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Search results 2101 to 2200 out of 2616 for Fgfr1

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Type Details Score
Protein
Q3V3J9
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Publication
10413050 | -
First Author: Abdeen HH
Year: 1999
Journal: Mol Biochem Parasitol
Title: Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen.
Volume: 101
Issue: 1-2
Pages: 149-59
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Publication
16281057 | -
First Author: Huang J
Year: 2005
Journal: EMBO J
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Volume: 24
Issue: 23
Pages: 4018-28
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Publication
14527947 | -
First Author: Sukotjo C
Year: 2003
Journal: J Biol Chem
Title: Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro.
Volume: 278
Issue: 51
Pages: 51527-34
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Publication
7925469 | -
First Author: Van Dam GJ
Year: 1994
Journal: Eur J Biochem
Title: The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit.
Volume: 225
Issue: 1
Pages: 467-82
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Publication
25596749 | -
First Author: Chang CH
Year: 2015
Journal: Oncotarget
Title: Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.
Volume: 6
Issue: 3
Pages: 1478-89
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Protein Domain
IPR046355 | Gab1-4-like
Type: Family
Description: This entry represents GRB2-associated-binding proteins 1-4 (Gab1-4) and similar proteins from animals. Proteins in this family contain one PH domain. GAB1 from humans and its orthologues dos and soc-1 from Drosophila and C. elegans [], respectively, function as adapter proteins that modulate intracellular signalling cascades triggered by activated receptor-type kinases. Gab1 from human plays a role in FGFR1 signalling, is involved in the MET/HGF-signalling pathway and functions as an important upstream regulator in EGF-mediated activation of mTORCs [, ].
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Protein Domain
IPR008555 | SIKE
Type: Family
Description: Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1 []. IKKepsilon and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3).Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke) [, ], and FGFR1 oncogene partner 2, which may be involved in wound healing pathway [].
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Publication
23047985 | J:192116
First Author: Rochester JR
Year: 2012
Journal: Am J Physiol Endocrinol Metab
Title: Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.
Volume: 303
Issue: 12
Pages: E1428-39
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Genotype
Genotype
Symbol: Tg(Pbsn-FGFR1*K656E)#Wmck/? Tg(Pbsn-FGFR2_iiib*)#Ng/?
Background: involves: FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-rtTA)8585Jam/? Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor/?
Background: involves: 129 * C57BL/6 * FVB/N * FVB/NTac
Zygosity: cx
Has Mutant Allele: true
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Protein Coding Gene
MGI:1914362 | Fgf22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1099809 | Fgf10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95517 | Fgf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein Domain
IPR027112 | Neuroplastin
Type: Family
Description: Neuroplastin and basigin are members of the immunoglobulin (Ig) superfamily. They have two Ig domains that project into the extracellular space. They are also present as isoforms containing an additional N-terminal Ig domain. They contain a glutamate (E) at exactly the same position in the transmembrane domain, which may be important for molecular interactions within the membrane region [].Neuroplastin is a probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK []. It may also regulate neurite outgrowth by activating the FGFR1 signaling pathway []. It may play a role in synaptic plasticity [].
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Publication
8619928 | J:42705
First Author: Hecht D
Year: 1995
Journal: Growth Factors
Title: Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4.
Volume: 12
Issue: 3
Pages: 223-33
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Publication
24651014 | J:210815
First Author: Cao Z
Year: 2014
Journal: Cancer Cell
Title: Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.
Volume: 25
Issue: 3
Pages: 350-65
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Publication
38781024 | J:351316
 
