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Search results 2001 to 2100 out of 3113 for Rac1

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Type Details Score
Publication
16041389 | J:100455
First Author: Zhang J
Year: 2005
Journal: Nat Immunol
Title: An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
Volume: 6
Issue: 9
Pages: 911-9
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Publication
19625617 | J:152011
First Author: Cahill ME
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.
Volume: 106
Issue: 31
Pages: 13058-63
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Publication
21349274 | J:177236
First Author: Primeau M
Year: 2011
Journal: FEBS Lett
Title: Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif.
Volume: 585
Issue: 6
Pages: 847-53
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Publication
10843388 | J:111999
First Author: Yang FC
Year: 2000
Journal: Immunity
Title: Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Volume: 12
Issue: 5
Pages: 557-68
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Publication
15170212 | J:91126
First Author: Filippi MD
Year: 2004
Journal: Nat Immunol
Title: Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.
Volume: 5
Issue: 7
Pages: 744-51
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Publication
15161978 | J:90845
First Author: Yamauchi J
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.
Volume: 101
Issue: 23
Pages: 8774-9
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Publication
17251438 | J:117784
First Author: Liu G
Year: 2007
Journal: J Neurosci
Title: p130CAS is required for netrin signaling and commissural axon guidance.
Volume: 27
Issue: 4
Pages: 957-68
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Protein Coding Gene
MGI:88508 | Crk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339984 | Pak2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102718 | Vav2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1888518 | Vav3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109277 | Pik3r3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102709 | Cav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8CIN4
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
Q64010
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q64143
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
P49817
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Publication
16054028 | J:100589
First Author: Yang C
Year: 2005
Journal: Dev Cell
Title: Mammalian CARMIL inhibits actin filament capping by capping protein.
Volume: 9
Issue: 2
Pages: 209-21
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Publication
18805096 | J:156046
First Author: Napoli I
Year: 2008
Journal: Cell
Title: The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Volume: 134
Issue: 6
Pages: 1042-54
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Publication
21350944 | J:177235
First Author: Tsuji T
Year: 2011
Journal: Cell Mol Neurobiol
Title: Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells.
Volume: 31
Issue: 5
Pages: 663-8
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Publication
15147912 | -
First Author: Sakakibara T
Year: 2004
Journal: FEBS Lett
Title: Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis.
Volume: 566
Issue: 1-3
Pages: 294-300
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Protein
Q810V4
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
F6QD74
Organism: Mus musculus/domesticus
Length: 948  
Fragment?: true
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Protein
G3UZI5
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
D3Z107
Organism: Mus musculus/domesticus
Length: 45  
Fragment?: true
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Protein
E9Q6V8
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
Q8K118
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Publication
26824476 | -
First Author: Nebel RA
Year: 2016
Journal: PLoS One
Title: Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks.
Volume: 11
Issue: 1
Pages: e0148039
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Publication
15269173 | -
First Author: Bogdan S
Year: 2004
Journal: Development
Title: Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila.
Volume: 131
Issue: 16
Pages: 3981-9
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Publication
15294869 | -
First Author: Basu D
Year: 2004
Journal: Development
Title: Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.
Volume: 131
Issue: 17
Pages: 4345-55
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Publication
27524794 | J:236982
First Author: Tiwari SS
Year: 2016
Journal: Brain
Title: Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss.
Volume: 139
Issue: Pt 10
Pages: 2751-2765
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Publication
14624449 | -
First Author: Tatsumoto T
Year: 2003
Journal: J Cell Biochem
Title: Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts.
Volume: 90
Issue: 5
Pages: 892-900
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Publication
16103226 | -
First Author: Yüce O
Year: 2005
Journal: J Cell Biol
Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Volume: 170
Issue: 4
Pages: 571-82
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Publication
14645260 | -
First Author: Saito S
Year: 2004
Journal: J Biol Chem
Title: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.
Volume: 279
Issue: 8
Pages: 7169-79
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Publication
15073184 | -
First Author: Solski PA
Year: 2004
Journal: J Biol Chem
Title: Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
Volume: 279
Issue: 24
Pages: 25226-33
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Publication
10579713 | -
First Author: Tatsumoto T
Year: 1999
Journal: J Cell Biol
Title: Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
Volume: 147
Issue: 5
Pages: 921-8
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Publication
19896966 | -
First Author: Fields AP
Year: 2010
Journal: Adv Enzyme Regul
Title: The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.
