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Search results 2101 to 2200 out of 7122 for App

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:7607740 | C57BL/6NTac-Bace1<em1(IMPC)H>/Mmnc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6717130 | C57BL/6NTac-Bace1<em1(IMPC)H>/H
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Bace1<tm1.1Twr> | MGI:6415537
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Thomas W Rosahl
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Bace1<tm1.1Mrl> | MGI:6431251
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.1, Merck Research Laboratory
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Bace1<tm1.2Mrl> | MGI:6431253
Name: beta-site APP cleaving enzyme 1; targeted mutation 1.2, Merck Research Laboratory
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Bace1<em14Gpt> | MGI:7295784
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 14, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Bace1<em1Gpt> | MGI:7295785
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7592889 | C57BL/6J-Bace1<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Bace1<em1Smoc> | MGI:7750376
Name: beta-site APP cleaving enzyme 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CD-1)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S2/SvPas * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: C57BL/6-Bace1
Zygosity: hm
Has Mutant Allele: true
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Publication
29325091 | J:276403
First Author: Wang X
Year: 2018
Journal: J Mol Cell Biol
Title: α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
Volume: 10
Issue: 5
Pages: 411-422
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DO Term
DOID:0080348 | Alzheimer's disease 1
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Publication
30524268 | J:275173
 
First Author: Lippi SLP
Year: 2018
Journal: Front Aging Neurosci
Title: A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.
Volume: 10
Pages: 382
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Publication
18055549 | J:129196
First Author: Bolmont T
Year: 2007
Journal: Am J Pathol
Title: Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
Volume: 171
Issue: 6
Pages: 2012-20
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Publication
26196079 | J:225495
 
First Author: Fujiwara N
Year: 2015
Journal: Exp Neurol
Title: Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells.
Volume: 271
Pages: 423-31
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Publication
30803762 | J:291180
First Author: Quartey MO
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice.
Volume: 511
Issue: 2
Pages: 454-459
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Publication
28028177 | J:240707
First Author: Feng T
Year: 2017
Journal: J Biol Chem
Title: Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
Volume: 292
Issue: 5
Pages: 1679-1690
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Publication
32913125 | J:348430
First Author: Mori T
Year: 2020
Journal: J Biol Chem
Title: Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Volume: 295
Issue: 48
Pages: 16251-16266
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Publication
28869759 | J:257178
First Author: Saadipour K
Year: 2018
Journal: J Neurochem
Title: p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
Volume: 144
Issue: 3
Pages: 302-317
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Publication
26296617 | J:227022
First Author: Lundgren JL
Year: 2015
Journal: J Neurochem
Title: ADAM10 and BACE1 are localized to synaptic vesicles.
Volume: 135
Issue: 3
Pages: 606-15
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Publication
27716410 | J:329588
First Author: Pigoni M
Year: 2016
Journal: Mol Neurodegener
Title: Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Volume: 11
Issue: 1
Pages: 67
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Publication
28481921 | J:245918
First Author: Fusco FB
Year: 2017
Journal: PLoS One
Title: Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice.
Volume: 12
Issue: 5
Pages: e0177086
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Publication
38729241 | J:349438
 
