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Search results 2001 to 2100 out of 3029 for Pdx1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:7266706
Assay Type: Immunohistochemistry
Annotation Date: 2022-05-05
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3564520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7266737
Age: embryonic day 12.5
Note: Increased in expression compared with control specifically within the Pdx1 expression domain.
Specimen Label: 6E/F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7852636
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564719
Pattern: Scattered
Stage: TS19
Assay Id: MGI:7853921
Age: embryonic day 11.5
Note: All Cpa1-positive cells co-express Pdx1 and constitute a subset of Pdx1-positive epithelial cells.
Specimen Label: 3I
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:3763264
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1725617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6695715
Age: embryonic day 10.5
Image: 5A YFP (lower)
Note: Expression coincident with Pdx1 throughout ventral pancreatic epithelium, except for first wave endocrine cells.
Specimen Label: 5A YFP (lower)
Detected: true
Specimen Num: 25
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GXD Expression
GXD Expression
Probe: MGI:3763264
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6695715
Age: embryonic day 10.5
Image: 5A YFP (upper)
Note: Expression coincident with Pdx1 throughout dorsal pancreatic epithelium, except for first wave endocrine cells.
Specimen Label: 5A YFP (upper)
Detected: true
Specimen Num: 24
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GXD Expression
GXD Expression
 
Probe: MGI:6695355
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6695726
Age: embryonic day 11.5
Note: Expression still coincides with that of Pdx1 in almost all pancreatic epithelial cells.
Specimen Label: E11.5 +/+ not shown
Detected: true
Specimen Num: 2
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DO Term
DOID:0061003 | pancreatic agenesis 1
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Publication
20637728 | -
First Author: An R
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.
Volume: 399
Issue: 2
Pages: 155-61
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Allele
Tg(Pdx1-Ffar1)AHeed | MGI:3774304
Name: transgene insertion A, Helena Edlund
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Pdx1-cre)1Heed | MGI:3774305
Name: transgene insertion 1, Helena Edlund
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Pdx1-EGFP)1Heed | MGI:3774306
Name: transgene insertion 1, Helena Edlund
Allele Type: Transgenic
Attribute String: Reporter
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HT Experiment
GSE77896 | Pdx1-Oc1 cooperatively drive the induction of the endocrine pancreatic program
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Pdx1<tm1Ted> | MGI:2152755
Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Thomas Edlund
Allele Type: Targeted
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:3051329
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6361261
Age: embryonic day 10.5
Image: 6G
Note: The loss of both Pdx1 and Sox9 results in ectopic Cdx2 expression. There was extensive overlap between the Pdx1 and Cdx2 domains.
Specimen Label: 6G
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
Probe: MGI:7510072
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7510116
Age: embryonic day 14.5
Image: S4D
Note: Almost complete overlap between Foxa2 and Pdx1 expression. Most of the Pdx1 highly expressed cells did not display the highest levels of Foxa2.
Specimen Label: S4D
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5430034
Assay Type: Immunohistochemistry
Annotation Date: 2019-10-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706716
Stage: TS16
Assay Id: MGI:6361504
Age: embryonic day 9.5
Image: S3D
Note: The combined Pdx1 and Sox9 deletion did not result in ectopic expression of the stomach marker Sox2 in the Pdx1+ domain.
Specimen Label: S3D
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6405151
Assay Type: RNA in situ
Annotation Date: 2020-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6405174
Age: embryonic day 9.5
Image: 1A inset
Note: Expression in all cells that have no contact with mesenchyme (inner cell layers) and some cells of external layers. Authors report co-expression with Pdx1 protein.
Specimen Label: 1A inset
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6695355
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706717
Pattern: Scattered
Stage: TS17
Assay Id: MGI:6695726
Age: embryonic day 10.5
Image: 5B Ptf1a
Note: Expression in pancreatic progenitor cells of dorsal pancreatic bud at E10.5 coinciding with Pdx1 and Ngn3 expression in scattered cells throughout pancreatic epithelium.
Specimen Label: 5B Ptf1a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6695359
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6695730
Age: embryonic day 10.5
Image: 5B Ngn3
Note: Expression in pancreatic progenitor cells of dorsal pancreatic bud at E10.5 coinciding with Ptf1a and Pdx1 in scattered cells throughout pancreatic epithelium.
Specimen Label: 5B Ngn3
Detected: true
Specimen Num: 1
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Allele
Pdx1<em1(cre/ERT2)Smoc> | MGI:6758042
Name: pancreatic and duodenal homeobox 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Epitope tag, Inducible, Recombinase
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)1Heed/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pdx1-EGFP)1Heed/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pdx1-Ffar1)AHeed/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
9710595 | -
First Author: Swift GH
Year: 1998
Journal: Mol Cell Biol
Title: An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).
Volume: 18
Issue: 9
Pages: 5109-20
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Genotype
Genotype
Symbol: Pdx1/Pdx1<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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GXD Expression
GXD Expression
 
Probe: MGI:7852636
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564921
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7853921
Age: embryonic day 13.5
Note: The tip-restricted expression pattern of expression persists through successive branching and growth of the pancreatic tree. All Cpa1-positive cells co-express Pdx1 and constitute a subset of Pdx1-positive epithelial cells (representing 13.6% of total Pdx1-positive cells at E13.5).
Specimen Label: 3K
Detected: true
Specimen Num: 11
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Publication
23040067 | J:356276
First Author: Morán I
Year: 2012
Journal: Cell Metab
Title: Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Volume: 16
Issue: 4
Pages: 435-48
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Allele
Tg(Pdx1-Neurog3)1Heed | MGI:3693631
Name: transgene insertion 1, Helena Edlund
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Pdx1-Notch3)1Heed | MGI:3693633
Name: transgene insertion 1, Helena Edlund
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Pdx1-flpo)#Dsa | MGI:5616872
Name: transgene insertion, Dieter Saur
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:6355111 | C57BL/6JSmoc-Pdx1<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
19380737 | J:148327
First Author: Zhang SS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells.
Volume: 106
Issue: 18
Pages: 7531-6
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Allele
Gt(ROSA)26Sor<tm1(tetO-Pdx1,-Mafa,-Neurog3,-GFP)Stang> | MGI:6120506
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ben Stanger
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Tg(Pdx1-Neurog3)1Heed/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pdx1-Notch3)1Heed/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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GXD Expression
GXD Expression
 
Probe: MGI:7852636
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7853921
Age: embryonic day 14.5
Note: The tip-restricted expression pattern of expression persists through successive branching and growth of the pancreatic tree. Expression levels vary among tip cells. All Cpa1-positive cells co-express Pdx1 and constitute a subset of Pdx1-positive epithelial cells (representing 16.8% of total Pdx1-positive cells at E14.5).
Specimen Label: 3L
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:7852636
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3564920
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7853921
Age: embryonic day 12.5
Note: By E12.5, there were well-formed primary branches in the pancreas, and Cpa1 expression was largely restricted to the branching tips. All Cpa1-positive cells co-express Pdx1 and constitute a subset of Pdx1-positive epithelial cells (representing 13.3% of total Pdx1-positive cells at E12.5).
Specimen Label: 3J
Detected: true
Specimen Num: 10
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Publication
22717537 | J:189204
First Author: da Silva Xavier G
Year: 2012
Journal: Diabetologia
Title: Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.
Volume: 55
Issue: 10
Pages: 2667-2676
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Publication
17908556 | J:130028
First Author: Gao N
Year: 2007
Journal: Cell Metab
Title: Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.
Volume: 6
Issue: 4
Pages: 267-79
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Publication
29263149 | J:257507
First Author: Villamayor L
Year: 2018
Journal: Diabetes
Title: GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.
Volume: 67
Issue: 3
Pages: 448-460
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Publication
33039594 | J:304600
First Author: Yuan J
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Volume: 1867
Issue: 1
Pages: 165987
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Allele
Tg(Pdx1-cre/Esr1*)35.10Dam | MGI:2684321
Name: transgene insertion 35.10, Douglas A Melton
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Tg(Pdx1-cre)PBMga | MGI:4839473
Name: transgene insertion PB, Maureen A Gannon
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Pdx1<tm1.1(flpo)Most> | MGI:6119579
Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, Michael C Ostrowski
Allele Type: Targeted
Attribute String: Recombinase
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Strain
MGI:6120508 | B6.Cg-Gt(ROSA)26Sor<tm1(tetO-Pdx1,-Mafa,-Neurog3,-GFP)Stang>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Tg(Pdx1-DNMT1)#Ggu | MGI:6357900
Name: transgene insertion, Guoqiang Gu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm14.1(tetO-Pdx1,-YFP)Mgn> | MGI:6470479
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 14.1, Mark A Magnussen
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Reporter
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Publication
23012647 | J:207267
 
First Author: Elghazi L
Year: 2012
Journal: Sci Rep
Title: Importance of β-Catenin in glucose and energy homeostasis.
Volume: 2
Pages: 693
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Publication
26542580 | J:226753
First Author: Perelis M
Year: 2015
Journal: Science
Title: Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Volume: 350
Issue: 6261
Pages: aac4250
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Publication
24981769 | J:216999
First Author: Wang L
Year: 2014
Journal: Diabetologia
Title: Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.
