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Search results 2201 to 2300 out of 4141 for Mtor

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Mlst8/Mlst8<+> Pten/Pten<+>
Background: involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
15118098 | J:89950
First Author: Vomastek T
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.
Volume: 101
Issue: 18
Pages: 6981-6
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Protein Coding Gene
MGI:1891343 | Prkag3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2145955 | Prkaa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108411 | Prkag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929183 | Tsc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95541 | Fkbp1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1336185 | Prkab2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1336153 | Prkag2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1336167 | Prkab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99878 | Ppm1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102548 | Tsc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BGM7
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q6PAM0
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
O54950
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q91WG5
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q5EG47
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
P26883
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
P49443
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Protein
Q9R078
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q61037
Organism: Mus musculus/domesticus
Length: 1814  
Fragment?: false
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Protein
Q9EP53
Organism: Mus musculus/domesticus
Length: 1161  
Fragment?: false
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Publication
30808980 | J:275490
First Author: Sakai Y
Year: 2019
Journal: Sci Rep
Title: Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells.
Volume: 9
Issue: 1
Pages: 2799
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HT Experiment
E-GEOD-74893 | Regulation of PERK-eIF2alpha Signaling by Tuberous Sclerosis Complex-1 Controls Homeostasis and Survival of Myelinating Oligodendrocytes
Series Id: GSE74893
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
36526657 | J:332774
First Author: Ang SJ
Year: 2022
Journal: Nat Commun
Title: Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice.
Volume: 13
Issue: 1
Pages: 7792
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Publication
28561066 | J:281251
 
