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Search results 2201 to 2300 out of 2972 for Ca2

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0.017s

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein
A0A3Q4L326
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: true
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Protein
A0A3Q4EBU5
Organism: Mus musculus/domesticus
Length: 940  
Fragment?: false
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Protein
Z4YKE7
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q8R563
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
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Protein
Z4YKH8
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Z4YKD9
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q9ET74
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: true
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Protein
A2A6I8
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
O35157
Organism: Mus musculus/domesticus
Length: 940  
Fragment?: false
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Protein
Q3UV38
Organism: Mus musculus/domesticus
Length: 797  
Fragment?: true
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Protein
Q61064
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: true
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Protein
A2A6I5
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
A0A1Y7VJC3
Organism: Mus musculus/domesticus
Length: 996  
Fragment?: true
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Protein
A0A1Y7VNC5
Organism: Mus musculus/domesticus
Length: 1979  
Fragment?: false
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Protein
A0A1Y7VIQ3
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Z4YKG3
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Z4YNB2
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
G5E8Y0
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
A2A6J0
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Protein
G3UZ03
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
J3QP61
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
A2A6J1
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
Q91ZJ7
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: true
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Protein
Q6PCQ6
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
A0A0R4J1B1
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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Protein
V9GXH0
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
I6L9E6
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
G3X9J1
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
Q4FJL9
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Publication
18824526 | -
First Author: Gibbs GM
Year: 2008
Journal: Endocr Rev
Title: The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
Volume: 29
Issue: 7
Pages: 865-97
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Publication
11850634 | J:74961
First Author: Lembo PM
Year: 2002
Journal: Nat Neurosci
Title: Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.
Volume: 5
Issue: 3
Pages: 201-9
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Publication
12915402 | -
First Author: Robas N
Year: 2003
Journal: J Biol Chem
Title: MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Volume: 278
Issue: 45
Pages: 44400-4
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Publication
15862286 | -
 
First Author: Yang S
Year: 2005
Journal: Gene
Title: Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Volume: 352
Pages: 30-5
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Publication
15823563 | -
First Author: Kamohara M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides.
Volume: 330
Issue: 4
Pages: 1146-52
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Publication
24847877 | -
First Author: Schauder CM
Year: 2014
Journal: Nature
Title: Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.
Volume: 510
Issue: 7506
Pages: 552-5
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Publication
19285944 | -
First Author: Rodríguez A
Year: 2009
Journal: Mol Cell
Title: A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Volume: 33
Issue: 5
Pages: 616-26
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Protein Domain
IPR014044 | CAP_domain
Type: Domain
Description: The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily proteins are found in a wide range of organisms, including prokaryotes []and non-vertebrate eukaryotes [], The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences []. The Ca2-chelating function []would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how blocks the Ca2 transporting ryanodine receptors. This entry represents the CAP domain common to all members of the CAP superfamily. The CAP domain forms a unique 3 layer α-β-α fold with some, though not all, of the structural elements found in proteases [].
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Protein Domain
IPR014258 | CAP_domain_YkwD-like
Type: Domain
Description: The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily proteins are found in a wide range of organisms, including prokaryotes []and non-vertebrate eukaryotes [], The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences []. The Ca2-chelating function []would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how blocks the Ca2 transporting ryanodine receptors. This entry represents a subgroup of the CAP domains found only in bacteria capable of endospore formation. Proteins containing this domain include YkwD of Bacillus subtilis. This domain is generally found at the C-terminal region of these proteins, while the N-terminal region sometimes contains a domain homologous to the spore coat assembly protein SafA ().
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Protein Domain
IPR027338 | MRGPCRX1/MRGPCRX2
Type: Family
Description: Members of the mas-related receptor family (also known as oncogene-like MAS and mas-related G-protein coupled receptor MRG) have been implicated in the development, regulation and function of nociceptive neurons, specifically in the modulation of pain. Most members are orphaned, with no endogeneous ligand identified. Of the human mas-related GPCRs, four (MRGPRD, MRGPRE, MRGPRF and MRGPRG) are also found in rodents, whereas MRGPRX1, MRGPRX2, MRGPRX3 and MRGPRX4 are found exclusively in primates. Certain rodent MRGs have been reported to respond to adenine []and to RF-amide peptides, including neuropeptide FF [, ], but the relevance of these findings to man is unclear. MRGs are expressed predominantly in small diameter sensory neurons of the dorsal root ganglia, where there is emerging evidence that they may be mediators of histamine-independent itch [, ].This entry represents Mas-related G protein-coupled receptor X1 and X2.Mas-related G protein-coupled receptor X1 (MRGPRX1) is thought to be involved with nociceptor function and development, and in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may potently be activated by enkephalins: BAM22 evokes a large and dose-dependent release of intracellular calcium in cells stably transfected with the receptor []. Mas-related G protein-coupled receptor X2 (MRGPRX2) is thought to be involved with nociceptor function and development, and directly involved in the modulation of pain. The receptor is currently orphaned, no specific endogenous ligand having been identified. However, it may be activated by neuropeptides: stimulation by cortistatin-14 in receptor-expressing cells potently increases intracellular Ca2 [, ]. MRGPRX2 is also thought to be a human PAMP-12 receptor that regulates catecholamine secretion from adrenal glands [].
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Publication
34380034 | J:316945
First Author: Benthall KN
Year: 2021
Journal: Cell Rep
Title: Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning.
Volume: 36
Issue: 6
Pages: 109511
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Publication
29662214 | J:264515
First Author: Albergaria C
Year: 2018
Journal: Nat Neurosci
Title: Locomotor activity modulates associative learning in mouse cerebellum.
Volume: 21
Issue: 5
Pages: 725-735
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Publication
34399854 | J:310473
First Author: Gao FJ
Year: 2021
Journal: Acta Neuropathol Commun
Title: Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.
Volume: 9
Issue: 1
Pages: 137
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Publication
29107517 | J:256111
First Author: Mateo C
Year: 2017
Journal: Neuron
Title: Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State" Connectivity.
Volume: 96
Issue: 4
Pages: 936-948.e3
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Publication
29898392 | J:270677
First Author: Benthall KN
Year: 2018
Journal: Cell Rep
Title: Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1.
Volume: 23
Issue: 11
Pages: 3197-3208
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Publication
33535035 | J:304282
First Author: Balbi M
Year: 2021
Journal: Cell Rep
Title: Gamma frequency activation of inhibitory neurons in the acute phase after stroke attenuates vascular and behavioral dysfunction.
Volume: 34
Issue: 5
Pages: 108696
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Publication
24991961 | J:224118
First Author: Plotkin JL
Year: 2014
Journal: Neuron
Title: Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease.
Volume: 83
Issue: 1
Pages: 178-88
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Publication
28942925 | J:252156
First Author: Wang X
Year: 2017
Journal: Cell
Title: Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills.
Volume: 171
Issue: 2
Pages: 440-455.e14
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Publication
25543142 | J:350648
First Author: Wu YW
Year: 2015
Journal: Cell Rep
Title: Input- and cell-type-specific endocannabinoid-dependent LTD in the striatum.
Volume: 10
Issue: 1
Pages: 75-87
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Publication
32343225 | J:291129
   