Volume: 57
Issue: 9
Pages: 1889-98
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Publication
27803029 | J:316520
First Author: Saloustros E
Year: 2017
Journal: Endocr Relat Cancer
Title: Prkar1a gene knockout in the pancreas leads to neuroendocrine tumorigenesis.
Volume: 24
Issue: 1
Pages: 31-40
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Publication
17849436 | J:125513
First Author: Fujikura J
Year: 2007
Journal: Dev Dyn
Title: Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
Volume: 236
Issue: 10
Pages: 2779-91
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Publication
22215655 | J:184645
First Author: Kobayashi M
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice.
Volume: 302
Issue: 5
Pages: E603-13
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Allele
Tg(Pdx1-cre)1Herr | MGI:2387562
Name: transgene insertion 1, Pedro Luis Herrera
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Pdx1-cre)89.1Dam | MGI:2684317
Name: transgene insertion 89.1, Douglas A Melton
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:4839765 | STOCK Tg(Pdx1-cre/Esr1*)35.10Dam/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(Pdx1-cre)XBMga | MGI:4839475
Name: transgene insertion XB, Maureen A Gannon
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:6474320 | STOCK Gt(ROSA)26Sor<tm14.1(tetO-Pdx1,-YFP)Mgn>/Vu
Attribute String: targeted mutation, mutant stock
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Allele
Tg(Pdx1-flpo)#Koli | MGI:6758746
Name: transgene insertion, Kenneth Olive
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Pdx1-flpo)#Ybi | MGI:7513809
Name: transgene insertion, Yan Bi
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
19121634 | J:146914
First Author: Elghazi L
Year: 2009
Journal: Gastroenterology
Title: Regulation of pancreas plasticity and malignant transformation by Akt signaling.
Volume: 136
Issue: 3
Pages: 1091-103
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Publication
14500813 | J:88430
First Author: Kim YS
Year: 2003
Journal: Nucleic Acids Res
Title: GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.
Volume: 31
Issue: 19
Pages: 5513-25
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Publication
23737756 | -
First Author: Nogueira TC
Year: 2013
Journal: PLoS Genet
Title: GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.
Volume: 9
Issue: 5
Pages: e1003532
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Publication
19481545 | J:150077
First Author: Watanabe N
Year: 2009
Journal: FEBS Lett
Title: A murine model of neonatal diabetes mellitus in Glis3-deficient mice.
Volume: 583
Issue: 12
Pages: 2108-13
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Publication
21139041 | -
First Author: Dimitri P
Year: 2011
Journal: Eur J Endocrinol
Title: Novel GLIS3 mutations demonstrate an extended multisystem phenotype.
Volume: 164
Issue: 3
Pages: 437-43
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Publication
7030741 | -
First Author: Kresze GB
Year: 1981
Journal: Eur J Biochem
Title: Pyruvate dehydrogenase complex from baker's yeast. 2. Molecular structure, dissociation, and implications for the origin of mitochondria.
Volume: 119
Issue: 3
Pages: 581-7
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Publication
9399911 | -
First Author: Aral B
Year: 1997
Journal: Am J Hum Genet
Title: Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis.
Volume: 61
Issue: 6
Pages: 1318-26
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Publication
16049940 | -
First Author: Head RA
Year: 2005
Journal: Ann Neurol
Title: Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.
Volume: 58
Issue: 2
Pages: 234-41
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Publication
9655933 | -
First Author: de Kok A
Year: 1998
Journal: Biochim Biophys Acta
Title: The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria.
Volume: 1385
Issue: 2
Pages: 353-66
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Protein Domain
IPR030405 | GLIS3
Type: Family
Description: GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. They play key roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Glis1-3 share a highly homologous zinc finger domain (ZFD) containing five Cys2-His2-type zinc finger (ZF) motifs with members of the Gli and Zic family [].Glis3 has repressor and activation functions []and is involved in pancreatic beta cell generation and insulin gene expression []. Glis3 deficient mice have decreased expression of several key transcription factors required for the endocrine development of the pancreas, such as Neurogenin3, NeuroD1, MafA and Pdx1 [, ]. Mutations in human glis3 cause a rare disease known as diabetes mellitus, neonatal, with congenital hypothyroidism (NDH) []. The glis3 gene has been identified as a susceptibility locus for the risk of type 1 and 2 diabetes [].
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Protein Domain
IPR045257 | E2/Pdx1
Type: Family
Description: In prokaryotes and eukaryotes, pyruvate dehydrogenase complex (PDC) contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) []. PDC catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. In eukaryotes, PDC is located in the mitochondrial matrix [, ]. This entry represents agroup of E3-binding proteins, including dihydrolipoamide acetyltransferase (E2) and pyruvate dehydrogenase protein X component (known as Pdx1). Pdx1, found only in eukaryotes, plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core []. Mutations in the Pdx1 gene has been linked to human disease [, ]. Mutations in the E2 gene cause pyruvate dehydrogenase deficiency [].
