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Search results 201 to 300 out of 639 for Xrcc1

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Type Details Score
Protein Coding Gene
MGP_SPRETEiJ_G0031187 | -
Type: protein_coding_gene
Organism: Mus spretus
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Allele
Xndc1<Gt(OST239864)Lex> | MGI:4246406
 
Name: Xrcc1 N-terminal domain containing 1; gene trap OST239864, Lexicon Genetics
Allele Type: Gene trapped
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Interaction Experiment
Gabel SA (2013)
Description: XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.
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Publication
19155274 | -
First Author: Ali AA
Year: 2009
Journal: Nucleic Acids Res
Title: Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.
Volume: 37
Issue: 5
Pages: 1701-12
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Publication
15987676 | -
First Author: Beernink PT
Year: 2005
Journal: J Biol Chem
Title: Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein.
Volume: 280
Issue: 34
Pages: 30206-13
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Publication
10467102 | -
First Author: Marintchev A
Year: 1999
Journal: Nat Struct Biol
Title: Solution structure of the single-strand break repair protein XRCC1 N-terminal domain.
Volume: 6
Issue: 9
Pages: 884-93
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Allele
Xndc1<tm1a(EUCOMM)Hmgu> | MGI:4435515
Name: Xrcc1 N-terminal domain containing 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Xndc1<tm2e(EUCOMM)Hmgu> | MGI:4436189
Name: Xrcc1 N-terminal domain containing 1; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Xndc1<tm1a(EUCOMM)Wtsi> | MGI:4441710
Name: Xrcc1 N-terminal domain containing 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Xndc1<Gt(IST13785D9)Tigm> | MGI:5185506
 
Name: Xrcc1 N-terminal domain containing 1; gene trap IST13785D9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Xndc1<em3Gpt> | MGI:7308691
Name: Xrcc1 N-terminal domain containing 1; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
33330937 | -
First Author: Hammel M
Year: 2021
Journal: Nucleic Acids Res
Title: An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
Volume: 49
Issue: 1
Pages: 306-321
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Publication
9799248 | -
First Author: Zhang X
Year: 1998
Journal: EMBO J
Title: Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.
Volume: 17
Issue: 21
Pages: 6404-11
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DO Term
DOID:0080260 | autosomal recessive spinocerebellar ataxia 26
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Strain
MGI:6370373 | C57BL/6N-Xndc1<tm1a(EUCOMM)Wtsi>/Wtsi
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6770026 | C57BL/6JGpt-Xndc1<em3Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Xndc1/Xndc1
Background: C57BL/6N-Xndc1/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Publication
24409475 | -
First Author: Gabel SA
Year: 2013
Journal: DNA Repair (Amst)
Title: XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.
Volume: 12
Issue: 12
Pages: 1105-13
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Publication
21854574 | J:202088
 
