| Type |
Details |
Score |
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor |
| Background: |
involves: BALB/c |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1218
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Allele |
| Name: |
notch 1; targeted mutation 6.1, Raphael Kopan |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
notch 2; targeted mutation 3.1, Raphael Kopan |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals []. NOD (NOTCH protein domain) represents a region present in many NOTCH proteins and NOTCH homologues in multiple species such as 0, NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals []. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologues in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
106
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Six2/Six2<+> |
| Background: |
involves: 129/Sv * 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch2/Notch2 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1<+> |
| Background: |
involves: C57BL/6NTac |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang P |
| Year: |
2015 |
| Journal: |
Tumour Biol |
| Title: |
The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue. |
| Volume: |
36 |
| Issue: |
9 |
| Pages: |
7061-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim J |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
TC1(C8orf4) is a novel endothelial inflammatory regulator enhancing NF-kappaB activity. |
| Volume: |
183 |
| Issue: |
6 |
| Pages: |
3996-4002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang YD |
| Year: |
2008 |
| Journal: |
BMB Rep |
| Title: |
TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition. |
| Volume: |
41 |
| Issue: |
10 |
| Pages: |
733-8 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry includes arginine vasopressin-induced protein 1 (Avpi1) and C8orf4 protein. Avpi1 is thought to be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling []. C8orf4, also known as transcriptional and immune response regulator (TCIM) or thyroid cancer 1 (TC-1), plays important roles in many signalling pathways, such as Wnt/beta-catenin signalling pathway, and is involved in the development of many cancers []. C8orf4 also suppresses NOTCH2 signalling in liver cancer stem cells []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Transcriptional and immune response regulator (Tcim; also known as C8orf4 or TC1) is a regulator implicated in cancer and inflammation []. It is highly expressed in several tumours and implicated in tumorigenesis. It plays a role in the mitogen-activated MAPK2/3 signaling pathway, and positively regulates G1-to-S-phase transition of the cell cycle []. It negatively regulates the self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tuck E |
| Year: |
2015 |
| Journal: |
Dis Model Mech |
| Title: |
A gene expression resource generated by genome-wide lacZ profiling in the mouse. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
1467-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Centre for Phenogenomics |
| Year: |
2022 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Direct Data Submission for The Centre for Phenogenomics Alleles. |
|
|
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor |
| Background: |
involves: C57BL/6 * C57BL/6NTac |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nicod M |
| Year: |
2002 |
| Journal: |
EMBO J |
| Title: |
A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation. |
| Volume: |
21 |
| Issue: |
19 |
| Pages: |
5109-17 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
142
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
79
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Speer6-ps1/? |
| Background: |
involves: BALB/c * C57BL/6 * DBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ndor1/? |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ndor1/? |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1<+> Notch2/Notch2 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1<+> Notch2/Notch2 Tg(Pax3-cre)1Joe/? |
| Background: |
involves: 129S1/Sv * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1 Notch2/Notch2 Tg(Pax3-cre)1Joe/? |
| Background: |
involves: 129S1/Sv * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Notch1/Notch1 |
| Background: |
involves: 129X1/SvJ * C57BL/6NTac |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1020
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1135
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
739
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1170
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nam Y |
| Year: |
2006 |
| Journal: |
Cell |
| Title: |
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. |
| Volume: |
124 |
| Issue: |
5 |
| Pages: |
973-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kovall RA |
| Year: |
2008 |
| Journal: |
Oncogene |
| Title: |
More complicated than it looks: assembly of Notch pathway transcription complexes. |
| Volume: |
27 |
| Issue: |
38 |
| Pages: |
5099-109 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McElhinny AS |
| Year: |
2008 |
| Journal: |
Oncogene |
| Title: |
Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. |
| Volume: |
27 |
| Issue: |
38 |
| Pages: |
5138-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen H |
| Year: |
2006 |
| Journal: |
Genes Dev |
| Title: |
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. |
| Volume: |
20 |
| Issue: |
6 |
| Pages: |
675-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao Y |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
The notch regulator MAML1 interacts with p53 and functions as a coactivator. |
| Volume: |
282 |
| Issue: |
16 |
| Pages: |
11969-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alves-Guerra MC |
| Year: |
2007 |
| Journal: |
Cancer Res |
| Title: |
Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. |
| Volume: |
67 |
| Issue: |
18 |
| Pages: |
8690-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiang MY |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. |
