |
Fragment?: |
false |
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•
•
•
•
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UniProt Feature |
Begin: |
1 |
Description: |
Guanine nucleotide exchange factor VAV2 |
Type: |
chain |
End: |
868 |
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•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2. |
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Protein Domain |
Type: |
Domain |
Description: |
VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2. |
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Publication |
First Author: |
Krause-Gruszczynska M |
Year: |
2011 |
Journal: |
Cell Commun Signal |
Title: |
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. |
Volume: |
9 |
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Pages: |
32 |
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Publication |
First Author: |
Holthusen K |
Year: |
2009 |
Journal: |
Am J Ther |
Title: |
Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease. |
Volume: |
16 |
Issue: |
6 |
Pages: |
496-507 |
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Publication |
First Author: |
Arora PD |
Year: |
2008 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2. |
Volume: |
295 |
Issue: |
1 |
Pages: |
C130-7 |
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Publication |
First Author: |
Heo J |
Year: |
2005 |
Journal: |
Biochemistry |
Title: |
Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors. |
Volume: |
44 |
Issue: |
17 |
Pages: |
6573-85 |
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Publication |
First Author: |
Romero F |
Year: |
1996 |
Journal: |
Cell Signal |
Title: |
Structure and function of vav. |
Volume: |
8 |
Issue: |
8 |
Pages: |
545-53 |
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Publication |
First Author: |
Tybulewicz VL |
Year: |
2005 |
Journal: |
Curr Opin Immunol |
Title: |
Vav-family proteins in T-cell signalling. |
Volume: |
17 |
Issue: |
3 |
Pages: |
267-74 |
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Publication |
First Author: |
Hornstein I |
Year: |
2004 |
Journal: |
Cell Signal |
Title: |
Vav proteins, masters of the world of cytoskeleton organization. |
Volume: |
16 |
Issue: |
1 |
Pages: |
1-11 |
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Allele |
Name: |
vav 2 oncogene; targeted mutation 1, Xose R Bustelo |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Constitutively active, Inserted expressed sequence |
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Allele |
Name: |
vav 2 oncogene; targeted mutation 1.1, Xose R Bustelo |
Allele Type: |
Targeted |
Attribute String: |
Constitutively active, Inserted expressed sequence |
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Publication |
First Author: |
Liu S |
Year: |
2016 |
Journal: |
FEBS Lett |
Title: |
Structural basis for a novel interaction between TXNIP and Vav2. |
Volume: |
590 |
Issue: |
6 |
Pages: |
857-65 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH2 domain of VAV2, which is a member of the VAV family. The SH2 domain of VAV2 has been shown to interact with PPxY motifs of TXNIP (thioredoxin-interacting protein) []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. |
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Publication |
First Author: |
Hawkins MB |
Year: |
2021 |
Journal: |
Cell |
Title: |
Latent developmental potential to form limb-like skeletal structures in zebrafish. |
Volume: |
184 |
Issue: |
4 |
Pages: |
899-911.e13 |
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Publication |
First Author: |
Liu Y |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. |
Volume: |
201 |
Issue: |
6 |
Pages: |
863-73 |
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Publication |
First Author: |
Erasmus JC |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Defining functional interactions during biogenesis of epithelial junctions. |
Volume: |
7 |
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Pages: |
13542 |
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Publication |
First Author: |
Faccio R |
Year: |
2005 |
Journal: |
Nat Med |
Title: |
Vav3 regulates osteoclast function and bone mass. |
Volume: |
11 |
Issue: |
3 |
Pages: |
284-90 |
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Publication |
First Author: |
Ulc A |
Year: |
2017 |
Journal: |
Biol Chem |
Title: |
Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity. |
Volume: |
398 |
Issue: |
5-6 |
Pages: |
663-675 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH2 domain of VAV3, which belongs to the VAV family. VAV3 is involved in the regulation of osteoclast function []and in central nervous system development and plasticity [].The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. |
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Publication |
First Author: |
Trenkle T |
Year: |
2000 |
Journal: |
Gene |
Title: |
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. |
Volume: |
245 |
Issue: |
1 |
Pages: |
139-49 |
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Publication |
First Author: |
Dekel I |
Year: |
2000 |
Journal: |
FEBS Lett |
Title: |
Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav. |
Volume: |
472 |
Issue: |
1 |
Pages: |
99-104 |
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Publication |
First Author: |
Fernández-Espartero CH |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation. |
Volume: |
126 |
Issue: |
Pt 10 |
Pages: |
2285-93 |
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Publication |
First Author: |
Swat W |
Year: |
2005 |
Journal: |
Immunol Res |
Title: |
The Vav family: at the crossroads of signaling pathways. |
Volume: |
32 |
Issue: |
1-3 |
Pages: |
259-65 |
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Publication |
First Author: |
Fang WB |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. |
Volume: |
283 |
Issue: |
23 |
Pages: |
16017-26 |
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Publication |
First Author: |
Angibaud J |
Year: |
2011 |
Journal: |
J Neurochem |
Title: |
The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis. |
Volume: |
119 |
Issue: |
4 |
Pages: |
708-22 |
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Publication |
First Author: |
Takahashi M |
Year: |
2008 |
Journal: |
Genes Cells |
Title: |
Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells. |
Volume: |
13 |
Issue: |
6 |
Pages: |
549-69 |
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Publication |
First Author: |
Donnelly SK |
Year: |
2017 |
Journal: |
J Cell Biol |
Title: |
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. |
Volume: |
216 |
Issue: |
12 |
Pages: |
4331-4349 |
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