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Search results 2101 to 2200 out of 3140 for Sod1

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Type Details Score
Publication  
First Author: Haidet-Phillips AM
Year: 2013
Journal: Exp Neurol
Title: Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Volume: 250
Pages: 250-9
Publication  
First Author: Yanpallewar S
Year: 2021
Journal: Exp Neurol
Title: Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous.
Volume: 337
Pages: 113576
Publication
First Author: Wang J
Year: 2005
Journal: Hum Mol Genet
Title: Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation.
Volume: 14
Issue: 16
Pages: 2335-47
Publication  
First Author: Ouali Alami N
Year: 2020
Journal: Life Sci Alliance
Title: Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.
Volume: 3
Issue: 11
Publication
First Author: Lemieux N
Year: 1992
Journal: Cytogenet Cell Genet
Title: New gene assignments to rabbit chromosomes; implications for chromosome evolution.
Volume: 61
Issue: 2
Pages: 132-4
Protein Domain
Type: Homologous_superfamily
Description: Superoxide dismutases (SODs) are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide []. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [, ].There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form []. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type. The Cu/Zn form has an immunoglobulin-like β-sandwich fold.Defects in the human SOD1 gene causes familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Cytoplasmic and periplasmic SODs exist as dimers, whereas chloroplastic and extracellular enzymes exist as tetramers. Structural analysis supports the notion of independent functional evolution in prokaryotes (P-class) and eukaryotes (E-class) [, , , , , , , ].
Protein Domain
Type: Domain
Description: Superoxide dismutases (SODs) are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide []. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxidative phosphorylation and photosynthesis. The dismutase enzymes have a very high catalytic efficiency due to the attraction of superoxide to the ions bound at the active site [, ].There are three forms of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types. The Fe and Mn forms are similar in their primary, secondary and tertiary structures, but are distinct from the Cu/Zn form []. Prokaryotes and protists contain Mn, Fe or both types, while most eukaryotic organisms utilise the Cu/Zn type.Defects in the human SOD1 gene causes familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Cytoplasmic and periplasmic SODs exist as dimers, whereas chloroplastic and extracellular enzymes exist as tetramers. Structural analysis supports the notion of independent functional evolution in prokaryotes (P-class) and eukaryotes (E-class) [, , , , , , , ].
Publication
First Author: Beltran S
Year: 2019
Journal: Mol Neurodegener
Title: Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.
Volume: 14
Issue: 1
Pages: 14
Publication
First Author: Pandeya SR
Year: 2021
Journal: PLoS One
Title: Relationships between in vivo surface and ex vivo electrical impedance myography measurements in three different neuromuscular disorder mouse models.
Volume: 16
Issue: 10
Pages: e0259071
Publication
First Author: Heiman-Patterson TD
Year: 2005
Journal: J Neurol Sci
Title: Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS.
Volume: 236
Issue: 1-2
Pages: 1-7
Publication
First Author: Pehar M
Year: 2014
Journal: PLoS One
Title: Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.
Volume: 9
Issue: 7
Pages: e103438
Publication
First Author: Pan L
Year: 2012
Journal: PLoS One
Title: Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice.
Volume: 7
Issue: 3
Pages: e33409
Publication
First Author: Liu JQ
Year: 2004
Journal: J Biol Chem
Title: Reoxygenation-induced constriction in murine coronary arteries: the role of endothelial NADPH oxidase (gp91phox) and intracellular superoxide.
Volume: 279
Issue: 23
Pages: 24493-7
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Henriques A
Year: 2017
Journal: Sci Rep
Title: Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 7
Issue: 1
Pages: 5235
Publication
First Author: Teuling E
Year: 2008
Journal: Hum Mol Genet
Title: A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.
Volume: 17
Issue: 18
Pages: 2849-62
Publication
First Author: Poon HF
Year: 2005
Journal: Free Radic Biol Med
Title: Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Volume: 39
Issue: 4
Pages: 453-62
Publication  
First Author: McIntosh J
Year: 2023
Journal: Front Mol Neurosci
Title: Development of abnormalities at the neuromuscular junction in the SOD1-G93A mouse model of ALS: dysfunction then disruption of postsynaptic structure precede overt motor symptoms.
Volume: 16
Pages: 1169075
Publication
First Author: Tesla R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.
Volume: 109
Issue: 42
Pages: 17016-21
Publication
First Author: Perluigi M
Year: 2005
Journal: Free Radic Biol Med
Title: Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Volume: 38
Issue: 7
Pages: 960-8
Publication  
First Author: Li C
Year: 2019
Journal: Front Mol Neurosci
Title: Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice.
Volume: 12
Pages: 114
Publication
First Author: Storkebaum E
Year: 2005
Journal: Nat Neurosci
Title: Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Volume: 8
Issue: 1
Pages: 85-92
Strain
Attribute String: congenic, mutant strain, transgenic
Publication
First Author: Arbour D
Year: 2015
Journal: J Neurosci
Title: Early and persistent abnormal decoding by glial cells at the neuromuscular junction in an ALS model.
