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Search results 2001 to 2100 out of 3140 for Sod1

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0.019s

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:5492390 | B6;SJL-Tg(Prnp-CCS)17Jlel/J
Attribute String: mutant stock, transgenic
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Allele
Tg(SOD1*H46R*C111S)QAra | MGI:5699327
Name: transgene insertion Q, Toshiyuki Araki
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(SOD1*H46R*C111S)PAra | MGI:5699338
Name: transgene insertion P, Toshiyuki Araki
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(SOD1)2Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(SOD1)2Gur/?
Background: involves: C57BL/6 * CBA * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-CCS)17Jlel/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Publication
15356208 | J:92633
First Author: Kiaei M
Year: 2004
Journal: J Neurosci
Title: Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.
Volume: 24
Issue: 36
Pages: 7945-50
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Publication
17079668 | J:114680
First Author: Gowing G
Year: 2006
Journal: J Neurosci
Title: Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations.
Volume: 26
Issue: 44
Pages: 11397-402
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Publication
15857390 | J:98232
First Author: Liu J
Year: 2005
Journal: J Neurochem
Title: Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis.
Volume: 93
Issue: 4
Pages: 875-82
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Publication
17435754 | J:121861
First Author: Di Giorgio FP
Year: 2007
Journal: Nat Neurosci
Title: Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.
Volume: 10
Issue: 5
Pages: 608-14
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Publication
35044815 | J:355728
First Author: Powell JE
Year: 2022
Journal: Sci Adv
Title: Targeted gene silencing in the nervous system with CRISPR-Cas13.
Volume: 8
Issue: 3
Pages: eabk2485
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Publication
12127151 | J:119631
First Author: Wang J
Year: 2002
Journal: Neurobiol Dis
Title: Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.
Volume: 10
Issue: 2
Pages: 128-38
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Publication
11112346 | J:66226
First Author: Kunst CB
Year: 2000
Journal: Genomics
Title: Genetic mapping of a mouse modifier gene that can prevent ALS onset.
Volume: 70
Issue: 2
Pages: 181-9
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Publication
25761970 | J:357699
First Author: Tokuda E
Year: 2015
Journal: Neurotherapeutics
Title: Regulation of Intracellular Copper by Induction of Endogenous Metallothioneins Improves the Disease Course in a Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 12
Issue: 2
Pages: 461-76
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Publication
10964497 | J:64503
First Author: Kuntz C 4th
Year: 2000
Journal: Exp Neurol
Title: Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Volume: 165
Issue: 1
Pages: 184-90
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Publication
16002469 | J:100349
First Author: Lobsiger CS
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.
Volume: 102
Issue: 29
Pages: 10351-6
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Publication
19762508 | J:153047
First Author: Hetz C
Year: 2009
Journal: Genes Dev
Title: XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Volume: 23
Issue: 19
Pages: 2294-306
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Publication
16290266 | J:129220
First Author: Virgili M
Year: 2006
Journal: Neurochem Int
Title: Regional and temporal alterations of ODC/polyamine system during ALS-like neurodegenerative motor syndrome in G93A transgenic mice.
Volume: 48
Issue: 3
Pages: 201-7
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Publication
8643599 | J:78612
First Author: Mourelatos Z
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.
Volume: 93
Issue: 11
Pages: 5472-7
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Publication
27114530 | J:232197
First Author: Nagy M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110.
Volume: 113
Issue: 19
Pages: 5424-8
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Publication
31250273 | J:289335
First Author: Zeldich E
Year: 2019
Journal: J Mol Neurosci
Title: Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS.
Volume: 69
Issue: 2
Pages: 264-285
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Publication
16753145 | J:144898
First Author: Pardo AC
Year: 2006
Journal: Exp Neurol
Title: Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.
Volume: 201
Issue: 1
Pages: 120-30
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Publication
27083773 | J:232476
First Author: Almad AA
Year: 2016
Journal: Glia
Title: Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.
Volume: 64
Issue: 7
Pages: 1154-69
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Publication
25283820 | J:230467
First Author: Nandar W
Year: 2014
Journal: Biochim Biophys Acta
Title: H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.
Volume: 1842
Issue: 12 Pt A
Pages: 2413-26
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Publication
39019135 | J:357636
 
