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Search results 201 to 300 out of 324 for Zw10

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Type Details Score
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_11
Specimen Label: euxassay_009942_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1715823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_12
Specimen Label: euxassay_009942_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_04
Specimen Label: euxassay_009942_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_05
Specimen Label: euxassay_009942_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_06
Specimen Label: euxassay_009942_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_19
Specimen Label: euxassay_009942_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_20
Specimen Label: euxassay_009942_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1756923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_21
Specimen Label: euxassay_009942_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4886237
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945233
Age: embryonic day 15.5
Image: g00706 E15.5
Specimen Label: g00706 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886237
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945233
Age: postnatal day 7
Image: g00706 P7
Note: Expression was region specific and scattered.
Specimen Label: g00706 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4886237
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945233
Age: embryonic day 15.5
Image: g00706 E15.5
Specimen Label: g00706 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_07
Specimen Label: euxassay_009942_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_18
Specimen Label: euxassay_009942_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_19
Specimen Label: euxassay_009942_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_09
Specimen Label: euxassay_009942_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_10
Specimen Label: euxassay_009942_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_11
Specimen Label: euxassay_009942_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_12
Specimen Label: euxassay_009942_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_13
Specimen Label: euxassay_009942_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_14
Specimen Label: euxassay_009942_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_15
Specimen Label: euxassay_009942_15
Detected: true
Specimen Num: 15
GXD Expression
Probe: MGI:4886237
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945233
Age: embryonic day 15.5
Image: g00706 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00706 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886237
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945233
Age: postnatal day 7
Image: g00706 P7
Note: Expression was region specific and scattered.
Specimen Label: g00706 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_07
Specimen Label: euxassay_009942_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_08
Specimen Label: euxassay_009942_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1679823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_18
Specimen Label: euxassay_009942_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_01
Specimen Label: euxassay_009942_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_02
Specimen Label: euxassay_009942_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_03
Specimen Label: euxassay_009942_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_04
Specimen Label: euxassay_009942_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_05
Specimen Label: euxassay_009942_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_06
Specimen Label: euxassay_009942_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_07
Specimen Label: euxassay_009942_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_08
Specimen Label: euxassay_009942_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_09
Specimen Label: euxassay_009942_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_10
Specimen Label: euxassay_009942_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_11
Specimen Label: euxassay_009942_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_12
Specimen Label: euxassay_009942_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_13
Specimen Label: euxassay_009942_13
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_14
Specimen Label: euxassay_009942_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_15
Specimen Label: euxassay_009942_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_16
Specimen Label: euxassay_009942_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_17
Specimen Label: euxassay_009942_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_18
Specimen Label: euxassay_009942_18
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_19
Specimen Label: euxassay_009942_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_20
Specimen Label: euxassay_009942_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_21
Specimen Label: euxassay_009942_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_22
Specimen Label: euxassay_009942_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_23
Specimen Label: euxassay_009942_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1786923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_11
Specimen Label: euxassay_009942_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4416628
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1786923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829372
Age: embryonic day 14.5
Image: euxassay_009942_14
Specimen Label: euxassay_009942_14
Detected: true
Specimen Num: 14
Allele  
Name: ZW10 interactor; gene trap OST422948, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: zw10 kinetochore protein; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: ZW10 interactor; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: ZW10 interactor; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: ZW10 interactor; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Griffis ER
Year: 2007
Journal: J Cell Biol
Title: Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore.
Volume: 177
Issue: 6
Pages: 1005-15
Allele
Name: ZW10 interactor; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: zw10 kinetochore protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: zw10 kinetochore protein; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: ZW10 interactor; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: ZW10 interactor; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: ZW10 interactor; endonuclease-mediated mutation 4, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Zwint/Zwint
Background: C57BL/6NJ-Zwint/J
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Gentil BJ
Year: 2014
Journal: J Neurochem
Title: A two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30.
Volume: 131
Issue: 5
Pages: 588-601
Genotype
Symbol: Zwint/Zwint<+>
Background: C57BL/6NJ-Zwint/J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Arasaki K
Year: 2006
Journal: Mol Biol Cell
Title: RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
Volume: 17
Issue: 6
Pages: 2780-8
Publication
First Author: van Vlijmen T
Year: 2008
Journal: FEBS Lett
Title: A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.
Volume: 582
Issue: 19
Pages: 2838-42
Protein
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
Publication
First Author: Williams BC
Year: 2003
Journal: Mol Biol Cell
Title: Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.
