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Search results 2101 to 2200 out of 2412 for Comp

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Type Details Score
Publication
15593368 | -
First Author: Waugh JL
Year: 2005
Journal: J Comp Neurol
Title: Regional, cellular, and subcellular localization of RGS10 in rodent brain.
Volume: 481
Issue: 3
Pages: 299-313
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Publication
25907657 | -
 
First Author: Ramesh N
Year: 2015
Journal: Gen Comp Endocrinol
Title: Nucleobindin-1 encodes a nesfatin-1-like peptide that stimulates insulin secretion.
Volume: 216
Pages: 182-9
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Publication
10753578 | -
First Author: Yasuda-Kamatani Y
Year: 2000
Journal: Gen Comp Endocrinol
Title: Identification of orcokinin gene-related peptides in the brain of the crayfish Procambarus clarkii by the combination of MALDI-TOF and on-line capillary HPLC/Q-Tof mass spectrometries and molecular cloning.
Volume: 118
Issue: 1
Pages: 161-72
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Publication
18181141 | -
First Author: Lim ST
Year: 2008
Journal: J Comp Neurol
Title: Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.
Volume: 507
Issue: 2
Pages: 1228-44
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Allele
Tg(Col2a1-rtTA,tetO-COMP)1Jath | MGI:4361027
Name: transgene insertion 1, Jacqueline Hecht
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Transactivator
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Publication
12021245 | J:140382
First Author: Yokota T
Year: 2002
Journal: J Clin Invest
Title: Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.
Volume: 109
Issue: 10
Pages: 1303-10
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Strain
MGI:4361184 | C57BL/6-Tg(Col2a1-rtTA,tetO-COMP)1Jath
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(Comp-tTA)#Yeli | MGI:6270426
Name: transgene insertion, Yefu Li
Allele Type: Transgenic
Attribute String: Transactivator
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Genotype
Genotype
Symbol: Tg(Col2a1-rtTA,tetO-COMP)1Jath/?
Background: C57BL/6-Tg(Col2a1-rtTA,tetO-COMP)1Jath
Zygosity: ot
Has Mutant Allele: true
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Publication
19762713 | J:152756
First Author: Posey KL
Year: 2009
Journal: Am J Pathol
Title: An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype.
Volume: 175
Issue: 4
Pages: 1555-63
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Publication
11004006 | -
First Author: Johnson KA
Year: 2000
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.
Volume: 279
Issue: 4
Pages: R1365-77
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Publication
17045831 | -
First Author: Miyazaki M
Year: 2006
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase.
Volume: 145
Issue: 3-4
Pages: 270-7
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Publication
23576606 | -
First Author: Richards J
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Mechanism of the circadian clock in physiology.
Volume: 304
Issue: 12
Pages: R1053-64
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Publication
14720597 | -
First Author: Chang BY
Year: 2004
Journal: Comp Biochem Physiol A Mol Integr Physiol
Title: The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins.
Volume: 137
Issue: 1
Pages: 115-29
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Publication
17928512 | -
First Author: Chen LM
Year: 2007
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain.
Volume: 293
Issue: 6
Pages: R2412-20
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Publication
9253175 | -
First Author: Kagan RM
Year: 1997
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Molecular phylogenetics of a protein repair methyltransferase.
Volume: 117
Issue: 3
Pages: 379-85
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Publication
17462931 | -
First Author: Zhang Z
Year: 2007
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Ribosomal protein L24 is differentially expressed in ovary and testis of the marine shrimp Marsupenaeus japonicus.
Volume: 147
Issue: 3
Pages: 466-74
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Publication
11250542 | -
First Author: Biagini A
Year: 2001
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Sequence analysis of the aminoacylase-1 family. A new proposed signature for metalloexopeptidases.
Volume: 128
Issue: 3
Pages: 469-81
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Publication
20868765 | -
First Author: Badariotti F
Year: 2011
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Identification of three singular glycosyl hydrolase family 18 members from the oyster Crassostrea gigas: Structural characterization, phylogenetic analysis and gene expression.
Volume: 158
Issue: 1
Pages: 56-63
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Publication
12798932 | -
First Author: Muñoz ME
Year: 2003
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Pyruvate kinase: current status of regulatory and functional properties.
