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Search results 2201 to 2300 out of 2589 for Pcna

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:6726088
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7516178
Age: embryonic day 15.0
Note: Coexpressed with Phgdh and Pcna in the ventricular border of the IV ventricle.
Specimen Label: 4J/M
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:7444384
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7444407
Age: embryonic day 13.5
Image: 3D/D'
Note: Co-localization with Pcna expression in small fraction of retinal ganglion cells.
Specimen Label: 3D/D'
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:7707814
Assay Type: Immunohistochemistry
Annotation Date: 2024-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7707819
Age: embryonic day 16.5
Note: Coexpressed with Pcna in the mesenchymal cells beneath the inner enamel epithelia.
Specimen Label: S1l/v
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6726088
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7516178
Age: embryonic day 15.0
Note: Coexpressed with Phgdh and Pcna in the ventricular border of the IV ventricle.
Specimen Label: 4J/M
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:5620496
Assay Type: Immunohistochemistry
Annotation Date: 2015-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5620507
Age: embryonic day 15.5
Image: 2A,B
Note: There was no co-label with Pcna in proliferating cells in the ventricular zone.
Specimen Label: 2A,B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6726088
Assay Type: Immunohistochemistry
Annotation Date: 2023-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1779023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7516178
Age: embryonic day 15.0
Note: Coexpressed with Phgdh and Pcna in the ventricular border of the IV ventricle.
Specimen Label: 4J/M
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6360256
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1844428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6360286
Age: postnatal adult
Image: 8B
Note: No co-expressed with Pcna in vomeronasal organ, but expressed in more apical cell layers.
Specimen Label: 8B
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:7707814
Assay Type: Immunohistochemistry
Annotation Date: 2024-08-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7707819
Age: embryonic day 12.5
Note: Coexpressed with Pcna in both the dental epithelium and the underlying mesenchyme.
Specimen Label: S1k/u
Detected: true
Specimen Num: 1
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Publication
15964801 | -
First Author: Bylund GO
Year: 2005
Journal: Mol Cell Biol
Title: Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex.
Volume: 25
Issue: 13
Pages: 5445-55
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Publication
11682605 | -
First Author: Scott M
Year: 2001
Journal: J Cell Sci
Title: UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.
Volume: 114
Issue: Pt 19
Pages: 3455-62
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Publication
11313979 | -
First Author: Yu P
Year: 2001
Journal: Oncogene
Title: p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.
Volume: 20
Issue: 4
Pages: 484-9
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Publication
24209743 | J:205132
First Author: Jun S
Year: 2013
Journal: Cell Rep
Title: PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.
Volume: 5
Issue: 2
Pages: 314-22
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Strain
MGI:5700727 | C57BL/6N-Pclaf<tm1a(EUCOMM)Wtsi>/Wtsi
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6122499 | C57BL/6N-A<tm1Brd> Pclaf<tm1a(EUCOMM)Wtsi>/WtsiPh
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6475962 | C57BL/6JSmoc-Pclaf<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Pclaf/Pclaf
Background: C57BL/6N-Pclaf/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Publication
24055345 | J:204894
First Author: Jung HY
Year: 2013
Journal: Mol Cell
Title: PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.
Volume: 52
Issue: 2
Pages: 193-205
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GXD Expression
GXD Expression
 
Probe: MGI:6453825
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6888384
Age: embryonic day 14.5
Note: Co-expression with Pcna in numerous cells in mesenchymal cell condensation of medial pterygoid process of sphenoid bone.
Specimen Label: 2A/E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2249795
Assay Type: RNA in situ
Annotation Date: 2024-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7593873
Age: embryonic day 18.5
Image: 3E
Note: Dll3 expression overlaps with PCNA immunolabeling in the neuroblast layer. Occasional Dll3+ cells that were not PCNA+ were observed.
Specimen Label: 3E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5431437
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1844428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6360281
Age: postnatal day 5
Image: 8A
Note: Expression in nuclei of vomeronasal organ, co-expressed with Pcna in vomeronasal epithelium, but not in respiratory epithelium.
Specimen Label: 8A
Detected: true
Specimen Num: 15
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Publication
25732820 | -
First Author: Perry JJ
Year: 2015
Journal: Cell Rep
Title: Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.
