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Search results 2001 to 2071 out of 2071 for Jag1

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Type Details Score
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5467409
Age: embryonic day 10.5
Note: The region of the neuroepithelium from which the expressing cells derive corresponds to the region of Jag1 expression in the ventricular zone.
Specimen Label: not shown
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5467409
Age: embryonic day 10.5
Note: The region of the neuroepithelium from which the expressing cells derive corresponds to the region of Jag1 expression in the ventricular zone.
Specimen Label: not shown
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2013-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5467409
Age: embryonic day 11.5
Note: The region of the neuroepithelium from which the expressing cells derive corresponds to the region of Jag1 expression in the ventricular zone.
Specimen Label: not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5762877
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6763035
Age: embryonic day 12.5
Image: 10H
Note: Jag1 and Sox2 exhibited largely overlapping expression in anterior and lateral cristae. In the anterior cristae, expression had a negative patch in the middle, whereas Sox2 expression did not.
Specimen Label: 10H
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:5762877
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6763035
Age: embryonic day 12.5
Image: 10B
Note: Jag1 and Sox2 exhibited largely overlapping expression in posterior cristae and saccular macula. In the posterior cristae, expression had a negative patch in the middle, whereas Sox2 expression did not.
Specimen Label: 10B
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:5506718
Assay Type: RNA in situ
Annotation Date: 2016-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759820
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5704120
Age: embryonic day 12.5
Image: 1C
Note: Expressed in the portion of the cochlea opposite to the thickened epithelium. No longer expressed at the epithelial thickening and did not overlap with either Sox2 or Jag1 expression.
Specimen Label: 1C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5506718
Assay Type: RNA in situ
Annotation Date: 2016-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5704120
Age: embryonic day 13.5
Image: 1D
Note: Expressed in the portion of the cochlea opposite to the thickened epithelium. No longer expressed at the epithelial thickening and did not overlap with either Sox2 or Jag1 expression.
Specimen Label: 1D
Detected: true
Specimen Num: 4
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Strain
MGI:5004366 | STOCK Tg(Jag1-EGFP)OM21Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Tg(Cdh5-tTA)D5Lbjn/? Tg(tetO-Jag1)1Rha/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE116272 | Generation of esophageal basal progenitor cells from human pluripotent stem cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
25747658 | -
First Author: McMillan BJ
Year: 2015
Journal: Mol Cell
Title: A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.
Volume: 57
Issue: 5
Pages: 912-924
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Protein Domain
IPR040847 | SH3_15
Type: Domain
Description: The REP domain of Mind bomb which serves as the substrate recognition domain for a second, membrane-distal epitope of the Notch ligand (C-box). Although the first Mib repeat of REP may play a dominant role in ligand binding, the two repeats appear to cooperate in the engagement of the Jag1 tail. Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. The structure and functional analysis, show that Mib1 contains two independent substrate recognition domains that engage two distinct epitopes from the cytoplasmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other near the C terminus. REP domains have a five-stranded anti-parallel twisted beta sheet topology similar to that of SH3 domains [].
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HT Experiment
E-GEOD-31643 | Conditional ablation of the Notch2 receptor in the ocular lens
Series Id: GSE31643
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE230792 | Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic Hematopoietic stem cell fate [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
33792563 | J:305797
 
First Author: Zhang Q
Year: 2021
Journal: J Clin Invest
Title: Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.
Volume: 131
Issue: 7
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Publication
23831026 | J:200998
First Author: Hu X
Year: 2013
Journal: Cell Rep
Title: BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.
Volume: 4
Issue: 1
Pages: 40-9
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Publication
38958606 | J:360648
 