Volume: 135
Issue: 2
Pages: 197-218
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Publication
15528401 | -
First Author: Meyer RA
Year: 2004
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Aerobic performance and the function of myoglobin in human skeletal muscle.
Volume: 287
Issue: 6
Pages: R1304-5
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Publication
17395511 | -
First Author: Ye HQ
Year: 2007
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Molecular cloning and characterization of the Myf5 gene in sea perch (Lateolabrax japonicus).
Volume: 147
Issue: 3
Pages: 452-9
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Publication
17451989 | -
First Author: Saha N
Year: 2007
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Air-breathing catfish, Clarias batrachus upregulates glutamine synthetase and carbamyl phosphate synthetase III during exposure to high external ammonia.
Volume: 147
Issue: 3
Pages: 520-30
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Publication
8590372 | -
First Author: De Kleijn DP
Year: 1995
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Molecular biology of neurohormone precursors in the eyestalk of Crustacea.
Volume: 112
Issue: 4
Pages: 573-9
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Publication
24726622 | -
 
First Author: Zera AJ
Year: 2014
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Purification and characterization of 6-phosphogluconate dehydrogenase from the wing-polymorphic cricket, Gryllus firmus, and assessment of causes of morph-differences in enzyme activity.
Volume: 172-173
Pages: 29-38
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Publication
10048185 | -
First Author: Ali SA
Year: 1998
Journal: Comp Biochem Physiol A Mol Integr Physiol
Title: Purification and primary structure of low molecular mass peptides from scorpion (Buthus sindicus) venom.
Volume: 121
Issue: 4
Pages: 323-32
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Publication
11997226 | -
First Author: Simonet G
Year: 2002
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods.
Volume: 132
Issue: 1
Pages: 247-55
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Publication
10584297 | -
First Author: Ginger MR
Year: 1999
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Comparative aspects of milk caseins.
Volume: 124
Issue: 2
Pages: 133-45
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Publication
10425740 | -
First Author: Andersen SO
Year: 1999
Journal: Comp Biochem Physiol A Mol Integr Physiol
Title: Exoskeletal proteins from the crab, Cancer pagurus.
Volume: 123
Issue: 2
Pages: 203-11
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Publication
12628379 | -
First Author: Ditzel N
Year: 2003
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Cuticular proteins from the horseshoe crab, Limulus polyphemus.
Volume: 134
Issue: 3
Pages: 489-97
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Publication
16766219 | -
First Author: Chabasse C
Year: 2006
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: The multigenic family of the extracellular hemoglobin from the annelid polychaete Arenicola marina.
Volume: 144
Issue: 3
Pages: 319-25
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Publication
10896885 | -
First Author: Cutler CP
Year: 2000
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Expression of a duplicate Na,K-ATPase beta(1)-isoform in the European eel (Anguilla anguilla).
Volume: 279
Issue: 1
Pages: R222-9
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Publication
2906827 | -
First Author: Swain UG
Year: 1988
Journal: Comp Biochem Physiol A Comp Physiol
Title: Heart rates in the captive, free-ranging beaver.
Volume: 91
Issue: 3
Pages: 431-5
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Publication
10817902 | -
First Author: Fernández-Centeno E
Year: 2000
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: 2',3'-cyclic nucleotide 2'-phosphodiesterase from Fusarium culmorum.
Volume: 125
Issue: 2
Pages: 161-7
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Publication
9972448 | -
First Author: Nelson DR
Year: 1998
Journal: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
Title: Metazoan cytochrome P450 evolution.
Volume: 121
Issue: 1-3
Pages: 15-22
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Publication
18499493 | -
First Author: Andrews LD
Year: 2008
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Characterization of a novel bacterial arginine kinase from Desulfotalea psychrophila.
Volume: 150
Issue: 3
Pages: 312-9
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Publication
12524037 | -
First Author: Gollub M
Year: 2003
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Isolation and characterization of cytidine-5'-monophosphate-N-acetylneuraminate hydroxylase from the starfish Asterias rubens.
