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Search results 2201 to 2300 out of 2657 for Igf2

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Type Details Score
Publication
First Author: Schoenherr CJ
Year: 2003
Journal: Nat Genet
Title: CTCF maintains differential methylation at the Igf2/H19 locus.
Volume: 33
Issue: 1
Pages: 66-9
Publication
First Author: Hur SK
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.
Volume: 113
Issue: 39
Pages: 10938-43
Publication  
First Author: Aykroyd BRL
Year: 2022
Journal: Development
Title: Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse.
Volume: 149
Issue: 1
Publication
First Author: Susiarjo M
Year: 2015
Journal: Endocrinology
Title: Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse.
Volume: 156
Issue: 6
Pages: 2049-58
Publication
First Author: Thorvaldsen JL
Year: 2002
Journal: Mol Cell Biol
Title: Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.
Volume: 22
Issue: 8
Pages: 2450-62
Publication
First Author: Matsuzaki H
Year: 2020
Journal: Epigenetics Chromatin
Title: Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus.
Volume: 13
Issue: 1
Pages: 2
Regulatory Region
Type: imprinting_control_region
Organism: mouse, laboratory
Allele
Name: transgene insertion Ml1, Rama Khokha
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Rr28/Rr28<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rr28/Rr28<+>
Background: involves: 129S1/Sv
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Rr28/Rr28
Background: involves: 129S1/Sv
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Chen KS
Year: 2018
Journal: Genes Dev
Title: Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1.
Volume: 32
Issue: 15-16
Pages: 996-1007
Publication
First Author: Saferali A
Year: 2010
Journal: Mamm Genome
Title: Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12).
Volume: 21
Issue: 7-8
Pages: 377-87
Publication
First Author: Srivastava M
Year: 2003
Journal: J Biol Chem
Title: Imprint control element-mediated secondary methylation imprints at the Igf2/H19 locus.
Volume: 278
Issue: 8
Pages: 5977-83
Regulatory Region
Type: imprinting_control_region
Organism: mouse, laboratory
Publication
First Author: Zhou J
Year: 2019
Journal: Cell Stem Cell
Title: Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development.
Volume: 24
Issue: 2
Pages: 285-298.e5
Publication
First Author: Bergström R
Year: 2010
Journal: J Biol Chem
Title: Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
Volume: 285
Issue: 26
Pages: 19727-37
Publication
First Author: Guibert S
Year: 2012
Journal: Epigenetics
Title: CTCF-binding sites within the H19 ICR differentially regulate local chromatin structures and cis-acting functions.
Volume: 7
Issue: 4
Pages: 361-9
Publication
First Author: Moorehead RA
Year: 2001
Journal: Cell Death Differ
Title: Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice.
Volume: 8
Issue: 1
Pages: 16-29
Publication
First Author: Moorehead RA
Year: 2003
Journal: Oncogene
Title: Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma.
Volume: 22
Issue: 6
Pages: 853-7
Allele
Name: transgene insertion b, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: regulatory region 27; targeted mutation 1.1, Jeffrey R Mann
Allele Type: Targeted
Attribute String: Modified regulatory region
Allele
Name: transgene insertion May, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Theresa, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Tiberius, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Tilly, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Genotype
Symbol: Rr28/Rr28<+> Igf2/Igf2<+>
Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Nielsen J
Year: 1999
Journal: Mol Cell Biol
Title: A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.
Volume: 19
Issue: 2
Pages: 1262-70
Publication
First Author: Suvasini R
Year: 2011
Journal: J Biol Chem
Title: Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.
Volume: 286
Issue: 29
Pages: 25882-90
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3).IGF2BP3 plays an important role in the differentiation process during early embryogenesis. It is known to bind to and repress the translation of IGF2 leader 3 mRNA []. IGF2BP3 also acts as a Glioblastoma-specific proproliferative and proinvasive marker acting through IGF2 resulting in the activation of oncogenic phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways []. IGF2BP3 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.IGF2BP3 belongs to the IGF2BP family (includes IGF2BP1, IGF2BP2, IGF2BP3). They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation [].
