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Search results 2001 to 2100 out of 4706 for Coil

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0.032s

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Hits by Strain

Type Details Score
Protein
Q7TMW6
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Publication
25241935 | J:243477
First Author: Thom CS
Year: 2014
Journal: Dev Cell
Title: Trim58 degrades Dynein and regulates terminal erythropoiesis.
Volume: 30
Issue: 6
Pages: 688-700
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Publication
18222470 | J:166580
First Author: Koyama S
Year: 2008
Journal: J Mol Biol
Title: Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.
Volume: 376
Issue: 5
Pages: 1224-36
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Protein
Q9CYQ7
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q8BQX4
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
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Protein
A0A140LJ37
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Protein
F6XRI9
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: true
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Protein
M0QWC0
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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Protein
D5MCW5
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Protein
A0A220D9Z4
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
D3Z6P6
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
D3YXC9
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
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Protein
D6RFR7
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
Q8CEL3
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A1B0GRS5
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Protein
C4PFH6
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
Q8CA59
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
M0QW56
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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Protein
A2A5V1
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
Q6LD55
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
D3Z340
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
B1AV64
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
Q8C914
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein
D3YUL4
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
R9W2T8
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
D3YVR4
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
Q5D222
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
F6SWV4
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
Q8BWC3
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Protein
A0A0N4SW43
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Protein
B2BY37
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Protein
H3BL43
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
M0QWI1
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
A7YL62
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
A0A1L1SSL0
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q9D333
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
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Protein
Q6PCW7
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Publication
11160821 | -
First Author: Darsow T
Year: 2001
Journal: Mol Biol Cell
Title: Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and interaction with AP-3 through two distinct domains.
Volume: 12
Issue: 1
Pages: 37-51
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Publication
2300204 | -
First Author: Kodama T
Year: 1990
Journal: Nature
Title: Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.
Volume: 343
Issue: 6258
Pages: 531-5
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Publication
2251254 | -
First Author: Matsumoto A
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.
Volume: 87
Issue: 23
Pages: 9133-7
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Publication
24563502 | -
First Author: Prabhudas M
Year: 2014
Journal: J Immunol
Title: Standardizing scavenger receptor nomenclature.
Volume: 192
Issue: 5
Pages: 1997-2006
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Publication
23782937 | -
 
First Author: Yu XH
Year: 2013
Journal: Clin Chim Acta
Title: Foam cells in atherosclerosis.
Volume: 424
Pages: 245-52
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Publication
8846787 | -
First Author: Borden KL
Year: 1995
Journal: EMBO J
Title: Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development.
Volume: 14
Issue: 23
Pages: 5947-56
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Publication
9923704 | -
First Author: Borden KL
Year: 1998
Journal: Biochem Cell Biol
Title: RING fingers and B-boxes: zinc-binding protein-protein interaction domains.
Volume: 76
Issue: 2-3
Pages: 351-8
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Publication
8118759 | -
First Author: Catalano-Sherman J
Year: 1994
Journal: Calcif Tissue Int
Title: Production of a monoclonal antibody against human amelogenin.
Volume: 54
Issue: 1
Pages: 76-80
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Publication
8454575 | -
First Author: Goto Y
Year: 1993
Journal: J Biochem
Title: Molecular conformation of porcine amelogenin in solution: three folding units at the N-terminal, central, and C-terminal regions.
Volume: 113
Issue: 1
Pages: 55-60
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Publication
2598664 | -
First Author: Renugopalakrishnan V
Year: 1989
Journal: Connect Tissue Res
Title: Secondary structure and limited three-dimensional structure of bovine amelogenin.
Volume: 22
Issue: 1-4
Pages: 131-8
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Publication
7782077 | J:48366
First Author: Lagerström-Fermér M
Year: 1995
Journal: Genomics
Title: Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta.
Volume: 26
Issue: 1
Pages: 159-62
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Publication
15124630 | -
First Author: Yeats C
Year: 2004
Journal: Trends Biochem Sci
Title: The PepSY domain: a regulator of peptidase activity in the microbial environment?
Volume: 29
Issue: 4
Pages: 169-72
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Publication
12037319 | -
First Author: Krzywda S
Year: 2002
Journal: Acta Crystallogr D Biol Crystallogr
Title: Crystallization of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli.
Volume: 58
Issue: Pt 6 Pt 2
Pages: 1066-7
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Publication
22498346 | -
First Author: Janska H
Year: 2013
Journal: Biochim Biophys Acta
Title: Protein quality control in organelles - AAA/FtsH story.
