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Search results 201 to 300 out of 379 for Xcr1

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Type Details Score
Publication
37024121 | J:334918
 
First Author: Miallot R
Year: 2023
Journal: Life Sci Alliance
Title: An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity.
Volume: 6
Issue: 6
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Publication
23670193 | J:204851
First Author: Yamazaki C
Year: 2013
Journal: J Immunol
Title: Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.
Volume: 190
Issue: 12
Pages: 6071-82
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Publication
23630347 | J:204779
First Author: Shimizu K
Year: 2013
Journal: J Immunol
Title: Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction.
Volume: 190
Issue: 11
Pages: 5609-19
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Publication
33915109 | J:305565
     
First Author: Devi S
Year: 2021
Journal: Immunity
Title: Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses.
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Publication
27424807 | J:234914
First Author: Roberts EW
Year: 2016
Journal: Cancer Cell
Title: Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma.
Volume: 30
Issue: 2
Pages: 324-336
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Publication
34518373 | J:311163
 
First Author: Salei N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Selective depletion of a CD64-expressing phagocyte subset mediates protection against toxic kidney injury and failure.
Volume: 118
Issue: 39
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Publication
38688934 | J:349001
First Author: Xiao H
Year: 2024
Journal: Nat Commun
Title: Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses.
Volume: 15
Issue: 1
Pages: 3554
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Publication
35190724 | J:322753
First Author: Salomon R
Year: 2022
Journal: Nat Cancer
Title: Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting.
Volume: 3
Issue: 3
Pages: 287-302
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Publication
34003499 | J:313621
First Author: Dimonte S
Year: 2021
Journal: Immunology
Title: Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses.
Volume: 164
Issue: 2
Pages: 279-291
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Publication
34017133 | J:335309
First Author: Deczkowska A
Year: 2021
Journal: Nat Med
Title: XCR1(+) type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Volume: 27
Issue: 6
Pages: 1043-1054
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Publication
37902602 | J:354876
 
First Author: Brabec T
Year: 2024
Journal: J Exp Med
Title: Segmented filamentous bacteria-induced epithelial MHCII regulates cognate CD4+ IELs and epithelial turnover.
Volume: 221
Issue: 1
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Publication
29942093 | J:271622
First Author: Barry KC
Year: 2018
Journal: Nat Med
Title: A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Volume: 24
Issue: 8
Pages: 1178-1191
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Publication
35830859 | J:351519
First Author: Lança T
Year: 2022
Journal: Immunity
Title: IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage.
Volume: 55
Issue: 8
Pages: 1431-1447.e11
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Publication
32581358 | J:291344
First Author: Zhou T
Year: 2020
Journal: Nature
Title: IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy.
Volume: 583
Issue: 7817
Pages: 609-614
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Publication
37463581 | J:341387
First Author: Ugur M
Year: 2023
Journal: Immunity
Title: Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks.
Volume: 56
Issue: 8
Pages: 1778-1793.e10
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Publication
27739478 | J:265115
 
First Author: Yamasaki S
Year: 2016
Journal: Sci Rep
Title: In vivo dendritic cell targeting cellular vaccine induces CD4+ Tfh cell-dependent antibody against influenza virus.
Volume: 6
Pages: 35173
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Publication
26104914 | J:318797
First Author: Daniels NJ
Year: 2016
Journal: Mucosal Immunol
Title: Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.
Volume: 9
Issue: 1
Pages: 229-39
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Publication
32066949 | J:306849
First Author: De Giovanni M
Year: 2020
Journal: Nat Immunol
Title: Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells.
Volume: 21
Issue: 3
Pages: 321-330
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Publication
32516589 | J:290366
First Author: Ruhland MK
Year: 2020
Journal: Cancer Cell
Title: Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.
Volume: 37
Issue: 6
Pages: 786-799.e5
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Publication
35464475 | J:324189
 
First Author: Muleta KG
Year: 2022
Journal: Front Immunol
Title: Rotavirus-Induced Expansion of Antigen-Specific CD8 T Cells Does Not Require Signaling via TLR3, MyD88 or the Type I Interferon Receptor.
Volume: 13
Pages: 814491
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Publication
35366396 | J:328757
First Author: Dähling S
Year: 2022
Journal: Immunity
Title: Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.
Volume: 55
Issue: 4
Pages: 656-670.e8
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Publication
38935717 | J:352250
First Author: Mahadevan KK
Year: 2024
Journal: Science
Title: Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer.
Volume: 384
Issue: 6703
Pages: eadh4567
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Publication
35911733 | J:327135
 
First Author: Dahlgren MW
Year: 2022
Journal: Front Immunol
Title: Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages.
Volume: 13
Pages: 932388
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Publication
36515659 | J:333867
 
First Author: Ahmadi F
Year: 2023
Journal: J Exp Med
Title: cDC1-derived IL-27 regulates small intestinal CD4+ T cell homeostasis in mice.
Volume: 220
Issue: 3
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Publication
36807146 | J:334156
First Author: Hildreth AD
Year: 2023
Journal: Cell Rep
Title: Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production.
Volume: 42
Issue: 2
Pages: 112141
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Publication
37407815 | J:342910
First Author: Guo C
Year: 2023
Journal: Nature
Title: SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity.
Volume: 620
Issue: 7972
Pages: 200-208
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Publication
31577946 | J:286924
First Author: Tsuchiya N
Year: 2019
Journal: Cell Rep
Title: Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.
Volume: 29
Issue: 1
Pages: 162-175.e9
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Publication
39214091 | J:355474
First Author: Mitchell JS
Year: 2024
Journal: Immunity
Title: CD4(+) T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Volume: 57
Issue: 10
Pages: 2399-2415.e8
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Publication
34437840 | J:318009
First Author: Flommersfeld S
Year: 2021
Journal: Immunity
Title: Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
Volume: 54
Issue: 10
Pages: 2288-2304.e7
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Publication
34526403 | J:310657
 
First Author: Diener N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
Volume: 118
Issue: 38
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Publication
36271147 | J:333733
First Author: Wu R
Year: 2022
Journal: Nat Immunol
Title: Mechanisms of CD40-dependent cDC1 licensing beyond costimulation.
Volume: 23
Issue: 11
Pages: 1536-1550
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Publication
32788723 | J:294175
First Author: Ferris ST
Year: 2020
Journal: Nature
Title: cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity.
Volume: 584
Issue: 7822
Pages: 624-629
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Publication
35704993 | J:326217
First Author: Gargaro M
Year: 2022
Journal: Immunity
Title: Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Volume: 55
Issue: 6
Pages: 1032-1050.e14
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Publication
36179012 | J:355087
First Author: Christian DA
Year: 2022
Journal: Sci Immunol
Title: cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Volume: 7
Issue: 75
Pages: eabq7432
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Publication
36736322 | J:339206
First Author: Zagorulya M
Year: 2023
Journal: Immunity
Title: Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
Volume: 56
Issue: 2
Pages: 386-405.e10
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Publication
29084838 | J:256756
First Author: Fernandez-Ruiz D
Year: 2017
Journal: J Immunol
Title: Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.
Volume: 199
Issue: 12
Pages: 4165-4179
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Publication
33979578 | J:314462
First Author: de Mingo Pulido Á
Year: 2021
Journal: Immunity
Title: The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Volume: 54
Issue: 6
Pages: 1154-1167.e7
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Publication
38053332 | J:348863
First Author: Kumar SRP
Year: 2024
Journal: Mol Ther
Title: TLR9-independent CD8(+) T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
Volume: 32
Issue: 2
Pages: 325-339
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Publication
37451271 | J:346107
First Author: Meiser P
Year: 2023
Journal: Cancer Cell
Title: A distinct stimulatory cDC1 subpopulation amplifies CD8(+) T cell responses in tumors for protective anti-cancer immunity.
Volume: 41
Issue: 8
Pages: 1498-1515.e10
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Publication
29632368 | J:267501
First Author: Gopinath S
Year: 2018
Journal: Nat Microbiol
Title: Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.
Volume: 3
Issue: 5
Pages: 611-621
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Publication
12461651 | J:80594
First Author: Kiss H
Year: 2002
Journal: Mamm Genome
Title: Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
Volume: 13
Issue: 11
Pages: 646-55
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Publication
32895539 | J:306423
First Author: Williams JW
Year: 2020
Journal: Nat Immunol
Title: Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.
Volume: 21
Issue: 10
Pages: 1194-1204
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Publication
30675064 | J:301468
First Author: Tanoue T
Year: 2019
Journal: Nature
Title: A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Volume: 565
Issue: 7741
Pages: 600-605
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11181058 | J:172902
First Author: Huang H
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin.
Volume: 281
Issue: 2
Pages: 378-82
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Publication
22100876 | -
First Author: Lei Y
Year: 2012
Journal: Microbes Infect
Title: XCL1 and XCR1 in the immune system.
Volume: 14
Issue: 3
Pages: 262-7
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Allele
Xcr1<em1(icre)Smoc> | MGI:7293200
Name: chemokine (C motif) receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Publication
31026469 | -
 