First Author: Basu R
Year: 2024
Journal: Mol Metab
Title: Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs.
Volume: 84
Pages: 101951
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Publication
32943702 | J:296378
First Author: Silva LEF
Year: 2020
Journal: Sci Rep
Title: Th17/Treg imbalance in COPD development: suppressors of cytokine signaling and signal transducers and activators of transcription proteins.
Volume: 10
Issue: 1
Pages: 15287
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Publication
28159908 | J:239680
First Author: Ye X
Year: 2017
Journal: J Neurosci
Title: Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 10
Pages: 2639-2655
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Allele
Tg(Thy1-APPSwe)1Lngn | MGI:4420244
Name: transgene insertion 1, Lars Nilsson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
18341989 | J:132937
First Author: Wen Y
Year: 2008
Journal: Neuron
Title: Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Volume: 57
Issue: 5
Pages: 680-90
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Genotype
Genotype
Symbol: Bace1/Bace1<+> Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Protein
P56818
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Genotype
Genotype
Symbol: Tg(PDGFB-APPSwDutLon)46Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Protein
Q9JL18
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Allele
Tg(Thy1-APP)16Ppa | MGI:4438891
Name: transgene insertion 16, Paolo Paganetti
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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GO Term
GO:0042983 | amyloid precursor protein biosynthetic process
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GO Term
GO:1902991 | regulation of amyloid precursor protein catabolic process
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Publication
24889041 | J:218077
First Author: Devi L
Year: 2014
Journal: Neurobiol Aging
Title: PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.
Volume: 35
Issue: 10
Pages: 2272-81
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Transgene
MGI:3510557 | Tg(APPSw)40Btla
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3693358 | Tg(APPSwLon)96Btla
Type: transgene
Organism: mouse, laboratory
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Publication
23507144 | J:202419
First Author: Barroso E
Year: 2013
Journal: Biochim Biophys Acta
Title: Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.
Volume: 1832
Issue: 8
Pages: 1241-8
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Publication
15364953 | J:337599
First Author: Kitazume S
Year: 2005
Journal: J Biol Chem
Title: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
Volume: 280
Issue: 9
Pages: 8589-95
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Publication
29979789 | J:263821
First Author: Causevic M
Year: 2018
Journal: PLoS One
Title: BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Volume: 13
Issue: 7
Pages: e0200344
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Allele
Tg(PDGFB-APPSwInd)J9Lms | MGI:3717718
Name: transgene insertion J9, Lennart Mucke
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(PDGFB-APPSwDutLon)46Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSweAut)A7Tiwa/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
28855330 | J:248926
First Author: Choi GE
Year: 2017
Journal: J Neurosci
Title: Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and Aβ Generation: Involvement of Lipid Raft-Mediated CREB Activation.
Volume: 37
Issue: 35
Pages: 8459-8476
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSWE)2576Kha/?
Background: involves: 129 * C57BL/6 * CD-1 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSWE)2576Kha/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pin1/Pin1 Tg(APPSWE)2576Kha/?
Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
26900752 | J:236654
First Author: Oliverio M
Year: 2016
Journal: Nat Cell Biol
Title: Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.
Volume: 18
Issue: 3
Pages: 328-36
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Publication
19920078 | J:155566
First Author: Ono Y
Year: 2009
Journal: J Cell Sci
Title: Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
Volume: 122
Issue: Pt 24
Pages: 4427-38
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Publication
17400334 | J:140915
First Author: Ryman D
Year: 2008
Journal: Neurobiol Aging
Title: Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.
Volume: 29
Issue: 8
Pages: 1190-8
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Publication
39609418 | J:360697
First Author: Miskalis A
Year: 2024
Journal: Nat Commun
Title: SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping.
Volume: 15
Issue: 1
Pages: 10354
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Genotype
Genotype
Symbol: Qpct/Qpct Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: B6.Cg-Qpct Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: C57BL/6 * C57BL/6J * CBA * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Becn1/Becn1 Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:2676925 | B6.129-Bace1<tm1Pcw>/J
Attribute String: mutant strain, targeted mutation
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Strain
MGI:7539011 | B6.Cg-Bace1<tm1.1Yanr> Tg(Thy1-cre)1Vln
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:6438764 | C57BL/6-Bace1<tm1.1Mrl>/Tac
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6438734 | C57BL/6-Bace1<tm1.2Mrl>/Tac
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7751604 | C57BL/6JSmoc-Bace1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S5/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1 Tg(Thy1-Nrg1*I)1Kan/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1
Background: B6.129-Bace1/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bace1/Bace1 Tg(Thy1-cre)1Vln/?
Background: B6.Cg-Bace1 Tg(Thy1-cre)1Vln
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSwe)1Lngn/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(Thy1-APPLon)2Vln/?
Background: involves: C57BL/6 * CBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/?
Background: involves: C57BL/6 * C57BL/6N * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPArc)M8Cagr/Tg(Thy1-APPArc)M8Cagr
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Publication
23639209 | J:211730
First Author: Subaiea GM
Year: 2013
Journal: Neurobiol Aging
Title: Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice.
Volume: 34
Issue: 10
Pages: 2421-30
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Allele
Tg(PDGFB-APPSweIndArc)6Lms | MGI:3603942
Name: transgene insertion 6, Lennart Mucke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPV717F)109Ili/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPV717F)109Ili/? Tg(GFAP-APOE_i2)14Hol/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPV717F)109Ili/? Tg(Prnp-Abca1)EHol/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-ITM2B)8.4Ldad/? Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Tg(APPSWE)2576Kha/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
24462621 | J:215369
 
First Author: Adwan L
Year: 2014
Journal: Neuropharmacology
Title: Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers.
Volume: 79
Pages: 596-602
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HT Experiment
E-GEOD-48622 | Transcriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice
Series Id: GSE48622
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
16364896 | J:107571
First Author: Cirrito JR
Year: 2005
Journal: Neuron
Title: Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Volume: 48
Issue: 6
Pages: 913-22
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Publication
36717226 | J:348868
First Author: Ma F
Year: 2023
Journal: J Neurosci
Title: The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.
Volume: 43
Issue: 10
Pages: 1830-1844
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Transgene
MGI:3696469 | Tg(Prnp-App/APPswe)E1-2Dbo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Thy1-APP)16Ppa/?
Background: involves: C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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GO Term
GO:0042984 | regulation of amyloid precursor protein biosynthetic process
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Genotype
Genotype
Symbol: Tg(APP695)3Dbo/? Tg(PSEN1dE9)S9Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSw)40Btla/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSw)40Btla/Tg(APPSw)40Btla
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSwLon)96Btla/? Tg(PSEN1H163R)G9Btla/?
Background: involves: 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSw)40Btla/Tg(APPSw)40Btla
Background: B6.129-Tg(APPSw)40Btla
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPV717F)109Ili/? Tg(GFAP-APOE_i4)#Hol/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(APPV717F)109Ili/? Tg(GFAP-APOE_i3)37Hol/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Brabq3/Brabq3 Tg(APPSw)40Btla/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
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