| Type |
Details |
Score |
| Publication |
| First Author: |
Olive V |
| Year: |
2013 |
| Journal: |
Elife |
| Title: |
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. |
| Volume: |
2 |
|
| Pages: |
e00822 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pogontke C |
| Year: |
2022 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Dynamic Epicardial Contribution to Cardiac Interstitial c-Kit and Sca1 Cellular Fractions. |
| Volume: |
10 |
|
| Pages: |
864765 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vaquié A |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration. |
| Volume: |
27 |
| Issue: |
11 |
| Pages: |
3152-3166.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeanette H |
| Year: |
2021 |
| Journal: |
Glia |
| Title: |
YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration. |
| Volume: |
69 |
| Issue: |
4 |
| Pages: |
1061-1074 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bremer M |
| Year: |
2011 |
| Journal: |
Glia |
| Title: |
Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve. |
| Volume: |
59 |
| Issue: |
7 |
| Pages: |
1022-32 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park JA |
| Year: |
2013 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. |
| Volume: |
304 |
| Issue: |
10 |
| Pages: |
L701-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nalbandian A |
| Year: |
2015 |
| Journal: |
Hum Gene Ther Methods |
| Title: |
Targeted excision of VCP R155H mutation by Cre-LoxP technology as a promising therapeutic strategy for valosin-containing protein disease. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
13-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang L |
| Year: |
2020 |
| Journal: |
Cell Metab |
| Title: |
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
860-877.e9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lodhi IJ |
| Year: |
2017 |
| Journal: |
Cell Rep |
| Title: |
PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. |
| Volume: |
20 |
| Issue: |
12 |
| Pages: |
2766-2774 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Khan MP |
| Year: |
2016 |
| Journal: |
Bone |
| Title: |
BMP signaling is required for adult skeletal homeostasis and mediates bone anabolic action of parathyroid hormone. |
| Volume: |
92 |
|
| Pages: |
132-144 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schulze RJ |
| Year: |
2013 |
| Journal: |
J Cell Biol |
| Title: |
Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. |
| Volume: |
203 |
| Issue: |
2 |
| Pages: |
315-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ziegler AN |
| Year: |
2019 |
| Journal: |
Stem Cell Reports |
| Title: |
Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. |
| Volume: |
12 |
| Issue: |
4 |
| Pages: |
816-830 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ware M |
| Year: |
2016 |
| Journal: |
Neural Dev |
| Title: |
Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hamdane N |
| Year: |
2017 |
| Journal: |
Gene |
| Title: |
Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies. |
| Volume: |
612 |
|
| Pages: |
5-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Collins C |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. |
| Volume: |
111 |
| Issue: |
27 |
| Pages: |
9899-904 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Musthafa A |
| Year: |
2023 |
| Journal: |
Kobe J Med Sci |
| Title: |
Acute Amelioration of Inflammatory Activity Caused by Endothelin-2 Deficiency during Acute Lung Injury. |
| Volume: |
69 |
| Issue: |
3 |
| Pages: |
E96-E105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maruyama T |
| Year: |
2011 |
| Journal: |
Nat Immunol |
| Title: |
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
86-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carré GA |
| Year: |
2018 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and causes XY gonadal sex reversal. |
| Volume: |
27 |
| Issue: |
1 |
| Pages: |
190-198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pei W |
| Year: |
2017 |
| Journal: |
Nature |
| Title: |
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. |
| Volume: |
548 |
| Issue: |
7668 |
| Pages: |
456-460 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruppert R |
| Year: |
2015 |
| Journal: |
J Exp Med |
| Title: |
Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. |
| Volume: |
212 |
| Issue: |
9 |
| Pages: |
1415-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen S |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
The importance of LAT in the activation, homeostasis, and regulatory function of T cells. |
| Volume: |
285 |
| Issue: |
46 |
| Pages: |
35393-405 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Crotta S |
| Year: |
2023 |
| Journal: |
Nat Commun |
| Title: |
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
721 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang H |
| Year: |
2023 |
| Journal: |
Life Sci Alliance |
| Title: |
EZH2 controls epicardial cell migration during heart development. |
| Volume: |
6 |
| Issue: |
6 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Da Costa CR |
| Year: |
2016 |
| Journal: |
Personal Communication |
| Title: |
Deletion of FRT-flanked neo cassette from Grem1tm1Ecan |
|
|
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ikbkb/Ikbkb |
| Background: |
involves: 129S/SvEvBrd |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stk11/Stk11<+> Tagln/Tagln<+> |
| Background: |
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stk11/Stk11 Tagln/Tagln<+> |
| Background: |
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mylk/Mylk Tagln/? |
| Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Kras/Kras |
| Background: |
involves: 129S4/SvJae * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Aurka/Aurka Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129 * 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor |
| Background: |
involves: 129 * 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Slc16a8-cre/ERT2,-EGFP)1Moss/? |
| Background: |
involves: 129S/SvEv * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dnai1/Dnai1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129 * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Agr2/Agr2 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129 * 129S6/SvEvTac * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tardbp/Tardbp |
| Background: |
involves: 129 * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tardbp/Tardbp<+> |
| Background: |
involves: 129 * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gpx4/Gpx4 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd1/Pkd1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sirt1/Sirt1 |
| Background: |
involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nt5c2/Nt5c2<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
involves: 129 * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cmip/Cmip Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
| Background: |
B6.Cg-Cmip Gt(ROSA)26Sor |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Drosha/Drosha Wt1/Wt1<+> |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJae |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Il1r2/Il1r2 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ggps1/Ggps1 Tagln/Tagln<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Plp1-cre/ERT2)1Ueli/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Plp1-cre/ERT2)1Ueli/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tek/Tek<+> |