First Author: Xu F
Year: 2019
Journal: Dev Comp Immunol
Title: Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents.
Volume: 98
Pages: 80-88
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Strain
MGI:6476624 | C57BL/6JSmoc-Xcr1<em1(icre)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Xcr1<tm1(icre)Ciphe> | MGI:6279765
Name: chemokine (C motif) receptor 1; targeted mutation 1, Centre d'ImmunoPhenomique
Allele Type: Targeted
Attribute String: Recombinase
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Publication
21300913 | J:176844
First Author: Lei Y
Year: 2011
Journal: J Exp Med
Title: Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.
Volume: 208
Issue: 2
Pages: 383-94
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Publication
9632725 | J:172918
First Author: Yoshida T
Year: 1998
Journal: J Biol Chem
Title: Identification of single C motif-1/lymphotactin receptor XCR1.
Volume: 273
Issue: 26
Pages: 16551-4
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HT Experiment
GSE112270 | Expansion of tolerogenic dendritic cells in neonatal lungs programs lymph node maturation, but impairs T cell proliferation
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
34135058 | J:320468
First Author: Bagadia P
Year: 2021
Journal: J Immunol
Title: Bcl6-Independent In Vivo Development of Functional Type 1 Classical Dendritic Cells Supporting Tumor Rejection.
Volume: 207
Issue: 1
Pages: 125-132
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Publication
27545885 | J:238929
First Author: Calabro S
Year: 2016
Journal: Cell Rep
Title: Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity.
Volume: 16
Issue: 9
Pages: 2472-85
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Publication
26389678 | J:226390
First Author: Kim TS
Year: 2015
Journal: J Clin Invest
Title: Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells.
Volume: 125
Issue: 10
Pages: 3965-80
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Publication
37327322 | J:341050
First Author: Silva-Sanchez A
Year: 2023
Journal: Sci Immunol
Title: Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.
Volume: 8
Issue: 84
Pages: eadc9081
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Publication
37965348 | J:348002
 
First Author: Moorman CD
Year: 2023
Journal: Front Immunol
Title: CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis.
Volume: 14
Pages: 1235222
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Publication
30542351 | J:295102
 