First Author: Cao M
Year: 2024
Journal: Brain Res
Title: Inhibiting NF-κB inducing kinase improved the motor performance of ALS animal model.
Volume: 1843
Pages: 149124
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Publication
27818323 | J:260249
First Author: Bayer H
Year: 2017
Journal: Neurobiol Dis
Title: ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues.
Volume: 97
Issue: Pt A
Pages: 36-45
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Publication
14561497 | J:128781
First Author: Veldink JH
Year: 2003
Journal: Neuromuscul Disord
Title: Sexual differences in onset of disease and response to exercise in a transgenic model of ALS.
Volume: 13
Issue: 9
Pages: 737-43
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Publication
24163136 | J:206215
First Author: Tokuda E
Year: 2014
Journal: Hum Mol Genet
Title: Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1.
Volume: 23
Issue: 5
Pages: 1271-85
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Publication
16740261 | J:114432
First Author: Niessen HG
Year: 2006
Journal: Exp Neurol
Title: In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient.
Volume: 201
Issue: 2
Pages: 293-300
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Publication
26810478 | J:357823
 
First Author: Tokuda E
Year: 2016
Journal: Acta Neuropathol Commun
Title: Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase.
Volume: 4
Pages: 6
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Publication
17823119 | J:126836
First Author: Gibb SL
Year: 2007
Journal: J Biol Chem
Title: A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis.
Volume: 282
Issue: 44
Pages: 32480-90
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Publication
17432958 | J:122876
First Author: Niessen HG
Year: 2007
Journal: Eur J Neurosci
Title: Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Volume: 25
Issue: 6
Pages: 1669-77
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Publication
27425885 | J:260634
 
First Author: Bonifacino T
Year: 2016
Journal: Neurobiol Dis
Title: Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease.
Volume: 95
Pages: 122-33
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Publication
22117694 | J:182278
First Author: Thompson M
Year: 2012
Journal: J Neurochem
Title: Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
Volume: 120
Issue: 4
Pages: 598-610
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Publication
30816241 | J:275524
First Author: Camerino GM
Year: 2019
Journal: Sci Rep
Title: Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options.
Volume: 9
Issue: 1
Pages: 3185
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Publication
19656261 | J:153644
First Author: Tokuda E
Year: 2009
Journal: J Neurochem
Title: Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis.
Volume: 111
Issue: 1
Pages: 181-91
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Publication
30370540 | J:328968
First Author: Kefalakes E
Year: 2019
Journal: J Cell Physiol
Title: Characterizing the multiple roles of FGF-2 in SOD1G93A ALS mice in vivo and in vitro.
Volume: 234
Issue: 5
Pages: 7395-7410
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Publication
15634778 | J:96714
First Author: Kirkinezos IG
Year: 2005
Journal: J Neurosci
Title: Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.
Volume: 25
Issue: 1
Pages: 164-72
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Publication
22431618 | J:182654
First Author: Brotherton TE
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS.
Volume: 109
Issue: 14
Pages: 5505-10
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Publication
24501372 | J:206946
First Author: Kawamata H
Year: 2014
Journal: J Neurosci
Title: Abnormal intracellular calcium signaling and SNARE-dependent exocytosis contributes to SOD1G93A astrocyte-mediated toxicity in amyotrophic lateral sclerosis.
Volume: 34
Issue: 6
Pages: 2331-48
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Publication
15009685 | J:88474
First Author: Takahashi S
Year: 2004
Journal: J Neurochem
Title: Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25.
Volume: 88
Issue: 5
Pages: 1295-304
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Publication
25497732 | J:219295
 
