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Search results 2101 to 2200 out of 2356 for Bax

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Type Details Score
Publication
20363911 | J:160754
First Author: Kern TS
Year: 2010
Journal: Am J Pathol
Title: Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy.
Volume: 176
Issue: 5
Pages: 2550-8
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Publication
20463184 | J:160973
First Author: Scheerer N
Year: 2010
Journal: Am J Physiol Regul Integr Comp Physiol
Title: The anemia of the newborn induces erythropoietin expression in the developing mouse retina.
Volume: 299
Issue: 1
Pages: R111-8
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Publication
20569988 | J:163784
First Author: Ye Z
Year: 2010
Journal: Mol Immunol
Title: LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R.
Volume: 47
Issue: 14
Pages: 2411-21
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Publication
19247369 | J:164188
First Author: Gama V
Year: 2009
Journal: Cell Death Differ
Title: Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.
Volume: 16
Issue: 5
Pages: 758-69
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Publication
19656851 | J:164483
First Author: Wang CY
Year: 2009
Journal: Mol Biol Cell
Title: Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis.
Volume: 20
Issue: 19
Pages: 4153-61
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Publication
20050918 | J:168272
First Author: Xiao Y
Year: 2010
Journal: FEBS J
Title: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-gamma-dependent and mediated by the caspase-3-dependent apoptotic pathway.
Volume: 277
Issue: 3
Pages: 687-96
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Publication
20840860 | J:170212
First Author: Laska MJ
Year: 2010
Journal: Biochim Biophys Acta
Title: p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses.
Volume: 1800
Issue: 12
Pages: 1231-40
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Publication
11388671 | J:173900
First Author: Nelson V
Year: 2001
Journal: Apoptosis
Title: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.
Volume: 6
Issue: 3
Pages: 221-34
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Publication
21362508 | J:175012
First Author: Gu H
Year: 2011
Journal: Biochim Biophys Acta
Title: DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2).
Volume: 1809
Issue: 4-6
Pages: 276-83
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Publication
21724914 | J:181402
First Author: Medearis S
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The role of Bcl-xL in mouse RPE cell survival.
Volume: 52
Issue: 9
Pages: 6545-51
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Publication
22301689 | J:184089
First Author: Gao Y
Year: 2012
Journal: Int Immunol
Title: Bim regulates B-cell receptor-mediated apoptosis in the presence of CD40 signaling in CD40-pre-activated splenic B cells differentiating into plasma cells.
Volume: 24
Issue: 5
Pages: 283-92
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Publication
20978005 | J:186036
First Author: Konishi M
Year: 2011
Journal: Cardiovasc Res
Title: Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation.
Volume: 89
Issue: 2
Pages: 309-19
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Publication
22306083 | J:186221
First Author: Chimento A
Year: 2012
Journal: Mol Cell Endocrinol
Title: 17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line.
Volume: 355
Issue: 1
Pages: 49-59
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Publication
22999860 | J:192755
First Author: Das A
Year: 2012
Journal: J Mol Cell Cardiol
Title: Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Volume: 53
Issue: 6
Pages: 858-69
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Publication
23404709 | J:195771
First Author: Leshchiner ES
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Direct activation of full-length proapoptotic BAK.
Volume: 110
Issue: 11
Pages: E986-95
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Publication
23383327 | J:195996
First Author: Hamann S
Year: 2013
Journal: PLoS One
Title: Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis.
Volume: 8
Issue: 2
Pages: e55372
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Publication
23274568 | J:197220
First Author: Chaudhary SC
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis.
Volume: 268
Issue: 3
Pages: 249-55
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Publication
23275004 | J:198080
 
