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Details |
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| First Author: |
Wang H |
| Year: |
2010 |
| Journal: |
Nucleic Acids Res |
| Title: |
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. |
| Volume: |
38 |
| Issue: |
10 |
| Pages: |
3245-51 |
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•
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•
•
•
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| First Author: |
Wang X |
| Year: |
2007 |
| Journal: |
Cell Death Differ |
| Title: |
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality. |
| Volume: |
14 |
| Issue: |
5 |
| Pages: |
924-31 |
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•
•
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| First Author: |
Bhargava R |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency. |
| Volume: |
114 |
| Issue: |
4 |
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728-733 |
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| First Author: |
Pierce AJ |
| Year: |
2001 |
| Journal: |
Genes Dev |
| Title: |
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. |
| Volume: |
15 |
| Issue: |
24 |
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3237-42 |
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| First Author: |
Stark JM |
| Year: |
2004 |
| Journal: |
Mol Cell Biol |
| Title: |
Genetic steps of mammalian homologous repair with distinct mutagenic consequences. |
| Volume: |
24 |
| Issue: |
21 |
| Pages: |
9305-16 |
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•
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| First Author: |
Koike M |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues. |
| Volume: |
38 |
| Issue: |
1 |
| Pages: |
38-44 |
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•
•
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| First Author: |
Wu P |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
No overt nucleosome eviction at deprotected telomeres. |
| Volume: |
28 |
| Issue: |
18 |
| Pages: |
5724-35 |
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•
•
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| First Author: |
Dreveny I |
| Year: |
2004 |
| Journal: |
EMBO J |
| Title: |
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. |
| Volume: |
23 |
| Issue: |
5 |
| Pages: |
1030-9 |
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| First Author: |
Xing M |
| Year: |
2017 |
| Journal: |
DNA Repair (Amst) |
| Title: |
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70. |
| Volume: |
57 |
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| First Author: |
Sekiguchi J |
| Year: |
2001 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. |
| Volume: |
98 |
| Issue: |
6 |
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3243-8 |
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| First Author: |
Gurley KE |
| Year: |
2009 |
| Journal: |
EMBO Rep |
| Title: |
DNA-PK suppresses a p53-independent apoptotic response to DNA damage. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
87-93 |
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•
•
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| Publication |
| First Author: |
Helmink BA |
| Year: |
2009 |
| Journal: |
J Exp Med |
| Title: |
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. |
| Volume: |
206 |
| Issue: |
3 |
| Pages: |
669-79 |
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•
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| First Author: |
Garaycoechea JI |
| Year: |
2018 |
| Journal: |
Nature |
| Title: |
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. |
| Volume: |
553 |
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7687 |
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171-177 |
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| First Author: |
Difilippantonio MJ |
| Year: |
2002 |
| Journal: |
J Exp Med |
| Title: |
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. |
| Volume: |
196 |
| Issue: |
4 |
| Pages: |
469-80 |
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•
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| First Author: |
Mills KD |
| Year: |
2003 |
| Journal: |
Immunol Rev |
| Title: |
The role of DNA breaks in genomic instability and tumorigenesis. |
| Volume: |
194 |
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| First Author: |
Gu Y |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. |
| Volume: |
97 |
| Issue: |
6 |
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2668-73 |
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| First Author: |
Griffin C |
| Year: |
2005 |
| Journal: |
DNA Repair (Amst) |
| Title: |
The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells. |
| Volume: |
4 |
| Issue: |
9 |
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1019-27 |
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| First Author: |
Bunting SF |
| Year: |
2012 |
| Journal: |
Mol Cell |
| Title: |
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. |
| Volume: |
46 |
| Issue: |
2 |
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125-35 |
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| First Author: |
Oksenych V |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. |
| Volume: |
110 |
| Issue: |
6 |
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2234-9 |
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| First Author: |
Lur G |
| Year: |
2011 |
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Biochem J |
| Title: |
InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. |
| Volume: |
436 |
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2 |
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231-9 |
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| First Author: |
Baughman G |
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1991 |
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Mol Endocrinol |
| Title: |
Genes newly identified as regulated by glucocorticoids in murine thymocytes. |
| Volume: |
5 |
| Issue: |
5 |
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637-44 |
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| First Author: |
Hammer F |
| Year: |
2004 |
| Journal: |
Endocrinology |
| Title: |
Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. |
| Volume: |
145 |
| Issue: |
2 |
| Pages: |
901-12 |
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| First Author: |
Hung PJ |
| Year: |
2018 |
| Journal: |
Mol Cell |
| Title: |
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. |
| Volume: |
71 |
| Issue: |
2 |
| Pages: |
332-342.e8 |
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| First Author: |
Jiang W |
| Year: |
2015 |
| Journal: |
Mol Cell |
| Title: |
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining. |
| Volume: |
58 |
| Issue: |
1 |
| Pages: |
172-85 |
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| First Author: |
Gong Y |
| Year: |
2017 |
| Journal: |
Genes Dev |
| Title: |
PHF11 promotes DSB resection, ATR signaling, and HR. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
46-58 |
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| First Author: |
Stetson DB |
| Year: |
2006 |
| Journal: |
Immunity |
| Title: |
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. |
| Volume: |
24 |
| Issue: |
1 |
| Pages: |
93-103 |
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| First Author: |
Kappei D |
| Year: |
2013 |
| Journal: |
EMBO J |
| Title: |
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. |
| Volume: |
32 |
| Issue: |
12 |
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1681-701 |
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Xing J |
| Year: |
2016 |
| Journal: |
Nat Immunol |
| Title: |
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. |
| Volume: |
17 |
| Issue: |
12 |
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1373-1380 |
