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Search results 2001 to 2100 out of 2368 for Tpr

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Type Details Score
Protein Domain
IPR056420 | GEMI5_RBS
Type: Domain
Description: This entry represents the RNA-binding domains RBS1 and RBS2 found at the C-terminal of Gem-associated protein 5 (GEMI5) from vertebrates. The RBS1 domain is involved in the recognition of viral IRES elements and cellular RNAs. This domain is intrinsically unstructured and interacts with RNA through conserved Arg and aromatic residues [].GEMI5 is a component of the survival of motor neurons (SMN) complex, that binds small nuclear RNAs (snRNAs). The SMN complex assembles the heptameric Sm protein core on snRNAs playing a critical role in the biogenesis of small nuclear ribonucleoproteins (snRNPs) [, ]. GEMI5 is also implicated in translation control, and gene expression reprogramming []. GEMI5 from animals share a domain architecture consisting of two N-terminal ��-propellers followed by a TPR domain and a C-terminal RNA-binding domain.
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Protein Domain
IPR056432 | Beta-prop_GEMI5_1st
Type: Domain
Description: This entry represents the first ��-propeller found at the N-terminal of Protein rigor mortis (RIG) from Drosophila melanogaster, also known as Gem-associated protein 5 (GEMI5), the orthologue of GEMI5 from vertebrates []. RIG, apart from being a component of the survival motor neuron (SMN) complex, it is a nuclear receptor-interacting protein required for the response to steroid hormone ecdysone during larval development [].GEMI5 is a component of the survival of motor neurons (SMN) complex, that binds small nuclear RNAs (snRNAs). The SMN complex assembles the heptameric Sm protein core on snRNAs playing a critical role in the biogenesis of small nuclear ribonucleoproteins (snRNPs) [, ]. GEMI5 is also implicated in translation control, and gene expression reprogramming []. GEMI5 from animals share a domain architecture consisting of two N-terminal ��-propellers followed by a TPR domain and a C-terminal RNA-binding domain.
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Protein Domain
IPR056802 | ATR-like_M-HEAT
Type: Domain
Description: This region of HEAT repeats is found in human Serine/threonine-protein kinase ATR andsimilar eukaryotic proteins. This entry represents the M-HEAT region.This region is also found in Serine/threonine-protein kinase MEC1 from Saccharomyces cerevisiae, which activates checkpoint signalling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor [, , , ].ATR acts as a DNA damage sensor and is associated with severe disorders such as Seckel syndrome 1. This protein is organised into a large N-terminal ��-solenoid containing HEAT repeats, a FAT (FRAP, ATM, TRRAP) domain (), a kinase domain (), and a C-terminal short segment referred to as FATC (). N-terminal part has two continuous HEAT repeat regions, the N-HEAT and the M-HEAT. The FAT domain contains TPR (tetratricopeptide) repeats followed by a HEAT repeat domain [].
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Protein Domain
IPR057311 | GrebAB-C-like
Type: Domain
Description: This is a GreAB-C-like domain found mostly in the N-terminal of uncharacterised bacterial proteins. This domain has been found in antiviral immunity systems, where it forms a circular permuted domain embedded in TPR repeats. In these proteins, the GreAB-C domain is located at the C-terminal followed, usually, by a PIN domain with a variable N-terminal domain often harbouring effector domains [, ].GreA and GreB are prokaryotic transcript cleavage factors that play a crucial role in regulating RNA polymerase (RNAP) transcript elongation. They have several key functions in preventing elongation arrest, improving transcription accuracy, and facilitating the transition from transcription initiation to elongation. They have a similar structural organisation and consist of two domains: a C-terminal globular and an extended N-terminal coiled-coil domain. Their structural features, particularly the coiled-coil domain, are essential for modifying the RNAP active site to perform these cleavage reactions [].