Volume: 14
Issue: 4
Pages: 1379-91
Publication
First Author: Buffin E
Year: 2005
Journal: Curr Biol
Title: Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.
Volume: 15
Issue: 9
Pages: 856-61
Protein Domain
Type: Family
Description: The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores [, , ]. Zwilch is a component of the RZZ complex, which is composed of Rod, Zw10 and Zwilch.
Publication
First Author: Ye A
Year: 2017
Journal: PLoS One
Title: PEG3 control on the mammalian MSL complex.
Volume: 12
Issue: 6
Pages: e0178363
Publication
First Author: Varma D
Year: 2012
Journal: J Cell Sci
Title: The KMN protein network--chief conductors of the kinetochore orchestra.
Volume: 125
Issue: Pt 24
Pages: 5927-36
Publication
First Author: Lampert F
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: A blueprint for kinetochores - new insights into the molecular mechanics of cell division.
Volume: 12
Issue: 7
Pages: 407-12
Publication
First Author: Urano T
Year: 2009
Journal: Biochem Biophys Res Commun
Title: TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.
Volume: 383
Issue: 2
Pages: 263-8
Publication
First Author: Woodsmith J
Year: 2012
Journal: Mol Cell Proteomics
Title: Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.
Volume: 11
Issue: 7
Pages: M111.016162
Protein Domain
Type: Domain
Description: This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM17, also known as RING finger protein 16 (RNF16) or testis RING finger protein (terf). TRIM17 domain is composed of RING/B-box/coiled-coil core and also known as RBCC protein, expressed almost exclusively in the testis. It exhibits E3 ligase activity, causing protein degradation of ZW10 interacting protein (ZWINT), a known component of the kinetochore complex required for the mitotic spindle checkpoint, and negatively regulates proliferation of breast cancer cells [, , ]. TRIM17 undergoes ubiquitination in COS7 fibroblast-like cells but is inhibited and stabilized by TRIM44 [].
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
Publication  
First Author: Scaërou F
Year: 1999
Journal: J Cell Sci
Title: The rough deal protein is a new kinetochore component required for accurate chromosome segregation in Drosophila.
Volume: 112 ( Pt 21)
Pages: 3757-68
Publication
First Author: Basto R
Year: 2004
Journal: Curr Biol
Title: In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis.
Volume: 14
Issue: 1
Pages: 56-61
Protein Domain
Type: Domain
Description: Rod, the Rough deal protein (also known as Kinetochore-associated protein 1) displays a dynamic intracellular staining pattern, localising first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10 [], and indeed the two proteins function together, localisation of each depending upon the other []. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C- terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase[]. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in Caenorhabditis elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint [].
Publication
First Author: Endo H
Year: 2012
Journal: J Biochem
Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
Volume: 151
Issue: 2
Pages: 139-44
Protein Domain
Type: Homologous_superfamily
Description: Zeste white 10 (ZW10) was initially identified as a mitotic checkpoint protein involved in chromosome segregation as part of the RZZ (Rod-Zwilch-Zw10) complex, and then implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, but it is also important in non-dividing cells. These include cytoplasmic dynein targeting to Golgi and other membranes, andSNARE-mediated ER-Golgi trafficking in the context of Zw10-Rint1-Nag complex which are DSL11, Tip20, and Sec39 orthologues, respectively [, , ]. Yeast DSL1, is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum, part of the Dsl1p complex (Dsl1Tip20-Sec20-Sec39) [, , ]. These proteins are members of the CATCHR (complexes associated with tethering containing helical rods) family which includes subunits of evolutionarily related complex, such as conserved oligomeric Golgi (COG), Golgi-associated retrograde protein (GARP) and exocyst []. This entry represents the C-terminal domain of Zw10 and DSL1 which consists of an α-helical bundle.
Publication
First Author: Bochkis IM
Year: 2012
Journal: PLoS Genet
Title: Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
Volume: 8
Issue: 6
Pages: e1002770
Protein
Organism: Mus musculus/domesticus
Length: 2207  
Fragment?: false
Publication      
First Author: Mager J
Year: 2019
Journal: MGI Direct Data Submission
Title: A Catalog of Early Lethal KOMP Phenotypes
Publication
First Author: Schmitt HD
Year: 2010
Journal: Trends Cell Biol
Title: Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules.
Volume: 20
Issue: 5
Pages: 257-68
Publication
First Author: Schilling K
Year: 2009
Journal: Cerebellum
Title: The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.
Volume: 8
Issue: 4
Pages: 477-89