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Search results 2101 to 2200 out of 2795 for Egfr

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Type Details Score
Publication
26005835 | J:299352
First Author: Depeille P
Year: 2015
Journal: Nat Cell Biol
Title: RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Volume: 17
Issue: 6
Pages: 804-15
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39059397 | J:353294
First Author: Huang P
Year: 2024
Journal: Cell Host Microbe
Title: Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK.
Volume: 32
Issue: 8
Pages: 1365-1379.e10
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Publication
24763051 | J:320320
 
First Author: Li D
Year: 2014
Journal: Cell Death Dis
Title: A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.
Volume: 5
Pages: e1194
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Publication
21907924 | J:175969
First Author: Sugiarto S
Year: 2011
Journal: Cancer Cell
Title: Asymmetry-defective oligodendrocyte progenitors are glioma precursors.
Volume: 20
Issue: 3
Pages: 328-40
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Publication
19234449 | J:147264
First Author: Keng VW
Year: 2009
Journal: Nat Biotechnol
Title: A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Volume: 27
Issue: 3
Pages: 264-74
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Publication
29872037 | J:353594
First Author: Muta Y
Year: 2018
Journal: Nat Commun
Title: Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.
Volume: 9
Issue: 1
Pages: 2174
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Publication
36477656 | J:332124
First Author: Flanagan DJ
Year: 2022
Journal: Nat Commun
Title: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Volume: 13
Issue: 1
Pages: 7551
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Publication
26289340 | J:254087
 
First Author: Fu Y
Year: 2015
Journal: Sci Rep
Title: Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.
Volume: 5
Pages: 13347
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Publication
32499547 | J:291857
First Author: Shankar S
Year: 2020
Journal: Nat Commun
Title: An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.
Volume: 11
Issue: 1
Pages: 2817
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Publication
36841240 | J:334912
First Author: Simpson Ragdale H
Year: 2023
Journal: Curr Biol
Title: Injury primes mutation-bearing astrocytes for dedifferentiation in later life.
Volume: 33
Issue: 6
Pages: 1082-1098.e8
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Publication
20621056 | J:162238
First Author: Curtis SJ
Year: 2010
Journal: Cell Stem Cell
Title: Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.
Volume: 7
Issue: 1
Pages: 127-33
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Publication
19155296 | J:144978
First Author: Bode AM
Year: 2009
Journal: Cancer Res
Title: Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.
Volume: 69
Issue: 3
Pages: 905-13
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Publication
26058079 | J:222915
First Author: Stratikopoulos EE
Year: 2015
Journal: Cancer Cell
Title: Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
Volume: 27
Issue: 6
Pages: 837-51
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Publication
34739325 | J:319926
First Author: Doke T
Year: 2021
Journal: Sci Adv
Title: Genome-wide association studies identify the role of caspase-9 in kidney disease.
Volume: 7
Issue: 45
Pages: eabi8051
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Publication
27633013 | J:235647
First Author: Liu X
Year: 2016
Journal: Genes Dev
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Volume: 30
Issue: 17
Pages: 1943-55
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Publication
24843006 | J:213217
 
First Author: Mich JK
Year: 2014
Journal: Elife
Title: Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
Volume: 3
Pages: e02669
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11809799 | J:74283
First Author: Chan R
Year: 2002
Journal: Mol Cell Biol
Title: The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development.
Volume: 22
Issue: 4
Pages: 1073-8
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Publication
24726384 | J:214778
First Author: Xie H
Year: 2014
Journal: Cell Metab
Title: Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.
Volume: 19
Issue: 5
Pages: 795-809
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Publication
16885338 | J:112090
First Author: Wei Q
Year: 2006
Journal: Cancer Res
Title: High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model.
Volume: 66
Issue: 15
Pages: 7429-37
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28875931 | J:257174
   
First Author: Remaud S
Year: 2017
Journal: Elife
Title: Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain.
Volume: 6
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29358709 | J:282523
First Author: Gao L
Year: 2018
Journal: Nat Immunol
Title: Tumor-derived exosomes antagonize innate antiviral immunity.
Volume: 19
Issue: 3
Pages: 233-245
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Publication
23378339 | J:196975
First Author: Miyabayashi K
Year: 2013
Journal: Cancer Res
Title: Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Volume: 73
Issue: 7
Pages: 2221-34
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Publication
36534084 | J:352926
 
