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Search results 2001 to 2100 out of 2424 for Ran

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Type Details Score
Publication
33431691 | J:300757
 
First Author: MacDonald CJ
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory.
Volume: 118
Issue: 3
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Publication
30322141 | J:272366
 
First Author: Marimoutou M
Year: 2018
Journal: Antioxidants (Basel)
Title: Oxidation of Methionine 77 in Calmodulin Alters Mouse Growth and Behavior.
Volume: 7
Issue: 10
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Publication
7825727 | J:20667
First Author: Ohsaki Y
Year: 1994
Journal: Anat Rec
Title: Type III collagen is a major component of interodontoblastic fibers of the developing mouse molar root.
Volume: 240
Issue: 3
Pages: 308-13
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Publication
11389929 | J:70058
First Author: Kohut ML
Year: 2001
Journal: Mech Ageing Dev
Title: Moderate exercise is associated with enhanced antigen-specific cytokine, but not IgM antibody production in aged mice.
Volume: 122
Issue: 11
Pages: 1135-50
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Publication
11455416 | J:68889
First Author: Koizumi K
Year: 2001
Journal: Dev Genes Evol
Title: A search for Drosophila neural precursor genes identifies ran.
Volume: 211
Issue: 2
Pages: 67-75
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Publication
8126562 | J:17128
First Author: Deal KK
Year: 1994
Journal: J Neurosci
Title: The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing.
Volume: 14
Issue: 3 Pt 2
Pages: 1666-76
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Publication
8146616 | J:17908
First Author: Mizuta K
Year: 1993
Journal: Scanning Microsc
Title: Scanning electron microscopy of age-related changes in the C57BL/6J mouse cochlea.
Volume: 7
Issue: 3
Pages: 889-96
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Publication
7978110 | J:20483
First Author: Dudek BC
Year: 1994
Journal: Alcohol Clin Exp Res
Title: Biometrical genetic analysis of ethanol's psychomotor stimulant effect.
Volume: 18
Issue: 4
Pages: 956-63
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Publication
7545760 | J:26577
First Author: Navarro X
Year: 1995
Journal: J Neurosci Res
Title: Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study.
Volume: 41
Issue: 1
Pages: 111-20
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Publication
9111043 | J:39773
First Author: Zolotukhin AS
Year: 1997
Journal: J Biol Chem
Title: Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.
Volume: 272
Issue: 17
Pages: 11356-60
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Publication
9365272 | J:45030
 
First Author: Nicolás FJ
Year: 1997
Journal: J Cell Sci
Title: Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts.
Volume: 110 ( Pt 24)
Pages: 3019-30
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Publication
9802419 | J:50710
 
First Author: Mercer JG
Year: 1998
Journal: Regul Pept
Title: Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem.
Volume: 75-76
Pages: 271-8
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Publication
12223567 | J:79140
First Author: Werme M
Year: 2002
Journal: J Neurosci
Title: Delta FosB regulates wheel running.
Volume: 22
Issue: 18
Pages: 8133-8
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Publication
15572412 | J:94443
First Author: Ciciarello M
Year: 2004
Journal: J Cell Sci
Title: Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells.
Volume: 117
Issue: Pt 26
Pages: 6511-22
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Publication
17035634 | J:117946
First Author: Goffin L
Year: 2006
Journal: Mol Biol Cell
Title: The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.
Volume: 17
Issue: 12
Pages: 5309-23
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Publication
17716967 | J:126959
First Author: Hakimi P
Year: 2007
Journal: J Biol Chem
Title: Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.
Volume: 282
Issue: 45
Pages: 32844-55
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Publication
20026644 | J:156701
First Author: von Knethen A
Year: 2010
Journal: J Cell Sci
Title: Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol.
Volume: 123
Issue: Pt 2
Pages: 192-201
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Publication
21803074 | J:179948
First Author: Klaus F
Year: 2012
Journal: Behav Brain Res
Title: Different regulation of adult hippocampal neurogenesis in Western house mice (Mus musculus domesticus) and C57BL/6 mice.