Publication
First Author: Martinet C
Year: 2016
Journal: Development
Title: H19 controls reactivation of the imprinted gene network during muscle regeneration.
Volume: 143
Issue: 6
Pages: 962-71
Publication
First Author: Wise TL
Year: 2006
Journal: Cancer Res
Title: Delayed onset of Igf2-induced mammary tumors in Igf2r transgenic mice.
Volume: 66
Issue: 3
Pages: 1327-36
Allele
Name: insulin-like growth factor 2 receptor; targeted mutation 1.1, Randy L Jirtle
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: regulatory region 27; targeted mutation 3.1, Piroska E Szabo
Allele Type: Targeted
Attribute String: Modified regulatory region
Allele
Name: transgene insertion Harold, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Arramis, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion April, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Ayah, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Hector, Andrew Ward
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion c, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion Harry1, Andrew Ward
Allele Type: Transgenic
Attribute String: Modified regulatory region, Null/knockout, Reporter
Genotype
Symbol: Rr28/Rr28<+> Igf2/Igf2<+> Igf2r/Igf2r<+>
Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rr28/Rr28<+> Tg(CRP-TAg)60-3Urt/?
Background: involves: 129S1/Sv * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rr27/Rr27<+>
Background: involves: 129S1/Sv * CAST/Ei * FVB/NJ * Swiss
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Ainscough JF
Year: 2000
Journal: Mech Dev
Title: Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb.
Volume: 91
Issue: 1-2
Pages: 365-8
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: transgene insertion 1, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1a, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1b, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 10a, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 10b, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 18a, Dimitrina D Pravtcheva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion YZ15, Justin Ainscough
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
Allele
Name: transgene insertion YZ8, Justin Ainscough
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: transgene insertion YZ46, Justin Ainscough
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Allele
Name: transgene insertion YZ20, Justin Ainscough
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Allele
Name: transgene insertion YZ17, Justin Ainscough
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Publication
First Author: Antonellis A
Year: 2006
Journal: Hum Mol Genet
Title: Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome.
Volume: 15
Issue: 2
Pages: 259-71
Genotype
Symbol: Igf2r/Igf2r<+>
Background: involves: 129/Sv * BALB/cJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Pilia G
Year: 1996
Journal: Nat Genet
Title: Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.
Volume: 12
Issue: 3
Pages: 241-7
Publication
First Author: Lindsay S
Year: 1997
Journal: J Med Genet
Title: Large scale deletions in the GPC3 gene may account for a minority of cases of Simpson-Golabi-Behmel syndrome.
Volume: 34
Issue: 6
Pages: 480-3
Publication
First Author: Filmus J
Year: 1988
Journal: Mol Cell Biol
Title: Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine.
Volume: 8
Issue: 10
Pages: 4243-9
Protein Domain
Type: Family
Description: Glypicans [, ]are a group of heparan sulphate proteoglycans which are anchored to cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Structurally, these proteins consist of three separate domains:a) A signal sequence;b) An extracellular domain of about 500 residues that contains 12 conserved cysteines probably involved in disulphide bonds and also contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;c) A C-terminal hydrophobic region that is post-translationally removed after formation of the GPI-anchor. Six members (GPC1-6) are known in vertebrates []. GPC3 encodes a putative extracellular proteoglycan, glypican 3 that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. Initial western- and ligand-blotting experiments suggest that glypican 3 forms a complex with insulin-like growth factor 2 (IGF2), and might thereby modulate IGF2 action []. GPC3 gene defects in a wider range of overgrowth disorders []. GPC3 shares a number of features with the GPC1 [].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: transgenic, mutant stock
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: transgenic, mutant stock
Publication
First Author: Wise TL
Year: 1997
Journal: Mol Reprod Dev
Title: Perinatal lethality in H19 enhancers-Igf2 transgenic mice.
Volume: 48
Issue: 2
Pages: 194-207
Publication
First Author: Pravtcheva DD
Year: 1998
Journal: J Exp Zool
Title: Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice.