First Author: Kaiser KA
Year: 2023
Journal: J Exp Med
Title: Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells.
Volume: 220
Issue: 3
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Publication
31221853 | J:277368
First Author: Engle DD
Year: 2019
Journal: Science
Title: The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.
Volume: 364
Issue: 6446
Pages: 1156-1162
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17785207 | J:124969
First Author: Siveke JT
Year: 2007
Journal: Cancer Cell
Title: Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Volume: 12
Issue: 3
Pages: 266-79
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38921956 | J:352253
   
First Author: Gao C
Year: 2024
Journal: Elife
Title: FAK loss reduces BRAF(V600E)-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation.
Volume: 13
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Publication
20495549 | J:208978
First Author: Singh M
Year: 2010
Journal: Nat Biotechnol
Title: Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.
Volume: 28
Issue: 6
Pages: 585-93
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Publication
37828026 | J:341629
First Author: Blair LM
Year: 2023
Journal: Nat Commun
Title: Oncogenic context shapes the fitness landscape of tumor suppression.
Volume: 14
Issue: 1
Pages: 6422
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Publication
24813888 | J:211798
First Author: Pirazzoli V
Year: 2014
Journal: Cell Rep
Title: Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1.
Volume: 7
Issue: 4
Pages: 999-1008
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Publication
22036563 | J:178690
First Author: Ding BS
Year: 2011
Journal: Cell
Title: Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.
Volume: 147
Issue: 3
Pages: 539-53
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Publication
16054021 | J:135488
First Author: Higashiyama S
Year: 2005
Journal: Biochim Biophys Acta
Title: ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Volume: 1751
Issue: 1
Pages: 110-7
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Publication
25355554 | J:232536
First Author: Xu C
Year: 2014
Journal: IUBMB Life
Title: Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium.
Volume: 66
Issue: 10
Pages: 694-703
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Publication
12573256 | J:82006
First Author: Johnson KR
Year: 2003
Journal: Genomics
Title: Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
Volume: 81
Issue: 1
Pages: 6-14
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Publication
29642017 | J:271776
First Author: Walter W
Year: 2018
Journal: Cell Rep
Title: Deciphering the Dynamic Transcriptional and Post-transcriptional Networks of Macrophages in the Healthy Heart and after Myocardial Injury.
Volume: 23
Issue: 2
Pages: 622-636
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Publication
39423817 | J:358173
First Author: Fu M
Year: 2024
Journal: Cancer Cell
Title: Overcoming tyrosine kinase inhibitor resistance in lung cancer brain metastasis with CTLA4 blockade.
Volume: 42
Issue: 11
Pages: 1882-1897.e7
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Publication
31875547 | J:292171
First Author: Apicco DJ
Year: 2019
Journal: Cell Rep
Title: Dysregulation of RNA Splicing in Tauopathies.
Volume: 29
Issue: 13
Pages: 4377-4388.e4
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Publication
37611070 | J:340566
First Author: Phan QT
Year: 2023
Journal: PLoS Pathog
Title: Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection.
Volume: 19
Issue: 8
Pages: e1011579
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Publication
34096503 | J:332713
   
First Author: Nászai M
Year: 2021
Journal: Elife
Title: RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.
Volume: 10
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Publication
32009252 | J:310043
First Author: Wu J
Year: 2020
Journal: EMBO J
Title: Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone.
Volume: 39
Issue: 5
Pages: e101679
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Publication
26977878 | J:231766
First Author: Goel S
Year: 2016
Journal: Cancer Cell
Title: Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.
Volume: 29
Issue: 3
Pages: 255-69
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Publication
16644672 | J:108626
First Author: Buteau J
Year: 2006
Journal: Diabetes
Title: Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
Volume: 55
Issue: 5
Pages: 1190-6
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Publication
28416796 | J:249695
 