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HT Experiment
E-GEOD-16048 | Expression profiling of pancreatic beta-cells harboring a pancreatic-specific deletion of PPAR-beta
Series Id: GSE16048
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
16169464 | J:102226
First Author: Stanger BZ
Year: 2005
Journal: Cancer Cell
Title: Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
Volume: 8
Issue: 3
Pages: 185-95
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Publication
37429756 | J:338537
     
First Author: Zhu X
Year: 2023
Journal: Pancreatology
Title: A mouse model for high-efficient Flp-recombinase-mediated genetic manipulation in the pancreas.
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Publication
36496541 | J:337677
First Author: Wakabayashi Y
Year: 2022
Journal: Sci Rep
Title: STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1.
Volume: 12
Issue: 1
Pages: 21419
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Publication
21763240 | J:309440
First Author: Criscimanna A
Year: 2011
Journal: Gastroenterology
Title: Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice.
Volume: 141
Issue: 4
Pages: 1451-62, 1462.e1-6
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Publication
23580576 | J:197039
First Author: Gurung B
Year: 2013
Journal: Cancer Res
Title: Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Volume: 73
Issue: 8
Pages: 2650-8
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Publication
20862307 | J:165664
First Author: Chun MG
Year: 2010
Journal: PLoS Genet
Title: Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis.
Volume: 6
Issue: 9
Pages: e1001120
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Strain
MGI:3829508 | STOCK Tg(Pdx1-cre)89.1Dam/Mmucd
Attribute String: transgenic, mutant stock
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Strain
MGI:3849969 | STOCK Tg(Pdx1-cre)89.1Dam/2Mmucd
Attribute String: transgenic, mutant stock
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•
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•
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Strain
MGI:3038208 | STOCK Tg(Pdx1-cre)89.1Dam/J
Attribute String: mutant stock, transgenic
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•
Publication
31451647 | J:279335
First Author: Zhu L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.
Volume: 116
Issue: 37
Pages: 18684-18690
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Allele
Tg(Pdx1-cre)6Tuv | MGI:3032531
Name: transgene insertion 6, David A Tuveson
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:6383413 | FVB(B6)-Tg(Pdx1-cre)6Tuv/JwkimJ
Attribute String: mutant strain, targeted mutation
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Strain
MGI:5293639 | B6.FVB-Tg(Pdx1-cre)6Tuv/J
Attribute String: congenic, mutant strain
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Strain
MGI:6144446 | B6.FVB-Tg(Pdx1-cre)6Tuv/Nci
Attribute String: Not specified
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Publication
29907771 | J:267415
First Author: Su W
Year: 2018
Journal: Oncogene
Title: miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways.
Volume: 37
Issue: 42
Pages: 5618-5632
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Publication
34462260 | J:314545
First Author: Lin H
Year: 2021
Journal: Diabetes
Title: β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice.
Volume: 70
Issue: 11
Pages: 2626-2638
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Publication
32115146 | J:306986
First Author: Liu Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: The circadian clock protects against ferroptosis-induced sterile inflammation.
Volume: 525
Issue: 3
Pages: 620-625
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Publication
16054069 | J:129843
First Author: Steneberg P
Year: 2005
Journal: Cell Metab
Title: The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Volume: 1
Issue: 4
Pages: 245-58
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Strain
MGI:6771241 | C57BL/6JSmoc-Pdx1<em1(cre/ERT2)Smoc> Kras<em4Smoc> Trp53<em4Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Pdx1<tm1.1(dre)Gkg> | MGI:6359751
Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, George K Gittes
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(tetO-CAT-Pdx1)1Miya | MGI:7505583
Name: transgene insertion 1, Jun-ichi Miyazaki
Allele Type: Transgenic
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tcf7l2/Tcf7l2 Tg(Pdx1-cre)89.1Dam/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ppard/Ppard Tg(Pdx1-cre)1Herr/?
Background: involves: 129 * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)6Tuv/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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•
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6J * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6J * C57BL/6N * FVB/N
Zygosity: ot
Has Mutant Allele: true
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•
•
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)6Tuv/?
Background: involves: C57BL/6 * FVB/N
Zygosity: ot
Has Mutant Allele: true
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•
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Genotype
Genotype
Symbol: Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Publication
22363422 | J:223993
First Author: Blondeau B
Year: 2012
Journal: PLoS One
Title: Novel transgenic mice for inducible gene overexpression in pancreatic cells define glucocorticoid receptor-mediated regulations of beta cells.
Volume: 7
Issue: 2
Pages: e30210
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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