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Kim H |
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PLoS One |
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Ihermann-Hella A |
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2014 |
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PLoS Genet |
| Title: |
Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. |
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Xu Y |
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J Neurosci |
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Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. |
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Tai G |
| Year: |
2013 |
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Biol Open |
| Title: |
FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. |
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Boivin FJ |
| Year: |
2015 |
| Journal: |
PLoS One |
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Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium. |
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10 |
| Issue: |
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Hemker SL |
| Year: |
2020 |
| Journal: |
FASEB J |
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Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number. |
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Ventéo S |
| Year: |
2019 |
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Cell Rep |
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Neurog2 Deficiency Uncovers a Critical Period of Cell Fate Plasticity and Vulnerability among Neural-Crest-Derived Somatosensory Progenitors. |
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29 |
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2953-2960.e2 |
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Nagy II |
| Year: |
2016 |
| Journal: |
BMC Dev Biol |
| Title: |
Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. |
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Nat Commun |
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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•
•
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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Dev Cell |
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Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. |
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FASEB J |
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Nat Commun |
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ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. |
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J Neurosci |
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Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. |
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PLoS One |
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PLoS Genet |
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e1004081 |
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| UniProt Feature |
| Begin: |
577 |
| Description: |
Phosphotyrosine; by RET and SRC |
| Type: |
modified residue |
| End: |
577 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
576 |
| Description: |
Phosphotyrosine; by RET and SRC |
| Type: |
modified residue |
| End: |
576 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
29 |
| Description: |
Proto-oncogene tyrosine-protein kinase receptor Ret |
| Type: |
chain |
| End: |
1115 |
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Neuron |
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The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. |
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Mao Y |
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Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. |
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EMBO J |
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Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. |
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Hum Mol Genet |
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Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. |
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17 |
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24 |
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Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. |
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D'Autréaux F |
| Year: |
2007 |
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Development |
| Title: |
Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. |
| Volume: |
134 |
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12 |
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Goggolidou P |
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Hum Mol Genet |
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Atmin mediates kidney morphogenesis by modulating Wnt signaling. |
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Lokmane L |
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Development |
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vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. |
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Gay MH |
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BMC Biol |
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Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. |
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2024 |
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Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. |
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Dykes IM |
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Neural Dev |
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Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. |
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Kidney Int |
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Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. |
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Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia. |
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Development |
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Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. |
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RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells. |
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16 |
| Pages: |
5362-73 |
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•
•
•
•