Volume: 281
Issue: 1
Pages: 43-57
Publication
First Author: Bell JL
Year: 2013
Journal: Cell Mol Life Sci
Title: Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
Volume: 70
Issue: 15
Pages: 2657-75
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Protein Domain
Type: Family
Description: The insulin family of proteins groups together several evolutionarily related active peptides []: these include insulin [, ], relaxin [, ], insect prothoracicotropic hormone (bombyxin) [], insulin-like growth factors (IGF1 and IGF2) [, ], mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related peptides (MIP) and Caenorhabditis elegans insulin-like peptides. The 3D structures of a number of family members have been determined [, , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of 4 cysteines in their A chain, the first of which is linked by a disulphide bond to the third, while the second and fourth are linked by interchain disulphide bonds to cysteines in the B chain. The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGFI expression is regulated by growth hormone and mediates post-natal growth []. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency), an autosomal recessive disorder characterised by growth retardation, sensorineural deafness and mental retardation []. IGF2 appears to be induced by placental lactogen and is thought to play a role in foetal development [].
Publication
First Author: Ishihara K
Year: 2006
Journal: Mol Cell
Title: CTCF-dependent chromatin insulator is linked to epigenetic remodeling.
Volume: 23
Issue: 5
Pages: 733-42
Publication
First Author: Komatsu S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M).
Volume: 267
Issue: 1
Pages: 109-17
Publication
First Author: Kagitani F
Year: 1997
Journal: Nucleic Acids Res
Title: Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse.
Volume: 25
Issue: 17
Pages: 3428-32
Publication
First Author: Walendzik K
Year: 2023
Journal: FASEB J
Title: Dermal white adipose tissue development and metabolism: The role of transcription factor Foxn1.
Volume: 37
Issue: 10
Pages: e23171
Publication
First Author: Vanaja KG
Year: 2018
Journal: Mol Cell
Title: A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network.
Volume: 72
Issue: 1
Pages: 60-70.e3
Publication
First Author: Zhang C
Year: 2020
Journal: Commun Biol
Title: Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.
Volume: 3
Issue: 1
Pages: 210
Publication
First Author: Ouchi Y
Year: 2013
Journal: J Neurosci
Title: Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Volume: 33
Issue: 22
Pages: 9408-19
Publication
First Author: Valdmanis PN
Year: 2018
Journal: Nat Commun
Title: miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression.
Volume: 9
Issue: 1
Pages: 5321
Publication
First Author: Zhai Q
Year: 2022
Journal: iScience
Title: Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.
Volume: 25
Issue: 5
Pages: 104267
Publication
First Author: Killian JK
Year: 2000
Journal: Mol Cell
Title: M6P/IGF2R imprinting evolution in mammals.
Volume: 5
Issue: 4
Pages: 707-16
Publication
First Author: Kalscheuer VM
Year: 1993
Journal: Nat Genet
Title: The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans.
Volume: 5
Issue: 1
Pages: 74-8
Publication
First Author: Tsang P
Year: 1995
Journal: Hum Mol Genet
Title: A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.
Volume: 4
Issue: 9
Pages: 1499-507
Publication
First Author: Miyamoto T
Year: 1996
Journal: Cytogenet Cell Genet
Title: Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).
Volume: 73
Issue: 4
Pages: 312-4
Publication
First Author: Li M
Year: 1998
Journal: Clin Genet
Title: Overgrowth syndromes and genomic imprinting: from mouse to man.
Volume: 53
Issue: 3
Pages: 165-70
Publication
First Author: Müller S
Year: 2020
Journal: Nucleic Acids Res
Title: The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer.
Volume: 48
Issue: 15
Pages: 8576-8590
Publication
First Author: Wylie AA
Year: 2003
Journal: Am J Pathol
Title: Tissue-specific inactivation of murine M6P/IGF2R.
Volume: 162
Issue: 1
Pages: 321-8
Protein
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
Publication
First Author: Woods KA
Year: 1996
Journal: N Engl J Med
Title: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
Volume: 335
Issue: 18
Pages: 1363-7
HT Experiment
Series Id: GSE25965
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress