Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Sang Q |
Year: |
2018 |
Journal: |
Am J Hum Genet |
Title: |
Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. |
Volume: |
102 |
Issue: |
4 |
Pages: |
649-657 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Brain |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Thymus |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Heart |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Lung |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737327 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Kidney |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684627 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Liver |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2991527 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Uterus |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797227 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Testis |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796227 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852168 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Ovary |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796220 |
|
Stage: |
TS20 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 12.5 |
Image: |
5 |
|
Specimen Label: |
E12.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796220 |
|
Stage: |
TS20 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 12.5 |
Image: |
5 |
|
Specimen Label: |
E12.5 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 14.5 |
Image: |
5 |
|
Specimen Label: |
E14.5 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 14.5 |
Image: |
5 |
|
Specimen Label: |
E14.5 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796225 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 17.5 |
Image: |
5 |
|
Specimen Label: |
E17.5 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796225 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3852170 |
Age: |
embryonic day 17.5 |
Image: |
5 |
|
Specimen Label: |
E17.5 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796227 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852170 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Newborn |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3851955 |
Assay Type: |
RT-PCR |
Annotation Date: |
2009-08-06 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796227 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3852170 |
Age: |
postnatal newborn |
Image: |
5 |
|
Specimen Label: |
Newborn |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369796 |
Assay Type: |
Western blot |
Annotation Date: |
2019-11-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3570528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6369820 |
Age: |
postnatal adult |
|
|
Specimen Label: |
GV |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369796 |
Assay Type: |
Western blot |
Annotation Date: |
2019-11-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3575528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6369820 |
Age: |
postnatal adult |
|
|
Specimen Label: |
MII |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3570528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6369822 |
Age: |
postnatal adult |
|
|
Specimen Label: |
GV |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3575528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6369822 |
Age: |
postnatal adult |
|
|
Specimen Label: |
MII |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160331 |
|
Stage: |
TS01 |
Assay Id: |
MGI:6369822 |
Age: |
embryonic day 0.5 |
|
|
Specimen Label: |
1-cell |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:160362 |
|
Stage: |
TS02 |
Assay Id: |
MGI:6369822 |
Age: |
embryonic day 1.0 |
|
|
Specimen Label: |
2-cell |
|
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:318643 |
|
Stage: |
TS03 |
Assay Id: |
MGI:6369822 |
Age: |
embryonic day 2.0 |
|
|
Specimen Label: |
4-cell |
|
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:318653 |
|
Stage: |
TS03 |
Assay Id: |
MGI:6369822 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-cell |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6369798 |
Assay Type: |
RT-PCR |
Annotation Date: |
2019-11-06 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:360354 |
|
Stage: |
TS04 |
Assay Id: |
MGI:6369822 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
blastocyst |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_07 |
|
Specimen Label: |
euxassay_004978_07 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_08 |
|
Specimen Label: |
euxassay_004978_08 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_09 |
|
Specimen Label: |
euxassay_004978_09 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_10 |
|
Specimen Label: |
euxassay_004978_10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_11 |
|
Specimen Label: |
euxassay_004978_11 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_13 |
|
Specimen Label: |
euxassay_004978_13 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_14 |
|
Specimen Label: |
euxassay_004978_14 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_15 |
|
Specimen Label: |
euxassay_004978_15 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_16 |
|
Specimen Label: |
euxassay_004978_16 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_17 |
|
Specimen Label: |
euxassay_004978_17 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3119322 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4829214 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004978_18 |
|
Specimen Label: |
euxassay_004978_18 |
Detected: |
true |
Specimen Num: |
11 |
|
•
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GXD Expression |
Probe: |
MGI:3851950 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-06 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3852183 |
Age: |
postnatal adult |
Image: |
6I |
|
Specimen Label: |
6I |
Detected: |
true |
Specimen Num: |
1 |
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•
•
•
•
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Strain |
Attribute String: |
mutant strain, coisogenic, endonuclease-mediated mutation |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Allele |
Name: |
WEE1 homolog 2 (S. pombe); endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Allele |
Name: |
WEE1 homolog 2 (S. pombe); endonuclease-mediated mutation 4, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
WEE1 homolog 2 (S. pombe); endonuclease-mediated mutation 1, Martin M Matzuk |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
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•
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Allele |
Name: |
WEE1 homolog 2 (S. pombe); endonuclease-mediated mutation 2, Martin M Matzuk |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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•
•
•
•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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•
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Genotype |
Symbol: |
Wee2/Wee2 |
Background: |
C57BL/6NJ-Wee2/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
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Publication |
First Author: |
Yu ZY |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase. |
Volume: |
126 |
Issue: |
Pt 21 |
Pages: |
4995-5004 |
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•
•
•
•
•
|
Genotype |
Symbol: |
Wee2/Wee2 |
Background: |
involves: C57BL/6J * DBA/2J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Wee2/Wee2 |
Background: |
involves: C57BL/6J * DBA/2J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Publication |
First Author: |
Muñoz MJ |
Year: |
1999 |
Journal: |
Genetics |
Title: |
The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts. |
Volume: |
153 |
Issue: |
4 |
Pages: |
1561-72 |
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•