Volume: 10
Issue: 8
Pages: 1288-96
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Publication
10828065 | -
First Author: Vairapandi M
Year: 2000
Journal: J Biol Chem
Title: Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control.
Volume: 275
Issue: 22
Pages: 16810-9
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Publication
32701997 | -
First Author: Yang C
Year: 2020
Journal: PLoS One
Title: Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers.
Volume: 15
Issue: 7
Pages: e0236291
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Publication
33504653 | J:302046
 
First Author: Lei Q
Year: 2021
Journal: Sci Transl Med
Title: Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration.
Volume: 13
Issue: 578
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Genotype
Genotype
Symbol: Pclaf/Pclaf Trp53/Trp53<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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GO Term
GO:0061860 | DNA clamp unloader activity
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GXD Expression
GXD Expression
Probe: MGI:5703067
Assay Type: Immunohistochemistry
Annotation Date: 2016-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5703075
Age: embryonic day 16.5
Image: 4J
Note: Greatly increased expression in the cortical proliferative zone near the striatopallial angle, primarily in the location of the subventricular zone. These cells were not mitotically active, based on their lack of PCNA expression.
Specimen Label: 4J
Detected: true
Specimen Num: 1
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Allele
Tg(Pcna*K164R)1Mdsc | MGI:3817318
Name: transgene insertion 1, Matthew D Scharff
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein
F6ZKR0
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
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Publication
17108083 | -
First Author: Unk I
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.
Volume: 103
Issue: 48
Pages: 18107-12
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Publication
10924462 | -
First Author: Xiao W
Year: 2000
Journal: Genetics
Title: The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways.
Volume: 155
Issue: 4
Pages: 1633-41
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Publication
23034805 | -
First Author: Parker JL
Year: 2012
Journal: Nucleic Acids Res
Title: A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA.
Volume: 40
Issue: 22
Pages: 11380-8
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Protein Domain
IPR039577 | Rad18
Type: Family
Description: This entry includes Rad18 from eukaryotes. Rad18 is a E3 ubiquitin ligase required for postreplication repair []. In budding yeast, Rad18 forms a heterodimer with Rad6 to monoubiquitinate PCNA at a highly conserved lysine, 'Lys-164' []. In humans, Rad18 associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164' [].
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Protein
E9QA71
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
E9Q6W8
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
E9QAI0
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Publication
9092549 | -
First Author: Uhlmann F
Year: 1997
Journal: J Biol Chem
Title: Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities.
Volume: 272
Issue: 15
Pages: 10058-64
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Publication
16040599 | -
First Author: Kim J
Year: 2005
Journal: Nucleic Acids Res
Title: Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.
Volume: 33
Issue: 13
Pages: 4078-89
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Publication
28894029 | J:248791
 
First Author: Mochizuki AL
Year: 2017
Journal: Mol Cell Biol
Title: PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.
Volume: 37
Issue: 23
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Publication
22153967 | -
First Author: Moldovan GL
Year: 2012
Journal: Mol Cell
Title: Inhibition of homologous recombination by the PCNA-interacting protein PARI.
Volume: 45
Issue: 1
Pages: 75-86
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Protein Domain
IPR038932 | PARPBP
Type: Family
Description: PCNA-interacting partner (also known as PARI) is an antirecombinase. It interacts with PCNA and inhibits homologous recombination []. It also modulates stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress [].
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Protein Domain
IPR022648 | Pr_cel_nuc_antig_N
Type: Domain
Description: Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein []that plays a key role in the control of eukaryotic DNA replication []. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNAreplication []. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes []. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [, ]and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses. The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA [].
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Protein Domain
IPR022649 | Pr_cel_nuc_antig_C
Type: Domain
Description: Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein []that plays a key role in the control of eukaryotic DNA replication []. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNAreplication []. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes []. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [, ]and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses. The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA [].
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Protein Domain
IPR013725 | DNA_replication_fac_RFC1_C
Type: Domain
Description: This is the C-terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [, ].
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Publication
16980295 | -
First Author: Johnson A
Year: 2006
Journal: J Biol Chem
Title: The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading.
Volume: 281
Issue: 46
Pages: 35531-43
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Publication
15210332 | -
 
First Author: Majka J
Year: 2004
Journal: Prog Nucleic Acid Res Mol Biol
Title: The PCNA-RFC families of DNA clamps and clamp loaders.