First Author: Jackman SL
Year: 2020
Journal: Elife
Title: Cerebellar Purkinje cell activity modulates aggressive behavior.
Volume: 9
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Publication
35579422 | J:343999
   
First Author: Matityahu L
Year: 2022
Journal: Elife
Title: A tonic nicotinic brake controls spike timing in striatal spiny projection neurons.
Volume: 11
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Publication
32169206 | J:292614
First Author: Vecchia D
Year: 2020
Journal: Curr Biol
Title: Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex.
Volume: 30
Issue: 9
Pages: 1589-1599.e10
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Publication
35815934 | J:351506
   
First Author: Oz O
Year: 2022
Journal: Elife
Title: Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons.
Volume: 11
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Publication
17442243 | J:122790
First Author: Arenkiel BR
Year: 2007
Journal: Neuron
Title: In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2.
Volume: 54
Issue: 2
Pages: 205-18
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Publication
33080230 | J:300545
First Author: Brunner C
Year: 2020
Journal: Neuron
Title: A Platform for Brain-wide Volumetric Functional Ultrasound Imaging and Analysis of Circuit Dynamics in Awake Mice.
Volume: 108
Issue: 5
Pages: 861-875.e7
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Publication
35715209 | J:351498
 
First Author: Luis-Islas J
Year: 2022
Journal: eNeuro
Title: Optoception: Perception of Optogenetic Brain Perturbations.
Volume: 9
Issue: 3
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Publication
24473077 | J:207975
 
First Author: Herman AM
Year: 2014
Journal: Elife
Title: Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2.
Volume: 3
Pages: e01481
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Publication
18398684 | J:165249
First Author: Berglund K
Year: 2006
Journal: Brain Cell Biol
Title: Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon.
Volume: 35
Issue: 4-6
Pages: 207-28
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Publication
16387641 | J:165251
First Author: Duebel J
Year: 2006
Journal: Neuron
Title: Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon.
Volume: 49
Issue: 1
Pages: 81-94
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Publication
18850274 | J:165248
First Author: Berglund K
Year: 2008
Journal: Brain Cell Biol
Title: Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon.
Volume: 36
Issue: 1-4
Pages: 101-18
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Publication
24501126 | J:206829
First Author: Rodriguez-Garcia A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: GAP, an aequorin-based fluorescent indicator for imaging Ca2+ in organelles.
Volume: 111
Issue: 7
Pages: 2584-9
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Protein Coding Gene
MGI:109484 | Ywhaz
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913299 | Rogdi
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923036 | Ckap5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107688 | Kif3b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859638 | Pqbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338016 | Bex3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1278336 | Cdkl5
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Gli3<Pdn> | MGI:1856282
Name: GLI-Kruppel family member GLI3; polydactyly Nagoya
Allele Type: Spontaneous
Attribute String: Hypomorph
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Allele
Fyn<tm1Sor> | MGI:1857172
Name: Fyn proto-oncogene; targeted mutation 1, Philippe Soriano
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Lrp8<tm1Her> | MGI:1861964
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 1, Joachim Herz
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Lmx1a<dr-J> | MGI:1888413
 
