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Search results 2001 to 2100 out of 2158 for Notch2

0.019s

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Type Details Score
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: BALB/c
Zygosity: hm
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: notch 1; targeted mutation 6.1, Raphael Kopan
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Allele
Name: notch 2; targeted mutation 3.1, Raphael Kopan
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Protein Domain
Type: Domain
Description: NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals []. NOD (NOTCH protein domain) represents a region present in many NOTCH proteins and NOTCH homologues in multiple species such as 0, NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.
Protein Domain
Type: Domain
Description: NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals []. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologues in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Six2/Six2<+>
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch2/Notch2
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1<+>
Background: involves: C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Zhang P
Year: 2015
Journal: Tumour Biol
Title: The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.
Volume: 36
Issue: 9
Pages: 7061-7
Publication
First Author: Kim J
Year: 2009
Journal: J Immunol
Title: TC1(C8orf4) is a novel endothelial inflammatory regulator enhancing NF-kappaB activity.
Volume: 183
Issue: 6
Pages: 3996-4002
Publication
First Author: Wang YD
Year: 2008
Journal: BMB Rep
Title: TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition.
Volume: 41
Issue: 10
Pages: 733-8
Protein Domain
Type: Domain
Description: This entry includes arginine vasopressin-induced protein 1 (Avpi1) and C8orf4 protein. Avpi1 is thought to be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling []. C8orf4, also known as transcriptional and immune response regulator (TCIM) or thyroid cancer 1 (TC-1), plays important roles in many signalling pathways, such as Wnt/beta-catenin signalling pathway, and is involved in the development of many cancers []. C8orf4 also suppresses NOTCH2 signalling in liver cancer stem cells [].
Protein Domain
Type: Family
Description: Transcriptional and immune response regulator (Tcim; also known as C8orf4 or TC1) is a regulator implicated in cancer and inflammation []. It is highly expressed in several tumours and implicated in tumorigenesis. It plays a role in the mitogen-activated MAPK2/3 signaling pathway, and positively regulates G1-to-S-phase transition of the cell cycle []. It negatively regulates the self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling [].
Publication
First Author: Tuck E
Year: 2015
Journal: Dis Model Mech
Title: A gene expression resource generated by genome-wide lacZ profiling in the mouse.
Volume: 8
Issue: 11
Pages: 1467-78
Publication      
First Author: The Centre for Phenogenomics
Year: 2022
Journal: MGI Direct Data Submission
Title: Direct Data Submission for The Centre for Phenogenomics Alleles.
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Nicod M
Year: 2002
Journal: EMBO J
Title: A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.
Volume: 21
Issue: 19
Pages: 5109-17
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Speer6-ps1/?
Background: involves: BALB/c * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ndor1/?
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ndor1/?
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1<+> Notch2/Notch2 Tg(Pax3-cre)1Joe/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1 Notch2/Notch2 Tg(Pax3-cre)1Joe/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1
Background: involves: 129X1/SvJ * C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
Publication
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
Publication
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
Publication
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
Publication
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
Publication
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
Publication
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
Publication
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
Publication
First Author: Liu H
Year: 2009
Journal: Circ Res
Title: NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Volume: 104
Issue: 4
Pages: 466-75
Publication
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
Publication
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20
Publication
First Author: Wu L
Year: 2002
Journal: Mol Cell Biol
Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Volume: 22
Issue: 21
Pages: 7688-700
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Publication
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Protein Domain
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Publication
First Author: Hu QD
Year: 2003
Journal: Cell
Title: F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Volume: 115
Issue: 2
Pages: 163-75
Publication
First Author: Cao Z
Year: 2014
Journal: Cancer Cell
Title: Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.
Volume: 25
Issue: 3
Pages: 350-65
Publication
First Author: Zhang J
Year: 2015
Journal: Cancer Res
Title: miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.
Volume: 75
Issue: 9
Pages: 1859-67
Publication
First Author: Croquelois A
Year: 2005
Journal: Hepatology
Title: Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice.
Volume: 41
Issue: 3
Pages: 487-96
Publication
First Author: Wei H
Year: 2021
Journal: J Immunol
Title: Protein Kinase CK2 Regulates B Cell Development and Differentiation.
Volume: 207
Issue: 3
Pages: 799-808
Publication
First Author: Kang JA
Year: 2014
Journal: Immunology
Title: Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand.
Volume: 143
Issue: 4
Pages: 550-9
Publication
First Author: Hu X
Year: 2008
Journal: Immunity
Title: Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Volume: 29
Issue: 5
Pages: 691-703
Publication
First Author: Colom B
Year: 2020
Journal: Nat Genet
Title: Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.
Volume: 52
Issue: 6
Pages: 604-614
Publication
First Author: Pardo-Saganta A
Year: 2015
Journal: Cell Stem Cell
Title: Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.
Volume: 16
Issue: 2
Pages: 184-97
Publication
First Author: Mori M
Year: 2015
Journal: Development
Title: Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Volume: 142
Issue: 2
Pages: 258-67
Publication
First Author: Hammad H
Year: 2017
Journal: Nat Immunol
Title: Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
Volume: 18
Issue: 3
Pages: 313-320
Publication  
First Author: Shawber CJ
Year: 2019
Journal: Biol Open
Title: Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation.