First Author: Bakula D
Year: 2017
Journal: Nat Commun
Title: WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.
Volume: 8
Pages: 15637
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Publication
21317285 | -
First Author: Ho H
Year: 2011
Journal: J Biol Chem
Title: WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.
Volume: 286
Issue: 14
Pages: 12509-23
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Publication
23088497 | -
First Author: Gaugel A
Year: 2012
Journal: J Mol Signal
Title: Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition.
Volume: 7
Issue: 1
Pages: 16
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Publication
17618624 | -
First Author: Proikas-Cezanne T
Year: 2007
Journal: FEBS Lett
Title: Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy.
Volume: 581
Issue: 18
Pages: 3396-404
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Protein Domain
IPR032909 | WIPI1
Type: Family
Description: WIPI1 is a homologue of the yeast Atg18 protein that also contains the multiple WD40 repeat domains, which allows it to bind to phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate [, ]. It plays a role in autophagy and is involved in the MTOR signalling in melanogenesis [, ].
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HT Experiment
GSE38741 | The Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Series Id: E-GEOD-38741
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
32553155 | J:299228
First Author: De Pace R
Year: 2020
Journal: Cell Rep
Title: Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons.
Volume: 31
Issue: 11
Pages: 107775
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Protein Coding Gene
MGI:1918839 | Slc38a9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95304 | Eif4b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098604 | Rragd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915691 | Rraga
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1336173 | Prkaa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858751 | Rragc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97912 | Rheb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3038613 | Rragb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BRK8
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q8BGD6
Organism: Mus musculus/domesticus
Length: 560  
Fragment?: false
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Protein
Q8BGD9
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
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Protein
Q921J2
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q80X95
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
Q99K70
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: false
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Protein
Q7TT45
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
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Protein
Q6NTA4
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
Q9DCJ1
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Publication
26121750 | J:224536
First Author: Tsai S
Year: 2015
Journal: J Clin Invest
Title: Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.
Volume: 125
Issue: 8
Pages: 2952-64
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Protein
F6QK86
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Publication
18172023 | -
First Author: Rinaldi T
Year: 2008
Journal: Mol Biol Cell
Title: Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function.
Volume: 19
Issue: 3
Pages: 1022-31
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Publication
19073596 | -
First Author: Csibi A
Year: 2009
Journal: J Biol Chem
Title: MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines.
Volume: 284
Issue: 7
Pages: 4413-21
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Publication
12881430 | -
First Author: Gatfield D
Year: 2003
Journal: EMBO J
Title: Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways.
Volume: 22
Issue: 15
Pages: 3960-70
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Publication
11331269 | -
First Author: Denning G
Year: 2001
Journal: J Biol Chem
Title: Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.
Volume: 276
Issue: 25
Pages: 22709-14
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Publication
15175154 | -
First Author: Brumbaugh KM
Year: 2004
Journal: Mol Cell
Title: The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.
Volume: 14
Issue: 5
Pages: 585-98
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Publication
15314158 | -
First Author: Grimson A
Year: 2004
Journal: Mol Cell Biol
Title: SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans.
Volume: 24
Issue: 17
Pages: 7483-90
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Publication
22479207 | -
First Author: González-Estévez C
Year: 2012
Journal: PLoS Genet
Title: SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians.
Volume: 8
Issue: 3
Pages: e1002619
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Protein Domain
IPR031559 | SMG1
Type: Family
Description: Serine/threonine-protein kinase SMG1 is a phosphatidylinositol kinase-related protein that acts as an mRNA-surveillance protein and is a key component of nonsense-mediated decay (NMD) [, , , ]. In C.elegans, SMG1 is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in worms []and possibly also in higher eukaryotes.
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Protein Domain
IPR028267 | Pianissimo_N
Type: Domain
Description: The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].This domain is the N-terminal conserved section that may include several individual domains.
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Protein Domain
IPR024969 | Rpn11/EIF3F_C
Type: Domain
Description: This domain is found at the C terminus of many regulatory proteins, including the yeast proteasomal subunit Rpn11 and eukaryotic initiation factor 3 subunit F (eIF3f). The Rpn11 C-terminal domain is necessary for normal mitochondrial morphology and function and is thought to regulate the mitochondrial fission and tubulation processes []. The eIF3f C-terminal domain is critical for proper eIF3f activity in skeletal muscle through its interaction with mTOR (also known as FRAP, RAFT1 or RAPT) [, ].
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Protein Domain
IPR019155 | CLEC16A/TT9_N
Type: Domain
Description: CLEC16A (C-Type Lectin Domain Containing 16A) has an inhibitory role in autophagy, probably by activating the mTOR pathway []. It also has a role in beta-cells as a regulator of mitophagy [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [].This entry represents a domain found at the N terminus of CLEC16A and GFS9/TT9.
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HT Experiment
E-GEOD-39313 | The role of FGF21 in aging and aging-related diseases
Series Id: GSE39313
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE79508 | Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
Series Id: E-GEOD-79508
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE189327 | mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE151742 | Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
25258312 | J:218804
First Author: Agrawal P
Year: 2014
Journal: J Biol Chem
Title: DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells.
Volume: 289
Issue: 46
Pages: 31818-26
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Publication
39280263 | J:358818
 
First Author: Chen L
Year: 2024
Journal: Front Neurosci
Title: Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior.
Volume: 18
Pages: 1461178
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Publication
32720643 | J:293908
   
First Author: Arriola Apelo SI
Year: 2020
Journal: Elife
Title: Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging.
Volume: 9
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Publication
35793635 | J:348604
First Author: Pelgrom LR
Year: 2022
Journal: Cell Rep
Title: mTORC1 signaling in antigen-presenting cells of the skin restrains CD8(+) T cell priming.
Volume: 40
Issue: 1
Pages: 111032
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Publication
26743335 | J:235815
 
First Author: Kim K
Year: 2016
Journal: Nat Commun
Title: mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.
Volume: 7
Pages: 10255
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Publication
25310982 | J:315371
First Author: Norrmén C
Year: 2014
Journal: Cell Rep
Title: mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.
Volume: 9
Issue: 2
Pages: 646-60
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Publication
29614494 | J:339239
First Author: Ding Y
Year: 2018
Journal: Cell Physiol Biochem
Title: DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis.
Volume: 46
Issue: 2
Pages: 520-531
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Publication
32916025 | J:339240
First Author: Li K
Year: 2021
Journal: J Bone Miner Res
Title: DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes.
Volume: 36
Issue: 2
Pages: 400-411
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Publication
31685947 | J:297884
First Author: Chen X
Year: 2020
Journal: Oncogene
Title: DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
Volume: 39
Issue: 7
Pages: 1557-1571
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Publication
22815285 | J:189736
First Author: Tang F
Year: 2012
Journal: J Immunol
Title: A critical role for Rictor in T lymphopoiesis.
Volume: 189
Issue: 4
Pages: 1850-7
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Publication
32125271 | J:359262
   