Volume: 1833
Issue: 2
Pages: 381-7
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Publication
16966379 | -
First Author: Rainey RN
Year: 2006
Journal: Mol Cell Biol
Title: A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space.
Volume: 26
Issue: 22
Pages: 8488-97
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Publication
20657548 | -
First Author: Potting C
Year: 2010
Journal: EMBO J
Title: Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
Volume: 29
Issue: 17
Pages: 2888-98
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Publication
12119188 | -
First Author: Tailleux A
Year: 2002
Journal: Atherosclerosis
Title: Apolipoprotein A-II, HDL metabolism and atherosclerosis.
Volume: 164
Issue: 1
Pages: 1-13
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Publication
9538260 | -
First Author: Motizuki M
Year: 1998
Journal: J Biochem
Title: Purification, primary structure, and antimicrobial activities of bovine apolipoprotein A-II.
Volume: 123
Issue: 4
Pages: 675-9
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Publication
1554697 | -
First Author: Schluchter WM
Year: 1992
Journal: Biochemistry
Title: Molecular characterization of ferredoxin-NADP+ oxidoreductase in cyanobacteria: cloning and sequence of the petH gene of Synechococcus sp. PCC 7002 and studies on the gene product.
Volume: 31
Issue: 12
Pages: 3092-102
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Publication
2040095 | -
First Author: Fischer PW
Year: 1991
Journal: Clin Biochem
Title: An evaluation of plasma and erythrocyte magnesium concentration and the activities of alkaline phosphatase and creatine kinase as indicators of magnesium status.
Volume: 24
Issue: 2
Pages: 215-8
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Publication
4636046 | -
First Author: Bradham GB
Year: 1972
Journal: Med Biol Eng
Title: An automatically compensating gradient-layer calorimeter for animal metabolic studies.
Volume: 10
Issue: 6
Pages: 793-5
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Publication
9032387 | -
First Author: Suarez DL
Year: 1997
Journal: J Virol
Title: Size variation within the second hypervariable region of the surface envelope gene of the bovine lentivirus BIV in experimentally and naturally infected cattle.
Volume: 71
Issue: 3
Pages: 2482-6
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Publication
11448023 | -
First Author: Meas S
Year: 2001
Journal: Arch Virol
Title: Phylogenetic relationships of bovine immunodeficiency virus in cattle and buffaloes based on surface envelope gene sequences. Brief report.
Volume: 146
Issue: 5
Pages: 1037-45
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Publication
18622392 | -
First Author: Monahan BJ
Year: 2008
Journal: Nat Struct Mol Biol
Title: Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.
Volume: 15
Issue: 8
Pages: 873-80
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Publication
33263569 | -
First Author: Newman J
Year: 2020
Journal: Acta Crystallogr F Struct Biol Commun
Title: The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein.
Volume: 76
Issue: Pt 12
Pages: 583-589
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Publication
12923574 | -
First Author: Kostyuchenko VA
Year: 2003
Journal: Nat Struct Biol
Title: Three-dimensional structure of bacteriophage T4 baseplate.
Volume: 10
Issue: 9
Pages: 688-93
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Publication
10966799 | -
First Author: Leiman PG
Year: 2000
Journal: J Mol Biol
Title: Structure of bacteriophage T4 gene product 11, the interface between the baseplate and short tail fibers.
Volume: 301
Issue: 4
Pages: 975-85
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Publication
14990618 | -
First Author: Faivre-Rampant O
Year: 2004
Journal: J Exp Bot
Title: Regulated expression of a novel TCP domain transcription factor indicates an involvement in the control of meristem activation processes in Solanum tuberosum.
Volume: 55
Issue: 398
Pages: 951-3
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Publication
17645436 | -
First Author: Stephan A
Year: 2007
Journal: Traffic
Title: An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport.
Volume: 8
Issue: 10
Pages: 1323-30
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Publication
14536023 | -
 
First Author: Grynberg M
Year: 2003
Journal: BMC Bioinformatics
Title: Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.
Volume: 4
Pages: 46
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Publication
18156177 | -
First Author: Querin L
Year: 2008
Journal: J Biol Chem
Title: Proteomic analysis of a nutritional shift-up in Saccharomyces cerevisiae identifies Gvp36 as a BAR-containing protein involved in vesicular traffic and nutritional adaptation.
Volume: 283
Issue: 8
Pages: 4730-43
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Publication
12581524 | -
First Author: Culi J
Year: 2003
Journal: Cell
Title: Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.