Volume: 8
Issue: 4
Publication
First Author: Sun W
Year: 2017
Journal: FEBS Lett
Title: miR-181c protects CsA-induced renal damage and fibrosis through inhibiting EMT.
Volume: 591
Issue: 21
Pages: 3588-3599
Publication
First Author: Dang L
Year: 2006
Journal: Oncogene
Title: Notch3 signaling initiates choroid plexus tumor formation.
Volume: 25
Issue: 3
Pages: 487-91
Publication
First Author: Yamamoto S
Year: 2012
Journal: Science
Title: A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Volume: 338
Issue: 6111
Pages: 1229-32
Publication
First Author: Souilhol C
Year: 2016
Journal: Blood
Title: Developing HSCs become Notch independent by the end of maturation in the AGM region.
Volume: 128
Issue: 12
Pages: 1567-77
Publication  
First Author: Hurst LA
Year: 2017
Journal: Nat Commun
Title: TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Volume: 8
Pages: 14079
Publication
First Author: Suzuki IK
Year: 2018
Journal: Cell
Title: Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.
Volume: 173
Issue: 6
Pages: 1370-1384.e16
Publication  
First Author: Parmigiani E
Year: 2022
Journal: Cancers (Basel)
Title: Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain.
Volume: 14
Issue: 21
Publication
First Author: Wang YZ
Year: 2024
Journal: Cell Rep
Title: Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication.
Volume: 43
Issue: 2
Pages: 113680
Publication    
First Author: Cheung L
Year: 2018
Journal: Elife
Title: NOTCH activity differentially affects alternative cell fate acquisition and maintenance.
Volume: 7
Publication      
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
Publication
First Author: Kokubo H
Year: 2007
Journal: Development
Title: Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2.
Volume: 134
Issue: 4
Pages: 747-55
Publication
First Author: Li H
Year: 2015
Journal: J Cell Biol
Title: Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
Volume: 211
Issue: 3
Pages: 605-17
Publication
First Author: Guilmeau S
Year: 2010
Journal: Oncogene
Title: Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling.
Volume: 29
Issue: 7
Pages: 992-1002
Publication
First Author: Jastrzebski S
Year: 2019
Journal: J Immunol
Title: Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism.
Volume: 203
Issue: 1
Pages: 105-116
Publication
First Author: Foldi J
Year: 2010
Journal: J Immunol
Title: Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Volume: 185
Issue: 9
Pages: 5023-31
Publication
First Author: Hara-Kaonga B
Year: 2006
Journal: Transgenic Res
Title: Variable recombination efficiency in responder transgenes activated by Cre recombinase in the vasculature.
Volume: 15
Issue: 1
Pages: 101-6
Publication
First Author: Cao F
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells.
Volume: 394
Issue: 3
Pages: 843-7
Publication
First Author: Zanotti S
Year: 2008
Journal: Endocrinology
Title: Notch inhibits osteoblast differentiation and causes osteopenia.
Volume: 149
Issue: 8
Pages: 3890-9
Publication  
First Author: Quotti Tubi L
Year: 2022
Journal: Front Immunol
Title: CK2β-regulated signaling controls B cell differentiation and function.
Volume: 13
Pages: 959138
Publication
First Author: Cras-Méneur C
Year: 2009
Journal: Genes Dev
Title: Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Volume: 23
Issue: 17
Pages: 2088-101
Publication
First Author: Ong CT
Year: 2008
Journal: PLoS One
Title: Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.
Volume: 3
Issue: 7
Pages: e2823
Publication
First Author: Canalis E
Year: 2013
Journal: Endocrinology
Title: Osteoblast lineage-specific effects of notch activation in the skeleton.
Volume: 154
Issue: 2
Pages: 623-34
Publication
First Author: Ortega M
Year: 2015
Journal: Leukemia
Title: A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies.
Volume: 29
Issue: 4
Pages: 968-76
Publication
First Author: Tang Y
Year: 2013
Journal: Transgenic Res
Title: Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis.
Volume: 22
Issue: 2
Pages: 403-10
Publication
First Author: Zhang S
Year: 2020
Journal: Am J Transl Res
Title: POFUT1 is dispensable for structure, function and survival of mouse podocytes.
Volume: 12
Issue: 5
Pages: 2212-2224
Publication
First Author: Guo P
Year: 2017
Journal: J Clin Invest
Title: Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.
Volume: 127
Issue: 12
Pages: 4242-4256
Publication  
First Author: Rojo MD
Year: 2024
Journal: Life Sci Alliance
Title: C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle.
Volume: 7
Issue: 10
Publication  
First Author: Huang K
Year: 2018
Journal: Biol Open
Title: JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice.
Volume: 7
Issue: 1
Publication
First Author: Hallahan AR
Year: 2004
Journal: Cancer Res
Title: The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
Volume: 64
Issue: 21
Pages: 7794-800
Publication
First Author: Ma G
Year: 2018
Journal: Cytotherapy
Title: Evaluation of the differentiation status of neural stem cells based on cell morphology and the expression of Notch and Sox2.
Volume: 20
Issue: 12
Pages: 1472-1485