Type |
Details |
Score |
Publication |
First Author: |
Hirotsune S |
Year: |
1997 |
Journal: |
Genome Res |
Title: |
Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region. |
Volume: |
7 |
Issue: |
6 |
Pages: |
625-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen F |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. |
Volume: |
124 |
Issue: |
2 |
Pages: |
801-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wongsiriroj N |
Year: |
2014 |
Journal: |
J Lipid Res |
Title: |
Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue. |
Volume: |
55 |
Issue: |
1 |
Pages: |
104-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Byrne SM |
Year: |
2010 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. |
Volume: |
298 |
Issue: |
4 |
Pages: |
E862-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macé C |
Year: |
2020 |
Journal: |
Kidney Int |
Title: |
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases. |
Volume: |
97 |
Issue: |
4 |
Pages: |
753-764 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golczak M |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. |
Volume: |
283 |
Issue: |
15 |
Pages: |
9543-54 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ctnnb1/Ctnnb1<+> Hesx1/Hesx1 |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mga/Mga<+> Pou5f1/Pou5f1<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * ICR |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mga/Mga Pou5f1/Pou5f1<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * ICR |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Al-Barghouthi BM |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parker R |
Year: |
2000 |
Journal: |
Biochim Biophys Acta |
Title: |
Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. |
Volume: |
1491 |
Issue: |
1-3 |
Pages: |
369-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smahi A |
Year: |
1994 |
Journal: |
Hum Mol Genet |
Title: |
The gene for the familial form of incontinentia pigmenti (IP2) maps to the distal part of Xq28. |
Volume: |
3 |
Issue: |
2 |
Pages: |
273-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Deimling OH |
Year: |
1986 |
Journal: |
Mouse News Lett |
Title: |
Esterase 18 |
Volume: |
75 |
|
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mejia-Martinez F |
Year: |
2017 |
Journal: |
Genes (Basel) |
Title: |
The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans. |
Volume: |
8 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson DW |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e1004278 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Protein max is a transcription regulator that forms a complex with MYC or MAD []. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. MAX is also a component of the E2F6.com-1 []and MLL1 complexes []. Mutations in the MAX gene are associated with hereditary pheochromocytoma, which is a tumour of the chromaffin tissue of the adrenal medulla or sympathetic paraganglia resulting in hypertension [].This entry also includes Mxl-1 and Mxl-3 from Caenorhabditis elegans. Mxl-1 forms complexes with Mdl1. The Mdl-1:Mxl-1 complex functions in both the insulin signaling and dietary restriction pathways and is involved in the control of lifespan in response to dietary restriction []. Mxl-3 is a transcription factor that modulates the inhibition of lipolysis. It also regulates lipid metabolism during nutritional excess []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Staswick PE |
Year: |
1990 |
Journal: |
Plant Cell |
Title: |
Novel Regulation of Vegetative Storage Protein Genes. |
Volume: |
2 |
Issue: |
1 |
Pages: |
1-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Staswick PE |
Year: |
1994 |
Journal: |
Plant Physiol |
Title: |
Purification of the Major Soybean Leaf Acid Phosphatase That Is Increased by Seed-Pod Removal. |
Volume: |
104 |
Issue: |
1 |
Pages: |
49-57 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
These vegatative storage proteins are close relatives of the plant acid phosphatases () and are limited to members of the Phaseoleae including Glycine max (Soybean) and Phaseolus vulgaris (Kidney bean). These proteins are highly expressed in the leaves of repeatedly depodded plants [, ]. Vegetative storage protein (VSP) differs most strikingly from the acid phosphatases in the lack of the conserved nucleophilic aspartate residue in the N terminus, thus, they should be inactive as phosphatases. This issue was confused by the publication in 1992 of an article claiming activity for the G. max VSP. In 1994 this assertion was refuted by the separation of the activity from the VSP []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain can be found in the MAX gene-associated protein (Mga), which is a dual-specificity transcription factor that contains both a bHLHZip domain and a T-box domain and is able to bind to and regulate transcriptional targets through both E-box sites as well as T-box-binding elements (TBEs) []. MAX gene-associated protein (MGA) is a dual-specificity transcription factor, acting as a repressor or an activator and binding to 5'-AATTTCACACCTAGGTGTGAAATT-3'. MGA regulates genes targeted by MYC-MAX, suppressing transcriptional activation by MYC and inhibiting MYC-dependent cell transformation. MGA binds DNA via a T-Box []. MGA is a component of the MLL1 complex []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Park JS |
Year: |
2007 |
Journal: |
Development |
Title: |
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. |
Volume: |
134 |
Issue: |
13 |
Pages: |
2533-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amengual J |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
STRA6 is critical for cellular vitamin A uptake and homeostasis. |
Volume: |
23 |
Issue: |
20 |
Pages: |
5402-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrow JR |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. |
Volume: |
17 |
Issue: |
3 |
Pages: |
394-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu W |
Year: |
2008 |
Journal: |
Development |
Title: |
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. |
Volume: |
135 |
Issue: |
22 |
Pages: |
3687-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran TH |
Year: |
2010 |
Journal: |
Development |
Title: |
Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development. |
Volume: |
137 |
Issue: |
23 |
Pages: |
3973-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ibarra BA |
Year: |
2021 |
Journal: |
J Dev Biol |
Title: |
Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development. |
Volume: |
9 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ctnnb1/Ctnnb1<+> Hesx1/Hesx1 |
Background: |
involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ctnnb1/Ctnnb1 Hesx1/Hesx1 |
Background: |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Billin AN |
Year: |
2006 |
Journal: |
Curr Top Microbiol Immunol |
Title: |
The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism. |
Volume: |
302 |
|
Pages: |
255-78 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Mlx is a Max-like basic-helix-loop-helix zipper protein that interacts with the Max network of transcription factors [, , ]. Mlx forms a complex with MondoA (also known as MLXIP), and this complex regulates glucose-induced gene expression []. The transcriptional activity of the MondoA-Mlx complex is limited by mTOR-MondoA interaction []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Nili E |
Year: |
2001 |
Journal: |
J Cell Sci |
Title: |
Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). |
Volume: |
114 |
Issue: |
Pt 18 |
Pages: |
3297-307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hallonet M |
Year: |
1998 |
Journal: |
Development |
Title: |
Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. |
Volume: |
125 |
Issue: |
14 |
Pages: |
2599-610 |
|
•
•
•
•
•
|
Publication |
First Author: |
Descargues P |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. |
Volume: |
105 |
Issue: |
7 |
Pages: |
2487-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nabeshima R |
Year: |
2018 |
Journal: |
Elife |
Title: |
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hilton T |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue. |
Volume: |
285 |
Issue: |
15 |
Pages: |
11129-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radlwimmer FB |
Year: |
1997 |
Journal: |
Gene |
Title: |
Cloning and expression of the red visual pigment gene of goat (Capra hircus). |
Volume: |
198 |
Issue: |
1-2 |
Pages: |
211-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lindeman GJ |
Year: |
1994 |
Journal: |
Immunity |
Title: |
B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mouse strain. |
Volume: |
1 |
Issue: |
6 |
Pages: |
517-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
DiNuoscio G |
Year: |
2019 |
Journal: |
Genesis |
Title: |
Wnt/β-catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers. |
Volume: |
57 |
Issue: |
1 |
Pages: |
e23279 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodnough LH |
Year: |
2016 |
Journal: |
Dev Dyn |
Title: |
Twist1 contributes to cranial bone initiation and dermal condensation by maintaining Wnt signaling responsiveness. |
Volume: |
245 |
Issue: |
2 |
Pages: |
144-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheikh BN |
Year: |
2020 |
Journal: |
Nat Cell Biol |
Title: |
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. |
Volume: |
22 |
Issue: |
7 |
Pages: |
828-841 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
532
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hagen G |
Year: |
1985 |
Journal: |
Mol Cell Biol |
Title: |
Rapid induction of selective transcription by auxins. |
Volume: |
5 |
Issue: |
6 |
Pages: |
1197-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Staswick PE |
Year: |
2005 |
Journal: |
Plant Cell |
Title: |
Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid. |
Volume: |
17 |
Issue: |
2 |
Pages: |
616-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okrent RA |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Arabidopsis GH3.12 (PBS3) conjugates amino acids to 4-substituted benzoates and is inhibited by salicylate. |
Volume: |
284 |
Issue: |
15 |