First Author: McKimpson WM
Year: 2024
Journal: J Cell Biol
Title: Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells.
Volume: 223
Issue: 10
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Publication
35243230 | J:321641
First Author: Liu P
Year: 2022
Journal: iScience
Title: Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
Volume: 25
Issue: 3
Pages: 103867
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Publication
21693515 | J:173527
First Author: Hunkapiller NM
Year: 2011
Journal: Development
Title: A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.
Volume: 138
Issue: 14
Pages: 2987-98
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Publication
29073173 | J:246212
First Author: Sanghez V
Year: 2017
Journal: PLoS One
Title: Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.
Volume: 12
Issue: 10
Pages: e0186818
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HT Experiment
E-GEOD-67889 | Sequential Notch activation regulates ventricular chamber development
Series Id: GSE67889
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
12372254 | J:79025
First Author: Donovan J
Year: 2002
Journal: Curr Biol
Title: Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.
Volume: 12
Issue: 18
Pages: 1605-10
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Publication
22171069 | J:181569
First Author: Xiao SM
Year: 2012
Journal: Hum Mol Genet
Title: Post-genome wide association studies and functional analyses identify association of MPP7 gene variants with site-specific bone mineral density.
Volume: 21
Issue: 7
Pages: 1648-57
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Publication
35273151 | J:336698
First Author: Jaaro-Peled H
Year: 2022
Journal: Transl Psychiatry
Title: Sex-specific involvement of the Notch-JAG pathway in social recognition.
Volume: 12
Issue: 1
Pages: 99
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Publication
25744722 | J:220232
First Author: Banerjee D
Year: 2015
Journal: Cancer Res
Title: Notch suppresses angiogenesis and progression of hepatic metastases.
Volume: 75
Issue: 8
Pages: 1592-602
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Publication
29227285 | J:257522
First Author: Majumder S
Year: 2018
Journal: J Clin Invest
Title: Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease.
Volume: 128
Issue: 1
Pages: 483-499
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Publication
28302627 | J:263668
First Author: Riascos-Bernal DF
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury.
Volume: 37
Issue: 5
Pages: 879-888
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Publication
28498863 | J:250508
First Author: Sakai H
Year: 2017
Journal: PLoS One
Title: Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity.
Volume: 12
Issue: 5
Pages: e0177516
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Publication
18665263 | J:139496
First Author: Ong CT
Year: 2008
Journal: PLoS One
Title: Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.
Volume: 3
Issue: 7
Pages: e2823
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Publication
24167636 | J:209193
First Author: Redeker C
Year: 2013
Journal: PLoS One
Title: Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo.
Volume: 8
Issue: 10
Pages: e79050
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Publication
15389319 | J:93980
First Author: Fischer A
Year: 2004
Journal: Mamm Genome
Title: Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome.
Volume: 15
Issue: 9
Pages: 711-6
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Publication
26742650 | J:229932
First Author: Krebs LT
Year: 2016
Journal: Genesis
Title: Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure.
Volume: 54
Issue: 2
Pages: 86-90
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Publication
23646120 | J:221024
First Author: Li A
Year: 2013
Journal: PLoS One
Title: Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling.
Volume: 8
Issue: 4
Pages: e62215
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Publication
25822023 | J:222419
First Author: Kim KH
Year: 2015
Journal: J Clin Invest
Title: CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB.
Volume: 125
Issue: 5
Pages: 1886-900
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Publication
35660741 | J:361293
First Author: Won JH
Year: 2022
Journal: Nat Commun
Title: CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation.
Volume: 13
Issue: 1
Pages: 3117
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Publication
37329502 | J:338825
     
First Author: LoPilato RK
Year: 2023
Journal: Glycobiology
Title: Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis.
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Publication
34475534 | J:325307
First Author: Choi J
Year: 2021
Journal: Nat Cell Biol
Title: Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration.
Volume: 23
Issue: 9
Pages: 953-966
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Publication
27090805 | J:233750
First Author: Gu R
Year: 2016
Journal: Dev Biol
Title: Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti.
Volume: 414
Issue: 1
Pages: 72-84
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Publication
24896812 | J:218508
First Author: Tual-Chalot S
Year: 2014
Journal: PLoS One
Title: Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.
Volume: 9
Issue: 6
Pages: e98646
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Publication
29089413 | J:285849
First Author: Chen L
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.
Volume: 114
Issue: 46
Pages: E9989-E9998
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Publication
31796853 | J:297963
First Author: Klose R
Year: 2019
Journal: Sci Rep
Title: Loss of the serine protease HTRA1 impairs smooth muscle cells maturation.
Volume: 9
Issue: 1
Pages: 18224
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Publication
29713059 | J:264009
First Author: Klose R
Year: 2018
Journal: Oncogene
Title: Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis.
Volume: 37
Issue: 31
Pages: 4260-4272
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Publication
38480698 | J:353358
First Author: Sun K
Year: 2024
Journal: Int J Oral Sci
Title: A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning.
Volume: 16
Issue: 1
Pages: 25
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Publication
21224848 | J:169127
First Author: Brabletz S
Year: 2011
Journal: EMBO J
Title: The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.
Volume: 30
Issue: 4
Pages: 770-82
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Publication
22498974 | J:184608
First Author: Bae Y
Year: 2012
Journal: Hum Mol Genet
Title: miRNA-34c regulates Notch signaling during bone development.
Volume: 21
Issue: 13
Pages: 2991-3000
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Publication
24498290 | J:212851
First Author: Meng Q
Year: 2014
Journal: PLoS One
Title: Expression of signaling components in embryonic eyelid epithelium.
Volume: 9
Issue: 2
Pages: e87038
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Publication
27564686 | J:246094
First Author: Rong H
Year: 2016
Journal: Immunology
Title: Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis.
Volume: 149
Issue: 4
Pages: 447-459
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Publication
30042180 | J:266553
 
