Type |
Details |
Score |
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Yonemasu R |
Year: |
2005 |
Journal: |
DNA Repair (Amst) |
Title: |
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. |
Volume: |
4 |
Issue: |
4 |
Pages: |
479-91 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.This superfamily represents a domain of the XPA protein. |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarrett SG |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage. |
Volume: |
54 |
Issue: |
6 |
Pages: |
999-1011 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cleaver JE |
Year: |
1997 |
Journal: |
Biochem J |
Title: |
The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein. |
Volume: |
328 ( Pt 1) |
|
Pages: |
1-12 |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; wild type |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kang TH |
Year: |
2011 |
Journal: |
Nucleic Acids Res |
Title: |
Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein. |
Volume: |
39 |
Issue: |
8 |
Pages: |
3176-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cleaver JE |
Year: |
1994 |
Journal: |
Somat Cell Mol Genet |
Title: |
Mutation and expression of the XPA gene in revertants and hybrids of a xeroderma pigmentosum cell line. |
Volume: |
20 |
Issue: |
4 |
Pages: |
327-37 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
142
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Goulielmaki E |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3153 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 6-7 |
Image: |
P6/7 |
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 6 |
|
|
Specimen Label: |
CNS |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 6 |
|
|
Specimen Label: |
CNS |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844962 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270519 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:4848751 |
Age: |
embryonic day 11.5 |
|
Note: |
Staining is present in the middle limb. |
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 6 |
|
|
Specimen Label: |
CNS |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 2-3 |
Image: |
P2/3 |
Note: |
Expression was detected in the outer neuroblastic layer. |
Specimen Label: |
P2/3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 4-5 |
Image: |
P4/5 |
Note: |
Expression was detected in the outer neuroblastic layer but was higher in the vitreal outer neuroblastic layer. |
Specimen Label: |
P4/5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 6-7 |
Image: |
P6/7 |
|
Specimen Label: |
P6/7 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal day 8-10 |
Image: |
P8/10 |
|
Specimen Label: |
P8/10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1915728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3843998 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1609217 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:3844039 |
Age: |
embryonic day 10.5 |
|
Note: |
Expression was low in the dorsal spinal cord. |
Specimen Label: |
Table 1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3585165 |
Assay Type: |
RNA in situ |
Annotation Date: |
2005-08-30 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3574228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:3585663 |
Age: |
postnatal adult |
|
Note: |
Expression was detected in bipolar cells. |
Specimen Label: |
Adult |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844962 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4848751 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4844962 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-12-22 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4848751 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; targeted mutation 1, Kiyoji Tanaka |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; targeted mutation 2, Kiyoji Tanaka |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg R |
Year: |
2002 |
Journal: |
GenBank Submission |
Title: |
Mus musculus, similar to XPA binding protein 1; putative ATP (GTP)-binding protein, clone MGC: 27619 IMAGE: 4505118, mRNA, complete cds |
|
|
Pages: |
BC020174 |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; targeted mutation 2e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
XPA binding protein 2; targeted mutation 2a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Xab2/Xab2 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Xab2/Xab2 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
567
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
567
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
547
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Buchko GW |
Year: |
1999 |
Journal: |
Biochemistry |
Title: |
Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. |
Volume: |
38 |
Issue: |
46 |
Pages: |
15116-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang TH |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. |
Volume: |
107 |
Issue: |
11 |
Pages: |
4890-5 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ercc2/Ercc2 Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
xeroderma pigmentosum, complementation group A; targeted mutation 1, Kiyoji Tanaka |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Tripsianes K |
Year: |
2007 |
Journal: |
Nucleic Acids Res |
Title: |
Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization. |
Volume: |
35 |
Issue: |
17 |
Pages: |
5789-98 |
|
•
•
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Publication |
First Author: |
Zhang XM |
Year: |
2005 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Transgenic mice expressing Cre-recombinase specifically in retinal rod bipolar neurons. |
Volume: |
46 |
Issue: |
10 |
Pages: |
3515-20 |
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Genotype |
Symbol: |
Xpa/Xpa |
Background: |
involves: C57BL/6 * CBA |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Allele |
Name: |
xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Genotype |
Symbol: |
Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Protein Domain |
Type: |
Conserved_site |
Description: |
Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.This entry contains the zinc-finger containing region in the XPA protein. It is found N-terminal to () |
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Protein Domain |
Type: |
Domain |
Description: |
Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.This entry represents the uncharacterised C-terminal domain of the XPA protein. |
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Protein Domain |
Type: |
Conserved_site |
Description: |
Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.This entry corresponds to the second conserved site in the XPA protein. It is a highly conserved region located some 12 residues after the zinc finger region |
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Strain |
Attribute String: |
congenic, mutant strain, endonuclease-mediated mutation, targeted mutation |
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Genotype |
Symbol: |
Ercc2/Ercc2 Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Trp53/Trp53<+> Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
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Genotype |
Symbol: |
Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Nitta M |
Year: |
2000 |
Journal: |
Nucleic Acids Res |
Title: |
A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. |
Volume: |
28 |
Issue: |
21 |
Pages: |
4212-8 |
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Protein Domain |
Type: |
Family |
Description: |
GPN-loop GTPase 1 (Gpn1) belongs to the GPN-loop GTPase family []. It is also known as Npa3 in budding yeasts and XAB1 in humans.Npa3 has GTPase activity that is essential for its binding to RNA polymerase II (RNAPII) and the nuclear localisation of RNAPII [].XAB1 is a cytoplasmic GTPase involved in nuclear localisation of DNA repair protein XPA []. This entry also includes archaeal GPN-loop GTPases, such as PYRAB14380 from Pyrococcus abyssi []. |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Genotype |
Symbol: |
Ercc6/Ercc6 Xpa/Xpa |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Ercc6/Ercc6 Xpa/Xpa |
Background: |
B6.129P2-Xpa Ercc6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Publication |
First Author: |
Fishman R |
Year: |
2001 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese. |
Volume: |
57 |
Issue: |
Pt 11 |
Pages: |
1534-44 |
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Publication |
First Author: |
Heldwein EE |
Year: |
2001 |
Journal: |
Nature |
Title: |
Crystal structure of the transcription activator BmrR bound to DNA and a drug. |
Volume: |
409 |
Issue: |
6818 |
Pages: |
378-82 |
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Publication |
First Author: |
de Beer T |
Year: |
2002 |
Journal: |
Mol Cell |
Title: |
Insights into specific DNA recognition during the assembly of a viral genome packaging machine. |
Volume: |
9 |
Issue: |
5 |
Pages: |
981-91 |
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