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Search results 2101 to 2200 out of 2223 for Gata4

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:7610754 | B6;129S4-Gata4<tm2.1(cre/ERT2)Ykaw>/Rbrc
Attribute String: mutant stock, targeted mutation
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Strain
MGI:7610755 | B6;129S4-Gata4<tm1.1Ykaw>/Rbrc
Attribute String: mutant stock, targeted mutation
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GXD Expression
GXD Expression
Probe: MGI:5689407
Assay Type: Immunohistochemistry
Annotation Date: 2024-05-10
Strength: Present
Sex: Male
Emaps: EMAPS:2910624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7628675
Age: embryonic day 16.5
Image: 3B ScAttrxKO
Note: Widespread expresssion in Sertoli cells with regular-sized Gata4 foci (5.8%); localized expression in 43.7%. Expresssion in all G2/M arrested Sertoli cells with giant Gata4 foci (51% localized and 48.3% localized).
Specimen Label: 3B ScAttrxKO
Detected: true
Specimen Num: 2
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Publication
13587873 | J:13012
First Author: HUMMEL KP
Year: 1958
Journal: J Exp Zool
Title: The inheritance and expression of disorganization, an unusual mutation in the mouse.
Volume: 137
Issue: 3
Pages: 389-423
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Publication
8488837 | J:39902
First Author: Crosby JL
Year: 1993
Journal: Am J Hum Genet
Title: Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation.
Volume: 52
Issue: 5
Pages: 866-74
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Publication
8244336 | J:144170
First Author: Robin NH
Year: 1993
Journal: Hum Genet
Title: Human malformations similar to those in the mouse mutation disorganization (Ds).
Volume: 92
Issue: 5
Pages: 461-4
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Publication
11471156 | J:70218
First Author: Robin NH
Year: 2001
Journal: Am J Med Genet
Title: Disorganization in mice and humans.
Volume: 101
Issue: 4
Pages: 334-8
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Publication
1498039 | J:1477
First Author: Crosby JL
Year: 1992
Journal: Mech Dev
Title: Disorganization is a completely dominant gain-of-function mouse mutation causing sporadic developmental defects.
Volume: 37
Issue: 3
Pages: 121-6
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Publication
13613883 | J:2436
First Author: HUMMEL KP
Year: 1959
Journal: Pediatrics
Title: Developmental anomalies in mice resulting from action of the gene, disorganization, a semi-dominant lethal.
Volume: 23
Issue: 1 Part 2
Pages: 212-21
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Publication
- | J:145146
 
First Author: Hummel KP
Year: 1955
Journal: Mouse News Lett
Title: Disorganization (Ds)
Volume: 12
Pages: 29
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Publication
- | J:334481
     
First Author: Brihn LE
Year: 2008
Journal: PhD Thesis - Case Western Reserve University
Title: Positional Cloning of the Disorganization Mutation
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Publication
8741929 | J:147482
First Author: Teebi AS
Year: 1996
Journal: Am J Med Genet
Title: Another case of the human homologue of the mouse mutant disorganization.
Volume: 61
Issue: 1
Pages: 94
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Publication
- | J:15079
 