First Author: García-León MJ
Year: 2018
Journal: Development
Title: Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development.
Volume: 145
Issue: 16
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Publication
31570767 | J:284628
First Author: Newbury LJ
Year: 2019
Journal: Sci Rep
Title: Inhibition of Kirsten-Ras reduces fibrosis and protects against renal dysfunction in a mouse model of chronic folic acid nephropathy.
Volume: 9
Issue: 1
Pages: 14010
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Publication
34162749 | J:307729
 
First Author: Yu J
Year: 2021
Journal: Sci Transl Med
Title: Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Volume: 13
Issue: 599
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Publication
28688656 | J:318445
 
First Author: Zagory JA
Year: 2017
Journal: J Surg Res
Title: Notch signaling promotes ductular reactions in biliary atresia.
Volume: 215
Pages: 250-256
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Publication
35039472 | J:319707
First Author: Yang D
Year: 2022
Journal: Cell Death Dis
Title: The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis.
Volume: 13
Issue: 1
Pages: 60
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Publication
37155858 | J:342408
First Author: Shao L
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells.
Volume: 120
Issue: 20
Pages: e2210058120
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Publication
39198465 | J:353557
First Author: Carolina E
Year: 2024
Journal: Nat Commun
Title: Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel.
Volume: 15
Issue: 1
Pages: 7424
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Protein
A2A9P8
Organism: Mus musculus/domesticus
Length: 375  
Fragment?: true
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Publication
31240418 | J:294460
First Author: Foulquier S
Year: 2019
Journal: Angiogenesis
Title: The role of receptor MAS in microglia-driven retinal vascular development.
Volume: 22
Issue: 4
Pages: 481-489
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Publication
30940183 | J:295824
First Author: Tchekneva EE
Year: 2019
Journal: J Immunother Cancer
Title: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity.
Volume: 7
Issue: 1
Pages: 95
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Publication
27797378 | J:241261
First Author: Sizemore GM
Year: 2017
Journal: Oncogene
Title: Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.
Volume: 36
Issue: 16
Pages: 2297-2308
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Publication
35401837 | J:338333
First Author: Liu C
Year: 2022
Journal: Theranostics
Title: Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche.
Volume: 12
Issue: 6
Pages: 2894-2907
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Publication
29140985 | J:251636
First Author: Morell CM
Year: 2017
Journal: PLoS One
Title: Notch signaling and progenitor/ductular reaction in steatohepatitis.
Volume: 12
Issue: 11
Pages: e0187384
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Publication
30816935 | J:281082
First Author: Strell C
Year: 2019
Journal: J Natl Cancer Inst
Title: Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.
Volume: 111
Issue: 9
Pages: 983-995
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Publication
32980561 | J:301196
 
First Author: Kamalakar A
Year: 2021
Journal: Bone
Title: JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.
Volume: 143
Pages: 115657
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Publication
36400760 | J:334190
First Author: Gilels FA
Year: 2022
Journal: Cell Death Dis
Title: Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss.
Volume: 13
Issue: 11
Pages: 971
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Publication
28637464 | J:318455
First Author: Robinson SC
Year: 2017
Journal: Cell Commun Signal
Title: Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells.
Volume: 15
Issue: 1
Pages: 24
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Protein
Q3UTL6
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: true
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Protein
F6ZBL2
Organism: Mus musculus/domesticus
Length: 641  
Fragment?: true
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Protein
Q8R516
Organism: Mus musculus/domesticus
Length: 973  
Fragment?: false
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Protein
Q80SY4
Organism: Mus musculus/domesticus
Length: 1006  
Fragment?: false
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Protein
A2RRJ6
Organism: Mus musculus/domesticus
Length: 1006  
Fragment?: false
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Protein
B2RUG2
Organism: Mus musculus/domesticus
Length: 946  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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