First Author: Frankenberg S
Year: 2011
Journal: BMC Mol Biol
Title: Identification of two distinct genes at the vertebrate TRPC2 locus and their characterisation in a marsupial and a monotreme.
Volume: 12
Pages: 39
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Publication
15380105 | -
First Author: Clements PM
Year: 2004
Journal: DNA Repair (Amst)
Title: The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4.
Volume: 3
Issue: 11
Pages: 1493-502
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Strain
MGI:5556803 | B6NTac;B6N-A<tm1Brd> Trpc2<tm1a(EUCOMM)Wtsi>/WtsiCnbc
Attribute String: mutant strain, targeted mutation
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Allele
Xrcc1<tm1Rpe> | MGI:1932097
Name: X-ray repair complementing defective repair in Chinese hamster cells 1; targeted mutation 1, Roger A Pedersen
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3521931 | B6.129X1-Xrcc1<tm1Rpe>/Mmmh
Attribute String: congenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Xrcc1/Xrcc1
Background: involves: 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trp53/Trp53 Xrcc1/Xrcc1
Background: involves: 129S2/SvPas * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Publication
10467087 | -
First Author: Rice PA
Year: 1999
Journal: Nat Struct Biol
Title: Holding damaged DNA together.
Volume: 6
Issue: 9
Pages: 805-6
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Protein Domain
IPR002706 | Xrcc1_N
Type: Domain
Description: DNA-repair protein Xrcc1 functions in the repair of single-strand DNA breaks in mammalian cells and forms a repair complex with beta-Pol, ligase III and PARP []. The NMR solution structure of the Xrcc1 N-terminal domain (Xrcc1 NTD) shows that the structural core is a β-sandwich with β-strands connected by loops, three helices and two short two-stranded β-sheets at each connection side. The Xrcc1 NTD specifically binds single-strand break DNA (gapped and nicked) and a gapped DNA-beta-Pol complex [].
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Protein Domain
IPR041388 | FHA_2
Type: Domain
Description: This entry represents a divergent FHA domain which in human PNK (polynucleotide kinase 3'-phosphatase) binds to phosphorylated segment of XRCC1 [].
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Publication
16964241 | J:113297
First Author: Ahel I
Year: 2006
Journal: Nature
Title: The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates.
Volume: 443
Issue: 7112
Pages: 713-6
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Protein Domain
IPR045080 | BRCT_XRCC1_rpt1
Type: Domain
Description: XRCC1 plays a key role in multiple DNA repair pathways by acting as a scaffold that binds to both DNA single strand breaks and gaps, poly (ADP-ribose) and to numerous DNA repair enzymes. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1 [, ]. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This entry corresponds to the first (central) BRCT domain []. This domain has been shown to interact with poly(ADP-ribosyl)ated (PARylated) PARP1. Inactivation of the central X1BR1 domain results in DNA damage hypersensitivity due to a defect in S phase-dependent DNA repair [].
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Publication
24778456 | J:216526
First Author: Zhao K
Year: 2014
Journal: EMBO Rep
Title: S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair.
Volume: 15
Issue: 7
Pages: 792-800
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Protein
Q8CDC6
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q8BQS1
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
Q641L3
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
F7D6D1
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
F6WIA6
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
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Protein
Q8BRU2
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Publication
17507382 | -
First Author: Bekker-Jensen S
Year: 2007
Journal: J Biol Chem
Title: Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks.
Volume: 282
Issue: 27
Pages: 19638-43
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Publication
17396150 | -
First Author: Kanno S
Year: 2007
Journal: EMBO J
Title: A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
Volume: 26
Issue: 8
Pages: 2094-103
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Publication
18077224 | -
First Author: Macrae CJ
Year: 2008
Journal: DNA Repair (Amst)
Title: APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
Volume: 7
Issue: 2
Pages: 292-302
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Protein Domain
IPR039253 | APLF
Type: Family
Description: The protein APLF (aprataxin and PNK-like factor or Xip1; ) is a nuclease involved in single-strand and double-strand DNA break repair []. It has endo- and exonuclease activities and contains a FHA (forkhead-associated) domain and zinc-finger-like CYR motifs []. APLF interacts with XRCC1 and XRCC4 via its FHA domain [, ].
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Protein
Q3TN28
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
Q3TGI0
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q3U2B4
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Publication
17982172 | J:172172
First Author: Mortusewicz O
Year: 2007
Journal: Nucleic Acids Res
Title: Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.
Volume: 35
Issue: 22
Pages: 7665-75
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Publication
27513301 | J:249185
First Author: Connolly PF
Year: 2016
Journal: FEBS J
Title: DNA-PK activity is associated with caspase-dependent myogenic differentiation.
Volume: 283
Issue: 19
Pages: 3626-3636
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Publication
29983321 | J:266355
First Author: Hanzlikova H
Year: 2018
Journal: Mol Cell
Title: The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
Volume: 71
Issue: 2
Pages: 319-331.e3
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Publication
33932076 | J:307059
First Author: Komulainen E
Year: 2021
Journal: EMBO Rep
Title: Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
Volume: 22
Issue: 5
Pages: e51851
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Publication
22210862 | -
First Author: Tahbaz N
Year: 2012
Journal: Nucleic Acids Res
Title: Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair.
Volume: 40
Issue: 8
Pages: 3484-95
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Publication
16648365 | -
First Author: Dobson CJ
Year: 2006
Journal: Nucleic Acids Res
Title: The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks.
Volume: 34
Issue: 8
Pages: 2230-7
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Protein Domain
IPR006550 | PNKP
Type: Family
Description: This entry includes bifunctional polynucleotide phosphatase/kinase PNKP from animals. PNKP plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. It has been shown that the DNA 3'-phosphatase activity of PNKP takes precedence over its DNA 5'-kinase activity in vitro []. It contains a forkhead-associated domain, which is a protein-protein interaction domain required for the association of PNKP with CK2-phosphorylated XRCC1 and XRCC4, and independent DNA 3'-phosphatase and 5'-kinase domains [].
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Publication
10586886 | -
First Author: Macedo-Ribeiro S
Year: 1999
Journal: Nature
Title: Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
Volume: 402
Issue: 6760
Pages: 434-9
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Publication
11948190 | J:77259
First Author: Schreiber V
Year: 2002
Journal: J Biol Chem
Title: Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
Volume: 277
Issue: 25
Pages: 23028-36
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Publication
9001252 | J:37666
First Author: Mackey ZB
Year: 1997
Journal: Mol Cell Biol
Title: An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination.
Volume: 17
Issue: 2
Pages: 989-98
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Publication
22198154 | J:191503
First Author: Zimmer SN
Year: 2012
Journal: Exp Hematol
Title: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm.
Volume: 40
Issue: 4
Pages: 295-306.e5
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Publication
37487079 | J:340904
First Author: Shao Z
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Volume: 120
Issue: 31
Pages: e2301972120
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Publication
16648486 | J:109063
First Author: Puebla-Osorio N
Year: 2006
Journal: Mol Cell Biol
Title: Early embryonic lethality due to targeted inactivation of DNA ligase III.
Volume: 26
Issue: 10
Pages: 3935-41
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Publication
30523148 | J:334484
 