Volume: 227
Issue: 2
Pages: 340-7
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Publication
22079576 | J:184428
 
First Author: Cohen BN
Year: 2012
Journal: Neuroscience
Title: Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior.
Volume: 200
Pages: 31-41
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Publication
24286865 | J:210032
First Author: Ng IH
Year: 2014
Journal: Biochim Biophys Acta
Title: Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation.
Volume: 1843
Issue: 3
Pages: 483-94
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Publication
24403548 | J:210348
First Author: Tsai JH
Year: 2014
Journal: Biol Reprod
Title: The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice.
Volume: 90
Issue: 2
Pages: 34
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Publication
25274774 | J:218099
First Author: Kino Y
Year: 2015
Journal: Hum Mol Genet
Title: Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.
Volume: 24
Issue: 3
Pages: 740-56
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Publication
28550099 | J:243647
First Author: Herranz-Martin S
Year: 2017
Journal: Dis Model Mech
Title: Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.
Volume: 10
Issue: 7
Pages: 859-868
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Publication
28193732 | J:246892
First Author: Baumann C
Year: 2017
Journal: J Cell Sci
Title: Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin.
Volume: 130
Issue: 7
Pages: 1251-1262
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Publication
29715445 | J:268113
 
First Author: Jiang L
Year: 2018
Journal: Brain Res
Title: Effect of running exercise on the number of the neurons in the hippocampus of young transgenic APP/PS1 mice.
Volume: 1692
Pages: 56-65
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Publication
30274168 | J:305079
 
First Author: Ahn JS
Year: 2018
Journal: Int J Mol Sci
Title: Ectopic Overexpression of Porcine Myh1 Increased in Slow Muscle Fibers and Enhanced Endurance Exercise in Transgenic Mice.
Volume: 19
Issue: 10
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Publication
26136363 | J:345545
First Author: Lim YS
Year: 2015
Journal: J Cell Sci
Title: A role for Rab23 in the trafficking of Kif17 to the primary cilium.
Volume: 128
Issue: 16
Pages: 2996-3008
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Publication
33786989 | J:354574
First Author: Booher WC
Year: 2021
Journal: Genes Brain Behav
Title: Anxiety-related defensive behavioral responses in mice selectively bred for High and Low Activity.
Volume: 20
Issue: 7
Pages: e12730
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Publication
34616039 | J:326213
First Author: Guttenplan KA
Year: 2021
Journal: Nature
Title: Neurotoxic reactive astrocytes induce cell death via saturated lipids.
Volume: 599
Issue: 7883
Pages: 102-107
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Publication
35427794 | J:324459
First Author: Rajala A
Year: 2022
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Ribosomal targeting strategy and nuclear labeling to analyze photoreceptor phosphoinositide signatures.
Volume: 1867
Issue: 8
Pages: 159161
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Publication
28894085 | -
First Author: Stiegler AL
Year: 2017
Journal: Nat Commun
Title: p190RhoGAP proteins contain pseudoGTPase domains.
Volume: 8
Issue: 1
Pages: 506
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Publication
10591541 | J:68421
First Author: Jones BC
Year: 1999
Journal: Pharmacogenetics
Title: Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry.
Volume: 9
Issue: 5
Pages: 607-17
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Publication
10963672 | J:64380
First Author: Puech A
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Volume: 97
Issue: 18
Pages: 10090-5
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Publication
23077214 | J:191130
First Author: Maynard TM
Year: 2013
Journal: Hum Mol Genet
Title: 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.
Volume: 22
Issue: 2
Pages: 300-12
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Publication
15778864 | J:98850
First Author: Prescott K
Year: 2005
Journal: Hum Genet
Title: Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.