| Volume: |
26 |
| Issue: |
16 |
| Pages: |
6261-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu H |
| Year: |
2009 |
| Journal: |
Circ Res |
| Title: |
NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. |
| Volume: |
104 |
| Issue: |
4 |
| Pages: |
466-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu L |
| Year: |
2005 |
| Journal: |
EMBO J |
| Title: |
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. |
| Volume: |
24 |
| Issue: |
13 |
| Pages: |
2391-402 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fryer CJ |
| Year: |
2004 |
| Journal: |
Mol Cell |
| Title: |
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. |
| Volume: |
16 |
| Issue: |
4 |
| Pages: |
509-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu L |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. |
| Volume: |
22 |
| Issue: |
21 |
| Pages: |
7688-700 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
489
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
826
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
585
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
414
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
680
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
443
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
500
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
249
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
414
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fryer CJ |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. |
| Volume: |
16 |
| Issue: |
11 |
| Pages: |
1397-411 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu QD |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. |
| Volume: |
115 |
| Issue: |
2 |
| Pages: |
163-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao Z |
| Year: |
2014 |
| Journal: |
Cancer Cell |
| Title: |
Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
350-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2015 |
| Journal: |
Cancer Res |
| Title: |
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. |
| Volume: |
75 |
| Issue: |
9 |
| Pages: |
1859-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Croquelois A |
| Year: |
2005 |
| Journal: |
Hepatology |
| Title: |
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. |
| Volume: |
41 |
| Issue: |
3 |
| Pages: |
487-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei H |
| Year: |
2021 |
| Journal: |
J Immunol |
| Title: |
Protein Kinase CK2 Regulates B Cell Development and Differentiation. |
| Volume: |
207 |
| Issue: |
3 |
| Pages: |
799-808 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang JA |
| Year: |
2014 |
| Journal: |
Immunology |
| Title: |
Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand. |
| Volume: |
143 |
| Issue: |
4 |
| Pages: |
550-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu X |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. |
| Volume: |
29 |
| Issue: |
5 |
| Pages: |
691-703 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Colom B |
| Year: |
2020 |
| Journal: |
Nat Genet |
| Title: |
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium. |
| Volume: |
52 |
| Issue: |
6 |
| Pages: |
604-614 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pardo-Saganta A |
| Year: |
2015 |
| Journal: |
Cell Stem Cell |
| Title: |
Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. |
| Volume: |
16 |
| Issue: |
2 |
| Pages: |
184-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mori M |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. |
| Volume: |
142 |
| Issue: |
2 |
| Pages: |
258-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hammad H |
| Year: |
2017 |
| Journal: |
Nat Immunol |
| Title: |
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
313-320 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shawber CJ |
| Year: |
2019 |
| Journal: |
Biol Open |
| Title: |
Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation. |
| Volume: |
8 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun W |
| Year: |
2017 |
| Journal: |
FEBS Lett |
| Title: |
miR-181c protects CsA-induced renal damage and fibrosis through inhibiting EMT. |
| Volume: |
591 |
| Issue: |
21 |
| Pages: |
3588-3599 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dang L |
| Year: |
2006 |
| Journal: |
Oncogene |
| Title: |
Notch3 signaling initiates choroid plexus tumor formation. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
487-91 |
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| Publication |
| First Author: |
Yamamoto S |
| Year: |
2012 |
| Journal: |
Science |
| Title: |
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. |
| Volume: |
338 |
| Issue: |
6111 |
| Pages: |
1229-32 |
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| Publication |
| First Author: |
Souilhol C |
| Year: |
2016 |
| Journal: |
Blood |
| Title: |
Developing HSCs become Notch independent by the end of maturation in the AGM region. |
| Volume: |
128 |
| Issue: |
12 |
| Pages: |
1567-77 |
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| Publication |
| First Author: |
Hurst LA |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. |
| Volume: |
8 |
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| Pages: |
14079 |
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| Publication |
| First Author: |
Suzuki IK |
| Year: |
2018 |
| Journal: |
Cell |
| Title: |
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation. |
| Volume: |
173 |
| Issue: |
6 |
| Pages: |
1370-1384.e16 |
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•
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| Publication |
| First Author: |
Parmigiani E |
| Year: |
2022 |
| Journal: |
Cancers (Basel) |
| Title: |
Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain. |
| Volume: |
14 |
| Issue: |
21 |
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| Publication |
| First Author: |
Wang YZ |
| Year: |
2024 |
| Journal: |
Cell Rep |
| Title: |
Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication. |
| Volume: |
43 |
| Issue: |
2 |
| Pages: |
113680 |
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| Publication |
| First Author: |
Cheung L |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
NOTCH activity differentially affects alternative cell fate acquisition and maintenance. |
| Volume: |
7 |
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| Publication |
| First Author: |
Centre for Modeling Human Disease |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto |
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| Publication |
| First Author: |
Kokubo H |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. |
| Volume: |
134 |
| Issue: |
4 |
| Pages: |
747-55 |
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| Publication |
| First Author: |
Li H |
| Year: |
2015 |
| Journal: |
J Cell Biol |
| Title: |
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. |
| Volume: |
211 |
| Issue: |
3 |
| Pages: |
605-17 |
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| Publication |
| First Author: |
Guilmeau S |
| Year: |
2010 |
| Journal: |
Oncogene |
| Title: |
Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling. |
| Volume: |
29 |
| Issue: |
7 |
| Pages: |
992-1002 |
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| Publication |
| First Author: |
Jastrzebski S |
| Year: |
2019 |
| Journal: |
J Immunol |
| Title: |
Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism. |
| Volume: |
203 |
| Issue: |
1 |
| Pages: |
105-116 |
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| Publication |
| First Author: |
Foldi J |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. |
| Volume: |
185 |
| Issue: |
9 |
| Pages: |
5023-31 |
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| Publication |
| First Author: |
Hara-Kaonga B |
| Year: |
2006 |
| Journal: |
Transgenic Res |
| Title: |
Variable recombination efficiency in responder transgenes activated by Cre recombinase in the vasculature. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
101-6 |
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•
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| Publication |
| First Author: |
Cao F |
| Year: |
2010 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells. |
| Volume: |
394 |
| Issue: |
3 |
| Pages: |
843-7 |
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•
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| Publication |
| First Author: |
Zanotti S |
| Year: |
2008 |
| Journal: |
Endocrinology |
| Title: |
Notch inhibits osteoblast differentiation and causes osteopenia. |
| Volume: |
149 |
| Issue: |
8 |
| Pages: |
3890-9 |
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•
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| Publication |
| First Author: |
Quotti Tubi L |
| Year: |
2022 |
| Journal: |
Front Immunol |
| Title: |
CK2β-regulated signaling controls B cell differentiation and function. |
| Volume: |
13 |
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| Pages: |
959138 |
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| Publication |
| First Author: |
Cras-Méneur C |
| Year: |
2009 |
| Journal: |
Genes Dev |
| Title: |
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. |
| Volume: |
23 |
| Issue: |
17 |
| Pages: |
2088-101 |
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| Publication |
| First Author: |
Ong CT |
| Year: |
2008 |
| Journal: |
PLoS One |
| Title: |
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. |
| Volume: |
3 |
| Issue: |
7 |
| Pages: |
e2823 |
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| Publication |
| First Author: |
Canalis E |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Osteoblast lineage-specific effects of notch activation in the skeleton. |
| Volume: |
154 |
| Issue: |
2 |
| Pages: |
623-34 |
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| Publication |
| First Author: |
Ortega M |
| Year: |
2015 |
| Journal: |
Leukemia |
| Title: |
A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies. |
| Volume: |
29 |
| Issue: |
4 |
| Pages: |
968-76 |
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| Publication |
| First Author: |
Tang Y |
| Year: |
2013 |
| Journal: |
Transgenic Res |
| Title: |
Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
403-10 |
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| Publication |
| First Author: |
Zhang S |
| Year: |
2020 |
| Journal: |
Am J Transl Res |
| Title: |
POFUT1 is dispensable for structure, function and survival of mouse podocytes. |
| Volume: |
12 |
| Issue: |
5 |
| Pages: |
2212-2224 |
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| Publication |
| First Author: |
Guo P |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. |
| Volume: |
127 |
| Issue: |
12 |
| Pages: |
4242-4256 |
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| Publication |
| First Author: |
Rojo MD |
| Year: |
2024 |
| Journal: |
Life Sci Alliance |
| Title: |
C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle. |
| Volume: |
7 |
| Issue: |
10 |
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| Publication |
| First Author: |
Huang K |
| Year: |
2018 |
| Journal: |
Biol Open |
| Title: |
JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. |
| Volume: |
7 |
| Issue: |
1 |
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| Publication |
| First Author: |
Hallahan AR |
| Year: |
2004 |
| Journal: |
Cancer Res |
| Title: |
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. |
| Volume: |
64 |
| Issue: |
21 |
| Pages: |
7794-800 |
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•
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| Publication |
| First Author: |
Ma G |
| Year: |
2018 |
| Journal: |
Cytotherapy |
| Title: |
Evaluation of the differentiation status of neural stem cells based on cell morphology and the expression of Notch and Sox2. |
| Volume: |
20 |
| Issue: |
12 |
| Pages: |
1472-1485 |
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