First Author: Niture SK
Year: 2013
Journal: Free Radic Biol Med
Title: Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance.
Volume: 57
Pages: 119-31
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Publication
23618872 | J:198572
First Author: Hilgendorf KI
Year: 2013
Journal: Genes Dev
Title: The retinoblastoma protein induces apoptosis directly at the mitochondria.
Volume: 27
Issue: 9
Pages: 1003-15
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Publication
23555560 | J:199889
First Author: Ahmad A
Year: 2013
Journal: PLoS One
Title: Absence of TLR4 reduces neurovascular unit and secondary inflammatory process after traumatic brain injury in mice.
Volume: 8
Issue: 3
Pages: e57208
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Publication
22909821 | J:200477
First Author: Höpker K
Year: 2012
Journal: EMBO J
Title: AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.
Volume: 31
Issue: 20
Pages: 3961-75
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Publication
24080331 | J:205217
First Author: Zhang B
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: DNA damage and apoptosis of endometrial cells cause loss of the early embryo in mice exposed to carbon disulfide.
Volume: 273
Issue: 2
Pages: 381-9
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Publication
24140890 | J:206225
First Author: Drosos Y
Year: 2014
Journal: Gene Expr Patterns
Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
Volume: 14
Issue: 1
Pages: 19-29
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Publication
24105651 | J:208659
First Author: Deobagkar-Lele M
Year: 2014
Journal: Eur J Immunol
Title: c-Jun NH2 -terminal kinase is a critical node in the death of CD4+ CD8+ thymocytes during Salmonella enterica serovar Typhimurium infection.
Volume: 44
Issue: 1
Pages: 137-49
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Publication
24703880 | J:212465
First Author: Bodanovsky A
Year: 2014
Journal: Biochim Biophys Acta
Title: Halofuginone improves muscle-cell survival in muscular dystrophies.
Volume: 1843
Issue: 7
Pages: 1339-47
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Publication
25147362 | J:216161
First Author: Martorell-Riera A
Year: 2014
Journal: EMBO J
Title: Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.
Volume: 33
Issue: 20
Pages: 2388-407
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Publication
25205454 | J:218453
First Author: Bloemberg D
Year: 2014
Journal: Biochim Biophys Acta
Title: Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis.
Volume: 1843
Issue: 12
Pages: 2926-36
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Publication
25201726 | J:220094
First Author: Ji YR
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter.
Volume: 452
Issue: 3
Pages: 822-7
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Publication
24639483 | J:222762
First Author: Sin TK
Year: 2014
Journal: J Physiol
Title: Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart.
Volume: 592
Issue: 12
Pages: 2535-48
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Publication
26148447 | J:224527
First Author: Hao Y
Year: 2015
Journal: Toxicol Appl Pharmacol
Title: Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity.
Volume: 287
Issue: 3
Pages: 306-15
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Publication
26141845 | J:226282
 