Volume: 116
Issue: 6
Pages: 486-96
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Publication
18974875 | J:147414
First Author: Landry J
Year: 2008
Journal: PLoS Genet
Title: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Volume: 4
Issue: 10
Pages: e1000241
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Publication
10704284 | J:60871
First Author: Lund J
Year: 2000
Journal: Genomics
Title: Comparative sequence analysis of 634 kb of the mouse chromosome 16 region of conserved synteny with the human velocardiofacial syndrome region on chromosome 22q11.2.
Volume: 63
Issue: 3
Pages: 374-83
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Publication
10337614 | J:54501
First Author: Lund J
Year: 1999
Journal: Mamm Genome
Title: Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2.
Volume: 10
Issue: 5
Pages: 438-43
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Publication
14614146 | J:86704
First Author: Maynard TM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A comprehensive analysis of 22q11 gene expression in the developing and adult brain.
Volume: 100
Issue: 24
Pages: 14433-8
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Publication
16222336 | J:103359
First Author: Matsuura Y
Year: 2005
Journal: EMBO J
Title: Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling.
Volume: 24
Issue: 21
Pages: 3681-9
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Protein
Q8CCI5
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q571K4
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q91WA6
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
Q99K90
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Protein
Q99LW6
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
Q80WR0
Organism: Mus musculus/domesticus
Length: 1462  
Fragment?: false
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Protein
Q80UN3
Organism: Mus musculus/domesticus
Length: 928  
Fragment?: true
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Protein
E9Q3G8
Organism: Mus musculus/domesticus
Length: 1462  
Fragment?: false
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Protein
A0A1B0GQZ6
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q8BRF6
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: true
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Protein
G3UZD2
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
F6UHH8
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
Q3TQ31
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: true
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Protein
A0A286YE24
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
B1ASY9
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q91VQ2
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Publication
8817343 | -
First Author: Roepman R
Year: 1996
Journal: Hum Mol Genet
Title: Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1.
Volume: 5
Issue: 7
Pages: 1035-41
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Publication
8480369 | -
First Author: Dasso M
Year: 1993
Journal: Trends Biochem Sci
Title: RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles.
Volume: 18
Issue: 3
Pages: 96-101
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Publication
12372823 | -
First Author: Bayliss R
Year: 2002
Journal: J Biol Chem
Title: GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
Volume: 277
Issue: 52
Pages: 50597-606
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Publication
10367892 | -
First Author: Vetter IR
Year: 1999
Journal: Cell
Title: Structural view of the Ran-Importin beta interaction at 2.3 A resolution.
Volume: 97
Issue: 5
Pages: 635-46
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Publication
17161424 | -
First Author: Isgro TA
Year: 2007
Journal: J Mol Biol
Title: Association of nuclear pore FG-repeat domains to NTF2 import and export complexes.
Volume: 366
Issue: 1
Pages: 330-45
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Publication
9442897 | -
 
First Author: Fabre E
Year: 1997
Journal: Annu Rev Genet
Title: Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking.
Volume: 31
Pages: 277-313
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Publication
8443417 | -
First Author: Loeb JD
Year: 1993
Journal: Mol Biol Cell
Title: NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.
Volume: 4
Issue: 2
Pages: 209-22
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Publication
9640541 | -
First Author: Pemberton LF
Year: 1998
Journal: Curr Opin Cell Biol
Title: Transport routes through the nuclear pore complex.
Volume: 10
Issue: 3
Pages: 392-9
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Publication
9630243 | -
First Author: Izaurralde E
Year: 1998
Journal: RNA
Title: Transport of macromolecules between the nucleus and the cytoplasm.
Volume: 4
Issue: 4
Pages: 351-64
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Publication
8311839 | -
First Author: Hinshaw JE
Year: 1994
Journal: Biochem Pharmacol
Title: Architecture of the nuclear pore complex and its involvement in nucleocytoplasmic transport.
Volume: 47
Issue: 1
Pages: 15-20
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Publication
8740526 | -
First Author: Panté N
Year: 1996
Journal: Crit Rev Biochem Mol Biol
Title: Molecular dissection of the nuclear pore complex.