Volume: 112
Issue: 3
Pages: 343-54
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Publication
17488095 | J:122304
First Author: Koduri V
Year: 2007
Journal: Biochemistry
Title: Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
Volume: 46
Issue: 22
Pages: 6570-7
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Publication
20008324 | -
First Author: De Groot CO
Year: 2010
Journal: J Biol Chem
Title: Molecular insights into mammalian end-binding protein heterodimerization.
Volume: 285
Issue: 8
Pages: 5802-14
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Publication
21062375 | -
First Author: Liu H
Year: 2010
Journal: Mol Microbiol
Title: Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis.
Volume: 78
Issue: 4
Pages: 1038-54
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Publication
11877377 | -
First Author: Yazdi PT
Year: 2002
Journal: Genes Dev
Title: SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.
Volume: 16
Issue: 5
Pages: 571-82
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Publication
24756084 | -
First Author: Parenti I
Year: 2014
Journal: Epigenetics
Title: Overall and allele-specific expression of the SMC1A gene in female Cornelia de Lange syndrome patients and healthy controls.
Volume: 9
Issue: 7
Pages: 973-9
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Publication
18996922 | -
First Author: Revenkova E
Year: 2009
Journal: Hum Mol Genet
Title: Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.
Volume: 18
Issue: 3
Pages: 418-27
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Publication
22885700 | -
First Author: Deardorff MA
Year: 2012
Journal: Nature
Title: HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Volume: 489
Issue: 7415
Pages: 313-7
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Publication
23106691 | -
First Author: Gimigliano A
Year: 2012
Journal: J Proteome Res
Title: Proteomic profile identifies dysregulated pathways in Cornelia de Lange syndrome cells with distinct mutations in SMC1A and SMC3 genes.
Volume: 11
Issue: 12
Pages: 6111-23
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Publication
8392064 | -
First Author: Jessberger R
Year: 1993
Journal: J Biol Chem
Title: A mammalian protein complex that repairs double-strand breaks and deletions by recombination.
Volume: 268
Issue: 20
Pages: 15070-9
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Publication
28301465 | -
First Author: Chao LF
Year: 2017
Journal: PLoS Genet
Title: An SMC-like protein binds and regulates Caenorhabditis elegans condensins.
Volume: 13
Issue: 3
Pages: e1006614
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Publication
18480402 | -
First Author: Cooper KM
Year: 2008
Journal: Mol Biol Cell
Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
Volume: 19
Issue: 8
Pages: 3180-91
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Publication
24421327 | -
First Author: Starnes TW
Year: 2014
Journal: Blood
Title: The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
Volume: 123
Issue: 17
Pages: 2703-14
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Publication
22161697 | -
First Author: Demidowich AP
Year: 2012
Journal: Arthritis Rheum
Title: Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).
Volume: 64
Issue: 6
Pages: 2022-7
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Publication
14595024 | -
First Author: Shoham NG
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.
Volume: 100
Issue: 23
Pages: 13501-6
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Publication
24981858 | -
First Author: Remans K
Year: 2014
Journal: Cell Rep
Title: C2 domains as protein-protein interaction modules in the ciliary transition zone.
Volume: 8
Issue: 1
Pages: 1-9
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Publication
17558407 | -
First Author: Arts HH
Year: 2007
Journal: Nat Genet
Title: Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome.
Volume: 39
Issue: 7
Pages: 882-8
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Publication
12874105 | -
First Author: Castagnet P
Year: 2003
Journal: Hum Mol Genet
Title: RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons.
Volume: 12
Issue: 15
Pages: 1847-63
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Publication
21685204 | -
First Author: Coene KL
Year: 2011
Journal: Hum Mol Genet
Title: The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.
Volume: 20
Issue: 18
Pages: 3592-605
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Publication
18281315 | -
First Author: Devuyst O
Year: 2008
Journal: Nephrol Dial Transplant
Title: Mutations in RPGRIP1L: extending the clinical spectrum of ciliopathies.
Volume: 23
Issue: 5
Pages: 1500-3
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Publication
18270200 | -
First Author: Song D
Year: 2008
Journal: J Biol Chem
Title: A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.
Volume: 283
Issue: 14
Pages: 9231-8
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Publication
16432217 | -
First Author: Park YJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The structure of nucleosome assembly protein 1.
Volume: 103
Issue: 5
Pages: 1248-53
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Publication
18795805 | -
First Author: Mrosek M
Year: 2008
Journal: Biochemistry
Title: Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold.
Volume: 47
Issue: 40
Pages: 10722-30
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Publication
11679633 | J:77660
First Author: Bodine SC
Year: 2001
Journal: Science
Title: Identification of ubiquitin ligases required for skeletal muscle atrophy.
Volume: 294
Issue: 5547
Pages: 1704-8
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Publication
11927605 | -
First Author: McElhinny AS
Year: 2002
Journal: J Cell Biol
Title: Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.
Volume: 157
Issue: 1
Pages: 125-36
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Publication
18468620 | J:307450
First Author: Hirner S
Year: 2008
Journal: J Mol Biol
Title: MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.
Volume: 379
Issue: 4
Pages: 666-77
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Publication
17360532 | J:120068
First Author: Fielitz J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.
Volume: 104
Issue: 11
Pages: 4377-82
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Protein Domain
IPR043454 | NPH3/RPT2-like
Type: Family
Description: The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specificto higher plants. Several regions of sequence and predicted structuralconservation define members of the NRL family, with three domains being mostnotable: an N-terminal BTB domain, a centrally located NPH3domain, and a C-terminal coiled coil domain. The function of the NPH3 domainis not yet known [, , , , , , , ].Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves [].
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Protein Domain
IPR004116 | Amelogenin
Type: Family
Description: Amelogenins, cell adhesion proteins, play a role in the biomineralisation ofteeth. They seem to regulate formation of crystallites during the secretorystage of tooth enamel development and are thought to play a major role inthe structural organisation and mineralisation of developing enamel. Theextracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins [].Circulardichroism studies of porcine amelogenin have shown that the proteinconsists of 3 discrete folding units []: the N-terminal region appears tocontain β-strand structures, while the C-terminal region displayscharacteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain arepetitive β-turn segment and a "β-spiral"between Gln112 and Leu138,which sequester a (Pro, Leu, Gln) rich region []. The β-spiraloffers a probable site for interactions with Ca2+ ions.Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplasticamelogenesis imperfecta, a disease characterised by defective enamel. A 9bpdeletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disruptingthe 16-residue (Met1-Ala16) amelogenin signal peptide [].
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Protein Domain
IPR004148 | BAR_dom
Type: Domain
Description: Endocytosis and intracellular transport involve several mechanistic steps: (1) for the internalisation of cargo molecules, the membrane needs to bend to form a vesicular structure, which requires membrane curvature and a rearrangement of the cytoskeleton; (2) following its formation, the vesicle has to be pinched off the membrane; (3) the cargo has to be subsequently transported through the cell and the vesicle must fuse with the correct cellular compartment.Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis, involved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain, known as the BAR (Bin-Amphiphysin-Rvs)-domain, which is required for their in vivofunction and their ability to tubulate membranes []. The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic, aromatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise, heterodimerise or, in a few cases, interact with small GTPases.
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Protein Domain
IPR018859 | BAR_dom-cont
Type: Family
Description: Endocytosis and intracellular transport involve several mechanistic steps: (1) for the internalisation of cargo molecules, the membrane needs to bend to form a vesicular structure, which requires membrane curvature and a rearrangement of the cytoskeleton; (2) following its formation, the vesicle has to be pinched off the membrane; (3) the cargo has to be subsequently transported through the cell and the vesicle must fuse with the correct cellular compartment.Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis, involved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain, known as the BAR (Bin-Amphiphysin-Rvs)-domain, which is required for their in vivofunction and their ability to tubulate membranes []. The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic, aromatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise, heterodimerise or, in a few cases, interact with small GTPases. This entry identifies several fungal BAR domain-containing proteins, such as Gvp36, that are not detected by [].
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Protein Domain
IPR002164 | NAP_family
Type: Family
Description: It is thought that NAPs act as histone chaperones, shuttling both core and linker histones from their site of synthesis in the cytoplasm to the nucleus. The proteins may be involved in regulating gene expression and therefore cellular differentiation [, ].The centrosomal protein c-Nap1, also known as Cep250, has been implicated in the cell-cycle-regulated cohesion of microtubule-organizing centres. This 281kDa protein consists mainly of domains predicted to form coiled coil structures. The C-terminal region defines a novel histone-binding domain that is responsible for targeting CNAP1, and possibly condensin, to mitotic chromosomes []. During interphase, C-Nap1 localizes to the proximal ends of both parental centrioles, but it dissociates from these structures at the onset of mitosis. Re-association with centrioles then occurs in late telophase or at the very beginning of G1 phase, when daughter cells are still connected by post-mitotic bridges. Electron microscopic studies performed on isolated centrosomes suggest that a proteinaceous linker connects parental centrioles and C-Nap1 may be part of a linker structure that assures the cohesion of duplicated centrosomes during interphase, but that is dismantled upon centrosome separation at the onset of mitosis [].
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