Volume: 134
Issue: 1
Pages: 89-101
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Publication
7553344 | -
First Author: Ceciliani F
Year: 1994
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: The primary structure of a basic (pI 9.0) fatty acid-binding protein from liver of Gallus domesticus.
Volume: 109
Issue: 2-3
Pages: 261-71
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Publication
19341811 | -
First Author: Dardente H
Year: 2009
Journal: Comp Biochem Physiol A Mol Integr Physiol
Title: Transcriptional feedback loops in the ovine circadian clock.
Volume: 153
Issue: 4
Pages: 391-8
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Publication
9734337 | -
First Author: Medeiros MG
Year: 1998
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and glycuronidases in the mollusc Tagelus gibbus.
Volume: 119
Issue: 3
Pages: 539-47
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Publication
24990862 | -
First Author: Guan X
Year: 2014
Journal: Am J Physiol Regul Integr Comp Physiol
Title: The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis.
Volume: 307
Issue: 6
Pages: R585-96
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Publication
11959032 | -
First Author: Wilimowska-Pelc A
Year: 2002
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Kazal-type chymotrypsin inhibitor from duck pancreas.
Volume: 131
Issue: 3
Pages: 499-507
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Publication
15726626 | -
First Author: Zhou J
Year: 2005
Journal: J Exp Zool A Comp Exp Biol
Title: Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen.
Volume: 303
Issue: 3
Pages: 227-40
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Allele
Tg(Comp-EGFP)GN237Gsat | MGI:4846959
Name: transgene insertion GN237, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Comp<tm1Aol> | MGI:2180787
Name: cartilage oligomeric matrix protein; targeted mutation 1, Ake Oldberg
Allele Type: Targeted
Attribute String: Null/knockout
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HT Experiment
E-GEOD-11013 | Transcription profiling of mouse model for Potocki-Lupski Syndrome
Series Id: GSE11013
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
17021831 | -
First Author: Fehr J
Year: 2007
Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Title: Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.
Volume: 193
Issue: 1
Pages: 21-34
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Strain
MGI:5003683 | STOCK Tg(Comp-EGFP)GN237Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Comp/Comp
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Comp-tTA)#Yeli/? Tg(tetO-DDR2)#Yeli/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Publication
15384169 | J:93171
First Author: Cheverud JM
Year: 2004
Journal: J Exp Zool B Mol Dev Evol
Title: Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration.
Volume: 302
Issue: 5
Pages: 424-35
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Publication
21855682 | J:176308
First Author: Xu L
Year: 2011
Journal: Am J Pathol
Title: Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model.
Volume: 179
Issue: 3
Pages: 1338-46
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Publication
17708948 | J:40814
First Author: D S
Year: 1997
Journal: Trends Cell Biol
Title: Src: more than the sum of its parts.
Volume: 7
Issue: 6
Pages: 215-7
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Publication
19276170 | -
First Author: Tan K
Year: 2009
Journal: FASEB J
Title: The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding.
Volume: 23
Issue: 8
Pages: 2490-501
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Publication
16542502 | -
First Author: Koelling S
Year: 2006
Journal: Arthritis Res Ther
Title: Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis.
Volume: 8
Issue: 3
Pages: R56
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Protein Domain
IPR028492 | TSP-5
Type: Family
Description: Cartilage oligomeric matrix protein (COMP), or thrombospondin-5 (TSP-5), is a member of the thrombospondin gene familyand is found mainly in the extracellular matrix often associated with cartilage tissue. It plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin [, , ]. COMP is involved in human limb development and in the pathogenesis of osteoarthritis [].
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Publication
23983142 | J:241822
First Author: Willing J
Year: 2014
Journal: Dev Neurobiol
Title: Sensorimotor development in neonatal progesterone receptor knockout mice.
Volume: 74
Issue: 1
Pages: 16-24
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Publication
18353302 | J:136079
First Author: Spassky N
Year: 2008
Journal: Dev Biol
Title: Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.
Volume: 317
Issue: 1
Pages: 246-59
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Publication
16287859 | J:119855
First Author: Budde B
Year: 2005
Journal: Mol Cell Biol
Title: Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.