Volume: 31
Issue: 2
Pages: 153-99
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Publication
7574503 | -
 
First Author: Davis LI
Year: 1995
Journal: Annu Rev Biochem
Title: The nuclear pore complex.
Volume: 64
Pages: 865-96
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Publication
7537513 | -
First Author: Panté N
Year: 1994
Journal: J Struct Biol
Title: Toward the molecular details of the nuclear pore complex.
Volume: 113
Issue: 3
Pages: 179-89
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Publication
8227139 | -
First Author: Rout MP
Year: 1993
Journal: J Cell Biol
Title: Isolation of the yeast nuclear pore complex.
Volume: 123
Issue: 4
Pages: 771-83
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Publication
8045927 | -
First Author: Belanger KD
Year: 1994
Journal: J Cell Biol
Title: Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.
Volume: 126
Issue: 3
Pages: 619-30
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Publication
7638906 | -
First Author: Doye V
Year: 1995
Journal: Trends Genet
Title: Genetic approaches to nuclear pore structure and function.
Volume: 11
Issue: 6
Pages: 235-41
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Publication
7688974 | -
First Author: Newmeyer DD
Year: 1993
Journal: Curr Opin Cell Biol
Title: The nuclear pore complex and nucleocytoplasmic transport.
Volume: 5
Issue: 3
Pages: 395-407
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Publication
18591351 | -
First Author: Zhao Q
Year: 2008
Journal: Plant Cell
Title: Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP.
Volume: 20
Issue: 6
Pages: 1639-51
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Publication
25759303 | -
First Author: Zhou X
Year: 2015
Journal: Nucleus
Title: Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
Volume: 6
Issue: 2
Pages: 144-53
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Protein Domain
IPR000408 | Reg_chr_condens
Type: Repeat
Description: The regulator of chromosome condensation (RCC1) []is a eukaryotic proteinwhich binds to chromatin and interacts with ran, a nuclear GTP-bindingprotein , to promote the loss of bound GDP and the uptake offresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS).The interaction of RCC1 with ran probably plays an important role in theregulation of gene expression.RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 inDrosophila, is a protein that contains seven tandem repeats of a domain ofabout 50 to 60 amino acids. As shown in the following schematicrepresentation, the repeats make up the major part of the length of theprotein. Outside the repeat region, there is just a small N-terminal domain ofabout 40 to 50 residues and, in the Drosophila protein only, a C-terminaldomain of about 130 residues.+----+-------+-------+-------+-------+-------+-------+-------+-------------+|N-t.|Rpt. 1 |Rpt. 2 |Rpt. 3 |Rpt. 4 |Rpt. 5 |Rpt. 6 |Rpt. 7 | C-terminal |+----+-------+-------+-------+-------+-------+-------+-------+-------------+The RCC1-type of repeat is also found in the X-linked retinitis pigmentosaGTPase regulator []. The RCC repeats form a β-propellerstructure.
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Protein Domain
IPR009109 | Ran_GTPase_activating_1_C
Type: Domain
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Protein Domain
IPR036720 | RanGAP1_C_sf
Type: Homologous_superfamily
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Protein Domain
IPR015007 | NUP2/50/61
Type: Domain
Description: This entry represents a domain found in Nup2, 50 and 61, which are components of the nuclear pore complex. Nucleoporin 50kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha []. NUP2 encodes a non-essential nuclear pore protein that has a central domain similar to those of Nsp1 and Nup1[, ]. Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs through the nuclear pore complex (NPC), a large macromolecular complex that spans the nuclear envelope [, , ]. The structure of the vertebrate NPC has been studied extensively; recent reviews include [, , , ]. The yeast NPC shares several features with the vertebrate NPC, despite being smaller and less elaborate [, ]. Many yeast nuclear pore proteins, or nucleoporins, have been identified by a variety of genetic approaches [, , , ]. nup2 mutants show genetic interactions with nsp1 and nup1 conditional alleles [, ]. Nup1 interacts with the nuclear import factor Srp1 []and with the small GTPase Ran (encoded by GSP1) [].