Volume: 78
Pages: 227-60
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Publication
10702304 | -
First Author: Kelman Z
Year: 2000
Journal: J Biol Chem
Title: A unique organization of the protein subunits of the DNA polymerase clamp loader in the archaeon Methanobacterium thermoautotrophicum deltaH.
Volume: 275
Issue: 10
Pages: 7327-36
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Publication
12384579 | -
First Author: Seybert A
Year: 2002
Journal: Nucleic Acids Res
Title: Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus.
Volume: 30
Issue: 20
Pages: 4329-38
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Protein Domain
IPR023748 | Rep_factor-C_ssu_arc
Type: Family
Description: Replication factor C (RFC) is a multimeric AAA+ protein complex that loads the DNA polymerase processivity clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA using ATP to drive the reaction []. PCNA functions at multiple levels in directing DNA metabolic pathways []. When bound to DNA, PCNA organises various proteins involved in DNA replication, DNA repair, DNA modification, and chromatin modelling.In contrast to eukaryotic RFC, which has been shown to contain five distinct polypeptides, archaeal RFC contains only two types of subunit - large and small. The exact subunit stoichiometry in archaea is unclear. In Methanobacterium thermoautotrophicum, RFC is reported to be a heterohexamer, composed of four small and two large subunits []. In Sulfolobus solfataricus, meanwhile, it is reported to be a heteropentamer of four small subunits and one large [].This entry represents the archaeal RFC small subunit.
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Publication
31586391 | J:282456
First Author: Cheng L
Year: 2019
Journal: Nucleic Acids Res
Title: Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit.
Volume: 47
Issue: 21
Pages: 11114-11131
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Publication
9736714 | -
First Author: Belyavskyi M
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin.
Volume: 95
Issue: 19
Pages: 11205-10
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Protein Domain
IPR007978 | Baculo_ODV-E27
Type: Family
Description: This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 orE27) which appear to act as a multifuntional cyclins during the host cell cycle. The ODV-E27 protein has distinct functional characteristics compared to cellular and viralcyclins. When associated with cdc2, itexhibits cyclin B-like activity; when associated with cdk6, the complex possesses cyclin D-like activity and binds PCNA (proliferating cell nuclear antigen) [].
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Protein Domain
IPR033167 | Nre
Type: Family
Description: This entry represents archaeal Nre proteins. While most archaeal organisms encode only a single Nre protein, some encode two, NreA and NreB.NreA is an archaeal PCNA interacting protein that works together with the UvrABC proteins in repairing DNA damage resulting from exposure to DNA damaging agent MMC. NreA contains a putative PIP motif at its C terminus that is important for its function [].
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Protein Domain
IPR023935 | Rep_factor-C_lsu
Type: Family
Description: These proteins are part of the RFC clamp loader complex, which loads the PCNA sliding clamp onto DNA. The large subunits (RfcL) form a heteromultimer with small subunits (RfcS). Proteins in this entry belong to the activator 1 small subunit family RfcL subfamily.
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Protein Domain
IPR021639 | DNAPolymera_Pol_C
Type: Domain
Description: This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA [].
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Publication
1675981 | J:11272
First Author: Rao VV
Year: 1991
Journal: Cytogenet Cell Genet
Title: Chromosomal localization of the human proliferating cell nuclear antigen (PCNA) gene to or close to 20p12 by in situ hybridization.
Volume: 56
Issue: 3-4
Pages: 169-70
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Protein Domain
IPR022659 | Pr_cel_nuc_antig_CS
Type: Conserved_site
Description: Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein []that plays a key role in the control of eukaryotic DNA replication []. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNAreplication []. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes []. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [, ]and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses. This entry represents two conserved regions located in the N-terminal section. The second one has been proposed to bind DNA.
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Publication
15201901 | -
First Author: Bowman GD
Year: 2004
Journal: Nature
Title: Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex.
Volume: 429
Issue: 6993
Pages: 724-30
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Protein Domain
IPR006978 | Nre_N
Type: Domain
Description: This conserved region is found in the N-terminal region of archaeal Nre proteins. While most archaeal organisms encode only a single Nre protein, some encode two, NreA and NreB. NreA is an archaeal PCNA interacting protein that works together with the UvrABC proteins in repairing DNA damage resulting from exposure to DNA damaging agent MMC. NreA contains a putative PIP motif at its C terminus that is important for its function [].