First Author: Guenet JL
Year: 1976
Journal: Mouse News Lett
Title: The fate of Ds homozygotes
Volume: 54
Pages: 51
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Publication
17300661 | J:147481
First Author: Hivnor CM
Year: 2007
Journal: Pediatr Dermatol
Title: What syndrome is this? Disorganization syndrome.
Volume: 24
Issue: 1
Pages: 90-2
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Publication
9415470 | J:44298
First Author: Robin NH
Year: 1997
Journal: Am J Med Genet
Title: Disorganization in mice and humans and its relation to sporadic birth defects.
Volume: 73
Issue: 4
Pages: 425-36
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Allele
Gata4<tm2(Gata4)Wtp> | MGI:3801683
Name: GATA binding protein 4; targeted mutation 2, William T Pu
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(Gata4*G2-lacZ)1Blk | MGI:4356300
Name: transgene insertion 1, Brian L Black
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Myh6-Gata4)1Jmol | MGI:4399083
Name: transgene insertion 1, Jeffery D Molkentin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5657824 | STOCK Tg(Myh6/tetO-Gata4)1Jmol/J
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Ds/Ds<+>
Background: involves: 129T1/Sv * DA/Hu * DBA/1J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ds/Ds
Background: involves: 129T1/Sv * C3H/HeJ * DA/Hu * DBA/1J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ds/Ds
Background: involves: 129T1/Sv * DA/Hu * DBA/1J
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE92352 | GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis (1 of 3)
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:4462056 | STOCK Gata4<tm2(Gata4)Wtp>/Mmjax
Attribute String: mutant stock, targeted mutation
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Allele
Tg(Gata4*G4-cre)1Blk | MGI:4840244
Name: transgene insertion 1, Brian L Black
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Gata4*G2-cre)#Roja | MGI:5805214
Name: transgene insertion, Anabel Rojas
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Swhtr<tm1.1Phg> | MGI:7565401
Name: sweetheart long non-coding RNA; targeted mutation 1.1, Phillip Grote
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
7904557 | J:15282
First Author: Lints TJ
Year: 1993
Journal: Development
Title: Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Volume: 119
Issue: 2
Pages: 419-31
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Publication
7690144 | J:14414
First Author: Komuro I
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
Volume: 90
Issue: 17
Pages: 8145-9
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Publication
26897459 | J:231297
First Author: Furtado MB
Year: 2016
Journal: Differentiation
Title: A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.
Volume: 91
Issue: 1-3
Pages: 29-41
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Publication
19546853 | J:151895
First Author: Takeda M
Year: 2009
Journal: Lab Invest
Title: Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.
Volume: 89
Issue: 9
Pages: 983-93
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Publication
14607454 | -
First Author: McElhinney DB
Year: 2003
Journal: J Am Coll Cardiol
Title: NKX2.5 mutations in patients with congenital heart disease.
Volume: 42
Issue: 9
Pages: 1650-5
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Publication
9651244 | -
First Author: Schott JJ
Year: 1998
Journal: Science
Title: Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Volume: 281
Issue: 5373
Pages: 108-11
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Publication
26679770 | -
First Author: Ellesøe SG
Year: 2016
Journal: Congenit Heart Dis
Title: Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature.
Volume: 11
Issue: 3
Pages: 283-90
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Protein Domain
IPR033629 | NKX-2.5
Type: Family
Description: Homeobox genes play fundamental roles in specifying cell fate and positional identity in embryos. Homeobox gene Csx/Nkx2.5, one of the vertebrate homologues of Drosophila tinman, is expressed in the precardiac mesoderm and in the myocardium of the embryonic and adult heart [, ]and is one of the master regulators of cardiac development, homeostasis and disease [, ]. Csx associates with the transcription factor GATA4 and this interaction may regulate a subset of cardiac muscle-specific genes []. Nkx2-5 regulates the gene encoding the Kcnh2 channel [].Mutations of the human Nkx2.5 gene cause congenital heart disease ASD7, characterised by incomplete closure of the wall between the atria [, , ].
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HT Experiment
E-GEOD-77083 | RNA Seq analysis of e12.5 mouse pancreatic buds from control and Pdxcre; Gata4fl/fl;Gata6fl/fl; Tom mice
Series Id: GSE77083
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:2161880 | STOCK Myo5a<d> Ds/J
Attribute String: mutant stock, spontaneous mutation
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Genotype
Genotype
Symbol: Gata4/Gata4<+> Sox2/Sox2<+>
Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
32068311 | J:304944
First Author: Carmona R
Year: 2020
Journal: FASEB J
Title: Epicardial cell lineages and the origin of the coronary endothelium.
Volume: 34
Issue: 4
Pages: 5223-5239
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HT Experiment
E-GEOD-14906 | The Gene Expression Analysis in E12.5 Mouse Hearts with GATA4-FOG2 Interaction Loss
Series Id: GSE14906
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-11314 | Transcription profiling of mouse Gata4ki/ki ovaries reveals ovarian development in mice requires GATA4/FOG2 transcriptional complex
Series Id: GSE11314
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-29485 | Expression data from mouse embryo
Series Id: GSE29485
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
37919291 | J:342171
First Author: Rogala S
Year: 2023
Journal: Nat Commun
Title: The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males.
Volume: 14
Issue: 1
Pages: 7024
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Genotype
Genotype
Symbol: Wt1/Wt1 Tg(Gata4*G2-cre)#Roja/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Swhtr/Swhtr
Background: either: (involves: C57BL/6J) or (involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gata4*G2-cre)#Roja/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4<+> Tg(Myh6-cre)2182Mds/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gata4*G2-cre)#Roja/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
12100886 | J:78226
First Author: Patient RK
Year: 2002
Journal: Curr Opin Genet Dev
Title: The GATA family (vertebrates and invertebrates).
Volume: 12
Issue: 4
Pages: 416-22
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Publication
36653444 | J:333380
First Author: Palmquist-Gomes P
Year: 2023
Journal: Exp Mol Med
Title: Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development.
Volume: 55
Issue: 1
Pages: 228-239
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Genotype
Genotype
Symbol: Gata4/Gata4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE81489 | In fetal testis, SOX9 acts on transcription and splicing of its targets genes through binding to genomic regions with conserved signatures [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-53297 | Adult stem cells in the small intestine are intrinsically programmed with their location-specific function
Series Id: GSE53297
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Publication
34368133 | J:313609
 
First Author: Díaz Del Moral S
Year: 2021
Journal: Front Cell Dev Biol
Title: Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development.
Volume: 9
Pages: 683861
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Publication
17438289 | J:121109
First Author: Fisch S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.
Volume: 104
Issue: 17
Pages: 7074-9
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Publication
25001281 | J:212071
First Author: Fioret BA
Year: 2014
Journal: Cell Rep
Title: Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis.
Volume: 8
Issue: 1
Pages: 229-41
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Publication
17250807 | J:118183
First Author: Colston JT
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload.
Volume: 354
Issue: 2
Pages: 552-8
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Publication
29263149 | J:257507
First Author: Villamayor L
Year: 2018
Journal: Diabetes
Title: GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.
Volume: 67
Issue: 3
Pages: 448-460
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Publication
27721414 | J:242608
 
First Author: Pan X
Year: 2016
Journal: Nat Commun
Title: Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis.
Volume: 7
Pages: 13011
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Publication
28303890 | J:255772
First Author: Ji S
Year: 2017
Journal: Cell Res
Title: Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.
Volume: 27
Issue: 5
Pages: 642-656
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Publication
25145359 | J:315376
First Author: Wu M
Year: 2014
Journal: Cell Res
Title: Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node.
Volume: 24
Issue: 10
Pages: 1201-13
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Publication
26404840 | J:226546
First Author: Kang C
Year: 2015
Journal: Science
Title: The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Volume: 349
Issue: 6255
Pages: aaa5612
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Publication
26942853 | J:333637
First Author: Zhou Y
Year: 2016
Journal: Cell Stem Cell
Title: Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming.
Volume: 18
Issue: 3
Pages: 382-95
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HT Experiment
GSE236859 | FOXL2 interaction with different binding partners regulates the dynamics of granulosa cell differentiation across ovarian development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
20018908 | J:159743
First Author: Saito K
Year: 2010
Journal: Biol Reprod
Title: Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells.
Volume: 82
Issue: 4
Pages: 687-97
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Publication
16873442 | J:114953
First Author: Looyenga BD
Year: 2006
Journal: Mol Endocrinol
Title: Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex.
Volume: 20
Issue: 11
Pages: 2848-63
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Publication
15722554 | J:98721
First Author: Martinez-Ceballos E
Year: 2005
Journal: J Biol Chem
Title: Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal.
Volume: 280
Issue: 16
Pages: 16484-98
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Publication
27585489 | J:263634
 