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Protein Domain
IPR039006 | RhoGAP_pG2
Type: Domain
Description: GTPases bind to guanosine triphosphate (GTP), hydrolyze gamma-phosphate,release guanosine diphosphate (GDP) and then rebind GTP, a process termed'GTPase cycling'. GTPases are regulated by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). The Ras superfamily of small GTPases consists of five subgroups (Ras, Rho, Rab, Ran and Arf) that act as molecular switches in broad and diverse cellular pathways and processes. The Ras superfamily members contain five highly conserved sequence motifs, termed 'G-motifs', required for nucleotide-binding and catalytic activity. PseudoGTPases by definition would consist of a GTPase fold lacking one or more of these G motifs [].The p190RhoGAP proteins, p190RhoGAP-A (ARHGAP35) andp190RhoGAP-B (ARHGAP5), are key regulators of Rho GTP hydrolysis and arehighly important for maintenance of proper Rho signaling. They share a domainorganization containing a GTP-binding GTPase domain, four FF domains, twoGTPase-like folds (pG1 and pG2) and a C-terminal GAP domain. Their pG1 (pseudoGTPase1) and pG2 (pseudoGTPase2) domains lack conserved GTPase motifs and don't have nucleotide-binding activity []. This entry represents the pG2 domain.
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Protein Domain
IPR039007 | pG1
Type: Domain
Description: GTPases bind to guanosine triphosphate (GTP), hydrolyze gamma-phosphate,release guanosine diphosphate (GDP) and then rebind GTP, a process termed'GTPase cycling'. GTPases are regulated by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). The Ras superfamily of small GTPases consists of five subgroups (Ras, Rho, Rab, Ran and Arf) that act as molecular switches in broad and diverse cellular pathways and processes. The Ras superfamily members contain five highly conserved sequence motifs, termed 'G-motifs', required for nucleotide-binding and catalytic activity. PseudoGTPases by definition would consist of a GTPase fold lacking one or more of these G motifs [].The p190RhoGAP proteins, p190RhoGAP-A (ARHGAP35) andp190RhoGAP-B (ARHGAP5), are key regulators of Rho GTP hydrolysis and arehighly important for maintenance of proper Rho signaling. They share a domainorganization containing a GTP-binding GTPase domain, four FF domains, twoGTPase-like folds (pG1 and pG2) and a C-terminal GAP domain. Their pG1 (pseudoGTPase1) and pG2 (pseudoGTPase2) domains lack conserved GTPase motifs and don't have nucleotide-binding activity []. This entry represents the pG1 domain.
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Protein Domain
IPR001494 | Importin-beta_N
Type: Domain
Description: This entry represents the N-terminal domain of importin-beta (also known as karyopherins-beta) that is important for the binding of the Ran GTPase protein [].Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins [, ], which is important for importin-beta mediated transport.Ran GTPase helps to control the unidirectional transfer of cargo. The cytoplasm contains primarily RanGDP and the nucleus RanGTP through the actions of RanGAP and RanGEF, respectively. In the nucleus, RanGTP binds to importin-beta within the importin/cargo complex, causing a conformational change in importin-beta that releases it from importin-alpha-bound cargo. As a result, the N-terminal auto-inhibitory region on importin-alpha is free to loop back and bind to the major NLS-binding site, causing the cargo to be released []. There are additional release factors as well.
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Publication
12634303 | J:100014
First Author: Anway MD
Year: 2003
Journal: J Androl
Title: Expression of testicular germ cell genes identified by differential display analysis.
Volume: 24
Issue: 2
Pages: 173-84
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Publication
11039641 | J:65357
First Author: Colbert LH
Year: 2000
Journal: Med Sci Sports Exerc
Title: Exercise and tumor development in a mouse predisposed to multiple intestinal adenomas.