Volume: 35
Issue: 2
Pages: 688-706
Publication
First Author: Gowing G
Year: 2009
Journal: Exp Neurol
Title: Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.
Volume: 220
Issue: 2
Pages: 267-75
Publication
First Author: Nguyen MD
Year: 2004
Journal: J Neurosci
Title: Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.
Volume: 24
Issue: 6
Pages: 1340-9
Publication
First Author: Jeong SY
Year: 2009
Journal: J Neurosci
Title: Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.
Volume: 29
Issue: 3
Pages: 610-9
Publication
First Author: Roy D
Year: 2022
Journal: Neurochem Res
Title: Enhanced Cortical Metabolic Activity in Females and Males of a Slow Progressing Mouse Model of Amyotrophic Lateral Sclerosis.
Volume: 47
Issue: 6
Pages: 1765-1777
Publication  
First Author: Martin LJ
Year: 2014
Journal: Front Cell Neurosci
Title: GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis.
Volume: 8
Pages: 433
Strain
Attribute String: congenic, transgenic
Publication    
First Author: Molendijk J
Year: 2022
Journal: Elife
Title: Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.
Volume: 11
Allele  
Name: trisomy, (16C-tel), 1 Charles J Epstein
Allele Type: Spontaneous
Allele
Name: single-stranded DNA binding protein 3; transgene insertion 1, Hiroshi Sasaki
Allele Type: Transgenic
Attribute String: Hypomorph, Inserted expressed sequence
Allele
Name: transgene insertion 1, Raymond Roos
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Reporter
Strain
Attribute String: transgenic, congenic, mutant strain
Strain
Attribute String: transgenic, mutant strain, coisogenic
Publication  
First Author: Dobrowolny G
Year: 2015
Journal: Front Cell Neurosci
Title: Muscle Expression of SOD1(G93A) Modulates microRNA and mRNA Transcription Pattern Associated with the Myelination Process in the Spinal Cord of Transgenic Mice.
Volume: 9
Pages: 463
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Genotype
Symbol: Tg(SOD1*G86R)M3Jwg/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1)51Yg/Tg(SOD1)51Yg
Background: involves: BALB/c * C57BL/6J * DBA/2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1)69Yg/Tg(SOD1)69Yg
Background: involves: BALB/c * C57BL/6J * DBA/2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(APP)6209Kha/? Tg(SOD1)76Dpr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G93A)G20Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G93A)2Gur/?
Background: involves: C57BL/6 * FVB/N * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G37R)29Dpr/?
Background: involves: C3H/HeJ * C57BL/6 * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G127X)716Mrkl/?
Background: B6JBom.Cg-Tg(SOD1*G127X)716Mrkl
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G127X)832Mrkl/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*G127X)832Mrkl/Tg(SOD1*G127X)832Mrkl
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*A4V)A1073Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-CCS)17Jlel/? Tg(SOD1)2Gur/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*H46R*C111S)QAra/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*H46R*C111S)PAra/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(SOD1*H46R*C111S)PAra/Tg(SOD1*H46R*C111S)PAra
Background: involves: C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Martin LJ
Year: 2019
Journal: Front Neurol
Title: Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes.
Volume: 10
Pages: 635
Publication
First Author: Martineau É
Year: 2020
Journal: J Neurosci
Title: Properties of Glial Cell at the Neuromuscular Junction Are Incompatible with Synaptic Repair in the SOD1G37R ALS Mouse Model.
Volume: 40
Issue: 40
Pages: 7759-7777
Publication
First Author: Martin LJ
Year: 2005
Journal: J Neurosci
Title: Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.
Volume: 25
Issue: 27
Pages: 6449-59
Publication
First Author: Genç B
Year: 2022
Journal: Gene Ther
Title: Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons.
Volume: 29
Issue: 3-4
Pages: 178-192
Publication  
First Author: Starikov L
Year: 2020
Journal: Neuroscience
Title: Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function.
Volume: 450
Pages: 15-28
Publication
First Author: Okuno Y
Year: 2018
Journal: Diabetes
Title: Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression of SREBF1-Mediated Lipogenic Pathway.
Volume: 67
Issue: 6
Pages: 1113-1127
Protein
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
Publication
First Author: Banci L
Year: 2002
Journal: Eur J Biochem
Title: The solution structure of reduced dimeric copper zinc superoxide dismutase. The structural effects of dimerization.
Volume: 269
Issue: 7
Pages: 1905-15
Publication  
First Author: Dzhashiashvili Y
Year: 2019
Journal: Neurobiol Dis
Title: The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS.
Volume: 127
Pages: 527-544
Publication
First Author: Mouton-Liger F
Year: 2011
Journal: J Comp Neurol
Title: PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.
Volume: 519
Issue: 14
Pages: 2779-802
Publication
First Author: DeRubertis FR
Year: 2004
Journal: Diabetes
Title: Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction.