Pages: |
9742-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yadav SR |
Year: |
2011 |
Journal: |
Plant Cell Physiol |
Title: |
Auxin-responsive OsMGH3, a common downstream target of OsMADS1 and OsMADS6, controls rice floret fertility. |
Volume: |
52 |
Issue: |
12 |
Pages: |
2123-35 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
GH3 protein was first isolated from Glycine max (soybean) as an early auxin-responsive gene [, ]. Later, several plant GH3 family proteins have been identified and classified into three groups: group I proteins synthesise JA-amino acid conjugates [], group II proteins produce indole-3-acetic acid (IAA) conjugates [], group III protein are involved in the conjugation of amino acids to 4-substituted benzoate []. This entry also includes proteins from bacteria, fungi and animals. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lepoutre-Lussey C |
Year: |
2016 |
Journal: |
Mol Cell Endocrinol |
Title: |
From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma. |
Volume: |
421 |
|
Pages: |
40-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fejer G |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. |
Volume: |
110 |
Issue: |
24 |
Pages: |
E2191-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho S |
Year: |
2021 |
Journal: |
Mol Cell |
Title: |
mTORC1 promotes cell growth via m6A-dependent mRNA degradation. |
Volume: |
81 |
Issue: |
10 |
Pages: |
2064-2075.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Endoh M |
Year: |
2017 |
Journal: |
Elife |
Title: |
PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson KJ |
Year: |
1992 |
Journal: |
Genomics |
Title: |
Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis. |
Volume: |
14 |
Issue: |
3 |
Pages: |
745-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shapiro DN |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25. |
Volume: |
23 |
Issue: |
1 |
Pages: |
282-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weihua X |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. |
Volume: |
94 |
Issue: |
14 |
Pages: |
7227-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conacci-Sorrell M |
Year: |
2010 |
Journal: |
Cell |
Title: |
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. |
Volume: |
142 |
Issue: |
3 |
Pages: |
480-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yingling J |
Year: |
2003 |
Journal: |
Am J Hum Genet |
Title: |
Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse. |
Volume: |
73 |
Issue: |
3 |
Pages: |
475-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Juriloff DM |
Year: |
2001 |
Journal: |
Teratology |
Title: |
Multifactorial genetics of exencephaly in SELH/Bc mice. |
Volume: |
64 |
Issue: |
4 |
Pages: |
189-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darakhshan F |
Year: |
2006 |
Journal: |
Carcinogenesis |
Title: |
Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. |
Volume: |
27 |
Issue: |
2 |
Pages: |
311-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Binato R |
Year: |
2006 |
Journal: |
Biochem J |
Title: |
SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation. |
Volume: |
393 |
Issue: |
Pt 1 |
Pages: |
141-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rodda SJ |
Year: |
2006 |
Journal: |
Development |
Title: |
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. |
Volume: |
133 |
Issue: |
16 |
Pages: |
3231-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goodnough LH |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e1004152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimes JA |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. |
Volume: |
275 |
Issue: |
13 |
Pages: |
9461-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laherty CD |
Year: |
1998 |
Journal: |
Mol Cell |
Title: |
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. |
Volume: |
2 |
Issue: |
1 |
Pages: |
33-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duong HA |
Year: |
2011 |
Journal: |
Science |
Title: |
A molecular mechanism for circadian clock negative feedback. |
Volume: |
332 |
Issue: |
6036 |
Pages: |
1436-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi X |
Year: |
2012 |
Journal: |
Mol Cell Biochem |
Title: |
Sin3 interacts with Foxk1 and regulates myogenic progenitors. |
Volume: |
366 |
Issue: |
1-2 |
Pages: |
251-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Sin3a is a transcriptional repressor and a homologue of the SIN3 repressor from yeast. Sin3a associates with the strong repressive isoform of Mxi1, a helix-loop-helix leucone zipper that associates with Max to antagonize Myc oncogenic activities []. Unlike Mxi1 and Myc, expression of Sin3a does not vary during development []. Sin3a is a component of several complexes, including the REST-CoREST repressor complex [], the PER complex which maintains circadian rhythm []and the Sin3 HDAC complex []. Sin3a also interacts with FOXK1 to regulate cell cycle progression []. Sin3a has three PAH domains by which it interacts with HCFC1, REST and SAP30 [, ]. |
|
•
•
•
•
•
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