First Author: McCabe MP
Year: 2020
Journal: Elife
Title: Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission.
Volume: 9
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Tg(CAG-Mtor*)#Atai/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-Mtor*)#Atai/?
Background: involves: C57BL/6 * DBA/2 * ICR
Zygosity: cx
Has Mutant Allele: true
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Publication
24949970 | J:214528
First Author: Soleimanpour SA
Year: 2014
Journal: Cell
Title: The diabetes susceptibility gene Clec16a regulates mitophagy.
Volume: 157
Issue: 7
Pages: 1577-90
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Protein
Q80U30
Organism: Mus musculus/domesticus
Length: 1036  
Fragment?: false
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Protein
H7BXB6
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
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Protein
Z4YLG3
Organism: Mus musculus/domesticus
Length: 1036  
Fragment?: false
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Publication
25116949 | -
First Author: Ichino T
Year: 2014
Journal: Plant J
Title: GFS9/TT9 contributes to intracellular membrane trafficking and flavonoid accumulation in Arabidopsis thaliana.
Volume: 80
Issue: 3
Pages: 410-23
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Publication
14973226 | J:116239
First Author: Saito A
Year: 2004
Journal: J Neurosci
Title: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Volume: 24
Issue: 7
Pages: 1584-93
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Publication
16397181 | J:116422
First Author: Saito A
Year: 2006
Journal: Stroke
Title: Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Volume: 37
Issue: 2
Pages: 513-7
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Protein
E9QKI4
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
E9QKI5
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
D3YWZ1
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
F6R8S6
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
A0A140LHA0
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Publication
18089801 | -
First Author: Masri J
Year: 2007
Journal: Cancer Res
Title: mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor.
Volume: 67
Issue: 24
Pages: 11712-20
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Publication
15155881 | -
First Author: Dill A
Year: 2004
Journal: Plant Cell
Title: The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation.
Volume: 16
Issue: 6
Pages: 1392-405
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Protein Domain
IPR026682 | AKT1S1
Type: Family
Description: Proline-rich AKT1 substrate 1 protein (AKT1S1, PRAS40) is part of the mammalian target of rapamycin complex 1 (mTORC1, contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR), which regulates cell growth and survival in response to nutrient and hormonal signals []. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection [, ].
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Protein Domain
IPR029451 | RICTOR_M
Type: Domain
Description: This domain is found in the more conserved central section of Rictor (rapamycin-insensitive companion of mTOR) that may include several individual domains. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029452 | RICTOR_V
Type: Domain
Description: This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029453 | Rictor_IV
Type: Domain
Description: This entry represents the domain 4 of the Rictor (rapamycin-insensitive companion of mTOR) protein. It is found in the more conserved central section that may include several individual domainsThe mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR039272 | CLEC16A/TT9
Type: Family
Description: CLEC16A (C-Type Lectin Domain Containing 16A) an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation [, ]. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction []. It has an inhibitory role in autophagy, probably by activating the mTOR pathway [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [].
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Protein Domain
IPR045118 | FBXO9/FBXO48
Type: Family
Description: This entry represents a group of F-box only proteins, including FBXO9/48 from animals, Pof7/Hrt3 from yeasts and GID2/SKIP32 from plants.Hrt3 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. FBXO9 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signalling []. GID2 (also known as SLEEPY 1) is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signalling pathway [].
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Protein Domain
IPR045820 | CLEC16A/TT9_C
Type: Domain
Description: This entry represents a domain found at the C terminus of CLEC16A and TT9. CLEC16A (C-Type Lectin Domain Containing 16A) an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation [, ]. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction []. It has an inhibitory role in autophagy, probably by activating the mTOR pathway [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [].
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