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Search results 2001 to 2100 out of 2795 for Egfr

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*L858R)#Hev/?
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Egfr/Egfr
Background: C57BL/6J-Egfr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*T790M*L858R)19Kkw/?
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*)#Kkw/?
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
20585042 | J:165882
First Author: Thomas DH
Year: 2010
Journal: Blood
Title: A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.
Volume: 116
Issue: 14
Pages: 2570-8
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Publication
20670933 | -
First Author: Chen X
Year: 2010
Journal: J Biol Chem
Title: Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate.
Volume: 285
Issue: 41
Pages: 31268-76
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Publication
17679096 | J:134815
First Author: Mikhailik A
Year: 2007
Journal: Mol Cell
Title: A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling.
Volume: 27
Issue: 3
Pages: 486-97
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Publication
9223670 | -
First Author: Ueno H
Year: 1997
Journal: Oncogene
Title: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Volume: 14
Issue: 25
Pages: 3067-72
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Publication
18849880 | -
First Author: Yamada S
Year: 2008
Journal: Neuroreport
Title: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth.
Volume: 19
Issue: 17
Pages: 1733-8
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Publication
20548102 | -
First Author: Farhan H
Year: 2010
Journal: J Cell Biol
Title: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening.
Volume: 189
Issue: 6
Pages: 997-1011
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Publication
10445845 | J:227540
First Author: Honda H
Year: 1999
Journal: Oncogene
Title: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Volume: 18
Issue: 26
Pages: 3821-30
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Publication
30061385 | -
First Author: Reshetnyak AV
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Volume: 115
Issue: 33
Pages: 8340-8345
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Protein Domain
IPR026984 | LTK
Type: Family
Description: Leukocyte tyrosine kinase (LTK) receptor is an orphan receptor with a tyrosine-protein kinase activity [, , ]. This receptor is activated by ALKAL1 or ALKAL2 ligands at the cell surface and transduces an extracellular signal into an intracellular response [, ]. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway [].The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. LTK is involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport [, , ].
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Protein Domain
IPR035632 | UBASH3B_SH3
Type: Domain
Description: This entry represents the SH3 domain of UBASH3B. UBASH3B (also known as STS-1 or TULA-2), belongs to the TULA family, is an active phosphatase that is expressed ubiquitously []. The phosphatase activity of UBASH3B is essential for its roles in the suppression of TCR signaling []and the regulation of EGFR []. It also interacts with Syk and functions as a negative regulator of platelet glycoprotein VI signaling in platelets []. The TULA family includes two members termed p70/STS-1/TULA-2 and UBASH3A/STS-2/TULA/Cbl-InteractingProtein 4 (CLIP4). TULA proteins contain an N-terminal UBA domain, a central SH3 domain, and a C-terminal histidine phosphatase domain. They bind c-Cbl (a multidomain adaptor and an E3 ubiquitinligase) through the SH3 domain []and to ubiquitin via UBA [].
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Protein Domain
IPR035732 | VAV2_SH3_2
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2.
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Protein Domain
IPR035733 | VAV2_SH3_1
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2.
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Publication
8760305 | J:34966
First Author: Pelicci G
Year: 1996
Journal: Oncogene
Title: A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
Volume: 13
Issue: 3
Pages: 633-41
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Publication
18854019 | -
 
First Author: Lim JP
Year: 2008
Journal: BMC Cell Biol
Title: A role for SNX5 in the regulation of macropinocytosis.
Volume: 9
Pages: 58
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Publication
22204307 | -
 
First Author: Krause-Gruszczynska M
Year: 2011
Journal: Cell Commun Signal
Title: The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Volume: 9
Pages: 32
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Publication
20298788 | -
First Author: Moon MS
Year: 2010
Journal: Mol Cell Neurosci
Title: Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.
Volume: 44
Issue: 2
Pages: 118-28
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Publication
20140013 | -
First Author: Thalappilly S
Year: 2010
Journal: Oncogene
Title: VAV2 regulates epidermal growth factor receptor endocytosis and degradation.
Volume: 29
Issue: 17
Pages: 2528-39
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
19451809 | -
First Author: Holthusen K
Year: 2009
Journal: Am J Ther
Title: Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease.
Volume: 16
Issue: 6
Pages: 496-507
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Publication
18434624 | -
First Author: Arora PD
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.
