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Search results 2101 to 2200 out of 4141 for Mtor

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:6143076 | C57BL/6N-A<tm1Brd>/a Lamtor5<tm1a(EUCOMM)Hmgu>/BayMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Allele
Lamtor5<tm1e(EUCOMM)Hmgu> | MGI:5425820
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Lamtor4<tm1e(KOMP)Wtsi> | MGI:5444898
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Lamtor2<tm1a(EUCOMM)Hmgu> | MGI:5514568
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Lamtor5<tm1b(EUCOMM)Hmgu> | MGI:5614702
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:5812943 | C57BL/6N-Lamtor5<tm1b(EUCOMM)Hmgu>/Bay
Attribute String: coisogenic, targeted mutation
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Allele
Lamtor1<tm1b(KOMP)Wtsi> | MGI:5635168
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6261192 | C57BL/6N-Lamtor1<tm1b(KOMP)Wtsi>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6260979 | C57BL/6NCrl-Meak7<em3(IMPC)Tcp>/Tcp
Attribute String: coisogenic, targeted mutation
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Allele
Lamtor4<em1(IMPC)Ccpcz> | MGI:6341931
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4; endonuclease-mediated mutation 1, Institute of Molecular Genetics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6407718 | C57BL/6N-Lamtor4<em1(IMPC)Ccpcz>/Ccpcz
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6335809 | C57BL/6NCrl-Lamtor4<em1(IMPC)Ccpcz>/Ph
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Lamtor3<em1(IMPC)Hmgu> | MGI:6441124
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; endonuclease-mediated mutation 1, Helmholtz Zentrum Muenchen GmbH
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7414724 | C57BL/6NCrl-Lamtor3<em1(IMPC)Hmgu>/Ieg
Attribute String: coisogenic
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Strain
MGI:6768265 | C57BL/6JGpt-Lamtor3<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6768264 | C57BL/6JGpt-Lamtor3<em3Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Lamtor5<em1Smoc> | MGI:7290779
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770896 | C57BL/6JSmoc-Lamtor5<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7381789 | C57BL/6JGpt-Lamtor2<em3Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7589956 | C57BL/6J-Lamtor1<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7593057 | C57BL/6J-Lamtor5<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7590060 | C57BL/6J-Lamtor5<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Lamtor3<em1Smoc> | MGI:7626604
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6429097 | C57BL/6JSmoc-Lamtor3<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Lamtor2/Lamtor2
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mlst8/Mlst8
Background: involves: 129S5/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor1/Lamtor1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor1/Lamtor1
Background: C57BL/6N-Lamtor1/Tcp
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor3/Lamtor3
Background: C57BL/6NCrl-Lamtor3/Ieg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor4/Lamtor4
Background: C57BL/6N-Lamtor4/Ccpcz
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5
Background: C57BL/6N-Lamtor5/Bay
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Meak7/Meak7
Background: C57BL/6NCrl-Meak7/Tcp
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
20381137 | J:320089
First Author: Sancak Y
Year: 2010
Journal: Cell
Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Volume: 141
Issue: 2
Pages: 290-303
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Publication
16962653 | J:125618
First Author: Jacinto E
Year: 2006
Journal: Cell
Title: SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Volume: 127
Issue: 1
Pages: 125-37
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Protein
Q8BGP5
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
G3UZT7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
G3UXI2
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Publication
19346248 | -
First Author: Wang L
Year: 2009
Journal: J Biol Chem
Title: Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.
Volume: 284
Issue: 22
Pages: 14693-7
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Genotype
Genotype
Symbol: Lamtor2/Lamtor2 Tg(KRT5-cre)1Tak/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5 Tg(Ins2-cre)25Mgn/?
Background: involves: C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor2/Lamtor2 Tg(Alb1-cre)7Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
36217034 | J:347054
First Author: Zhang CS
Year: 2022
Journal: Nat Metab
Title: The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Volume: 4
Issue: 10
Pages: 1369-1401
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Publication
25484082 | -
First Author: Xiong Y
Year: 2014
Journal: Autophagy
Title: ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.
Volume: 10
Issue: 12
Pages: 2223-38
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Publication
17670836 | -
First Author: Minami K
Year: 2007
Journal: J Virol
Title: Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.