First Author: Liu W
Year: 2015
Journal: Neuroscience
Title: Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Volume: 303
Pages: 42-50
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Publication
23348567 | J:228261
First Author: Faccenda D
Year: 2013
Journal: Cell Death Differ
Title: IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling.
Volume: 20
Issue: 5
Pages: 686-97
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Publication
26484393 | J:229406
First Author: Liu M
Year: 2016
Journal: Gene
Title: MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells.
Volume: 576
Issue: 1 Pt 2
Pages: 304-11
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Publication
26431878 | J:233086
First Author: Zhou WJ
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation.
Volume: 467
Issue: 3
Pages: 562-9
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Publication
26742427 | J:233153
First Author: Du C
Year: 2016
Journal: Biochem Biophys Res Commun
Title: The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors.
Volume: 469
Issue: 4
Pages: 1146-52
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Publication
26257067 | J:234209
First Author: Merino D
Year: 2016
Journal: Oncogene
Title: Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.
Volume: 35
Issue: 15
Pages: 1877-87
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Publication
27389473 | J:236017
First Author: Mishra S
Year: 2016
Journal: Int J Cancer
Title: Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes.
Volume: 139
Issue: 9
Pages: 2033-46
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Publication
27510910 | J:237042
First Author: Zhang M
Year: 2016
Journal: Diabetologia
Title: MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.
Volume: 59
Issue: 11
Pages: 2435-2447
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Publication
27940357 | J:241717
First Author: Zhang C
Year: 2017
Journal: Biochem Biophys Res Commun
Title: The regulation of high insulin levels on ovary apoptosis in early pregnant mice.
Volume: 483
Issue: 1
Pages: 786-792
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Publication
28430874 | J:245731
First Author: Hermosilla VE
Year: 2017
Journal: Carcinogenesis
Title: Developmental SALL2 transcription factor: a new player in cancer.
Volume: 38
Issue: 7
Pages: 680-690
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Publication
28827819 | J:245179
First Author: Hułas-Stasiak M
Year: 2017
Journal: PLoS One
Title: The effects of dexamethasone administered during pregnancy on the postpartum spiny mouse ovary.
Volume: 12
Issue: 8
Pages: e0183528
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Publication
28890329 | J:251893
First Author: Liu T
Year: 2017
Journal: Biochim Biophys Acta
Title: Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway.
Volume: 1860
Issue: 10
Pages: 1094-1102
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Publication
29108912 | J:257547
First Author: Yeganeh B
Year: 2018
Journal: Biochim Biophys Acta
Title: Autophagy activation is required for influenza A virus-induced apoptosis and replication.
Volume: 1865
Issue: 2
Pages: 364-378
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Publication
24786833 | J:258842
First Author: Chang SC
Year: 2014
Journal: Cell Death Differ
Title: Ubiquitination by SAG regulates macrophage survival/death and immune response during infection.
Volume: 21
Issue: 9
Pages: 1388-98
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Publication
25862939 | J:259608
 
First Author: Slone SR
Year: 2015
Journal: Neurobiol Dis
Title: Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.
Volume: 79
Pages: 1-13
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Publication
28830684 | J:261308
First Author: Ye X
Year: 2017
Journal: Exp Cell Res
Title: Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
Volume: 359
Issue: 2
Pages: 441-448
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Publication
29784641 | J:263908
First Author: Pleines I
Year: 2018
Journal: Blood
Title: Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Volume: 132
Issue: 2
Pages: 197-209
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Publication
29981809 | J:264243
 
First Author: Lee YS
Year: 2018
Journal: Cancer Lett
Title: Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination.
Volume: 433
Pages: 156-164
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Publication
29709475 | J:273479
First Author: Zhang Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway.
Volume: 501
Issue: 1
Pages: 186-192
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Publication
30006533 | J:269625
First Author: Tang J
Year: 2018
Journal: Sci Rep
Title: Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.
Volume: 8
Issue: 1
Pages: 10601
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Publication
30220545 | J:270159
First Author: Huang Z
Year: 2018
Journal: Biochem Biophys Res Commun
Title: RhoA protects the podocytes against high glucose-induced apoptosis through YAP and plays critical role in diabetic nephropathy.
Volume: 504
Issue: 4
Pages: 949-956
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Publication
30605632 | J:277524
First Author: Hu H
Year: 2019
Journal: Exp Cell Res
Title: uPA affects the CRSsNP nasal mucosa epithelium apoptosis by regulating WIF1.
Volume: 377
Issue: 1-2
Pages: 75-85
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Publication
29022913 | J:278709
First Author: Wang J
Year: 2017
Journal: Cell Death Dis
Title: MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI.
Volume: 8
Issue: 10
Pages: e3120
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Publication
31676815 | J:287009
First Author: Khan AA
Year: 2019
Journal: Sci Rep
Title: Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice.
Volume: 9
Issue: 1
Pages: 15825
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Publication
31387190 | J:290453
 
First Author: Alves CRR
Year: 2019
Journal: Biomed Pharmacother
Title: Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.
Volume: 117
Pages: 109197
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Publication
33338480 | J:302128
First Author: Aly RG
Year: 2021
Journal: Exp Cell Res
Title: Antineoplastic activity of Salmonella Typhimurium outer membrane nanovesicles.
Volume: 399
Issue: 1
Pages: 112423
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Publication
33159990 | J:304535
 
First Author: Zhang J
Year: 2021
Journal: Mol Cell Endocrinol
Title: Melatonin alleviates the deterioration of oocytes and hormonal disorders from mice subjected to glyphosate.
Volume: 520
Pages: 111073
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Publication
32945413 | J:305680
First Author: Sun H
Year: 2020
Journal: Mol Med Rep
Title: Downregulation of lncRNA H19 alleviates atherosclerosis through inducing the apoptosis of vascular smooth muscle cells.
Volume: 22
Issue: 4
Pages: 3095-3102
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Publication
31761324 | J:306301
First Author: Peng JQ
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Chaperone-mediated autophagy regulates apoptosis and the proliferation of colon carcinoma cells.
Volume: 522
Issue: 2
Pages: 348-354
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Publication
33753723 | J:306842
First Author: Chen W
Year: 2021
Journal: Int J Oral Sci
Title: Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress.
Volume: 13
Issue: 1
Pages: 10
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Publication
33311472 | J:342784
First Author: Liang X
Year: 2020
Journal: Cell Death Dis
Title: Peroxiredoxin 4 protects against ovarian ageing by ameliorating D-galactose-induced oxidative damage in mice.
Volume: 11
Issue: 12
Pages: 1053
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Publication
30906210 | J:319608
First Author: Wang L
Year: 2019
Journal: Int J Biol Sci
Title: Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy.
Volume: 15
Issue: 4
Pages: 788-799
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Publication
34305630 | J:312593
 
First Author: Ng HH
Year: 2021
Journal: Front Physiol
Title: Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction.
Volume: 12
Pages: 650769
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Publication
29511172 | J:319597
First Author: Zhou Y
Year: 2018
Journal: Cell Death Dis
Title: Rb is required for retinal angiogenesis and lamination.
Volume: 9
Issue: 3
Pages: 370
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Publication
32771947 | J:314314
 
First Author: Liu M
Year: 2020
Journal: Int Immunopharmacol
Title: Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice.
Volume: 88
Pages: 106862
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Publication
30539006 | J:313188
 
First Author: Cao S
Year: 2018
Journal: Biomed Res Int
Title: Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis.
Volume: 2018
Pages: 2649585
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Publication
25457551 | J:315812
First Author: Feng J
Year: 2015
Journal: Neurobiol Aging
Title: Aβ induces PUMA activation: a new mechanism for Aβ-mediated neuronal apoptosis.
Volume: 36
Issue: 2
Pages: 789-800
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Publication
22946061 | J:316175
First Author: Montanez E
Year: 2012
Journal: J Cell Sci
Title: PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm.
Volume: 125
Issue: Pt 21
Pages: 5233-40
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Publication
34376637 | J:312542
First Author: Donahue RJ
Year: 2021
Journal: Cell Death Dis
Title: BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma.
Volume: 12
Issue: 8
Pages: 781
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Publication
23506954 | J:318999
First Author: Rattanavich R
Year: 2013
Journal: Exp Mol Pathol
Title: Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.
Volume: 94
Issue: 3
Pages: 445-52
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Publication
25520329 | J:319142
First Author: Daniel LL
Year: 2014
Journal: J Am Heart Assoc
Title: Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction.
Volume: 3
Issue: 6
Pages: e001286
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Publication
33043006 | J:313357
 
First Author: Naim S
Year: 2020
Journal: Front Cell Dev Biol
Title: The Multifaceted Roles of the BCL-2 Family Member BOK.
Volume: 8
Pages: 574338
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Publication
26464624 | J:317866
First Author: Zoheir KM
Year: 2015
Journal: Int J Clin Exp Pathol
Title: Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression.
Volume: 8
Issue: 8
Pages: 8821-31
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Publication
27999308 | J:318381
 
First Author: Jiang HZ
Year: 2016
Journal: Int J Mol Sci
Title: Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid.
Volume: 17
Issue: 12
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Publication
27016073 | J:318414
 