Volume: 295
Issue: 1
Pages: C130-7
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HT Experiment
E-GEOD-25926 | Comparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
Series Id: GSE25926
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
21830225 | J:227464
First Author: Feng L
Year: 2011
Journal: Cell Biochem Funct
Title: SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.
Volume: 29
Issue: 7
Pages: 589-96
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Publication
19116150 | J:144201
First Author: Tosoni D
Year: 2009
Journal: FEBS Lett
Title: CAP (Cbl associated protein) regulates receptor-mediated endocytosis.
Volume: 583
Issue: 2
Pages: 293-300
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Publication
28655741 | J:244160
First Author: Hosur V
Year: 2017
Journal: Biol Open
Title: Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis.
Volume: 6
Issue: 8
Pages: 1174-1179
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Publication
17169360 | J:117695
First Author: Sahin U
Year: 2007
Journal: FEBS Lett
Title: Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17.
Volume: 581
Issue: 1
Pages: 41-4
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Publication
16766261 | J:110134
First Author: Arteaga CL
Year: 2006
Journal: Cancer Cell
Title: EGF receptor mutations in lung cancer: from humans to mice and maybe back to humans.
Volume: 9
Issue: 6
Pages: 421-3
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Publication
16735510 | J:116476
First Author: Oved S
Year: 2006
Journal: J Biol Chem
Title: Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.
Volume: 281
Issue: 31
Pages: 21640-51
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Publication
17613432 | J:122851
First Author: Settleman J
Year: 2007
Journal: Cancer Cell
Title: Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.
Volume: 12
Issue: 1
Pages: 6-8
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Protein Coding Gene
MGI:1196464 | Adgre4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98397 | Src
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97595 | Prkca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106211 | Cdc42
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P60766
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
P20444
Organism: Mus musculus/domesticus
Length: 672  
Fragment?: false
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Protein
Q01279
Organism: Mus musculus/domesticus
Length: 1210  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Publication
29760047 | J:263944
First Author: Zhang F
Year: 2018
Journal: Cancer Res
Title: Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies.
Volume: 78
Issue: 13
Pages: 3718-3730
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Publication
39515330 | J:358842
     
First Author: Tang Z
Year: 2024
Journal: Dev Cell
Title: A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression.
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Publication
31940491 | J:287255
First Author: Blagih J
Year: 2020
Journal: Cell Rep
Title: Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Volume: 30
Issue: 2
Pages: 481-496.e6
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Publication
34696786 | J:339467
First Author: Vengoji R
Year: 2021
Journal: J Exp Clin Cancer Res
Title: Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma.
Volume: 40
Issue: 1
Pages: 335
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Publication
37067057 | J:335421
First Author: Tomoshige K
Year: 2023
Journal: Cancer Res
Title: FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung.
Volume: 83
Issue: 9
Pages: 1443-1458
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Publication
26883990 | J:234740
 
First Author: Koyama S
Year: 2016
Journal: Nat Commun
Title: Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.
Volume: 7
Pages: 10501
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Publication
36916958 | J:336141
First Author: Shibahara D
Year: 2023
Journal: Cancer Sci
Title: TIP60 is required for tumorigenesis in non-small cell lung cancer.
Volume: 114
Issue: 6
Pages: 2400-2413
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Publication
29054992 | J:253753
First Author: Rusan M
Year: 2018
Journal: Cancer Discov
Title: Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.
Volume: 8
Issue: 1
Pages: 59-73
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Publication
25193384 | J:216687
First Author: Martinengo C
Year: 2014
Journal: Cancer Res
Title: ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis.
Volume: 74
Issue: 21
Pages: 6094-106
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a Col1a1/Col1a1 Pten/Pten
Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
23100251 | -
First Author: Sakane A
Year: 2012
Journal: J Biol Chem
Title: Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development.
Volume: 287
Issue: 51
Pages: 42455-68
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Publication
18094055 | J:200405
First Author: Yamamura R
Year: 2008
Journal: Mol Biol Cell
Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Volume: 19
Issue: 3
Pages: 971-83
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Publication
23890175 | J:201396
First Author: Sakane A
Year: 2013
Journal: Genes Cells
Title: Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.
Volume: 18
Issue: 9
Pages: 810-22
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Publication
23673157 | J:199213
First Author: Ikonomov OC
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching.