Volume: 25
Issue: 23
Pages: 10465-78
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Publication
25859006 | J:222404
First Author: Posey KL
Year: 2015
Journal: Hum Mol Genet
Title: Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.
Volume: 24
Issue: 14
Pages: 3918-28
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Publication
9987683 | J:55993
First Author: Joosten LA
Year: 1999
Journal: Inflamm Res
Title: Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis.
Volume: 48
Issue: 1
Pages: 48-55
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Publication
16047381 | J:103255
First Author: Suzuki Y
Year: 2005
Journal: Anat Rec A Discov Mol Cell Evol Biol
Title: Role of IGFBPs in the morphogenesis of lingual papillae.
Volume: 286
Issue: 1
Pages: 841-7
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Publication
17889519 | J:135110
First Author: Schmitz M
Year: 2008
Journal: Matrix Biol
Title: Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations.
Volume: 27
Issue: 2
Pages: 67-85
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Publication
22995515 | J:207879
First Author: Du Y
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification.
Volume: 32
Issue: 11
Pages: 2580-8
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Publication
25766405 | J:224410
 
First Author: Etich J
Year: 2015
Journal: Matrix Biol
Title: MiR-26a modulates extracellular matrix homeostasis in cartilage.
Volume: 43
Pages: 27-34
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Publication
25381007 | J:231980
First Author: Tomás-Roca L
Year: 2016
Journal: Brain Struct Funct
Title: Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features.
Volume: 221
Issue: 2
Pages: 815-38
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Publication
17931911 | J:272211
First Author: Jaeger K
Year: 2008
Journal: Osteoarthritis Cartilage
Title: The genetics of osteoarthritis in STR/ort mice.
Volume: 16
Issue: 5
Pages: 607-14
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Publication
25742929 | J:310697
First Author: Zhang Y
Year: 2015
Journal: Mol Cell Biochem
Title: Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice.
Volume: 404
Issue: 1-2
Pages: 171-9
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Publication
38510179 | J:346547
 
First Author: Johnston SN
Year: 2024
Journal: Front Cell Dev Biol
Title: Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine.
Volume: 12
Pages: 1360376
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Protein
Q8K3G4
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Publication
20714802 | -
First Author: Koch M
Year: 2011
Journal: Breast Cancer Res Treat
Title: CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.
Volume: 128
Issue: 2
Pages: 337-46
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Publication
12225811 | -
First Author: Di Cesare PE
Year: 2002
Journal: Matrix Biol
Title: Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.
Volume: 21
Issue: 5
Pages: 461-70
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Publication
15964815 | J:99120
First Author: Hankenson KD
Year: 2005
Journal: Mol Cell Biol
Title: Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head.
Volume: 25
Issue: 13
Pages: 5599-606
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Protein Domain
IPR028507 | Thrombospondin-3
Type: Family
Description: Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.TSP3 may be involved in the regulation of skeletal maturation [].
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Protein Domain
IPR015455 | TSP2
Type: Family
Description: Thrombospondin-2 (TSP2) is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It has been shown to inhibit tumour growth and angiogenesis []. Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.
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Protein
A0A1D5RMB8
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Publication
15337766 | J:114110
First Author: Liu CJ
Year: 2004
Journal: J Biol Chem
Title: Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis.
Volume: 279
Issue: 45
Pages: 47081-91
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Publication
16677726 | J:108978
First Author: Billings LB
Year: 2006
Journal: Behav Brain Res
Title: Oxytocin null mice ingest enhanced amounts of sweet solutions during light and dark cycles and during repeated shaker stress.
Volume: 171
Issue: 1
Pages: 134-41
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Publication
31797255 | J:293621
First Author: Hanif A
Year: 2020
Journal: Mol Cell Biochem
Title: Ephx2-gene deletion affects acetylcholine-induced relaxation in angiotensin-II infused mice: role of nitric oxide and CYP-epoxygenases.
Volume: 465
Issue: 1-2
Pages: 37-51
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Publication
21584649 | J:326687
First Author: Müller M
Year: 2012
Journal: Brain Struct Funct
Title: Synaptology of ventral CA1 and subiculum projections to the basomedial nucleus of the amygdala in the mouse: relation to GABAergic interneurons.