First Author: Matsuo K
Year: 2018
Journal: Front Immunol
Title: A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells.
Volume: 9
Pages: 2775
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Publication
7973732 | J:29507
First Author: Kelner GS
Year: 1994
Journal: Science
Title: Lymphotactin: a cytokine that represents a new class of chemokine.
Volume: 266
Issue: 5189
Pages: 1395-9
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Publication
7602097 | J:26196
First Author: Kennedy J
Year: 1995
Journal: J Immunol
Title: Molecular cloning and functional characterization of human lymphotactin.
Volume: 155
Issue: 1
Pages: 203-9
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Publication
8977329 | -
First Author: Giancarlo B
Year: 1996
Journal: Eur J Immunol
Title: Migratory response of human natural killer cells to lymphotactin.
Volume: 26
Issue: 12
Pages: 3238-41
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Protein Domain
IPR005393 | Chemokine_XCR1
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressedon important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).Chemokine XC receptor 1 (XCR1), which this entry represents is a receptor for lymphotactin []. Lymphotactin is the only known member of the C (or XC) chemokine family, and is produced by certain subsets of T cells and natural killer cells and is also chemotactic for these cell types []. XCR1 is strongly expressed in placenta and at lower levels in the spleen and thymus and detected only at very low levels in peripheral blood leukocytes []. Within these tissues, expression is restricted to CD8+ T cells and natural killer cells [, ]. Binding of lymphotactin to XCR1 stimulates calcium mobilisation and migration in a pertussis toxin-sensitive manner, indicating coupling of the receptor to Gi type proteins [, ]. The matching expression patterns of both lymphotactin and its receptor suggest a role for the chemokine in self-recruitment of leukocytes [].
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Publication
26466066 | -
First Author: Palomino DC
Year: 2015
Journal: Einstein (Sao Paulo)
Title: Chemokines and immunity.
Volume: 13
Issue: 3
Pages: 469-73
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Protein Domain
IPR039809 | Chemokine_b/g/d
Type: Family
Description: The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family), or separated by an intervening residue (the CXC family), or have only one of the first two Cys residues (C chemokines), or contain both cysteines separated by three intervening residues (CX3C chemokines).This entry includes beta-chemokines (CC chemokines), in addition to gamma (C chemokines) and delta-chemokines (CX3C chemokines). CC chemokines stimulate mainly monocytes, but also basophils, eosinophils, T-lymphocytes, and natural killer (NK) cells. C-C motif chemokine 2 (CCL2) stimulates chemotaxis of monocytes and several cellular events associated with chemotaxis. Two other chemokines structurally related to CCL2 are CCL8 (MCP-2) and CCL7 (MCP-3) [].The C chemokine subfamily is composed of two members, XC chemokine ligand 1 (XCL1), also known as lymphotactin or SCM-1 alpha, and XC chemokine ligand 2 (XCL2), also known as SCM-1 beta []. The cognate receptor for these chemokines is XCR1 []. The only CX3C chemokine identified to date is CX3C chemokine ligand 1 (CX3CL1), also known as fractalkine or neurotactin. With its unique CX3CR1 receptor [], it is involved in adherence to the endothelium of the inflammatory monocyte population [].
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Publication
8849694 | -
First Author: Yoshida T
Year: 1996
Journal: FEBS Lett
Title: Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.
Volume: 395
Issue: 1
Pages: 82-8
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Publication
25497737 | -
First Author: Fox JC
Year: 2015
Journal: Cytokine
Title: Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily.
Volume: 71
Issue: 2
Pages: 302-11
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Publication
24155383 | -
First Author: Geyer H
Year: 2014
Journal: J Virol
Title: Cytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+ CD4- dendritic cells.
Volume: 88
Issue: 1
Pages: 292-302
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Protein Domain
IPR008105 | Chemokine_XCL1/XCL2
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helpercells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The C chemokine subfamily is composed of two members, XC chemokine ligand 1 (XCL1), also known as lymphotactin or SCM-1 alpha, and XC chemokine ligand 2 (XCL2), also known as SCM-1 beta []. The cognate receptor for these chemokines is XCR1 [].XCL1 is an inflammatory chemokine that produced by activated CD8+ T cells and natural killer cells. It is involved in the mediation of interactions between antigen-presenting dendritic cells and T-cells, and induction of CD8+ effector T-cell responses [, ]. It is also involved in the formation of self-tolerance mechanisms through the development of T regulatory cells within the thymus []. Less is known about its closely related paralogue XCL2, although the in vitro functional profiles are virtually identical []. Human XCL2 and XCL1 amino acid sequences differ at only two positions near the N terminus [].Viral XCL1 (vXCL1) exclusively binds to CD4(-) rat dendritic cells (DC), a subset of DC that express the corresponding chemokine receptor XCR1, a strategy to subvert cytotoxic immune responses [].
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Protein
P47993
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
Q9R0M1
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
A0A4D6YTE1
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
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