First Author: Dörner J
Year: 2017
Journal: Mol Cell Endocrinol
Title: GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue.
Volume: 441
Pages: 164-175
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Publication
25196150 | J:216295
First Author: Garnatz AS
Year: 2014
Journal: Dev Biol
Title: FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development.
Volume: 395
Issue: 1
Pages: 50-61
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Publication
11485993 | J:71204
First Author: Rossi JM
Year: 2001
Journal: Genes Dev
Title: Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
Volume: 15
Issue: 15
Pages: 1998-2009
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Publication
33247627 | J:325236
First Author: Cappetta D
Year: 2021
Journal: J Cell Mol Med
Title: Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction.
Volume: 25
Issue: 1
Pages: 217-228
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Publication
15939815 | J:112245
First Author: Tokudome T
Year: 2005
Journal: Circulation
Title: Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides.
Volume: 111
Issue: 23
Pages: 3095-104
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Publication
36322626 | J:333825
First Author: Lorenzana-Carrillo MA
Year: 2022
Journal: Sci Transl Med
Title: TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
Volume: 14
Issue: 669
Pages: eabm3565
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Publication
31735083 | J:302871
First Author: Yamamura S
Year: 2020
Journal: Hypertension
Title: Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.
Volume: 75
Issue: 1
Pages: 98-108
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Publication
22539273 | J:184604
First Author: Silversides DW
Year: 2012
Journal: Dev Dyn
Title: Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage.
Volume: 241
Issue: 7
Pages: 1192-204
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Publication
28401730 | J:243299
First Author: Kim HN
Year: 2017
Journal: Aging Cell
Title: DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.
Volume: 16
Issue: 4
Pages: 693-703
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Publication
25344074 | J:244244
First Author: Nam YJ
Year: 2014
Journal: Development
Title: Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.
Volume: 141
Issue: 22
Pages: 4267-78
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Publication
26160456 | J:233540
First Author: Cannon MV
Year: 2015
Journal: EMBO Mol Med
Title: Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization.
Volume: 7
Issue: 9
Pages: 1229-43
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Publication
25770146 | J:255691
First Author: Zhong L
Year: 2015
Journal: Cardiovasc Res
Title: Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy.
Volume: 106
Issue: 2
Pages: 261-71
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Publication
22706305 | J:190769
First Author: van den Boogaard M
Year: 2012
Journal: J Clin Invest
Title: Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.
Volume: 122
Issue: 7
Pages: 2519-30
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Publication
18771760 | J:140118
First Author: Canzonetta C
Year: 2008
Journal: Am J Hum Genet
Title: DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.
Volume: 83
Issue: 3
Pages: 388-400
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Publication
19652361 | J:152721
First Author: Sundaresan NR
Year: 2009
Journal: J Clin Invest
Title: Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Volume: 119
Issue: 9
Pages: 2758-71
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Publication
32870816 | J:301913
 
First Author: Kim HN
Year: 2020
Journal: JCI Insight
Title: Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence.
Volume: 5
Issue: 19
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Publication
19598113 | J:212308
First Author: Kappen C
Year: 2009
Journal: Int J Dev Biol
Title: Identification of regulatory elements in the Isl1 gene locus.
Volume: 53
Issue: 7
Pages: 935-46
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Publication
25955180 | J:226955
First Author: Witek B
Year: 2015
Journal: PLoS One
Title: Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism.
Volume: 10
Issue: 5
Pages: e0123542
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Publication
25928475 | J:307302
First Author: Pirouz M
Year: 2015
Journal: Cell Cycle
Title: Destabilization of pluripotency in the absence of Mad2l2.
Volume: 14
Issue: 10
Pages: 1596-610
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Publication
35369338 | J:332534
 
First Author: Yan Y
Year: 2022
Journal: Front Cardiovasc Med
Title: Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure.
Volume: 9
Pages: 857049
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Publication
18823970 | J:275182
First Author: Matoba S
Year: 2008
Journal: Dev Biol
Title: Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation.
Volume: 324
Issue: 1
Pages: 76-87
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Publication
27466370 | J:236924
First Author: Yariswamy M
Year: 2016
Journal: J Biol Chem
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