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Search results 2101 to 2200 out of 2462 for Gli3

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Type Details Score
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Allele
Gli3<Xt-J> | MGI:1856276
 
Name: GLI-Kruppel family member GLI3; extra toes Jackson
Allele Type: Spontaneous
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Publication
10433919 | J:56563
First Author: Sasaki H
Year: 1999
Journal: Development
Title: Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.
Volume: 126
Issue: 17
Pages: 3915-24
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Publication
39716738 | J:360072
 
First Author: Basu S
Year: 2024
Journal: Cereb Cortex
Title: Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis.
Volume: 34
Issue: 12
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Interaction Experiment
Quinn ME (2012)
Description: Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C3H * CD-1
Zygosity: hm
Has Mutant Allele: true
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GXD Expression
GXD Expression
Probe: MGI:5009297
Assay Type: RNA in situ
Annotation Date: 2011-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5009298
Age: embryonic day 14.5
Image: 6C
Note: Expression expands medially in the Gli3 mutant forebrain.
Specimen Label: 6C
Detected: true
Specimen Num: 7
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Allele
Bstk | MGI:5308660
 
Name: Belly streak
Allele Type: Radiation induced
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Publication
23026747 | J:188176
First Author: Caparrós-Martín JA
Year: 2013
Journal: Hum Mol Genet
Title: The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.
Volume: 22
Issue: 1
Pages: 124-39
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DO Term
DOID:0060985 | preaxial polydactyly type IV
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Pathway
R-MMU-5610785 | GLI3 is processed to GLI3R by the proteasome
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Interaction Experiment
Wang C (2010)
Description: Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
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Allele
Gli3<tm1Urt> | MGI:2182576
 
Name: GLI-Kruppel family member GLI3; targeted mutation 1, Ulrich Ruther
Allele Type: Targeted
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DO Term
DOID:14761 | Greig cephalopolysyndactyly syndrome
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Genotype
Genotype
Symbol: Bstk/Bstk<+>
Background: involves: C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bstk/Bstk
Background: involves: C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:9248 | Pallister-Hall syndrome
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HT Experiment
GSE93729 | Extensive Functional Redundancy of Mammalian Enhancers [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE178838 | GLI transcriptional repression is inert prior to HH pathway activation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1345643 | Sufu
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9Z0P7
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Allele
Gli3<add> | MGI:1856280
 
Name: GLI-Kruppel family member GLI3; anterior digit pattern deformity
Allele Type: Transgenic
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Protein
D4Q8H8
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A2RRI6
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
D4Q8I4
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Allele
Gli3<Xt> | MGI:1856275
 
Name: GLI-Kruppel family member GLI3; extra toes
Allele Type: Spontaneous
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Strain
MGI:5649603 | (C57BL/6 x SJL-Gli3<add>)F1
Attribute String: F1 hybrid, mutant stock
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Allele
Gli3<TgBR> | MGI:2183948
 
Name: GLI-Kruppel family member GLI3; transgenic insertion
Allele Type: Transgenic
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Allele
Gli2<tm2(Gli3)Blnw> | MGI:4941340
 
Name: GLI-Kruppel family member GLI2; targeted mutation 2, Baolin Wang
Allele Type: Targeted
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Protein
A5A9W4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
A5AA27
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: true
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Protein
A5AA25
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
A5A9W5
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
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Protein
A5A9W3
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Protein
F6UUE3
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
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Protein
A0A1B0GXK7
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Protein
Q8BKI7
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: true
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Protein
Q8K0K3
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: true
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Protein Domain
IPR043359 | GLI-like
Type: Family
Description: This entry includes a group of zinc finger transcription regulators, including GLI1-3 and GLIS1/3 from humans.GLI1-3 are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ].GLIS1/3 play key roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Glis1-3 share a highly homologous zinc finger domain (ZFD) containing five Cys2-His2-type zinc finger (ZF) motifs with members of the Gli and Zic family [].
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Publication
8378770 | -
First Author: Pavletich NP
Year: 1993
Journal: Science
Title: Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
Volume: 261
Issue: 5129
Pages: 1701-7
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Publication
2105456 | -
First Author: Kinzler KW
Year: 1990
Journal: Mol Cell Biol
Title: The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.
Volume: 10
Issue: 2
Pages: 634-42
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Publication
19081070 | -
First Author: Jiang J
Year: 2008
Journal: Dev Cell
Title: Hedgehog signaling in development and cancer.
Volume: 15
Issue: 6
Pages: 801-12
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Publication
19706761 | -
First Author: Lo HW
Year: 2009
Journal: Cancer Res
Title: A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
Volume: 69
Issue: 17
Pages: 6790-8
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Protein Domain
IPR032850 | GLI1
Type: Family
Description: GLI1 (glioma-associated oncogene homologue 1) is a central effector of the Hedgehog (HH) pathway, a pathway that governs many developmental processes []. It is a member of the GLI family of transcription factors, which also includes GLI2 and GLI3 []. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. GLI1 is amplified in a subset of human tumours []. It contains five repeats of a zinc finger DNA-binding motif and binds DNA in a sequence-specific fashion [, ].
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HT Experiment
GSE2808 | Gene expression in the Gli3Xt/Xt Vs wildtype developing limb
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1934950 | Csnk1a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BK63
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Strain
MGI:3579389 | C3H101H-Gli3<Xt>/H
Attribute String: spontaneous mutation, mutant stock
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Allele
Gli2<tm2.1(Gli3)Blnw> | MGI:4941341
 