•
•
•
•
|
Publication |
First Author: |
Francis D |
Year: |
2007 |
Journal: |
New Phytol |
Title: |
The plant cell cycle--15 years on. |
Volume: |
174 |
Issue: |
2 |
Pages: |
261-278 |
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•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
PKs catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This entry includes Wee1 from Arabidopsis. Wee1 is a cell cycle checkpoint kinase that is involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis [, ]. It has been shown that Arabidopsis Wee1 directly interacts with and phosphorylates the E3 ubiquitin ligase FBL17 that promotes the degradation of CDK inhibitors []. |
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•
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•
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Publication |
First Author: |
Kamata M |
Year: |
2008 |
Journal: |
J Virol |
Title: |
Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2. |
Volume: |
82 |
Issue: |
12 |
Pages: |
5672-82 |
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•
•
•
•
•
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Publication |
First Author: |
Oh JS |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. |
Volume: |
188 |
Issue: |
2 |
Pages: |
199-207 |
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•
•
•
•
•
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Publication |
First Author: |
Li Y |
Year: |
2015 |
Journal: |
MGI Direct Data Submission |
Title: |
Direct data submission for endonuclease mediated alleles from the Institute of Neuroscience, Chinese Academy of Sciences |
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•
•
•
•
•
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Publication |
First Author: |
Su YQ |
Year: |
2012 |
Journal: |
Science |
Title: |
MARF1 regulates essential oogenic processes in mice. |
Volume: |
335 |
Issue: |
6075 |
Pages: |
1496-9 |
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•
•
•
•
•
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Publication |
First Author: |
Joshi S |
Year: |
2007 |
Journal: |
BMC Dev Biol |
Title: |
Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. |
Volume: |
7 |
|
Pages: |
67 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray S |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. |
Volume: |
32 |
Issue: |
1 |
Pages: |
107858 |
|
•
•
•
•
•
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Publication |
First Author: |
Li B |
Year: |
2022 |
Journal: |
Blood |
Title: |
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation. |
Volume: |
139 |
Issue: |
25 |
Pages: |
3630-3646 |
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•
•
•
•
•
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Publication |
First Author: |
Mohamed TMA |
Year: |
2018 |
Journal: |
Cell |
Title: |
Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. |
Volume: |
173 |
Issue: |
1 |
Pages: |
104-116.e12 |
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•
•
•
•
•
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Publication |
First Author: |
Ruiz S |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors. |
Volume: |
62 |
Issue: |
2 |
Pages: |
307-13 |
|
•
•
•
•
•
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Publication |
First Author: |
Ayad NG |
Year: |
2003 |
Journal: |
Cell |
Title: |
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. |
Volume: |
113 |
Issue: |
1 |
Pages: |
101-13 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
187
 |
Fragment?: |
true |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
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•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes cell division cycle-associated protein 3 (CDCA3; also known as trigger of mitotic entry protein 1 or TOME-1), which is required for entry into mitosis. The protein is found at high levels during the G2 and M phases of mitosis, but declines rapidly during the G2 phase. Entry into mitosis requires the relocalization to the nucleus and activation of cyclin-dependent kinase 1 (cdk1) by association with cyclin B, and exit from mitosis occurs when cyclin B is degraded and the kinase activity decreases. Anaphase promoting complex (APC) is an E3 ligase active during anaphase and G1, and is required for the degradation of cyclin B. CDCA3 is a cytosolic protein and a substrate of APC. It associates with Skp-1 and is required for the degradation of the cdk1 inhibitor wee1, a tyrosine kinase. Degradation of CDCA3 leads to an accumulation of wee1 during interphase []. The CDCA3 protein contains an F-box-like region and a KEN box; the latter is required for association with the APC complex. |
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Publication |
First Author: |
Xu X |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy. |
Volume: |
28 |
Issue: |
5 |
Pages: |
842-857 |
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•
•
•
•
•
|
Publication |
First Author: |
Pagel R |
Year: |
2017 |
Journal: |
FASEB J |
Title: |
Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. |
Volume: |
31 |
Issue: |
11 |
Pages: |
4707-4719 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szmyd R |
Year: |
2019 |
Journal: |
Oncogene |
Title: |
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality. |
Volume: |
38 |
Issue: |
7 |
Pages: |
998-1018 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu D |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes. |
Volume: |
48 |
Issue: |
10 |
Pages: |
5349-5365 |
|
•
•
•
•
•
|
Publication |
First Author: |
Molinuevo R |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation. |
Volume: |
15 |
Issue: |
1 |
Pages: |
3288 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh P |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The genetics of human infertility by functional interrogation of SNPs in mice. |
Volume: |
112 |
Issue: |
33 |
Pages: |
10431-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forester CM |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. |
Volume: |
104 |
Issue: |
50 |
Pages: |
19867-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soták M |
Year: |
2013 |
Journal: |
Int J Cancer |
Title: |
An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors. |
Volume: |
132 |
Issue: |
5 |
Pages: |
1032-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatano K |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation. |
Volume: |
43 |
Issue: |
8 |
Pages: |
4075-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mteyrek A |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
Clock gene Per2 as a controller of liver carcinogenesis. |
Volume: |
7 |
Issue: |
52 |
Pages: |
85832-85847 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taylor A |
Year: |
2023 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Repurposing a Cyclin-Dependent Kinase 1 (CDK1) Mitotic Regulatory Network to Complete Terminal Differentiation in Lens Fiber Cells. |
Volume: |
64 |
Issue: |
2 |
Pages: |
6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu WC |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e0117246 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borden A |
Year: |
2019 |
Journal: |
Circ Res |
Title: |
Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury. |
Volume: |
125 |
Issue: |
1 |
Pages: |
14-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu C |
Year: |
2013 |
Journal: |
Science |
Title: |
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. |
Volume: |
342 |
Issue: |
6165 |
Pages: |
1518-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rong Y |
Year: |
2019 |
Journal: |
Nucleic Acids Res |
Title: |
ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. |
Volume: |
47 |
Issue: |
21 |
Pages: |
11387-11402 |
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•
•
•
•
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