First Author: Milanese M
Year: 2015
Journal: Neurobiol Dis
Title: Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Volume: 74
Pages: 314-24
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Publication
35354901 | J:322840
First Author: Genç B
Year: 2022
Journal: Sci Rep
Title: NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone.
Volume: 12
Issue: 1
Pages: 5383
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Publication
12699776 | J:109423
First Author: Geracitano R
Year: 2003
Journal: Neuroscience
Title: Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation.
Volume: 118
Issue: 2
Pages: 399-408
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Publication
30323744 | J:312052
 
First Author: Clark RM
Year: 2018
Journal: Front Cell Neurosci
Title: Reduced Excitability and Increased Neurite Complexity of Cortical Interneurons in a Familial Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 12
Pages: 328
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Publication
26074815 | J:242808
 
First Author: Zhang F
Year: 2015
Journal: Front Aging Neurosci
Title: Miro1 deficiency in amyotrophic lateral sclerosis.
Volume: 7
Pages: 100
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Publication
24365539 | J:211479
 
First Author: Marcuzzo S
Year: 2014
Journal: Exp Neurol
Title: Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells.
Volume: 253
Pages: 91-101
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Publication
19071115 | J:144363
First Author: Pieri M
Year: 2009
Journal: Exp Neurol
Title: Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis.
Volume: 215
Issue: 2
Pages: 368-79
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Publication
19880516 | J:158306
First Author: Stifanese R
Year: 2010
Journal: J Biol Chem
Title: Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis.
Volume: 285
Issue: 1
Pages: 631-43
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Publication
21486770 | J:185250
First Author: Quinlan KA
Year: 2011
Journal: J Physiol
Title: Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.
Volume: 589
Issue: Pt 9
Pages: 2245-60
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Publication
24141050 | J:215733
 
First Author: Peixoto PM
Year: 2013
Journal: Mol Cell Neurosci
Title: UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.
Volume: 57
Pages: 104-10
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Publication
22269142 | J:181281
First Author: Lee JC
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Volume: 418
Issue: 2
Pages: 359-65
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Publication
29906423 | J:269422
 
First Author: Hilton JB
Year: 2018
Journal: Exp Neurol
Title: The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.
Volume: 307
Pages: 118-128
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Publication
21072055 | J:186976
First Author: Aebischer J
Year: 2011
Journal: Cell Death Differ
Title: IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1.
Volume: 18
Issue: 5
Pages: 754-68
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Publication
35272709 | J:357650
First Author: Kim D
Year: 2022
Journal: Transl Neurodegener
Title: Autologous treatment for ALS with implication for broad neuroprotection.
Volume: 11
Issue: 1
Pages: 16
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Publication
24597481 | J:357676
 
First Author: Cui Y
Year: 2014
Journal: J Neuroinflammation
Title: Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.
Volume: 11
Pages: 42
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Publication
36967828 | J:345221
 
First Author: Gao T
Year: 2023
Journal: Front Aging Neurosci
Title: Protective effects of intrathecal injection of AAV9-RabGGTB-GFP(+) in SOD1(G93A) mice.
Volume: 15
Pages: 1092607
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Publication
29030231 | J:256983
 
First Author: Wang H
Year: 2018
Journal: Bone
Title: ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes.
Volume: 106
Pages: 126-138
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Publication
21354109 | J:172529
 
First Author: Alves CJ
Year: 2011
Journal: Brain Res
Title: Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome.
Volume: 1394
Pages: 90-104
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Genotype
Genotype
Symbol: Sod2/Sod2
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
25801706 | J:221599
First Author: Israelson A
Year: 2015
Journal: Neuron
Title: Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.
Volume: 86
Issue: 1
Pages: 218-32
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Publication
10675581 | J:127959
First Author: Stieber A
Year: 2000
Journal: J Neurol Sci
Title: The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene.
Volume: 173
Issue: 1
Pages: 63-72
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Publication
26853136 | J:229537
 