First Author: Steinacher R
Year: 2019
Journal: EMBO J
Title: SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation.
Volume: 38
Issue: 1
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Publication
9570955 | J:47551
First Author: Shannon M
Year: 1998
Journal: Genomics
Title: Analysis of homologous XRCC1-linked zinc-finger gene families in human and mouse: evidence for orthologous genes.
Volume: 49
Issue: 1
Pages: 112-21
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Publication
9776979 | J:49787
First Author: Zhou ZQ
Year: 1998
Journal: Somat Cell Mol Genet
Title: Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair.
Volume: 24
Issue: 1
Pages: 23-39
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Publication
37756636 | J:344467
First Author: Wang Y
Year: 2023
Journal: Hum Mol Genet
Title: Disrupted phase behavior of FUS underlies poly-PR-induced DNA damage in amyotrophic lateral sclerosis.
Volume: 33
Issue: 1
Pages: 64-77
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Protein
Q3TV70
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
D3YY48
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
Q99KJ6
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q3TZU4
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
Q8VEM0
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
G3UYI8
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
Q8BPE3
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
Q569V8
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
A0A1D5RLT0
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: false
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Protein
A0A087WPG9
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
Q69Z81
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Protein
D6RGR1
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Publication
17353262 | -
First Author: Iles N
Year: 2007
Journal: Mol Cell Biol
Title: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks.
Volume: 27
Issue: 10
Pages: 3793-803
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Protein Domain
IPR036420 | BRCT_dom_sf
Type: Homologous_superfamily
Description: The breast cancer susceptibility gene contains at its C terminus two copies of a conserved domain that was named BRCT for BRCA1 C terminus. This domain of about 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control [, , ]. The BRCT domain is not limited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. Some data []indicate that the BRCT domain functions as a protein-protein interaction module.The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has been determined by X-ray crystallography, it comprises a four-stranded parallel β-sheet surrounded by three α-helices, which form an autonomously folded domain [].
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Protein Domain
IPR040502 | GalBD-like
Type: Domain
Description: Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 []. The structure of the galactose-binding domain-like members consists of a β-sandwich, in which the strands making up the sheets exhibit a jellyroll fold [].This entry represents a galactose-binding domain-like fold domain found in endo-alpha-N-acetylgalactosaminidases from bacteria.
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Protein Domain
IPR008979 | Galactose-bd-like_sf
Type: Homologous_superfamily
Description: Proteins containing a galactose-binding-like domain fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [].The structure of the galactose-binding-like domain members consists of a β-sandwich, in which the strands making up the sheets exhibit a jelly roll fold. There is a high degree of similarity in the β-sandwich and in the loops between different family members, despite an often low level of sequence similarity.
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Protein
A0A0A6YW35
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A0A087WS55
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
A0A0A6YWI0
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
Q61944
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q3UJT6
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Publication
9000507 | -
First Author: Callebaut I
Year: 1997
Journal: FEBS Lett
Title: From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair.
Volume: 400
Issue: 1
Pages: 25-30
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Publication
8673121 | J:33731
First Author: Koonin EV
Year: 1996
Journal: Nat Genet
Title: BRCA1 protein products ... Functional motifs...
Volume: 13
Issue: 3
Pages: 266-8
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Protein
Q9EQ61
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q6ZQF0
Organism: Mus musculus/domesticus
Length: 1515  
Fragment?: false
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Protein
Q8C211
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
E0CX75
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: true
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Protein
G3UWE9
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
A0A0M3HEQ6
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: true
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Protein
Q5SQ20
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Publication
9034168 | J:38216
First Author: Bork P
Year: 1997
Journal: FASEB J
Title: A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
Volume: 11
Issue: 1
Pages: 68-76
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Publication
35907861 | J:327086
First Author: Mueller FS
Year: 2022
Journal: BMC Biol
Title: Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice.
Volume: 20
Issue: 1
Pages: 170
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Protein
Q8VIJ8
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Q9D6H2
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: false
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Protein
Q3V0M1
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: false
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Protein
A0A140LHU7
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: true
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Protein
B7ZWJ3
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: false
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Publication
11573086 | -
First Author: Williams RS
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Volume: 8
Issue: 10
Pages: 838-42
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Publication
15133503 | -
First Author: Williams RS
Year: 2004
Journal: Nat Struct Mol Biol
Title: Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.
Volume: 11
Issue: 6
Pages: 519-25
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