First Author: Ariza J
Year: 2016
Journal: Free Radic Biol Med
Title: Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2.
Volume: 95
Pages: 82-95
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Publication
25104317 | J:326994
First Author: Mu W
Year: 2014
Journal: Sci China Life Sci
Title: Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure.
Volume: 57
Issue: 9
Pages: 915-24
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Publication
26355019 | J:317007
First Author: Saadatdoust Z
Year: 2015
Journal: J Nutr Biochem
Title: Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway.
Volume: 26
Issue: 12
Pages: 1547-58
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Publication
35773307 | J:326745
First Author: Roy SK
Year: 2022
Journal: Sci Rep
Title: Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-β-catenin pathway.
Volume: 12
Issue: 1
Pages: 11062
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Publication
37729979 | J:341238
 
First Author: Stovall K
Year: 2023
Journal: Mol Cell Neurosci
Title: The intrinsic apoptotic pathway lies upstream of reactive species production in cortical neurons and age-related oxidative stress in the brain.
Volume: 127
Pages: 103901
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Protein
Q64373
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q07440
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
O55179
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
F6Q785
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q3T9W4
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q8K164
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
Q3TN22
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
Q4FK02
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
Q3U7X3
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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Protein
Q5HZH3
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
O55177
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
Q497M6
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein Domain
IPR013280 | Apop_reg_BclW
Type: Family
Description: Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans []. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contribute to the development of many major diseases including cancer, autoimmunity and neurodegenerative disorders. In most cases, proteins of the caspase family execute the genetic programme that leads to cell death.Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. At least 20 Bcl-2 proteins have been reported in mammals, and several others have been identified in viruses. Bcl-2 family proteins fall roughly into three subtypes, which either promote cell survival (anti-apoptotic) or trigger cell death (pro-apoptotic). All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Bcl-2 subfamily proteins, which contain at least BH1 and BH2, promote cell survival by inhibiting the adapters needed for the activation of caspases.Pro-apoptotic members potentially exert their effects by displacing the adapters from the pro-survival proteins; these proteins belong either to the Bax subfamily, which contain BH1-BH3, or to the BH3 subfamily, which mostly only feature BH3 []. Thus, the balance between antagonistic family members is believed to play a role in determining cell fate. Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and Mcl-1, are described by their similarity to Bcl-2 protein, a member of the pro-survival Bcl-2 subfamily []. Full-length Bcl-2 proteins feature all four BH domains, seven α-helices, and a C-terminal hydrophobic motif that targets the protein to the outer mitochondrial membrane, ER and nuclear envelope. In healthy cells, Bcl-w resides in the cytoplasm, and becomes membrane-associated in response to cytotoxic insults. Its 3D structure comprises a bundle of five amphipathic α-helices surrounding two central hydrophobic helical regions. A hydrophobic groove, formed by residues from BH1-BH3, is capable of binding the BH3 α-helix from a pro-apoptotic BH3-only family member [].
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Protein
O54918
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Protein
P10417
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q8BQK4
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q542N5
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Publication
33783314 | J:314395
First Author: Chang HC
Year: 2021
Journal: Autophagy
Title: The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore.
Volume: 17
Issue: 11
Pages: 3725-3739
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Publication
21084607 | J:182379
First Author: Zhong Z
Year: 2010
Journal: J Neurosci
Title: Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.
Volume: 30
Issue: 46
Pages: 15521-34
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Publication
28698281 | J:257892
First Author: Li H
Year: 2017
Journal: Am J Physiol Endocrinol Metab
Title: MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.
Volume: 313
Issue: 4
Pages: E391-E401
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Publication
28864114 | J:252971
 
First Author: Ding X
Year: 2017
Journal: Gene
Title: Leptin siRNA promotes ovarian granulosa cell apoptosis and affects steroidogenesis by increasing NPY2 receptor expression.
Volume: 633
Pages: 28-34
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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