| Background: |
involves: 129P2/OlaHsd * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rempola B |
| Year: |
2006 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. |
| Volume: |
346 |
| Issue: |
2 |
| Pages: |
546-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chazaud C |
| Year: |
1996 |
| Journal: |
Mech Dev |
| Title: |
AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. |
| Volume: |
54 |
| Issue: |
1 |
| Pages: |
83-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang HJ |
| Year: |
2014 |
| Journal: |
Cancer Res |
| Title: |
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. |
| Volume: |
74 |
| Issue: |
5 |
| Pages: |
1484-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim HJ |
| Year: |
1999 |
| Journal: |
Mol Cell Biol |
| Title: |
Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. |
| Volume: |
19 |
| Issue: |
9 |
| Pages: |
6323-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoo HM |
| Year: |
2014 |
| Journal: |
Mol Cell |
| Title: |
Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. |
| Volume: |
56 |
| Issue: |
2 |
| Pages: |
261-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization. |
| Volume: |
294 |
| Issue: |
27 |
| Pages: |
10663-10673 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The AFF (AF4/FMR2) family includes four members: AFF1/AF4, AFF2/FMR2, AFF3/LAF4 and AFF4/AF5q31. All AFF proteins are localized in the cell nucleus and are involved in regulation of gene expression [, ].In humans, AFF2/FMR2 is silenced in FRAXE intellectual disability, while the other three members have been reported to form fusion genes as a consequence of chromosome translocations with the myeloid/lymphoid or mixed lineage leukemia (MLL) gene in acute lymphoblastic leukemias (ALLs) [, ].This entry also includes Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [].This entry represents the C-terminal domain homology domain (CHD) that is conserved among AF4/FMR2 family proteins, including AFF1, AFF2, AFF3, and AFF4. This domain consists of eight helices and is distantly related to tetratricopeptide repeat motifs. The CHD domain mediates the formation of an AFF4 homodimer or an AFF1-AFF4 heterodimer. []. This domain is essential for AFF4 interaction with Transcription Start Site (TSS)-associated histone H3K27 whose acetylation signals SEC to regulate transcriptional elongation of the ESR1 gene []. Depletion of AFF4 reduces expression of ESR1, and, consequently inhibits breast cancer cell growth []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence 5'-GCCNNNGGC-3' and stimulate target gene transcription [, ]. Five different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma, delta and epsilon. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [].The AP-2 family have been shown to be critical regulators of gene expression during embryogenesis. They regulate the development of facial prominence and limb buds, and are essential for cranial closure and development of the lens [, ]; they have also been implicated in tumorigenesis. AP-2 protein expression levels have been found to affect cell transformation, tumour growth and metastasis, and may predict survival in some types of cancer [, ]. Mutations in human AP-2 have been linked with bronchio-occular-facial syndrome and Char Syndrome, congenital birth defects characterised by craniofacial deformities and patent ductus arteriosus, respectively []. AP-2 gamma was originally isolated from murine carcinoma cells []. The gene was found to be expressed in several embryonic areas whose development can be affected by retinoids, such as the forebrain, face and limb buds []. A human homologue has also been identified which is involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer []. The protein was initially termed AP-2.2, but has since been reclassified as AP-2 gamma. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hoshii T |
| Year: |
2007 |
| Journal: |
Biol Reprod |
| Title: |
LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. |
| Volume: |
76 |
| Issue: |
2 |
| Pages: |
303-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rottiers V |
| Year: |
2017 |
| Journal: |
Obesity (Silver Spring) |
| Title: |
MTCH2 is a conserved regulator of lipid homeostasis. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
616-625 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Majorini MT |
| Year: |
2020 |
| Journal: |
Cancer Res |
| Title: |
Infiltrating Mast Cell-Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype. |
| Volume: |
80 |
| Issue: |
11 |
| Pages: |
2311-2324 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barnett KR |
| Year: |
2007 |
| Journal: |
Biol Reprod |
| Title: |
The aryl hydrocarbon receptor affects mouse ovarian follicle growth via mechanisms involving estradiol regulation and responsiveness. |
| Volume: |
76 |
| Issue: |
6 |
| Pages: |
1062-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bader MI |
| Year: |
2012 |
| Journal: |
J Steroid Biochem Mol Biol |
| Title: |
Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice. |
| Volume: |
128 |
| Issue: |
1-2 |
| Pages: |
29-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Best SA |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary. |
| Volume: |
141 |
| Issue: |
16 |
| Pages: |
3159-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Griffiths RM |
| Year: |
2020 |
| Journal: |
Reproduction |
| Title: |
AMPK is required for uterine receptivity and normal responses to steroid hormones. |
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159 |
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Pabona JM |
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BMC Cancer |
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MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. |
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Front Endocrinol (Lausanne) |
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The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis. |
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PLoS Genet |
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Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. |
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Fekete C |
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2019 |
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Neuroscience |
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Chronic Amyloid β Oligomer Infusion Evokes Sustained Inflammation and Microglial Changes in the Rat Hippocampus via NLRP3. |
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405 |
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2024 |
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158 |
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11 |
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true |
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| Protein |
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true |
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