Type |
Details |
Score |
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Serine/threonine-protein kinase WNK4 |
Type: |
chain |
End: |
1222 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
371 |
Description: |
Phosphoserine; by WNK1 and WNK4 |
Type: |
modified residue |
End: |
371 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu G |
Year: |
2013 |
Journal: |
FEBS Lett |
Title: |
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. |
Volume: |
587 |
Issue: |
12 |
Pages: |
1717-22 |
|
•
•
•
•
•
|
Allele |
Name: |
WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 1, Chih-Jen Cheng |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1222
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
285
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
413
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
30
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin DH |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK). |
Volume: |
112 |
Issue: |
14 |
Pages: |
4495-500 |
|
•
•
•
•
•
|
Allele |
Name: |
WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Tatum R |
Year: |
2007 |
Journal: |
FEBS Lett |
Title: |
WNK4 phosphorylates ser(206) of claudin-7 and promotes paracellular Cl(-) permeability. |
Volume: |
581 |
Issue: |
20 |
Pages: |
3887-91 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohta A |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. |
Volume: |
451 |
Issue: |
1 |
Pages: |
111-22 |
|
•
•
•
•
•
|
Allele |
Name: |
WNK lysine deficient protein kinase 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Shinichi Uchida |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Cayuqueo KI |
Year: |
2018 |
Journal: |
Kidney Int |
Title: |
A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis. |
Volume: |
94 |
Issue: |
3 |
Pages: |
514-523 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Richard P Lifton |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Richard P Lifton |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Slc12a3/Slc12a3 Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3653659 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-09-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3592628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3653660 |
Age: |
postnatal |
|
|
Specimen Label: |
wt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3653659 |
Assay Type: |
Northern blot |
Annotation Date: |
2006-09-06 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3592628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3653660 |
Age: |
postnatal |
|
|
Specimen Label: |
db/db |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boyden LM |
Year: |
2012 |
Journal: |
Nature |
Title: |
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. |
Volume: |
482 |
Issue: |
7383 |
Pages: |
98-102 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Kelch-like protein 3 (KLHL3) is a substrate adaptor protein in the CUL3-KLHL3 E3 ubiquitin ligase complex. It targets WNK4 kinase 1 for ubiquitination and degradation, which in turn regulates electrolyte homeostasis []. Mutations in the KLHL3 gene cause cause pseudohypoaldosteronism type II (PHAII), which is a rare Mendelian syndrome featuring hypertension and hyperkalemia resulting from constitutive renal salt reabsorption and impaired K(+) secretion [, ]. The CUL3-KLHL3 E3 ligase complex may regulate blood pressure via its ability to interact with and ubiquitylate WNK isoforms [, ].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato A |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
WNK signaling is involved in neural development via Lhx8/Awh expression. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e55301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee BH |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. |
Volume: |
282 |
Issue: |
25 |
Pages: |
17985-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki E |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. |
Volume: |
37 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Richards J |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. |
Volume: |
289 |
Issue: |
17 |
Pages: |
11791-806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oi K |
Year: |
2012 |
Journal: |
Biol Open |
Title: |
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. |
Volume: |
1 |
Issue: |
2 |
Pages: |
120-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Araki Y |
Year: |
2015 |
Journal: |
Biol Open |
Title: |
Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene. |
Volume: |
4 |
Issue: |
11 |
Pages: |
1509-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cornelius RJ |
Year: |
2018 |
Journal: |
J Am Soc Nephrol |
Title: |
Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway. |
Volume: |
29 |
Issue: |
11 |
Pages: |
2627-2640 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuevas CA |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Potassium Sensing by Renal Distal Tubules Requires Kir4.1. |
Volume: |
28 |
Issue: |
6 |
Pages: |
1814-1825 |
|
•
•
•
•
•
|
Publication |
First Author: |
Al-Qusairi L |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. |
Volume: |
28 |
Issue: |
8 |
Pages: |
2431-2442 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maeoka Y |
Year: |
2022 |
Journal: |
J Am Soc Nephrol |
Title: |
Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice. |
Volume: |
33 |
Issue: |
3 |
Pages: |
584-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hadchouel J |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension. |
Volume: |
107 |
Issue: |
42 |
Pages: |
18109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderegg MA |
Year: |
2021 |
Journal: |
Kidney Int |
Title: |
The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney. |
Volume: |
99 |
Issue: |
2 |
Pages: |
350-363 |
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Publication |
First Author: |
Hoorn EJ |
Year: |
2011 |
Journal: |
Nat Med |
Title: |
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. |
Volume: |
17 |
Issue: |
10 |
Pages: |
1304-9 |
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Publication |
First Author: |
Lin CM |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain. |
Volume: |
33 |
Issue: |
1 |
Pages: |
1051-1061 |
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Publication |
First Author: |
Feng X |
Year: |
2015 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway. |
Volume: |
308 |
Issue: |
10 |
Pages: |
F1119-27 |
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Publication |
First Author: |
Rinehart J |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. |
Volume: |
102 |
Issue: |
46 |
Pages: |
16777-82 |
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Publication |
First Author: |
Choate KA |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia. |
Volume: |
100 |
Issue: |
2 |
Pages: |
663-8 |
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Publication |
First Author: |
Ishizawa K |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling. |
Volume: |
116 |
Issue: |
8 |
Pages: |
3155-3160 |
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Publication |
First Author: |
Ferdaus MZ |
Year: |
2017 |
Journal: |
JCI Insight |
Title: |
Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. |
Volume: |
2 |
Issue: |
24 |
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Publication |
First Author: |
Chan CH |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
MST3 Involvement in Na+ and K+ Homeostasis with Increasing Dietary Potassium Intake. |
Volume: |
22 |
Issue: |
3 |
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Publication |
First Author: |
Louis-Dit-Picard H |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis. |
Volume: |
130 |
Issue: |
12 |
Pages: |
6379-6394 |
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Publication |
First Author: |
Bazúa-Valenti S |
Year: |
2018 |
Journal: |
J Am Soc Nephrol |
Title: |
The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway. |
Volume: |
29 |
Issue: |
7 |
Pages: |
1838-1848 |
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Publication |
First Author: |
Murillo-de-Ozores AR |
Year: |
2022 |
Journal: |
Kidney Int |
Title: |
Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia. |
Volume: |
102 |
Issue: |
5 |
Pages: |
1030-1041 |
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