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Protein Domain
IPR033583 | BEND3
Type: Family
Description: BEND3 is a transcriptional repressor that associates with the nucleolar-remodeling complex (NoRC) and is involved in ribosomal DNA (rDNA) silencing []. SUMOylated BEND3 stabilizes the NoRC component Tip5 via USP21 deubiquitinase []. NorC serves as a molecular platform that recruits chromatin modifiers, such as histone deacetylases and histone methyltransferases, leading to deacetylation of histone H4 and trimethylation of H3K9 and H4K20 []. NoRC also targets histone deacetylases and histone methyltransferases to rDNA to establish a heterochromatic state that inhibits transcription activation. Hence, BEND3 and NoRC seem to play a concerted role in the maintenance of heterochromatin architecture [, ].BEND3 has also been shown to mediate Polycomb recruitment in the absence of H3K9Me3 or DNA methylation at the pericentromeric regions []. BEND3 interacts with PICH (ERCC6L), a DNA translocase required for the maintenance of chromosome stability, and stimulates its translocase and ATPase activities. This interaction occurs via an interface betweena TPR domain in PICH and a BEN domain in BEND3 [].
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Protein
O08796
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q3TYX3
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
Q8BIX9
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Protein
Q9D2Y5
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
Q9Z2G6
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Protein
Q3UR97
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q99JI4
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q5DTL8
Organism: Mus musculus/domesticus
Length: 832  
Fragment?: true
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Protein
Q7TPC7
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q8BNP6
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q8CEC8
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
A0A0R4J0D0
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
Q3TT70
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Protein
Q3UPJ3
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: true
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Protein
Q3UWZ1
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
Q9D177
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
A0A087WPX4
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Protein
Q149Q9
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q3TPW2
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Protein
Q80X51
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: false
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Publication
10361086 | -
First Author: Groves MR
Year: 1999
Journal: Curr Opin Struct Biol
Title: Topological characteristics of helical repeat proteins.
Volume: 9
Issue: 3
Pages: 383-9
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Publication
9256465 | -
First Author: Liu N
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.
Volume: 94
Issue: 17
Pages: 9232-7
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Publication
9806548 | -
First Author: de Winter JP
Year: 1998
Journal: Nat Genet
Title: The Fanconi anaemia group G gene FANCG is identical with XRCC9.
Volume: 20
Issue: 3
Pages: 281-3
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Publication
28556304 | -
First Author: Sjogren CA
Year: 2017
Journal: Plant Cell Environ
Title: SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
Volume: 40
Issue: 9
Pages: 1849-1860
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Publication
19619159 | -
First Author: Sakamoto AN
Year: 2009
Journal: Plant J
Title: A UVB-hypersensitive mutant in Arabidopsis thaliana is defective in the DNA damage response.
Volume: 60
Issue: 3
Pages: 509-17
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Publication
19619158 | -
First Author: Sweeney PR
Year: 2009
Journal: Plant J
Title: The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors.
Volume: 60
Issue: 3
Pages: 518-26
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Protein
Q9ERU9
Organism: Mus musculus/domesticus
Length: 3053  
Fragment?: false
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Protein
D3YY23
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: false
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Protein
Q9D4H7
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Protein
F6ZE64
Organism: Mus musculus/domesticus
Length: 754  
Fragment?: false
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Protein
A0A338P6W3
Organism: Mus musculus/domesticus
Length: 1624  
Fragment?: false
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Protein
E9PWW6
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
Q3TIQ4
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
Q3UBH9
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
A0A182DWE6
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Publication
28076793 | J:254044
First Author: Burikhanov R
Year: 2017
Journal: Cell Rep
Title: Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.
Volume: 18
Issue: 2
Pages: 508-519
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Protein
F6VIR4
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
P35761
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
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Protein
P51944
Organism: Mus musculus/domesticus
Length: 777  
Fragment?: false
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Protein
P56695
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
P97443
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q8BTK5
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q8R5A0
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q9CWR2
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q9JLI8
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
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Protein
Q8BKF1
Organism: Mus musculus/domesticus
Length: 1207  
Fragment?: false
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Protein
Q3TDI2
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q80UI9
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3U3J3
Organism: Mus musculus/domesticus
Length: 1207  
Fragment?: false
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Protein
Q3UMA8
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: false
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Protein
Q3UN10
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Protein
Q3V3C0
Organism: Mus musculus/domesticus
Length: 1069  
Fragment?: true
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Protein
Q6PD96
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
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Protein
Q8BY97
Organism: Mus musculus/domesticus
Length: 815  
Fragment?: false
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Protein
Q8C027
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Protein
E0CY15
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
E9PWD9
Organism: Mus musculus/domesticus
Length: 1133  
Fragment?: false
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Protein
F6VE70
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Protein
G5E8R7
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
Q3TIF7
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q3TR55
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q3UQT9
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
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Protein
Q6PES1
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Publication
23902771 | -
First Author: Ma C
Year: 2013
Journal: J Biol Chem
Title: Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.