Volume: 305
Issue: 1
Pages: E119-31
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Publication
17452444 | J:122785
First Author: Jones N
Year: 2007
Journal: Mol Cell Biol
Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Volume: 27
Issue: 13
Pages: 4759-73
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Protein
H3BKI0
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Protein
Q05DS2
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
Q3TRR8
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Publication
34646012 | -
First Author: De Munck S
Year: 2021
Journal: Nature
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
Volume: 600
Issue: 7887
Pages: 143-147
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Publication
21795389 | -
First Author: Abou-Zeid N
Year: 2011
Journal: Mol Biol Cell
Title: MICAL-like1 mediates epidermal growth factor receptor endocytosis.
Volume: 22
Issue: 18
Pages: 3431-41
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Publication
21951725 | -
First Author: Rahajeng J
Year: 2012
Journal: Traffic
Title: MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
Volume: 13
Issue: 1
Pages: 82-93
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Publication
18413246 | -
 
First Author: Nishimura N
Year: 2008
Journal: Methods Enzymol
Title: Identification and characterization of JRAB/MICAL-L2, a junctional Rab13-binding protein.
Volume: 438
Pages: 141-53
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Publication
20585517 | -
First Author: Sharma M
Year: 2010
Journal: Commun Integr Biol
Title: MICAL-L1: An unusual Rab effector that links EHD1 to tubular recycling endosomes.
Volume: 3
Issue: 2
Pages: 181-3
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Publication
22948967 | J:194646
First Author: Turco MY
Year: 2012
Journal: Stem Cells
Title: Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
Volume: 30
Issue: 11
Pages: 2423-36
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Publication
24430869 | -
First Author: Wills MK
Year: 2014
Journal: Mol Biol Cell
Title: The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.
Volume: 25
Issue: 6
Pages: 739-52
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Publication
19804359 | -
First Author: Camaj P
Year: 2009
Journal: Biol Chem
Title: EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
Volume: 390
Issue: 12
Pages: 1293-302
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Publication
22665268 | -
First Author: Hu B
Year: 2012
Journal: Cancer Res
Title: Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.
Volume: 72
Issue: 15
Pages: 3873-85
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Publication
20005202 | -
First Author: Wakabayashi T
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Fibulin-3 negatively regulates chondrocyte differentiation.
Volume: 391
Issue: 1
Pages: 1116-21
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Publication
15159412 | -
First Author: Kowanetz K
Year: 2004
Journal: J Biol Chem
Title: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.
Volume: 279
Issue: 31
Pages: 32786-95
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Publication
18344182 | -
First Author: Tsygankov AY
Year: 2008
Journal: IUBMB Life
Title: Multidomain STS/TULA proteins are novel cellular regulators.
Volume: 60
Issue: 4
Pages: 224-31
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Publication
19137586 | J:146175
First Author: Bacon C
Year: 2009
Journal: J Comp Neurol
Title: Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.
Volume: 513
Issue: 2
Pages: 224-36
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Publication
19423080 | -
First Author: Hadjighassem MR
Year: 2009
Journal: Biol Psychiatry
Title: Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
Volume: 66
Issue: 3
Pages: 214-22
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Publication
11895483 | -
First Author: Morishita M
Year: 2002
Journal: Genes Cells
Title: Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe.
Volume: 7
Issue: 2
Pages: 199-215
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Publication
30427760 | -
First Author: Miner GE
Year: 2019
Journal: Mol Biol Cell
Title: Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.
Volume: 30
Issue: 2
Pages: 201-208
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Publication
19846542 | -
First Author: Whitley P
Year: 2009
Journal: Plant Physiol
Title: Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen.
Volume: 151
Issue: 4
Pages: 1812-22
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Publication
21412048 | -
First Author: Hirano T
Year: 2011
Journal: Plant Signal Behav
Title: Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.
Volume: 6
Issue: 4
Pages: 583-5
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Publication
18950639 | J:168949
First Author: Sbrissa D
Year: 2008
Journal: J Mol Biol
Title: ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Volume: 384
Issue: 4
Pages: 766-79
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Protein Domain
IPR043560 | ZGPAT
Type: Family
Description: This entry represents the zinc finger CCCH-type with G patch domain-containing protein (ZIP) that acts as a transcription repressor through the recruitment of the Mi-2/nucleosome remodelling and deacetylase (NuRD) complex to target promoters. ZIP regulates several cellular signalling pathways like the epidermal growth factor receptor (EGFR) pathways, critically involved in cell proliferation, survival, and migration.ZIP contains several domains: a CCCH zinc finger, a TUDOR domain, a G-patch and a coiled-coil domain. The coiled-coil domain is responsible for the ZIP interaction with Mi-2 to recruit the NuRD complex, while its zinc finger structure specifically recognises the consensus sequence in the 5' upstream region of EGFR. The TUDOR domain is a chromatin-presenting module reading the methylated histone marks. ZIP is also involved in the recognition of RNA and other proteins, suggesting that it may coordinate an active coupling between transcription regulation and pre-mRNA splicing, especially considering that ZIP contains a CCCH-type of zinc finger and a G-patch domain, both of which have been featured in proteins functioning in mRNA processing. Additionally, ZIP inhibits cell proliferation and suppresses breast carcinogenesis, while its depletion leads to a drastic tumour growth in vivo. ZIP is downregulated in breast carcinomas and that its level of expression is negatively correlated with that of EGFR [].
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Protein Domain
IPR028563 | MICAL-L
Type: Family
Description: MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. MICAL-like protein 1 (MICAL-L1) interacts with small G proteins and regulates endocytic recycling of receptors [, ]. It forms a complex with Rab13 that regulates EGFR trafficking at late endocytic pathways []. MICAL-L1 also forms a complex with Arf6 that regulates Rab8a function. MICAL-L1 can be regulated by Rab35 [].MICAL-like protein 2 (MICAL-L2, also known as JRAB) interacts with Rab13 []and Rab8 to regulate the endocytic recycling of occludin, claudin and E-cadherin to the plasma membrane. It may thereby regulate the establishment of tight junctions and adherens junctions []. MICAL-L2/JRAB also regulates the reorganisation of the actin cytoskeleton through interactions with actinin-1, actinin-4, and filamentous actin [], and via filamins during cell spreading [].
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Protein Domain
IPR014637 | SNX5/SNX6/SNX32
Type: Family
Description: Sorting nexins (SNXs) are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif, the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting []. Members of this group also contain coiled-coil regions within their large C-terminal domains and a BAR domain, whose function has been defined as a dimerisation motif, as sensing and inducing membrane curvature, and/or likely to bind to small GTPases [].This entry includes SNX5, SNX6 and SNX32 (also known as SNX6B).SNX5 contains a BAR domain that is C teminus to the PX domain. SNX5 plays a role in macropinocytosis []and in the internalisation of EGFR after EGF stimulation [].SNX6 was found to interact with members of the transforming growth factor-beta family of receptor serine/threonine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivoof oligomeric complexes. SNX6 is localized in the cytoplasm where it is thought to target proteins to the trans-Golgi network []. In addition, SNX6 was found to be translocated from the cytoplasm to nucleus by Pim-1, an oncogene product of serine/threonine kinase. This translocation is not affected by Pim-1-dependent phosphorylation, but the functional significance is unknown [].
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Protein Domain
IPR044769 | PIKfyve_PIPKc
Type: Domain
Description: This entry represents the C-terminal catalytic lipid kinase domain related to PtdInsP kinases (PIPKc domain) found in PIKfyve and related proteins.1-phosphatidylinositol-3-phosphate 5-kinase (), also called FYVE finger-containing phosphoinositide kinase (PIKfyve), forms a complex with its regulators, the scaffolding protein Vac14 and the lipid phosphatase Fig4. The complex synthesises phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2]through the phosphorylation of phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) on the fifth hydroxyl of the myo-inositol ring. Then phosphatidylinositol-5-phosphate (PtdIns5P) is generated directly from PtdIns(3,5)P2. PtdIns(3,5)P2 and PtdIns5P regulate endosomal trafficking and responses to extracellular stimuli []. It is vital in early embryonic development and plays a role in different pathways, such as receptor tyrosine kinase (RTK) or EGFR degradation, regulation of the glutamate transporters EAAT2, EAAT3 and EAAT4 and the cystic fibrosis transmembrane conductance regulator (CFTR). It is also essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle [, , ].The yeast orthologue of human PIKfyve, Fab1, is required for endocytic-vacuolar pathway and nuclear migration [, ]. The plant orthologues such as FAB1A-D from Arabidopsis are important for the maintenance of endomembrane homeostasis and for development of viable pollen [, ].PIKfyve and its orthologues share a similar architecture consisting of a N-terminal FYVE domain, a middle region related to the CCT/TCP-1/Cpn60 chaperonins that are involved in productive folding of actin and tubulin, a second middle domain that contains a number of conserved cysteine residues (CCR) unique to these proteins, and a C-terminal catalytic lipid kinase domain related to PtdInsP kinases (or the PIPKc domain).