First Author: Tang H
Year: 2017
Journal: Nat Commun
Title: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
Volume: 8
Pages: 14909
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Publication
39055915 | J:352148
First Author: Chang VY
Year: 2024
Journal: iScience
Title: Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.
Volume: 27
Issue: 7
Pages: 110306
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Publication
30018330 | J:266099
First Author: Sizemore GM
Year: 2018
Journal: Nat Commun
Title: Stromal PTEN determines mammary epithelial response to radiotherapy.
Volume: 9
Issue: 1
Pages: 2783
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24240681 | J:216268
First Author: Bhattacharyya S
Year: 2014
Journal: Oncogene
Title: Arylsulfatase B regulates versican expression by galectin-3 and AP-1 mediated transcriptional effects.
Volume: 33
Issue: 47
Pages: 5467-76
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Publication
26108729 | J:223005
 
First Author: Dombernowsky SL
Year: 2015
Journal: Nat Commun
Title: The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Volume: 6
Pages: 7518
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Publication
27050949 | J:247595
First Author: Walker TL
Year: 2016
Journal: Stem Cell Reports
Title: Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells.
Volume: 6
Issue: 4
Pages: 552-565
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Publication
25183008 | J:238911
First Author: Zhang A
Year: 2014
Journal: J Biol Chem
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Volume: 289
Issue: 42
Pages: 29180-94
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Publication
33488625 | J:339371
 
First Author: Compte M
Year: 2020
Journal: Front Immunol
Title: Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR.
Volume: 11
Pages: 614363
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Publication
31080136 | J:352724
First Author: Hashimoto H
Year: 2019
Journal: Cell Stem Cell
Title: Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers.
Volume: 25
Issue: 1
Pages: 69-86.e5
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Publication
20510673 | J:317778
First Author: Xie Z
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.
Volume: 397
Issue: 2
Pages: 296-300
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Publication
23178117 | J:196210
First Author: Huang S
Year: 2012
Journal: Cell
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Volume: 151
Issue: 5
Pages: 937-50
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9419975 | J:114807
First Author: Komurasaki T
Year: 1997
Journal: Oncogene
Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Volume: 15
Issue: 23
Pages: 2841-8
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Publication
25594178 | J:227368
First Author: Tan X
Year: 2015
Journal: Cell
Title: A kinase-independent role for EGF receptor in autophagy initiation.
Volume: 160
Issue: 1-2
Pages: 145-60
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Publication
30574069 | J:322386
 
First Author: Yang Q
Year: 2018
Journal: Front Mol Neurosci
Title: Endocytic Adaptor Protein HIP1R Controls Intracellular Trafficking of Epidermal Growth Factor Receptor in Neuronal Dendritic Development.
Volume: 11
Pages: 447
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Publication
8101647 | J:13198
First Author: Segatto O
Year: 1993
Journal: Oncogene
Title: Shc products are substrates of erbB-2 kinase.
Volume: 8
Issue: 8
Pages: 2105-12
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7700649 | J:25152
First Author: Zimonjic DB
Year: 1995
Journal: Oncogene
Title: Localization of the human HER4/erbB-4 gene to chromosome 2.
Volume: 10
Issue: 6
Pages: 1235-7
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9781061 | J:48101
First Author: Wakeling EL
Year: 1998
Journal: Eur J Hum Genet
Title: Human EGFR, a candidate gene for the Silver-Russell syndrome, is biallelically expressed in a wide range of fetal tissues.
Volume: 6
Issue: 2
Pages: 158-64
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Publication
16357156 | J:104346
First Author: Fujimoto N
Year: 2005
Journal: Cancer Res
Title: High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.
Volume: 65
Issue: 24
Pages: 11478-85
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Publication
16319309 | J:129669
First Author: Aguirre A
Year: 2005
Journal: J Neurosci
Title: Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.
Volume: 25
Issue: 48
Pages: 11092-106
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Publication
18957516 | J:145772
First Author: Monaghan-Benson E
Year: 2008
Journal: J Cell Sci
Title: A dual role for caveolin-1 in the regulation of fibronectin matrix assembly by uPAR.
Volume: 121
Issue: Pt 22
Pages: 3693-703
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19433452 | J:150439
First Author: Shen S
Year: 2009
Journal: J Cell Biol
Title: Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy.
Volume: 185
Issue: 4
Pages: 629-39
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Publication
20398727 | J:168386
First Author: Liebmann C
Year: 2011
Journal: Mol Cell Endocrinol
Title: EGF receptor activation by GPCRs: an universal pathway reveals different versions.
Volume: 331
Issue: 2
Pages: 222-31
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23178880 | J:195243
First Author: Yang W
Year: 2012
Journal: Nat Cell Biol
Title: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Volume: 14
Issue: 12
Pages: 1295-304
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Publication
23512660 | J:195287
First Author: Wong CE
Year: 2013
Journal: Genes Dev
Title: Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.
Volume: 27
Issue: 6
Pages: 670-82
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24063894 | J:205059
First Author: Cho J
Year: 2013
Journal: Cancer Res
Title: Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.
Volume: 73
Issue: 22
Pages: 6770-9
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25533187 | J:219761
First Author: Kim YM
Year: 2015
Journal: Mol Cell
Title: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.
Volume: 57
Issue: 2
Pages: 207-18
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26280537 | J:227353
First Author: Zheng Y
Year: 2015
Journal: Nat Cell Biol
Title: Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation.
Volume: 17
Issue: 10
Pages: 1348-55
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Publication
27135741 | J:239470
First Author: Pozzi C
Year: 2016
Journal: Nat Med
Title: The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Volume: 22
Issue: 6
Pages: 624-31
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Publication
29677490 | J:265708
First Author: Lee JH
Year: 2018
Journal: Mol Cell
Title: EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
Volume: 70
Issue: 2
Pages: 197-210.e7
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30171165 | J:270206
First Author: Chen F
Year: 2018
Journal: J Immunol
Title: Neutrophils Promote Amphiregulin Production in Intestinal Epithelial Cells through TGF-β and Contribute to Intestinal Homeostasis.
Volume: 201
Issue: 8
Pages: 2492-2501
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Publication
31216465 | J:288424
First Author: Marcar L
Year: 2019
Journal: Cell Rep
Title: Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.
Volume: 27
Issue: 12
Pages: 3422-3432.e4
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Publication
31983436 | J:293240
First Author: Kim KM
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Transcriptional coactivator with PDZ-binding motif stimulates epidermal regeneration via induction of amphiregulin expression after ultraviolet damage.
Volume: 524
Issue: 1
Pages: 242-248
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Publication
33664246 | J:304929
First Author: Abbassi L
Year: 2021
Journal: Nat Commun
Title: Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation.
Volume: 12
Issue: 1
Pages: 1438
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Publication
33707748 | J:305474
First Author: Yeo AT
Year: 2021
Journal: Oncogene
Title: EGFRvIII tumorigenicity requires PDGFRA co-signaling and reveals therapeutic vulnerabilities in glioblastoma.
Volume: 40
Issue: 15
Pages: 2682-2696
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21037565 | J:322401
First Author: Su T
Year: 2010
Journal: Nat Cell Biol
Title: A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
Volume: 12
Issue: 12
Pages: 1143-53
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Publication
25077541 | J:310693
 
First Author: Du WW
Year: 2014
Journal: Cell Death Dis
Title: miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7.
Volume: 5
Pages: e1355
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Publication
26814435 | J:314627
First Author: Liu JC
Year: 2016
Journal: Oncotarget
Title: Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.
Volume: 7
Issue: 8
Pages: 9060-8
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32589309 | J:326402
First Author: Zhong C
Year: 2020
Journal: Cancer Sci
Title: ZNF251 promotes the progression of lung cancer by activating ERK signaling.
Volume: 111
Issue: 9
Pages: 3236-3244
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Publication
37095176 | J:335171
First Author: Bi J
Year: 2023
Journal: Nat Commun
Title: TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression.
Volume: 14
Issue: 1
Pages: 2342
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Publication
37253718 | J:336147
First Author: Zhan M
Year: 2023
Journal: Nat Commun
Title: Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.
Volume: 14
Issue: 1
Pages: 3123
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Publication
39096904 | J:353687
First Author: Zhao R
Year: 2024
Journal: Cell Stem Cell
Title: Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis.
Volume: 31
Issue: 9
Pages: 1344-1358.e6
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Publication
38871738 | J:349880
First Author: Hobor S
Year: 2024
Journal: Nat Commun
Title: Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Volume: 15
Issue: 1
Pages: 4871
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Publication
38904097 | J:353469
 
First Author: Young KA
Year: 2024
Journal: J Cell Sci
Title: The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression.
Volume: 137
Issue: 14
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Publication
38997284 | J:351990
First Author: Wang Y
Year: 2024
Journal: Nat Commun
Title: Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis.
Volume: 15
Issue: 1
Pages: 5874
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Publication
39660053 | J:359449
First Author: Jun HJ
Year: 2024
Journal: iScience
Title: Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesis.
Volume: 27
Issue: 12
Pages: 111278
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Publication
32639068 | J:297579
First Author: Chen Z
Year: 2020
Journal: Glia
Title: Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.
Volume: 68
Issue: 10
Pages: 2148-2166
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Publication
9115846 | -
First Author: Romero F
Year: 1996
Journal: Cell Signal
Title: Structure and function of vav.
Volume: 8
Issue: 8
Pages: 545-53
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Publication
14755250 | -
First Author: Li H
Year: 2004
Journal: Oncogene
Title: An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.
Volume: 23
Issue: 10
Pages: 1801-8
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Publication
19262463 | -
First Author: Jacque E
Year: 2009
Journal: EMBO J
Title: RNF11, a new piece in the A20 puzzle.
Volume: 28
Issue: 5
Pages: 455-6
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Publication
25195858 | -
First Author: Santonico E
Year: 2015
Journal: Oncogene
Title: RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Volume: 34
Issue: 26
Pages: 3377-90
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Publication
21765415 | J:176472
First Author: Shembade N
Year: 2011
Journal: Nat Immunol
Title: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Volume: 12
Issue: 9
Pages: 834-43
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Publication
14559117 | -
First Author: Kitching R
Year: 2003
Journal: Biochim Biophys Acta
Title: The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases.
Volume: 1639
Issue: 2
Pages: 104-12
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Publication
14562029 | -
First Author: Subramaniam V
Year: 2003
Journal: Br J Cancer
Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
Volume: 89
Issue: 8
Pages: 1538-44
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Publication
19528490 | -
First Author: Azmi PB
Year: 2009
Journal: Anticancer Res
Title: The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling.
Volume: 29
Issue: 6
Pages: 2253-63
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Protein Domain
IPR042981 | RNF11_RING-H2
Type: Domain
Description: RING finger protein 11 (RNF11) is an E3 ubiquitin-protein ligase that acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic. It is the downstream of an enzymatic cascade for the ubiquitination of specific substrates. It is also a molecular adaptor of homologous to E6-associated protein C terminus (HECT)-type ligases []. RNF11 has been implicated in the regulation of several signaling pathways. It enhances the transforming growth factor receptor (TGFR) signaling by both abrogating Smurf2-mediated receptor ubiquitination and by promoting the Smurf2-mediated degradation of AMSH (associated molecule with the SH3 domain of STAM), a de-ubiquitinating enzyme that enhances transforming growth factor-beta (TGF-beta) signalling and epidermal growth factor receptor (EGFR) endosomal recycling [, ]. It also acts directly on Smad4 to enhance Smad4 function, and plays a role in prolonged TGF-beta signalling []. Moreover, RNF11 functions as a critical component of the A20 ubiquitin-editing protein complex that negatively regulates tumor necrosis factor (TNF)-mediated nuclear factor (NF)-kappaB activation []. It also interacts with Smad anchor for receptor activation (SARA) and the endosomal sorting complex required for transport (ESCRT)-0 complex, thus participating in the regulation of lysosomal degradation of EGFR []. Furthermore, RNF11 acts as a novel GGA cargo actively participating in regulating the ubiquitination of the GGA protein family []. In addition, RNF11 functions together with TAX1BP1 to target TANK-binding kinase 1 (TBK1)/IkappaB kinase IKKi, and further restricts antiviral signaling and type I interferon (IFN)-beta production []. RNF11 contains an N-terminal PPPY motif that binds WW domain-containing proteins such as AIP4/itch, Nedd4 and Smurf1/2 (SMAD-specific E3 ubiquitin-protein ligase 1/2), and a C-terminal C3H2C3-type RING-H2 finger that functions as a scaffold for the coordinated transfer of ubiquitin to substrate proteins together with the E2 enzymes UbcH527 and Ubc13.
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Protein Coding Gene
MGI:104728 | Caml
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385459 | Socs5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352501 | Bcar3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106403 | Spg21
Type: protein_coding_gene
Organism: mouse, laboratory
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