Volume: 288
Issue: 38
Pages: 27220-27231
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Publication
7738036 | -
First Author: Liu H
Year: 1995
Journal: J Biol Chem
Title: PER3, a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import.
Volume: 270
Issue: 18
Pages: 10940-51
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Publication
15229592 | -
First Author: Dujon B
Year: 2004
Journal: Nature
Title: Genome evolution in yeasts.
Volume: 430
Issue: 6995
Pages: 35-44
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Publication
22576369 | J:241280
First Author: Sala V
Year: 2012
Journal: Mol Med
Title: Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.
Volume: 18
Issue: 1
Pages: 938-47
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Protein Coding Gene
MGI:894323 | Ranbp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919286 | Eny2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341857 | Mad1l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1860374 | Mad2l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109404 | Nup98
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22550182 | J:184786
First Author: Bankston JR
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
Volume: 109
Issue: 20
Pages: 7899-904
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Publication
25266290 | J:222663
First Author: Perini ED
Year: 2014
Journal: Traffic
Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.
Volume: 15
Issue: 12
Pages: 1366-89
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Protein
Q8C6I2
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Protein
A0A494B9B9
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
D3Z5H1
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
Q3TD73
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein
Q3TRL7
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q3TZM5
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q3UXJ0
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q9D3P3
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
Q9ERM4
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Publication
15569936 | -
First Author: Chan C
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Structural basis of activity and allosteric control of diguanylate cyclase.
Volume: 101
Issue: 49
Pages: 17084-9
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Publication
3187531 | -
First Author: Aggarwal AK
Year: 1988
Journal: Science
Title: Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.
Volume: 242
Issue: 4880
Pages: 899-907
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Publication
11972345 | -
First Author: Steinmetzer K
Year: 2002
Journal: Nucleic Acids Res
Title: CopR binds and bends its target DNA: a footprinting and fluorescence resonance energy transfer study.
Volume: 30
Issue: 9
Pages: 2052-60
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Publication
27909983 | -
First Author: Yang H
Year: 2016
Journal: Protein Cell
Title: 4.4 ? Resolution Cryo-EM structure of human mTOR Complex 1.
Volume: 7
Issue: 12
Pages: 878-887
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Publication
22119785 | -
First Author: Christianson JC
Year: 2011
Journal: Nat Cell Biol
Title: Defining human ERAD networks through an integrative mapping strategy.
Volume: 14
Issue: 1
Pages: 93-105
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Publication
19628817 | -
First Author: Hao HX
Year: 2009
Journal: Science
Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Volume: 325
Issue: 5944
Pages: 1139-42
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Publication
22474332 | -
First Author: McNeil MB
Year: 2012
Journal: J Biol Chem
Title: SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.
Volume: 287
Issue: 22
Pages: 18418-28
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Publication
11545737 | -
First Author: Fairall L
Year: 2001
Journal: Mol Cell
Title: Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.
Volume: 8
Issue: 2
Pages: 351-61
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Publication
9034194 | -
First Author: Cooper JP
Year: 1997
Journal: Nature
Title: Regulation of telomere length and function by a Myb-domain protein in fission yeast.
Volume: 385
Issue: 6618
Pages: 744-7
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Publication
11606046 | -
First Author: Ito R
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.
Volume: 288
Issue: 2
Pages: 321-7
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Publication
16428307 | -
First Author: Ito R
Year: 2005
Journal: J Biochem
Title: Identification of Pex5pM, and retarded maturation of 3-ketoacyl-CoA thiolase and acyl-CoA oxidase in CHO cells expressing mutant Pex5p isoforms.
Volume: 138
Issue: 6
Pages: 781-90
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Publication
11865044 | -
First Author: Otera H
Year: 2002
Journal: Mol Cell Biol
Title: Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.
Volume: 22
Issue: 6
Pages: 1639-55
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom