| Type |
Details |
Score |
| Publication |
| First Author: |
Louagie E |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. |
| Volume: |
105 |
| Issue: |
34 |
| Pages: |
12319-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kostromina E |
| Year: |
2010 |
| Journal: |
Endocrinology |
| Title: |
Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. |
| Volume: |
151 |
| Issue: |
5 |
| Pages: |
2050-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kostromina E |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Altered islet morphology but normal islet secretory function in vitro in a mouse model with microvascular alterations in the pancreas. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
e71277 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pierreux CE |
| Year: |
2010 |
| Journal: |
Dev Biol |
| Title: |
Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas. |
| Volume: |
347 |
| Issue: |
1 |
| Pages: |
216-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai EP |
| Year: |
2014 |
| Journal: |
Diabetologia |
| Title: |
Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action. |
| Volume: |
57 |
| Issue: |
12 |
| Pages: |
2555-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao X |
| Year: |
2019 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Involvement of the STAT5-cyclin D/CDK4-pRb pathway in β-cell proliferation stimulated by prolactin during pregnancy. |
| Volume: |
316 |
| Issue: |
1 |
| Pages: |
E135-E144 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu Y |
| Year: |
2004 |
| Journal: |
Diabetes |
| Title: |
Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes. |
| Volume: |
53 |
| Issue: |
12 |
| Pages: |
3131-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith TL |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas. |
| Volume: |
113 |
| Issue: |
9 |
| Pages: |
2466-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nilubol N |
| Year: |
2018 |
| Journal: |
J Natl Cancer Inst |
| Title: |
Novel Dual-Action Targeted Nanomedicine in Mice With Metastatic Thyroid Cancer and Pancreatic Neuroendocrine Tumors. |
| Volume: |
110 |
| Issue: |
9 |
| Pages: |
1019-1029 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hancock AS |
| Year: |
2010 |
| Journal: |
Mol Endocrinol |
| Title: |
Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. |
| Volume: |
24 |
| Issue: |
8 |
| Pages: |
1605-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu A |
| Year: |
2015 |
| Journal: |
Diabetologia |
| Title: |
LKB1 couples glucose metabolism to insulin secretion in mice. |
| Volume: |
58 |
| Issue: |
7 |
| Pages: |
1513-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2010 |
| Journal: |
Diabetes |
| Title: |
Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. |
| Volume: |
59 |
| Issue: |
1 |
| Pages: |
143-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2006 |
| Journal: |
Mol Endocrinol |
| Title: |
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. |
| Volume: |
20 |
| Issue: |
8 |
| Pages: |
1853-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu R |
| Year: |
2021 |
| Journal: |
PLoS One |
| Title: |
Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
e0241939 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mellado-Gil J |
| Year: |
2011 |
| Journal: |
Diabetes |
| Title: |
Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. |
| Volume: |
60 |
| Issue: |
2 |
| Pages: |
525-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Demirci C |
| Year: |
2012 |
| Journal: |
Diabetes |
| Title: |
Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus. |
| Volume: |
61 |
| Issue: |
5 |
| Pages: |
1143-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boutant M |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
e30847 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alvarez-Perez JC |
| Year: |
2014 |
| Journal: |
Diabetes |
| Title: |
Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration. |
| Volume: |
63 |
| Issue: |
1 |
| Pages: |
216-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossi M |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo. |
| Volume: |
112 |
| Issue: |
49 |
| Pages: |
E6818-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu EE |
| Year: |
2017 |
| Journal: |
Diabetes |
| Title: |
SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a. |
| Volume: |
66 |
| Issue: |
8 |
| Pages: |
2213-2219 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang R |
| Year: |
2014 |
| Journal: |
Gastroenterology |
| Title: |
Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice. |
| Volume: |
146 |
| Issue: |
4 |
| Pages: |
1097-107 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei T |
| Year: |
2023 |
| Journal: |
Diabetes |
| Title: |
Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice. |
| Volume: |
72 |
| Issue: |
5 |
| Pages: |
599-610 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2012 |
| Journal: |
Diabetes |
| Title: |
Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis. |
| Volume: |
61 |
| Issue: |
12 |
| Pages: |
3189-98 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cdkn2a/Cdkn2a Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: C57BL/6 * CBA * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Smad4/Smad4 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kras/Kras Tg(Pdx1-cre/Esr1*)35.10Dam/? |
| Background: |
involves: 129S4/SvJae * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Kras/Kras Tg(Pdx1-cre/Esr1*)35.10Dam/? |
| Background: |
involves: 129S4/SvJae * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Men1/Men1<+> Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Men1/Men1 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Vhl/Vhl Tg(Pdx1-cre)89.1Dam/? |
| Background: |
either: (involves: 129X1/SvJ * A/J * C57BL/6 * CBA) or (involves: 129X1/SvJ * BALB/c * C57BL/6 * CBA) |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Vhl/Vhl Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Trim33/Trim33 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S2/SvPas * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Myc/Myc Tg(Pdx1-cre)1Herr/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J * CBA/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stat5b/Stat5b Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gnao1/Gnao1 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Met/Met Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Grb10/Grb10 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: 129S/SvEv * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Slc1a2/Slc1a2 Tg(Pdx1-cre)1Heed/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Foxm1/Foxm1 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hmgb1/Hmgb1 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Clec16a/Clec16a Tg(Pdx1-cre)1Herr/? |
| Background: |
involves: C57BL/6 * C57BL/6J * CBA/J * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Senp1/Senp1 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Senp1/Senp1<+> Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prdm1/Prdm1 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Brf1/Brf1 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Rnf2/Rnf2 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sox9/Sox9 Tg(Pdx1-cre)89.1Dam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mettl3/Mettl3 Tg(Pdx1-cre)6Tuv/? |
| Background: |
involves: FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brink C |
| Year: |
2001 |
| Journal: |
Mech Dev |
| Title: |
Pax4 regulatory elements mediate beta cell specific expression in the pancreas. |
| Volume: |
100 |
| Issue: |
1 |
| Pages: |
37-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ashery-Padan R |
| Year: |
2004 |
| Journal: |
Dev Biol |
| Title: |
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. |
| Volume: |
269 |
| Issue: |
2 |
| Pages: |
479-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johansson KA |
| Year: |
2007 |
| Journal: |
Dev Cell |
| Title: |
Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. |
| Volume: |
12 |
| Issue: |
3 |
| Pages: |
457-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao X |
| Year: |
2018 |
| Journal: |
Cell Stem Cell |
| Title: |
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
78-90.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Elhanani O |
| Year: |
2020 |
| Journal: |
Cell Rep |
| Title: |
REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
107591 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nasteska D |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
PDX1LOW MAFALOW β-cells contribute to islet function and insulin release. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
674 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brink C |
| Year: |
2003 |
| Journal: |
Dev Dyn |
| Title: |
DNA sequence motifs conserved in endocrine promoters are essential for Pax4 expression. |
| Volume: |
228 |
| Issue: |
4 |
| Pages: |
617-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baumel-Alterzon S |
| Year: |
2022 |
| Journal: |
Diabetes |
| Title: |
Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation. |
| Volume: |
71 |
| Issue: |
5 |
| Pages: |
989-1011 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Barella LF |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
3385 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chopra DG |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
5629 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iwata TN |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
e78841 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chien CY |
| Year: |
2016 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A. |
| Volume: |
477 |
| Issue: |
4 |
| Pages: |
874-880 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hashimoto H |
| Year: |
2016 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans. |
| Volume: |
478 |
| Issue: |
3 |
| Pages: |
1254-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fai So DH |
| Year: |
2020 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism. |
| Volume: |
518 |
|
| Pages: |
111026 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
245
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christoffersson G |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue. |
| Volume: |
120 |
| Issue: |
23 |
| Pages: |
4653-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang A |
| Year: |
2014 |
| Journal: |
Cancer Discov |
| Title: |
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. |
| Volume: |
4 |
| Issue: |
8 |
| Pages: |
905-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen PY |
| Year: |
2018 |
| Journal: |
Cancer Res |
| Title: |
Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells. |
| Volume: |
78 |
| Issue: |
4 |
| Pages: |
985-1002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murakami T |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Distinctive detection of insulinoma using [18F]FB(ePEG12)12-exendin-4 PET/CT. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
15014 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gesina E |
| Year: |
2004 |
| Journal: |
Diabetes |
| Title: |
Dissecting the role of glucocorticoids on pancreas development. |
| Volume: |
53 |
| Issue: |
9 |
| Pages: |
2322-9 |
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