Volume: 81
Issue: 20
Pages: 11106-15
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Publication
17461779 | -
First Author: Pearce LR
Year: 2007
Journal: Biochem J
Title: Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Volume: 405
Issue: 3
Pages: 513-22
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Publication
16278292 | -
First Author: MacMillan D
Year: 2005
Journal: J Cell Sci
Title: In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.
Volume: 118
Issue: Pt 23
Pages: 5443-51
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Publication
15489897 | -
First Author: Aeder SE
Year: 2004
Journal: Oncogene
Title: PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Volume: 23
Issue: 56
Pages: 9062-9
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Publication
20418915 | -
First Author: Sparks CA
Year: 2010
Journal: Oncogene
Title: Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Volume: 29
Issue: 26
Pages: 3733-44
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Publication
12869586 | -
First Author: Inoki K
Year: 2003
Journal: Genes Dev
Title: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Volume: 17
Issue: 15
Pages: 1829-34
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Publication
16098514 | -
First Author: Tee AR
Year: 2005
Journal: FEBS Lett
Title: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
Volume: 579
Issue: 21
Pages: 4763-8
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Publication
26812014 | -
First Author: David-Morrison G
Year: 2016
Journal: Dev Cell
Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
Volume: 36
Issue: 2
Pages: 139-51
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Publication
19129461 | -
First Author: Miyazaki M
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
Volume: 296
Issue: 3
Pages: C583-92
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Strain
MGI:6475834 | C57BL/6JSmoc-Mtor<em1Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Publication
10708602 | J:61077
First Author: Bhartur SG
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Genomic structure of murine Rab11 family members.
Volume: 269
Issue: 2
Pages: 611-7
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Publication
31786107 | -
First Author: Cui X
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens.
Volume: 1864
Issue: 3
Pages: 129496
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Strain
MGI:7571067 | STOCK Lamtor2<tm1.1Lah>/Lamtor2<tm1.2Lah>/Biat
Attribute String: mutant stock, targeted mutation
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Strain
MGI:6344467 | C57BL/6N-A<tm1Brd> Lamtor1<tm1a(KOMP)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6344468 | C57BL/6N-A<tm1Brd> Lamtor1<tm1b(KOMP)Wtsi>/TcpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Lamtor2/Lamtor2 Meox2/Meox2<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor1/Lamtor1<+>
Background: C57BL/6N-Lamtor1/Tcp
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor3/Lamtor3<+>
Background: C57BL/6NCrl-Lamtor3/Ieg
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor4/Lamtor4<+>
Background: C57BL/6N-Lamtor4/Ccpcz
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5<+>
Background: C57BL/6N-Lamtor5/Bay
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lamtor5/Lamtor5<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
19878437 | -
First Author: Choi KC
Year: 2010
Journal: J Neurochem
Title: A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death.
Volume: 112
Issue: 2
Pages: 366-76
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Publication
20054236 | -
First Author: Matthew EM
Year: 2009
Journal: Cell Cycle
Title: The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.
Volume: 8
Issue: 24
Pages: 4168-75
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Publication
16899032 | -
First Author: Hong-Brown LQ
Year: 2006
Journal: Alcohol Clin Exp Res
Title: Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes.
Volume: 30
Issue: 8
Pages: 1297-307
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Publication
20127721 | -
First Author: Hong-Brown LQ
Year: 2010
Journal: J Cell Biochem
Title: Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.
Volume: 109
Issue: 6
Pages: 1172-84
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Publication
29644770 | J:274778
First Author: Hashimoto Y
Year: 2018
Journal: Genes Cells
Title: TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
Volume: 23
Issue: 6
Pages: 418-434
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Publication
24463270 | J:331285
First Author: Boggiatto PM
Year: 2014
Journal: Microbes Infect
Title: Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold.
Volume: 16
Issue: 4
Pages: 328-36
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Publication
20154675 | -
First Author: Qin Y
Year: 2010
Journal: Nat Genet
Title: Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.
Volume: 42
Issue: 3
Pages: 229-33
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Protein Domain
IPR046795 | TMEM127_TM
Type: Domain
Description: Transmembrane protein 127 (TMEM127) modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties [, ]. This entry represents the transmembrane region of this protein and similar animal sequences.
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Protein Coding Gene
MGI:1341870 | Stk11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914855 | Akt1s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103267 | Eif4ebp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60876
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
Q9WTK7
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Publication
19427866 | J:150016
First Author: Waters S
Year: 2009
Journal: FEBS Lett
Title: Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.