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Protein Domain
IPR032973 | EFEMP1
Type: Family
Description: Fibulins area family of ECM glycoproteins characterized by a fibulin-type C-terminal domain preceded by tandem calcium-binding epidermal growth factor (EGF)-like modules. They are involved in protein-protein interaction with the components of basement membrane and extracellular matrix proteins. There are five fibulins, which can be classified into two subgroups. Fibulin-1 and -2 constitute one subgroup. These fibulins are larger than the others due to the presence of a higher number of EGF modules and an extra domain with three anaphylatoxin modules []. Members of the second subgroup, fibulin-3, -4, and -5, are similarly small in size and highly homologous to one another in modular structure. They consist of a modified cbEGF domain at the N terminus followed by five tandem cbEGF modules and the fibulin-type C-terminal region.EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1, also known as Fibulin-3) binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signalling pathways []. It promotes glioma growth and resistance through a novel paracrine regulation of Notch signalling []and may function as a negative regulator of chondrocyte differentiation [].
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Protein Domain
IPR029596 | SHC4
Type: Family
Description: The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway []. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [].A fourth Shc family protein, ShcD/Shc4, is expressed in adult brain and skeletal muscle. ShcD can associate via its PTB domain with the phosphorylated muscle-specific kinase (MuSK) receptor tyrosine kinase and undergo tyrosine phosphorylation downstream of activated MuSK. Therefore, ShcD may mediate a specific aspect of signalling downstream of the MuSK receptor []. ShcD also interacts with EGFR receptor (epidermal growth factor receptor) and facilitates its ligand-independent phosphorylation []. ShcD has been shown to be a modulator in the transition of embryonic stem cell (ESC) to epiblast stem cells (EpiSCs), the initial step for ESCs to commit to differentiation [].
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Protein Domain
IPR039725 | CC2D1A/B
Type: Family
Description: This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including nuclear factor kappaB, PDK1/Akt, cAMP/PKA, Notch and bone morphogenetic protein []. It is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. CC2D1B binds to the 5-HT1A DRE and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons [].CC2D1A and CC2D1B have also been shown to interact with the CHMP4 family of proteins, the major subunit of the ESCRT-III complex. They may regulate degradation and signaling of EGFR and TLR4 [].CC2D1A and CC2D1B share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The CC2D1A C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The CC2D1B C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions []. Mutations in the CC2D1A gene has been linked to nonsyndromic mental retardation [, ].
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Protein Coding Gene
MGI:107445 | Dbx2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685790 | Garem1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P35235
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Publication
30446855 | J:276496
First Author: Farber G
Year: 2019
Journal: Angiogenesis
Title: ADAM10 controls the differentiation of the coronary arterial endothelium.
Volume: 22
Issue: 2
Pages: 237-250
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Publication
19683494 | J:154203
First Author: Descot A
Year: 2009
Journal: Mol Cell
Title: Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction.
Volume: 35
Issue: 3
Pages: 291-304
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Publication
21940500 | J:177354
First Author: Du YC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis.
Volume: 108
Issue: 40
Pages: 16753-8
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Publication
8647934 | J:33361
First Author: Vargas GA
Year: 1996
Journal: J Clin Invest
Title: Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice.
Volume: 97
Issue: 11
Pages: 2426-32
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Publication
31562298 | J:352078
First Author: Santos CP
Year: 2019
Journal: Nat Commun
Title: Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity.
Volume: 10
Issue: 1
Pages: 4407
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Publication
10987266 | J:64399
First Author: Ritland SR
Year: 2000
Journal: Cancer Res
Title: Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal injury.
Volume: 60
Issue: 17
Pages: 4678-81
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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