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Search results 201 to 234 out of 234 for Wdr4

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Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Type: chain
End: 413
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Protein
E9Q1L4
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Gene
100423801 | LOC100423801
Type: gene
Organism: macaque, rhesus
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Gene
100424812 | LOC100424812
Type: gene
Organism: macaque, rhesus
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Protein
F6VLT8
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Protein
Q9EP82
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A0A494B9R5
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: true
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Protein
A0A494BBN7
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
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Protein
A0A494B9T1
Organism: Mus musculus/domesticus
Length: 33  
Fragment?: true
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Protein
F6YNC4
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Interaction Experiment
Wu PR (2023)
Description: Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation.
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Publication
29983320 | -
First Author: Lin S
Year: 2018
Journal: Mol Cell
Title: Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
Volume: 71
Issue: 2
Pages: 244-255.e5
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DO Term
DOID:0081051 | microcephaly, growth deficiency, seizures, and brain malformations
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Publication
31031083 | -
First Author: Pandolfini L
Year: 2019
Journal: Mol Cell
Title: METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.
Volume: 74
Issue: 6
Pages: 1278-1290.e9
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Publication
31031084 | -
First Author: Zhang LS
Year: 2019
Journal: Mol Cell
Title: Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Volume: 74
Issue: 6
Pages: 1304-1316.e8
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Protein Domain
IPR028884 | Trm82
Type: Family
Description: This entry represents tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit Trm82 and its homologues, wuho from flies and WDR4 from humans. In Saccharomyces cerevisiae, Trm82 is the non-catalytic subunit of the tRNA methyltransferase complex which consists of Trm8 and Trm82 [, ]. It is essential for the enzyme activity and may function in regulating the the Trm8 protein []. In humans, WDR4 forms the tRNA methyltransferase complex with METTL1 (Trm8 homologue). It is required to stabilise and induce conformational changes of the catalytic subunit METTL1 []. It is required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA [, ]and also for the formation of N7-methylguanine at internal sites in a subset of mRNAs []. WDR4 is also involved in the methylation of a specific subset of miRNAs, such as let-7 []. Independently of METTL1, it also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 [].
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Publication
18184583 | -
First Author: Leulliot N
Year: 2008
Journal: Structure
Title: Structure of the yeast tRNA m7G methylation complex.
Volume: 16
Issue: 1
Pages: 52-61
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Publication
17382321 | -
First Author: Matsumoto K
Year: 2007
Journal: FEBS Lett
Title: RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex).
Volume: 581
Issue: 8
Pages: 1599-604
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Publication
35304469 | J:322611
First Author: Han H
Year: 2022
Journal: Nat Commun
Title: N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.
Volume: 13
Issue: 1
Pages: 1478
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Publication
12403464 | -
First Author: Alexandrov A
Year: 2002
Journal: RNA
Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.
Volume: 8
Issue: 10
Pages: 1253-66
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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