Volume: 583
Issue: 12
Pages: 1846-52
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Publication
19995915 | J:160501
First Author: Julien LA
Year: 2010
Journal: Mol Cell Biol
Title: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Volume: 30
Issue: 4
Pages: 908-21
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Protein Coding Gene
MGI:1921620 | Rptor
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31650481 | J:285112
First Author: Dai DF
Year: 2019
Journal: Geroscience
Title: Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure.
Volume: 41
Issue: 6
Pages: 847-860
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Publication
24841562 | J:216883
First Author: Schiefermeier N
Year: 2014
Journal: J Cell Biol
Title: The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.
Volume: 205
Issue: 4
Pages: 525-40
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Publication
19539012 | -
First Author: Stanfel MN
Year: 2009
Journal: Biochim Biophys Acta
Title: The TOR pathway comes of age.
Volume: 1790
Issue: 10
Pages: 1067-74
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Protein Domain
IPR037335 | DEPTOR_DEP_1
Type: Domain
Description: DEP domain-containing mTOR-interacting protein (DEPTOR) is an mTOR inhibitor that plays pivotal roles in the pathogenesis and progression of many tumours [, ].This entry represents the first DEP domain of DEPTOR. Its function is not clear.
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Protein Domain
IPR037336 | DEPTOR_DEP_2
Type: Domain
Description: DEP domain-containing mTOR-interacting protein (DEPTOR) is an mTOR inhibitor that plays pivotal roles in the pathogenesis and progression of many tumours [, ].This entry represents the second DEP domain of DEPTOR. Its function is not clear.
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Protein Domain
IPR015019 | LAMTOR3
Type: Family
Description: Ragulator complex protein LAMTOR3 (for lysosomal adaptor and MAPK and MTOR activator 3) is a regulator of the TOR pathway, which is a signalling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids [].
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Publication
26774477 | -
First Author: Shen K
Year: 2016
Journal: Cell Rep
Title: The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.
Volume: 14
Issue: 3
Pages: 547-559
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Publication
28932123 | -
 
First Author: Hu B
Year: 2017
Journal: Onco Targets Ther
Title: Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.
Volume: 10
Pages: 4379-4391
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Protein Domain
IPR034601 | LAMTOR4
Type: Family
Description: Lamtor4 is a component of the Ragulator complex, a complex that functions as a guanine nucleotide exchange factor for the Rag GTPases that signal amino acid levels to mTORC1. The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues. Lamtor4 is required for mTORC1 activation by amino acids []. The Rag-Ragulator complex also has functions independent of mTOR signaling; RagA and Lamtor4 are essential regulators of lysosomes in microglia [].
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Allele
Tg(CAG-Mtor*)#Atai | MGI:5634713
Name: transgene insertion, Atsu Aiba
Allele Type: Transgenic
Attribute String: Constitutively active, Inducible, Inserted expressed sequence
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Allele
Tg(tetO-Mtor*)#Atai | MGI:5634714
Name: transgene insertion, Atsu Aiba
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(CAG-GFP,-EIF4EBP1*)2969Als | MGI:5896791
Name: transgene insertion 2969, Albert La Spada
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Strain
MGI:5896793 | B6.Cg-Tg(CAG-GFP,-EIF4EBP1*)2969Als/J
Attribute String: congenic, mutant strain, transgenic
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Allele
Gt(ROSA)26Sor<tm1(tTA,tetO-Mtor*D2338A,-IRES-EGFP)Ebm> | MGI:6429840
Name: gene trap ROSA 26, Philippe Soriano; transgene insertion 1, Ernesto Bernal-Mizrachi
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Mtor/Mtor Cnp/Cnp<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
20574055 | -
First Author: Messina V
Year: 2010
Journal: Biol Reprod
Title: Differential contribution of the MTOR and MNK pathways to the regulation of mRNA translation in meiotic and postmeiotic mouse male germ cells.
Volume: 83
Issue: 4
Pages: 607-15
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Publication
23727834 | -
First Author: Cardenas-Rodriguez M
Year: 2013
Journal: Hum Mol Genet
Title: The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
Volume: 22
Issue: 20
Pages: 4031-42
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Publication
26668325 | J:230923
First Author: Finelli MJ
Year: 2016
Journal: J Biol Chem
Title: The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.
Volume: 291
Issue: 6
Pages: 2751-63
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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