Volume: 50
Issue: 1
Pages: 190-200
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Publication
19008376 | -
First Author: Salhia B
Year: 2008
Journal: Am J Pathol
Title: The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
Volume: 173
Issue: 6
Pages: 1828-38
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Publication
19118053 | -
First Author: Hirata D
Year: 2009
Journal: Clin Cancer Res
Title: Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.
Volume: 15
Issue: 1
Pages: 256-66
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Publication
18842503 | -
First Author: Zhang ML
Year: 2008
Journal: Hepatobiliary Pancreat Dis Int
Title: Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer.
Volume: 7
Issue: 5
Pages: 533-8
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Publication
19846667 | -
First Author: Liang Y
Year: 2009
Journal: Mol Biol Cell
Title: Distinct roles for CARMIL isoforms in cell migration.
Volume: 20
Issue: 24
Pages: 5290-305
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Publication
22411988 | -
First Author: Kim T
Year: 2012
Journal: J Biol Chem
Title: Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.
Volume: 287
Issue: 19
Pages: 15251-62
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Publication
12637522 | J:83589
First Author: Rossman KL
Year: 2003
Journal: J Biol Chem
Title: Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation.
Volume: 278
Issue: 20
Pages: 18393-400
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Publication
20926682 | J:182933
First Author: Sauzeau V
Year: 2010
Journal: Mol Biol Cell
Title: Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.
Volume: 21
Issue: 23
Pages: 4251-63
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Publication
21765461 | -
First Author: Rao S
Year: 2012
Journal: Oncogene
Title: A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer.
Volume: 31
Issue: 6
Pages: 716-27
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Publication
21455584 | -
First Author: Dong Z
Year: 2011
Journal: Oncol Rep
Title: Vav3 oncogene is involved in regulation of secretory phospholipase A2-IIa expression in prostate cancer.
Volume: 25
Issue: 6
Pages: 1511-6
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Publication
16101281 | -
First Author: Mott HR
Year: 2005
Journal: Biochemistry
Title: Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).
Volume: 44
Issue: 33
Pages: 10977-83
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Publication
16527308 | -
First Author: Hoelz A
Year: 2006
Journal: J Mol Biol
Title: Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
Volume: 358
Issue: 2
Pages: 509-22
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Protein Domain
IPR026799 | DOCK_2
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents DOCK2 (dedicator of cytokinesis 2). DOCK2 is involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. It activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. It may also participate in IL2 transcriptional activation via the activation of RAC2 [].
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Protein Domain
IPR026817 | Ect2
Type: Family
Description: Epithelial Cell Transforming Sequence 2 (Ect2) is a guanine nucleotide exchange factor (GEF) that catalyses the exchange of GDP for GTP. Like other GEFs, Ect2 serves as molecular switches in diverse signaling pathways, including cell polarity, mitotic spindle assembly, cytokinesis, etc [, , ]. Ect2 interacts with several members of the Rho GTPase family including, RhoA, RhoB, RhoC, RhoG, Rac1 and Cdc42 [, , , , ]. Ect2 regulates the formation of the actomyosin contractile ring at mitotic exit through activation of RhoA and functions in metaphase for the process of spindle assembly through activation of Cdc42 []. Ect2 is regulated through a number of mechanisms including phosphorylation, intracellular localization and intra- and inter-molecular interactions []. Ect2 is established as a human oncogene []. It is highly expressed in a variety of human tumors including brain lung, bladder, esophageal, pancreatic and ovarian tumors [, , , , ]. Ect2 is also suggested to play a role in neuronal differentiation and brain development [].
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Protein Domain
IPR035847 | SH3BP2_SH2
Type: Domain
Description: The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].This entry represents the SH2 domain of SH3BP2.
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Protein Domain
IPR015767 | ARHGAP27
Type: Family
Description: Members of Rho family are small G proteins that transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs), which stimulate the intrinsic GTPase activity of small G proteins.This entry represents Rho GTPase activating protein 27 (ARHGAP27, also known as CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, CAMGAP1), a binding protein for Cbl-interacting protein of 85kDa (CIN85), an adaptor protein involved in the endocytic process of several receptor tyrosine kinases. It also has activity towards Rac1 and Cdc42 [].
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Protein Domain
IPR035732 | VAV2_SH3_2
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2.
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Protein Domain
IPR035733 | VAV2_SH3_1
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2.
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Protein Domain
IPR035734 | VAV3_SH3_2
Type: Domain
Description: VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1 []. It has been implicated to function in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration []. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity [, ]. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This entry represents the SH3 domain of VAV3. The SH3 domain of VAV3 is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [].
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Protein Domain
IPR035789 | BetaPIX_SH3
Type: Domain
Description: Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7) or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ].PIX proteins contain an N-terminal SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains, and a C-terminal leucine-zipper domain for dimerization. The SH3 domain of PIX binds to an atypical PxxxPR motif in p21-activated kinases (PAKs) with high affinity. The binding of PAKs to PIX facilitate the localization of PAKs to focal complexes and also localizes PAKs to PIX targets Cdc43 and Rac, leading to the activation of PAKs [, ].This entry represents the SH3 domain of beta-PIX.
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Protein Domain
IPR035534 | DBS_PH
Type: Domain
Description: This entry represents the PH domain of guanine nucleotide exchange factor DBS. The DBS PH domain participates in binding to both the Cdc42 and RhoA GTPases []. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [].DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [, ]. Depending on cell type, DBS can also activate RhoA and RhoG [, ]. DBS contains a Sec14-like domain [], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [], and an SH3 domain.
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Protein Domain
IPR008081 | Cytoplasmic_FMR1-int
Type: Family
Description: This entry includes cytoplasmic fragile X messenger ribonucleoprotein 1-interacting proteins from humans and their homologues, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. In humans, there are two members, CYFIP1 and CYFIP2. They both interact with FMRP (Fragile X messenger ribonucleoprotein 1), which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1 [, ]. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E []. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses []. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila []. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization [].
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Protein Domain
IPR035848 | SH3BP2
Type: Family
Description: The adaptor protein 3BP2/SH3BP2 is a cytoplasmic adaptor that contributes to the regulation of immune responses []. The protein-tyrosine kinase Syk phosphorylates 3BP2 which results in the activation of Rac1 through the interaction with the SH2 domain of Vav1 and induces the binding to the SH2 domain of the upstream protein-tyrosine kinase Lyn and enhances its kinase activity []. 3BP2 has a positive regulatory role in IgE-mediated mast cell activation []. In lymphocytes, engagement of T cell or B cell receptors triggers tyrosine phosphorylation of 3BP2 []. 3BP2 is required for the proliferation of B cells and B cell receptor signaling. Mutations in the 3BP2 gene are responsible for cherubism resulting in excessive bone resorption in the jaw [].
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Protein Domain
IPR043120 | Rac1-db_N
Type: Homologous_superfamily
Description: The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. The N-terminal end of this domain (residues 434-615) consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end (residues 705-732) is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. The Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host [].This superfamily represents the N-terminal GTPase binding subdomain of the Rac1-binding domain.
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Publication
17000758 | J:118143
First Author: Kostenko EV
Year: 2006
Journal: Mol Cell Biol
Title: Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.
Volume: 26
Issue: 23
Pages: 8964-75
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Protein
Q9D2G5
Organism: Mus musculus/domesticus
Length: 1434  
Fragment?: false
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Publication
20361982 | -
First Author: Shepherd TR
Year: 2010
Journal: J Mol Biol
Title: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Volume: 398
Issue: 5
Pages: 730-46
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Protein
F8WHD8
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: false
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Protein
D3YZB2
Organism: Mus musculus/domesticus
Length: 1394  
Fragment?: false
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Protein
Q3TTB3
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Protein
J3QMH1
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
E9Q4P5
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Protein
Q3TQ81
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Publication
24308970 | -
First Author: Boissier P
Year: 2014
Journal: Cell Signal
Title: The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.
Volume: 26
Issue: 3
Pages: 483-91
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Publication
22204307 | -
 
First Author: Krause-Gruszczynska M
Year: 2011
Journal: Cell Commun Signal
Title: The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Volume: 9
Pages: 32
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Publication
20298788 | -
First Author: Moon MS
Year: 2010
Journal: Mol Cell Neurosci
Title: Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.