Volume: 53
Issue: 3
Pages: 762-8
Publication
First Author: Sampei K
Year: 2000
Journal: Stroke
Title: Stroke outcome in double-mutant antioxidant transgenic mice.
Volume: 31
Issue: 11
Pages: 2685-91
Publication
First Author: Peviani M
Year: 2007
Journal: Mol Cell Neurosci
Title: Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis.
Volume: 34
Issue: 4
Pages: 592-602
Publication
First Author: Vlug AS
Year: 2005
Journal: Eur J Neurosci
Title: ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation.
Volume: 22
Issue: 8
Pages: 1881-94
Publication
First Author: Dal Canto MC
Year: 1994
Journal: Am J Pathol
Title: Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis.
Volume: 145
Issue: 6
Pages: 1271-9
Publication  
First Author: Wong M
Year: 2013
Journal: Front Cell Neurosci
Title: Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS.
Volume: 7
Pages: 279
Publication
First Author: Liddell JR
Year: 2024
Journal: Mol Neurodegener
Title: Microglial ferroptotic stress causes non-cell autonomous neuronal death.
Volume: 19
Issue: 1
Pages: 14
Strain
Attribute String: chromosome aberration, mutant strain, trisomy
Strain
Attribute String: chromosome aberration, congenic, mutant strain, spontaneous mutation, translocation, trisomy
Strain
Attribute String: Mixed cross
Strain
Attribute String: chromosome aberration, mutant stock, translocation, trisomy
Publication
First Author: Urbano-Gámez JD
Year: 2021
Journal: Mol Brain
Title: Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model.
Volume: 14
Issue: 1
Pages: 84
Publication
First Author: Bala U
Year: 2018
Journal: PLoS One
Title: Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model.
Volume: 13
Issue: 5
Pages: e0197711
Publication
First Author: Guedj F
Year: 2015
Journal: Brain Pathol
Title: Analysis of adult cerebral cortex and hippocampus transcriptomes reveals unique molecular changes in the Ts1Cje mouse model of down syndrome.
Volume: 25
Issue: 1
Pages: 11-23
Publication
First Author: Alves-Sampaio A
Year: 2010
Journal: J Neurosci
Title: NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome.
Volume: 30
Issue: 40
Pages: 13537-48
Publication  
First Author: Andrade-Talavera Y
Year: 2015
Journal: Neurobiol Dis
Title: Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome.
Volume: 82
Pages: 516-525
Publication
First Author: Andrews FH
Year: 2016
Journal: Cell Rep
Title: Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Volume: 16
Issue: 12
Pages: 3195-3207
Publication
First Author: Kurabayashi N
Year: 2013
Journal: Genes Dev
Title: Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.
Volume: 27
Issue: 24
Pages: 2708-21
Publication  
First Author: Shimohata A
Year: 2017
Journal: Exp Neurol
Title: Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Volume: 293
Pages: 1-12
Publication  
First Author: Casañas JJ
Year: 2019
Journal: Mol Cell Neurosci
Title: CPEB1 is overexpressed in neurons derived from Down syndrome IPSCs and in the hippocampus of the mouse model Ts1Cje.
Volume: 95
Pages: 79-85
Publication
First Author: Dauphinot L
Year: 2005
Journal: Hum Mol Genet
Title: The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome.
Volume: 14
Issue: 3
Pages: 373-84
Publication
First Author: Alford KA
Year: 2010
Journal: Blood
Title: Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.
Volume: 115
Issue: 14
Pages: 2928-37
Publication
First Author: Kurabayashi N
Year: 2015
Journal: EMBO Rep
Title: DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model.
Volume: 16
Issue: 11
Pages: 1548-62
Publication
First Author: Guedj F
Year: 2020
Journal: Am J Hum Genet
Title: Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model.
Volume: 107
Issue: 5
Pages: 911-931
Publication
First Author: Ferrés MA
Year: 2016
Journal: PLoS One
Title: Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development.
Volume: 11
Issue: 12
Pages: e0168009
Publication
First Author: Vialard F
Year: 2000
Journal: Brain Res Dev Brain Res
Title: Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.
Volume: 121
Issue: 1
Pages: 73-8
Publication
First Author: Guedj F
Year: 2015
Journal: Am J Med Genet A
Title: The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome.
Volume: 167A
Issue: 9
Pages: 1993-2008
Publication  
First Author: Laffaire J
Year: 2009
Journal: BMC Genomics
Title: Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development.
Volume: 10
Pages: 138
Publication
First Author: Seth EA
Year: 2020
Journal: PLoS One
Title: Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome.
Volume: 15
Issue: 7
Pages: e0236826
Publication
First Author: Siarey RJ
Year: 2005
Journal: Neuropharmacology
Title: Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome.
Volume: 49
Issue: 1
Pages: 122-8
Publication
First Author: Hewitt CA
Year: 2010
Journal: PLoS One
Title: Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome.
Volume: 5
Issue: 7
Pages: e11561
Publication  
First Author: Créau N
Year: 2016
Journal: Brain Res
Title: Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models.
Volume: 1646
Pages: 342-353