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| First Author: |
Ehringer MA |
| Year: |
2001 |
| Journal: |
Mamm Genome |
| Title: |
High-throughput sequence identification of gene coding variants within alcohol-related QTLs. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
657-63 |
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| First Author: |
The Australian Phenomics Facility at The Australian National University |
| Year: |
2006 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University |
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| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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| First Author: |
Cobellis G |
| Year: |
2005 |
| Journal: |
Nucleic Acids Res |
| Title: |
Tagging genes with cassette-exchange sites. |
| Volume: |
33 |
| Issue: |
4 |
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e44 |
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| First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
| Year: |
2023 |
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| Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
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| First Author: |
University of California, Davis |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the University of California, Davis |
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| First Author: |
Guo G |
| Year: |
2010 |
| Journal: |
Dev Cell |
| Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
| Volume: |
18 |
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4 |
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675-85 |
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Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
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6 |
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Hansen J |
| Year: |
2003 |
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Proc Natl Acad Sci U S A |
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
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17 |
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| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
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Stryke D |
| Year: |
2003 |
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Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
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| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
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10 |
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The Gene Ontology Consortium |
| Year: |
2014 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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| First Author: |
UniProt-GOA |
| Year: |
2012 |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
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Gene Ontology annotation through association of InterPro records with GO terms |
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Carninci P |
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2005 |
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Science |
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The transcriptional landscape of the mammalian genome. |
| Volume: |
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Kawai J |
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2001 |
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Nature |
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Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
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Zambrowicz BP |
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2003 |
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Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Skarnes WC |
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Nature |
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A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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MGI Genome Annotation Group and UniGene Staff |
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Allen Institute for Brain Science |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Database Download |
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Mouse Genome Informatics Group |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
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2010 |
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Database Release |
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Protein Ontology Association Load. |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Obtaining and loading genome assembly coordinates from NCBI annotations |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Allele |
| Name: |
X-ray repair complementing defective repair in Chinese hamster cells 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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•
•
•
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| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Tang B |
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2020 |
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Am J Cancer Res |
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PARP6 suppresses the proliferation and metastasis of hepatocellular carcinoma by degrading XRCC6 to regulate the Wnt/β-catenin pathway. |
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10 |
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7 |
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2100-2113 |
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| Interaction Experiment |
| Description: |
PARP6 suppresses the proliferation and metastasis of hepatocellular carcinoma by degrading XRCC6 to regulate the Wnt/?-catenin pathway. |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3284226 |
| Pattern: |
Regionally restricted |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in molecular layer of cerebral cortex. Expression appears to be glial. |
| Specimen Label: |
3B P450scc Cortex |
| Detected: |
true |
| Specimen Num: |
5 |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271126 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in cortical plate and intermediate layer of cerebral cortex. |
| Specimen Label: |
3B P450scc Cortex |
| Detected: |
true |
| Specimen Num: |
5 |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271226 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in cortical plate and intermediate layer of cerebral cortex. |
| Specimen Label: |
3B P450scc Cortex |
| Detected: |
true |
| Specimen Num: |
5 |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3595826 |
| Pattern: |
Regionally restricted |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in both epithelial cells and glandular mucosal cells of nasal epithelium. |
| Specimen Label: |
P450scc E18.5 not shown |
| Detected: |
true |
| Specimen Num: |
8 |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3522326 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in Purkinje cell layer. Expression appears to be neuronal. |
| Specimen Label: |
3B P450scc Cerebellum |
| Detected: |
true |
| Specimen Num: |
6 |
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| GXD Expression |
| Probe: |
MGI:7579178 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-02-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1924126 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:7579184 |
| Age: |
embryonic day 18.5 |
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| Note: |
Expression co-localized with Xrcc6 in a nucleus in the position of the inferior olive. Expression appears to be neuronal. |
| Specimen Label: |
3B P450scc Hindbrain |
| Detected: |
true |
| Specimen Num: |
7 |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
608
 |
| Fragment?: |
false |
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