Volume: 44
Issue: 2
Pages: 118-28
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Publication
20140013 | -
First Author: Thalappilly S
Year: 2010
Journal: Oncogene
Title: VAV2 regulates epidermal growth factor receptor endocytosis and degradation.
Volume: 29
Issue: 17
Pages: 2528-39
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
19451809 | -
First Author: Holthusen K
Year: 2009
Journal: Am J Ther
Title: Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease.
Volume: 16
Issue: 6
Pages: 496-507
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Publication
18434624 | -
First Author: Arora PD
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.
Volume: 295
Issue: 1
Pages: C130-7
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Publication
16472649 | -
 
First Author: Baird D
Year: 2006
Journal: Methods Enzymol
Title: Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins.
Volume: 406
Pages: 58-69
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Publication
14988728 | J:88877
First Author: Tanaka M
Year: 2004
Journal: EMBO J
Title: Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.
Volume: 23
Issue: 5
Pages: 1075-88
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Protein Coding Gene
MGI:2139422 | Duox1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
D3YWM9
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
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Protein
D3YZB5
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Publication
9115846 | -
First Author: Romero F
Year: 1996
Journal: Cell Signal
Title: Structure and function of vav.
Volume: 8
Issue: 8
Pages: 545-53
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Publication
25533347 | J:243531
First Author: Hori K
Year: 2014
Journal: Cell Rep
Title: Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.
Volume: 9
Issue: 6
Pages: 2166-79
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Publication
15848799 | J:98309
First Author: Sahin M
Year: 2005
Journal: Neuron
Title: Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.
Volume: 46
Issue: 2
Pages: 191-204
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Publication
21396893 | J:174152
First Author: Xu K
Year: 2011
Journal: Dev Cell
Title: Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.
Volume: 20
Issue: 4
Pages: 526-39
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Publication
8570186 | J:45479
First Author: Park SH
Year: 1995
Journal: Oncogene
Title: A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.
Volume: 11
Issue: 11
Pages: 2349-55
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Publication
14507966 | J:85751
First Author: Kholmanskikh SS
Year: 2003
Journal: J Neurosci
Title: Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons.
Volume: 23
Issue: 25
Pages: 8673-81
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Publication
16369480 | J:105269
First Author: Kholmanskikh SS
Year: 2006
Journal: Nat Neurosci
Title: Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.
Volume: 9
Issue: 1
Pages: 50-7
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Publication
23209303 | J:195238
First Author: Cheadle L
Year: 2012
Journal: J Cell Biol
Title: The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization.
Volume: 199
Issue: 6
Pages: 985-1001
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Publication
23375260 | J:196400
First Author: He X
Year: 2013
Journal: Structure
Title: Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.
Volume: 21
Issue: 3
Pages: 355-64
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Publication
11336673 | J:69046
First Author: Shamah SM
Year: 2001
Journal: Cell
Title: EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.
Volume: 105
Issue: 2
Pages: 233-44
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Publication
15485661 | J:93225
First Author: Wang Y
Year: 2004
Journal: Biochem Biophys Res Commun
Title: WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
Volume: 324
Issue: 3
Pages: 1053-8
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Publication
27502165 | J:236911
First Author: García-Serna AM
Year: 2016
Journal: Immunobiology
Title: Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.
Volume: 221
Issue: 12
Pages: 1343-1350
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Publication
11595183 | J:72091
First Author: Gumienny TL
Year: 2001
Journal: Cell
Title: CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Volume: 107
Issue: 1
Pages: 27-41
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Publication
19118189 | J:144027
First Author: Lee HW
Year: 2008
Journal: J Neurosci
Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.
Volume: 28
Issue: 53
Pages: 14546-56
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Publication
12006984 | J:175102
First Author: Snyder JT
Year: 2002
Journal: Nat Struct Biol
Title: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Volume: 9
Issue: 6
Pages: 468-75
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Publication
16716191 | J:116446
First Author: Nasu-Nishimura Y
Year: 2006
Journal: Genes Cells
Title: Role of the Rho GTPase-activating protein RICS in neurite outgrowth.
Volume: 11
Issue: 6
Pages: 607-14
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Publication
26439400 | J:319958
First Author: Fritz RD
Year: 2015
Journal: Dev Cell
Title: SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion.
Volume: 35
Issue: 1
Pages: 78-92
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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