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| Publication |
| First Author: |
Vermeiren S |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. |
| Volume: |
26 |
| Issue: |
12 |
| Pages: |
108364 |
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•
•
•
•
•
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| Publication |
| First Author: |
Weiss AC |
| Year: |
2023 |
| Journal: |
Development |
| Title: |
Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. |
| Volume: |
150 |
| Issue: |
6 |
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•
•
•
•
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| Publication |
| First Author: |
Kettunen P |
| Year: |
2007 |
| Journal: |
Mech Dev |
| Title: |
Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. |
| Volume: |
124 |
| Issue: |
11-12 |
| Pages: |
868-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Law C |
| Year: |
2016 |
| Journal: |
J Neurosci |
| Title: |
Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. |
| Volume: |
36 |
| Issue: |
2 |
| Pages: |
561-76 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Karpinski BA |
| Year: |
2016 |
| Journal: |
Dev Biol |
| Title: |
A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. |
| Volume: |
415 |
| Issue: |
2 |
| Pages: |
228-241 |
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•
•
•
•
•
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| Publication |
| First Author: |
Neirijnck Y |
| Year: |
2018 |
| Journal: |
Kidney Int |
| Title: |
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). |
| Volume: |
93 |
| Issue: |
5 |
| Pages: |
1142-1153 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Osafune K |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. |
| Volume: |
133 |
| Issue: |
1 |
| Pages: |
151-61 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of Ret finger protein-like (RFPL) protein family, which includes RFPL1, RFPL2, RFPL3 and RFPL4. In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex []. The human RFPL1, 2, 3 genes have a role in neocortex development. RFPL1 is a primate-specific target gene of Pax6, a key transcription factor for pancreas, eye and neocortex development; human RFPL1 decreases cell number through its RFPL-defining motif (RDM) and SPRY domains []. The RFPL4 (also known as RFPL4A) gene encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells and interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway []. |
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•
•
•
•
•
|
| Publication |
| First Author: |
Shi M |
| Year: |
2012 |
| Journal: |
J Cell Sci |
| Title: |
Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. |
| Volume: |
125 |
| Issue: |
Pt 18 |
| Pages: |
4320-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen S |
| Year: |
2005 |
| Journal: |
Eur J Neurosci |
| Title: |
A semaphorin code defines subpopulations of spinal motor neurons during mouse development. |
| Volume: |
21 |
| Issue: |
7 |
| Pages: |
1767-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wickramasinghe SR |
| Year: |
2008 |
| Journal: |
Neuron |
| Title: |
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. |
| Volume: |
58 |
| Issue: |
4 |
| Pages: |
532-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Samadi AK |
| Year: |
2010 |
| Journal: |
Surgery |
| Title: |
A novel RET inhibitor with potent efficacy against medullary thyroid cancer in vivo. |
| Volume: |
148 |
| Issue: |
6 |
| Pages: |
1228-36; discussion 1236 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lang D |
| Year: |
2003 |
| Journal: |
Hum Mol Genet |
| Title: |
Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
937-45 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
9
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
266
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ide S |
| Year: |
2018 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. |
| Volume: |
29 |
| Issue: |
12 |
| Pages: |
2795-2808 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hadjab S |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. |
| Volume: |
33 |
| Issue: |
45 |
| Pages: |
17656-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reginensi A |
| Year: |
2013 |
| Journal: |
PLoS Genet |
| Title: |
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. |
| Volume: |
9 |
| Issue: |
3 |
| Pages: |
e1003380 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yan K |
| Year: |
2023 |
| Journal: |
Cereb Cortex |
| Title: |
TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6. |
| Volume: |
33 |
| Issue: |
5 |
| Pages: |
1752-1767 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Catela C |
| Year: |
2022 |
| Journal: |
Elife |
| Title: |
Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. |
| Volume: |
11 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kiyama T |
| Year: |
2018 |
| Journal: |
Mol Neurodegener |
| Title: |
Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oxburgh L |
| Year: |
2004 |
| Journal: |
Development |
| Title: |
TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. |
| Volume: |
131 |
| Issue: |
18 |
| Pages: |
4593-605 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gacem N |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Basta JM |
| Year: |
2014 |
| Journal: |
Development |
| Title: |
Sall1 balances self-renewal and differentiation of renal progenitor cells. |
| Volume: |
141 |
| Issue: |
5 |
| Pages: |
1047-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Q |
| Year: |
2018 |
| Journal: |
Cell Death Dis |
| Title: |
Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Daniel E |
| Year: |
2020 |
| Journal: |
Development |
| Title: |
Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. |
| Volume: |
147 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bibollet-Bahena O |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. |
| Volume: |
12 |
| Issue: |
5 |
| Pages: |
e0177977 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Yates LL |
| Year: |
2010 |
| Journal: |
Hum Mol Genet |
| Title: |
The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. |
| Volume: |
19 |
| Issue: |
23 |
| Pages: |
4663-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ghai R |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. |
| Volume: |
110 |
| Issue: |
8 |
| Pages: |
E643-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Robinson DR |
| Year: |
2000 |
| Journal: |
Oncogene |
| Title: |
The protein tyrosine kinase family of the human genome. |
| Volume: |
19 |
| Issue: |
49 |
| Pages: |
5548-57 |
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•
•
•
•
|