First Author: Carrasco DI
Year: 2016
Journal: Exp Neurol
Title: Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease.
Volume: 278
Pages: 116-26
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Publication
17368952 | J:122050
First Author: Liu D
Year: 2007
Journal: Neuroscience
Title: Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis.
Volume: 146
Issue: 1
Pages: 255-64
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Publication
8610185 | J:76718
First Author: Tu PH
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
Volume: 93
Issue: 7
Pages: 3155-60
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Publication
28103900 | J:357588
First Author: Cave C
Year: 2017
Journal: Mol Neurodegener
Title: GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord.
Volume: 12
Issue: 1
Pages: 8
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Publication
23752092 | J:214193
 
First Author: Caioli S
Year: 2013
Journal: Neuropharmacology
Title: Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
Volume: 73
Pages: 247-60
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Publication
22384126 | J:355716
First Author: Li Y
Year: 2012
Journal: PLoS One
Title: Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
Volume: 7
Issue: 2
Pages: e32008
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Publication
11682111 | J:92773
First Author: Ammassari-Teule M
Year: 2001
Journal: Behav Brain Res
Title: Learning about the context in genetically-defined mice.
Volume: 125
Issue: 1-2
Pages: 195-204
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Publication
16928866 | J:111890
First Author: Gould TW
Year: 2006
Journal: J Neurosci
Title: Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS.
Volume: 26
Issue: 34
Pages: 8774-86
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Publication
27233823 | J:242420
 
First Author: Preisig DF
Year: 2016
Journal: Behav Brain Res
Title: High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders.
Volume: 311
Pages: 340-353
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Publication
21107132 | J:357505
First Author: Philips T
Year: 2010
Journal: J Neuropathol Exp Neurol
Title: Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Volume: 69
Issue: 12
Pages: 1191-200
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Publication
31039129 | J:290351
First Author: Duan W
Year: 2019
Journal: Aging (Albany NY)
Title: Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.
Volume: 11
Issue: 8
Pages: 2457-2476
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Publication
23321002 | J:197756
 
First Author: Tokuda E
Year: 2013
Journal: Neurobiol Dis
Title: Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities.
Volume: 54
Pages: 308-19
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Publication
22952827 | J:191656
First Author: Dibaj P
Year: 2012
Journal: PLoS One
Title: Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.
Volume: 7
Issue: 8
Pages: e43963
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Publication
15827116 | J:97818
First Author: Kuner R
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit.
Volume: 102
Issue: 16
Pages: 5826-31
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Publication
14534160 | J:175594
First Author: Jonsson PA
Year: 2004
Journal: Brain
Title: Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis.
Volume: 127
Issue: Pt 1
Pages: 73-88
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Publication
34200232 | J:357639
 
First Author: Ozyurt T
Year: 2021
Journal: Brain Sci
Title: Differential Epigenetic Signature of Corticospinal Motor Neurons in ALS.
Volume: 11
Issue: 6
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Publication
36450833 | J:357830
First Author: Chen YA
Year: 2023
Journal: Gene Ther
Title: In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model.
Volume: 30
Issue: 5
Pages: 443-454
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Publication
24595038 | J:214698
First Author: Perera ND
Year: 2014
Journal: PLoS One
Title: Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
Volume: 9
Issue: 3
Pages: e90449
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Publication
28342750 | J:262114
 
First Author: Rosenblum LT
Year: 2017
Journal: Exp Neurol
Title: Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Volume: 292
Pages: 145-153
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Publication
28941811 | J:261236
First Author: Wiesner D
Year: 2018
Journal: Exp Neurol
Title: Reversible induction of TDP-43 granules in cortical neurons after traumatic injury.
Volume: 299
Issue: Pt A
Pages: 15-25
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Publication
19332122 | J:150474
First Author: Turner BJ
Year: 2009
Journal: Neurobiol Dis
Title: Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model.
Volume: 34
Issue: 3
Pages: 511-7
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Publication
22761934 | J:261334
First Author: Yanpallewar SU
Year: 2012
Journal: PLoS One
Title: Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis.
Volume: 7
Issue: 6
Pages: e39946
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Publication
16046140 | J:104655
First Author: Wang J
Year: 2005
Journal: Neurobiol Dis
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HT Experiment
E-GEOD-39159 | Skeletal muscle gene expression data from Down syndrome mice
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