Name: LIM homeobox transcription factor 1 alpha; dreher Jackson
Allele Type: Spontaneous
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Transgene
MGI:5430361 | Tg(Dyrk1a)189N3Yah
Type: transgene
Organism: mouse, laboratory
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Allele
Ei24<tm1Hzha> | MGI:5475023
Name: etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Epg5<tm1Ygz> | MGI:5505596
Name: ectopic P-granules 5 autophagy tethering factor; targeted mutation 1, Yan G Zhao
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Bicd2<tm1.1Hgrd> | MGI:5618154
Name: BICD cargo adaptor 2; targeted mutation 1.1, Casper Hoogenraad
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Brpf1<tm1c(EUCOMM)Wtsi> | MGI:5705131
Name: bromodomain and PHD finger containing, 1; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Fyn/Fyn
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Tg(Gfap-cre)1Sbk/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tsc1/Tsc1 Tg(Syn1-cre)671Jxm/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Macf1/Macf1 Tg(Nes-cre)1Kln/?
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Dyrk1a)189N3Yah/?
Background: B6.129P2-Tg(Dyrk1a)189N3Yah/Yah
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Eml1/Eml1
Background: C57BL/6N-Eml1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rogdi/Rogdi
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Protein
D3YVR2
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
A0A3B2W3E6
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Publication
14660577 | J:88968
First Author: Whittington DA
Year: 2004
Journal: J Biol Chem
Title: Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
Volume: 279
Issue: 8
Pages: 7223-8
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Publication
11532192 | J:82879
 
First Author: Savinova OV
Year: 2001
Journal: BMC Genet
Title: Intraocular pressure in genetically distinct mice: an update and strain survey.
Volume: 2
Pages: 12
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Publication
31518570 | J:281532
 
First Author: Jaquenod De Giusti C
Year: 2019
Journal: J Mol Cell Cardiol
Title: Carbonic anhydrase II/sodium-proton exchanger 1 metabolon complex in cardiomyopathy of ob-/- type 2 diabetic mice.
Volume: 136
Pages: 53-63
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Publication
16217040 | J:102478
First Author: Leppilampi M
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2.
Volume: 102
Issue: 42
Pages: 15247-52
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Publication
33536341 | J:301986
 
First Author: Barone S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.
Volume: 118
Issue: 6
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Publication
15385584 | J:150397
First Author: Dou H
Year: 2004
Journal: J Histochem Cytochem
Title: Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac.
Volume: 52
Issue: 10
Pages: 1377-84
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Publication
820740 | J:5671
First Author: Davisson MT
Year: 1976
Journal: J Hered
Title: Genes on chromosome 3 of the mouse.
Volume: 67
Issue: 3
Pages: 155-6
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Publication
825106 | J:5719
First Author: Eicher EM
Year: 1976
Journal: Biochem Genet
Title: Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse.
Volume: 14
Issue: 7-8
Pages: 651-60
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Publication
7387621 | J:6331
First Author: Racine RR
Year: 1980
Journal: Biochem Genet
Title: Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis.
Volume: 18
Issue: 1-2
Pages: 185-97
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Publication
3036869 | J:8761
First Author: Heuckeroth RO
Year: 1987
Journal: J Biol Chem
Title: Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein.
Volume: 262
Issue: 20
Pages: 9709-17
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Publication
2451911 | J:9139
First Author: Paul PR
Year: 1987
Journal: Biochem Genet
Title: Analysis of the mouse Amy locus in recombinant inbred mouse strains.
Volume: 25
Issue: 7-8
Pages: 569-79
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Publication
2111277 | J:10513
First Author: Beechey C
Year: 1990
Journal: Genomics
Title: Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8.
Volume: 6
Issue: 4
Pages: 692-6
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Publication
12930737 | J:85408
First Author: Knudsen B
Year: 2003
Journal: Genetics
Title: Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases.
Volume: 164
Issue: 4
Pages: 1261-9
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Publication
12625841 | -
 
First Author: Yeats C
Year: 2003
Journal: BMC Microbiol
Title: New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.
Volume: 3
Pages: 3
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Protein
Q9EQX4
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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