First Author: Zhang B
Year: 2024
Journal: J Clin Invest
Title: Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts.
Volume: 134
Issue: 14
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Publication
35580611 | J:334141
First Author: Oberkersch RE
Year: 2022
Journal: Dev Cell
Title: Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.
Volume: 57
Issue: 10
Pages: 1241-1256.e8
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Publication
21761482 | J:174195
First Author: Saarimäki-Vire J
Year: 2011
Journal: Dev Dyn
Title: Analysis of Cdh22 expression and function in the developing mouse brain.
Volume: 240
Issue: 8
Pages: 1989-2001
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Publication
30840894 | J:284216
First Author: Geng L
Year: 2019
Journal: Cell Rep
Title: Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.
Volume: 26
Issue: 10
Pages: 2738-2752.e4
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Publication
33937726 | J:306813
First Author: Fu Z
Year: 2021
Journal: iScience
Title: Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration.
Volume: 24
Issue: 4
Pages: 102376
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Publication
8612679 | J:32444
First Author: Pizette S
Year: 1996
Journal: Exp Cell Res
Title: FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells.
Volume: 224
Issue: 1
Pages: 143-51
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Publication
20932831 | J:165523
First Author: Browaeys-Poly E
Year: 2010
Journal: FEBS Lett
Title: Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.
Volume: 584
Issue: 21
Pages: 4383-8
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Publication
22941188 | J:190016
First Author: Peifer M
Year: 2012
Journal: Nat Genet
Title: Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Volume: 44
Issue: 10
Pages: 1104-10
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Publication
36930718 | J:334294
First Author: Eichner LJ
Year: 2023
Journal: Sci Adv
Title: HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer.
Volume: 9
Issue: 11
Pages: eadd3243
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Publication
28232668 | J:350102
 
First Author: Yu Y
Year: 2017
Journal: Nat Commun
Title: Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity.
Volume: 8
Pages: 14364
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Publication
21306635 | -
 
First Author: Riazuddin S
Year: 2011
Journal: BMC Med Genet
Title: Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome.
Volume: 12
Pages: 21
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Publication
7923352 | J:20551
First Author: Hébert JM
Year: 1994
Journal: Cell
Title: FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations.
Volume: 78
Issue: 6
Pages: 1017-25
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Publication
12713572 | J:83352
First Author: Cho YM
Year: 2003
Journal: J Invest Dermatol
Title: Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition.
Volume: 120
Issue: 5
Pages: 715-27
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Protein Domain
IPR028240 | FGF5
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 5 (FGF5). This protein plays an important role in the regulation of cell proliferation and cell differentiation. It is required for normal regulation of the hair growth cycle, as it functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen, the apoptosis-induced regression phase [, ]. FGF5 has a high affinity for FGFR1 and FGFR2 [].
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Protein Domain
IPR028232 | FGF3
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 3 (FGF3), also known as heparin-binding growth factor 3 and INT-2 proto-oncogene protein. The protein plays an important role in the regulation of embryonic development, cell proliferation and differentiation, and is required for normal ear development [, ]. FGF3 has a high affinity for FGFR3 and FGFR2, but a low affinity for FGFR1 [].
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Protein Coding Gene
MGI:1100860 | Frs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277980 | Fgf18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104723 | Fgf9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202401 | Fgf17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95515 | Fgf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99604 | Fgf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97615 | Plcg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95516 | Fgf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95519 | Fgf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95520 | Fgf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891427 | Fgf23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95518 | Fgf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891346 | Fgf20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q0VG15
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
D3YWD4
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
A0A7U3L698
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P35235
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Publication
10629055 | -
First Author: Ong SH
Year: 2000
Journal: Mol Cell Biol
Title: FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Volume: 20
Issue: 3
Pages: 979-89
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Publication
7537362 | -
First Author: Karlsson T
Year: 1995
Journal: Oncogene
Title: Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Volume: 10
Issue: 8
Pages: 1475-83
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Publication
10759566 | -
First Author: Smalla KH
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses.
Volume: 97
Issue: 8
Pages: 4327-32
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Publication
16925595 | -
First Author: Empson RM
Year: 2006
Journal: J Neurochem
Title: The cell adhesion molecule neuroplastin-65 inhibits hippocampal long-term potentiation via a mitogen-activated protein kinase p38-dependent reduction in surface expression of GluR1-containing glutamate receptors.
Volume: 99
Issue: 3