Volume: 217
Issue: 1
Pages: 5-17
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Publication
25211221 | J:222518
First Author: Yeung CY
Year: 2014
Journal: PLoS One
Title: Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.
Volume: 9
Issue: 9
Pages: e107036
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Publication
11687483 | -
 
First Author: Adams JC
Year: 2001
Journal: Annu Rev Cell Dev Biol
Title: Thrombospondins: multifunctional regulators of cell interactions.
Volume: 17
Pages: 25-51
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Publication
16186819 | -
First Author: Carlson CB
Year: 2005
Journal: Nat Struct Mol Biol
Title: Structure of the calcium-rich signature domain of human thrombospondin-2.
Volume: 12
Issue: 10
Pages: 910-4
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Publication
16051604 | -
First Author: Chen FH
Year: 2005
Journal: J Biol Chem
Title: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.
Volume: 280
Issue: 38
Pages: 32655-61
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Protein Domain
IPR000884 | TSP1_rpt
Type: Repeat
Description: Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.This repeat was first described in 1986 by Lawler and Hynes []. It was found in the thrombospondin protein where it is repeated 3 times. Now a number of proteins involved in the complement pathway (properdin, C6, C7, C8A, C8B, C9) []as well as extracellular matrix protein like mindin, F-spondin [], SCO-spondin and even the circumsporozoite surface protein 2 and TRAP proteins of Plasmodium [, ]contain one or more instance of this repeat. It has been involved in cell-cell interaction, inhibition of angiogenesis []and apoptosis [].The intron-exon organisation of the properdin gene confirms the hypothesis that the repeat might have evolved by a process involving exon shuffling []. A study of properdin structure provides some information about the structure of the thrombospondin type I repeat [].
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Protein Domain
IPR017897 | Thrombospondin_3_rpt
Type: Repeat
Description: Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.The calcium-binding TSP3 repeats are a tandem of aspartic acid-rich motifs, which resembles EF hands in the acidic side chains. But unlike EF hands, the calcium-binding loops of the TSP3 repeats are not flanked by secondary structure elements. The structure of the TSP3 repeats has been solved [, ]. They form a wire draped around the calcium ions. The individual calcium-binding repeats are linked by disulphide bonds to each other.
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Protein Domain
IPR008859 | Thrombospondin_C
Type: Domain
Description: Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.The globular C-terminal domain is a beta sandwich of two curved antiparallel β-sheets []. The fold is an elaboration of the jelly role topology, with strand B3-B7, B11 and B14-B15 forming the eight-stranded jelly roll motif. The function of the C-terminal domain is not yet known.
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Publication
32366677 | J:290413
 
First Author: Ahmadzadeh E
Year: 2020
Journal: Development
Title: A collection of genetic mouse lines and related tools for inducible and reversible intersectional mis-expression.
Volume: 147
Issue: 10
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Publication
29944650 | J:263621
First Author: Roselló-Díez A
Year: 2018
Journal: PLoS Biol
Title: Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.
Volume: 16
Issue: 6
Pages: e2005086
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Publication
- | J:39922
First Author: British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, United Kingdom, 22-23 September 1996. Bussoli T
Year: 1997
Journal: Br J Audiol
Title: Localization of the bronx waltzer mouse mutation and its effect on organ of Corti development.
Volume: 31
Issue: 2
Pages: 73-132 (83 Abstr.)
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Publication
15494543 | J:95418
First Author: Zheng J
Year: 2005
Journal: Am J Physiol Renal Physiol
Title: Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury.
Volume: 288
Issue: 2
Pages: F387-98
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Protein
P11680
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q9JM61
Organism: Mus musculus/domesticus
Length: 851  
Fragment?: false
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Protein
Q6P4U0
Organism: Mus musculus/domesticus
Length: 1607  
Fragment?: false
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Protein
Q69ZU6
Organism: Mus musculus/domesticus
Length: 1645  
Fragment?: false
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Protein
A0A1D5RMA0
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Protein
F7CVI0
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Protein
Q8BNI0
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
A0A1B0GT60
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Protein
A0A0R4J0U4
Organism: Mus musculus/domesticus
Length: 851  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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