Volume: 32
Issue: 10
Pages: 1704-8
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Publication
16699175 | J:113355
First Author: Colbert LH
Year: 2006
Journal: Carcinogenesis
Title: Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice.
Volume: 27
Issue: 10
Pages: 2103-7
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Publication
14523302 | J:101440
First Author: Colbert LH
Year: 2003
Journal: Med Sci Sports Exerc
Title: Exercise and intestinal polyp development in APCMin mice.
Volume: 35
Issue: 10
Pages: 1662-9
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Publication
29879154 | J:262828
First Author: Boulanger Piette A
Year: 2018
Journal: PLoS One
Title: Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.
Volume: 13
Issue: 6
Pages: e0198408
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Publication
9186010 | J:42644
First Author: Hasson T
Year: 1997
Journal: Cell Motil Cytoskeleton
Title: Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
Volume: 37
Issue: 2
Pages: 127-38
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Publication
21359188 | J:171082
First Author: Cesar L
Year: 2011
Journal: PLoS One
Title: An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE⁻/⁻ mice.
Volume: 6
Issue: 2
Pages: e17263
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Publication
16051635 | J:102840
First Author: Rebel H
Year: 2005
Journal: Carcinogenesis
Title: Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice.
Volume: 26
Issue: 12
Pages: 2123-30
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Publication
24030242 | J:324418
First Author: Phelps M
Year: 2013
Journal: Biogerontology
Title: Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice.
Volume: 14
Issue: 6
Pages: 729-39
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Publication
15740704 | J:154436
First Author: Kennaway DJ
Year: 2004
Journal: Reprod Fertil Dev
Title: Reproductive performance in female Clock Delta19 mutant mice.
Volume: 16
Issue: 8
Pages: 801-10
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Publication
8821757 | J:30810
First Author: Pickard GE
Year: 1995
Journal: Brain Res
Title: Mutagenesis and behavioral screening for altered circadian activity identifies the mouse mutant, Wheels.
Volume: 705
Issue: 1-2
Pages: 255-66
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Publication
31120949 | J:275656
First Author: Kang JJ
Year: 2019
Journal: PLoS One
Title: Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α-galactosidase A.
Volume: 14
Issue: 5
Pages: e0217214
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Publication
24654233 | J:229799
First Author: Dworatzek E
Year: 2014
Journal: Cardiovasc Res
Title: Sex differences in exercise-induced physiological myocardial hypertrophy are modulated by oestrogen receptor beta.
Volume: 102
Issue: 3
Pages: 418-28
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Publication
19233512 | J:168291
First Author: Zitman FM
Year: 2011
Journal: Neurobiol Aging
Title: Neuromuscular synaptic transmission in aged ganglioside-deficient mice.
Volume: 32
Issue: 1
Pages: 157-67
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Publication
20595537 | J:185924
First Author: Personius KE
Year: 2010
Journal: J Appl Physiol (1985)
Title: Grip force, EDL contractile properties, and voluntary wheel running after postdevelopmental myostatin depletion in mice.
Volume: 109
Issue: 3
Pages: 886-94
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Publication
20138171 | J:162362
First Author: Dubreucq S
Year: 2010
Journal: Exp Neurol
Title: CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.
Volume: 224
Issue: 1
Pages: 106-13
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Publication
31339770 | J:293569
First Author: Radhakrishnan J
Year: 2019
Journal: FASEB J
Title: Improved exercise capacity in cyclophilin-D knockout mice associated with enhanced oxygen utilization efficiency and augmented glucose uptake via AMPK-TBC1D1 signaling nexus.
Volume: 33
Issue: 10
Pages: 11443-11457
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Publication
28663375 | J:276696
First Author: Maricelli JW
Year: 2017
Journal: J Appl Physiol (1985)
Title: Sexually dimorphic skeletal muscle and cardiac dysfunction in a mouse model of limb girdle muscular dystrophy 2i.
Volume: 123
Issue: 5
Pages: 1126-1138
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