Name: GLI-Kruppel family member GLI2; targeted mutation 2.1, Baolin Wang
Allele Type: Targeted
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * 129 * C3H/HeH * C57BL/6 * CBA/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: 101/H * 129 * C3H/HeH * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * C3H/HeH * CBA/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: 101 * C3H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101 * C3H
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE164737 | Chromatin remodeling and expression dynamics reveal conserved and species-specific regulation during mouse and chicken limb development [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE169395 | Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and EedcKO Forebrain Transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
E0CX93
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Publication
25171405 | J:214801
First Author: Bordoli MR
Year: 2014
Journal: Cell
Title: A secreted tyrosine kinase acts in the extracellular environment.
Volume: 158
Issue: 5
Pages: 1033-1044
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Protein
F6YRX3
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Publication
26270962 | -
First Author: Vitorino M
Year: 2015
Journal: PLoS One
Title: Xenopus Pkdcc1 and Pkdcc2 Are Two New Tyrosine Kinases Involved in the Regulation of JNK Dependent Wnt/PCP Signaling Pathway.
Volume: 10
Issue: 8
Pages: e0135504
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Publication
25862977 | -
First Author: Sreelatha A
Year: 2015
Journal: Biochim Biophys Acta
Title: The secretory pathway kinases.
Volume: 1854
Issue: 10 Pt B
Pages: 1687-93
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Protein Domain
IPR042983 | PKDCC
Type: Family
Description: PKDCC (also known as vertebrate lonesome kinase, VLK) is a secreted tyrosine kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages []. It contains an N-terminal signal sequence and a divergent C-terminal catalytic protein kinase-like domain that replaces the canonical kinase 'DFG' and 'HRD' motifs with alternate, yet functional residues []. It has been shown to interact with Gli3 to regulate chondrocyte differentiation during mouse long bone development [].In Xenopus, there are two members of the PKDCC family, Pkdcc1 and Pkdcc2. They are involved in the regulation of JNK dependent Wnt/PCP signaling pathway [].
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Allele
Gli2<tm5(GLI3)Alj> | MGI:3032718
Name: GLI-Kruppel family member GLI2; targeted mutation 5, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Gli2<tm5.1(GLI3)Alj> | MGI:3032719
Name: GLI-Kruppel family member GLI2; targeted mutation 5.1, Alexandra L Joyner
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * 129S6/SvEvTac * C3H/HeH * C57BL/6 * CBA/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3 Shh/Shh
Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * CBA/H
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-11063 | Expression data from E11.5 mouse embryonic forelimbs - various mutant conditions or dissected limb domains
Series Id: GSE11063
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-59873 | Genome-wide RNA tomography in the zebrafish embryo
Series Id: GSE59873
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:5495136 | B10.C3-Gli3<Xt-J>/J
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:5651979 | either: (involves: C57BL/6J * C3H) or (involves: C57BL/6J * C3H-Gli3<Xt-J>/+)
Attribute String: mutant strain
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Strain
MGI:2162525 | B6.C3-Gli3<Xt-J>/J
Attribute String: congenic, mutant strain
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: Swiss Webster
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: C3H * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: B6.C3-Gli3/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 129/Sv * C3H/HeJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: 129/Sv * C3H/HeJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 129/Sv * C3H/HeJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C3H/HeJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3<+>
Background: involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: C3H/HeJ * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL/6J * CBA/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3<+>
Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2<+> Gli3/Gli3
Background: involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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