Pages: 850-60
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Publication
19952283 | -
First Author: Owczarek S
Year: 2010
Journal: FASEB J
Title: Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.
Volume: 24
Issue: 4
Pages: 1139-50
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Publication
11030354 | -
First Author: Schlessinger J
Year: 2000
Journal: Mol Cell
Title: Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Volume: 6
Issue: 3
Pages: 743-50
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Publication
2162671 | -
First Author: Itoh N
Year: 1990
Journal: Biochem Biophys Res Commun
Title: The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
Volume: 169
Issue: 2
Pages: 680-5
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Publication
17360555 | -
First Author: Riley BM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Impaired FGF signaling contributes to cleft lip and palate.
Volume: 104
Issue: 11
Pages: 4512-7
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Publication
21331089 | -
First Author: Dixon MJ
Year: 2011
Journal: Nat Rev Genet
Title: Cleft lip and palate: understanding genetic and environmental influences.
Volume: 12
Issue: 3
Pages: 167-78
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Protein Domain
IPR028174 | FGF_rcpt_1
Type: Domain
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].The FGFRs consist of an extracellular ligand-binding domain composed of three immunoglobulin-like domains (D1-D3), a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity []. The three immunoglobin(Ig)-like domains, D1, D2, and D3, present a stretch of acidic amino acids (known as the acid box) between D1 and D2. This acid box can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. FGFR family members differ from one another in their ligandaffinities and tissue distribution [, ]. Most FGFs can bind to several different FGFR subtypes. Indeed, FGF1 is sometimes referred to as the universal ligand, as it is capable of activating all of the different FGFRs []. However, there are some exceptions. For example, FGF7 only interacts with FGFR2 []and FGF18 was recently shown to only activate FGFR3 []. Fibroblast growth factor receptor 1 (FGFR1) binds both acidic and basic fibroblast growth factors and is involved in limb induction []. FGFR1 has been shown to be associated with Pfeiffer syndrome [], and cleft lip and/or palate [, ]. Fibroblast growth factor receptor 1 has been shown to interact with growth factor receptor-bound protein 14 (GRB14) [], Src homology 2 domain containing adaptor protein B (SHB) [], fibroblast growth factor receptor substrate 2 (FRS2)[]and fibroblast growth factor 1 (FGF1) [, ].This entry represents the catalytic domain of FGFR1.
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Publication
10366448 | J:55618
First Author: Still IH
Year: 1999
Journal: Genomics
Title: The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.
Volume: 58
Issue: 2
Pages: 165-70
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Publication
15142971 | J:91055
First Author: Kelly OG
Year: 2004
Journal: Development
Title: The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.
Volume: 131
Issue: 12
Pages: 2803-15
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Publication
21561999 | J:175280
First Author: Gattineni J
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.
Volume: 301
Issue: 2
Pages: F371-7
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Publication
18186042 | J:132070
First Author: Kwiatkowski BA
Year: 2008
Journal: J Cell Physiol
Title: FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation.
Volume: 215
Issue: 3
Pages: 803-17
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Publication
1630810 | J:1682
First Author: Dumont DJ
Year: 1992
Journal: Oncogene
Title: tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.
Volume: 7
Issue: 8
Pages: 1471-80
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Publication
11134040 | J:68797
First Author: Shimizu A
Year: 2001
Journal: J Biol Chem
Title: A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells.
Volume: 276
Issue: 14
Pages: 11031-40
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Publication
22174314 | J:183639
First Author: Wu AL
Year: 2011
Journal: Sci Transl Med
Title: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Volume: 3
Issue: 113
Pages: 113ra126
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Publication
38301966 | J:345705
 
First Author: Tang Q
Year: 2024
Journal: Biochem Pharmacol
Title: FGF1(ΔHBS) ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
Volume: 221
Pages: 116039
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Publication
28970581 | J:256510
First Author: Riuzzi F
Year: 2017
Journal: Sci Rep
Title: Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy.
Volume: 7
Issue: 1
Pages: 12537
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Publication
20554971 | J:164507
First Author: Agerstam H
Year: 2010
Journal: Blood
Title: Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.
Volume: 116
Issue: 12
Pages: 2103-11
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Publication
26517696 | J:229400
First Author: Chen PY
Year: 2015
Journal: J Clin Invest
Title: Endothelial-to-mesenchymal transition drives atherosclerosis progression.
Volume: 125
Issue: 12
Pages: 4514-28
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Publication
22361116 | J:181837
 
First Author: Jürgenson M
Year: 2012
Journal: Brain Res
Title: Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-related behaviour without cognitive impairment.
Volume: 1447
Pages: 106-18
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Publication
23443925 | J:196066
First Author: Touchberry CD
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy.
Volume: 304
Issue: 8
Pages: E863-73
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Publication
30144364 | J:322111
First Author: Burt PM
Year: 2019
Journal: J Cell Physiol
Title: Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Volume: 234
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