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Protein Domain
IPR006979 | Nre_C
Type: Domain
Description: This conserved region is found in the C-terminal region of archaeal Nre proteins. While most archaeal organisms encode only a single Nre protein, some encode two, NreA and NreB. NreA is an archaeal PCNA interacting protein that works together with the UvrABC proteins in repairing DNA damage resulting from exposure to DNA damaging agent MMC. NreA contains a putative PIP motif atits C terminus that is important for its function [].
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Protein Domain
IPR013748 | Rep_factorC_C
Type: Domain
Description: This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A [].
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Publication
26337406 | -
First Author: Giroux X
Year: 2016
Journal: Mol Microbiol
Title: A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner.
Volume: 99
Issue: 1
Pages: 1-14
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Genotype
Genotype
Symbol: Pcna/Pcna Tg(Pcna*K164R)1Mdsc/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
15885883 | J:106233
First Author: Fukumasu H
Year: 2006
Journal: Cancer Lett
Title: Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis.
Volume: 233
Issue: 1
Pages: 158-64
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Publication
10908331 | J:69176
First Author: Lechner MS
Year: 2000
Journal: Nucleic Acids Res
Title: PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin.
Volume: 28
Issue: 14
Pages: 2741-51
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Publication
12588986 | J:82319
First Author: Cho EA
Year: 2003
Journal: Mol Cell Biol
Title: BRCT domain-containing protein PTIP is essential for progression through mitosis.
Volume: 23
Issue: 5
Pages: 1666-73
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Publication
17925232 | J:128440
First Author: Patel SR
Year: 2007
Journal: Dev Cell
Title: The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
Volume: 13
Issue: 4
Pages: 580-92
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Publication
26744420 | J:229465
First Author: Starnes LM
Year: 2016
Journal: Genes Dev
Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
Volume: 30
Issue: 2
Pages: 149-63
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Publication
10882068 | -
First Author: Zuccola HJ
Year: 2000
Journal: Mol Cell
Title: The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Volume: 5
Issue: 2
Pages: 267-78
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Publication
9180692 | -
First Author: Kostrub CF
Year: 1997
Journal: Mol Gen Genet
Title: Molecular analysis of hus1+, a fission yeast gene required for S-M and DNA damage checkpoints.
Volume: 254
Issue: 4
Pages: 389-99
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Publication
16633336 | -
First Author: Huang TT
Year: 2006
Journal: Nat Rev Mol Cell Biol
Title: Regulation of DNA repair by ubiquitylation.
Volume: 7
Issue: 5
Pages: 323-34
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Publication
15694335 | -
First Author: Nijman SM
Year: 2005
Journal: Mol Cell
Title: The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Volume: 17
Issue: 3
Pages: 331-9
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Publication
19686080 | -
 
First Author: Moldovan GL
Year: 2009
Journal: Annu Rev Genet
Title: How the fanconi anemia pathway guards the genome.
Volume: 43
Pages: 223-49
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Protein Domain
IPR007150 | Hus1/Mec3
Type: Family
Description: This entry consists of the human Hus1 protein and budding yeast Mec3. They are components of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes [, ]. Hus1, Rad1, and Rad9 (which share homology with Mec1, Rad17, Ddc1 in budding yeast) are three evolutionarily conserved proteins required for checkpoint control. These proteins are known to form a stable complex. Structurally, the Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. Ddc1-Mec3-Rad17 plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].
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Protein Domain
IPR033815 | USP1
Type: Domain
Description: Peptidase C19 contains ubiquitin hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquitinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome [, ].This entry encompasses ubiquitin-specific hydrolase 1 (MEROPS identifier C19.019). It is required for deubiquitination of monoubiquitinated proteins involved in various DNA repair pathways and is a key regulator of DNA repair mechanisms []. Substrates include monoubiquitinated PCNA [], and components FANCD2 []and FANCI []of the Fanconi anemia pathway, a genetic disorder that resultsin the inability to monoubiquitinate these components [].
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Protein Domain
IPR037886 | Paxip1
Type: Family
Description: This entry includes PAX-interacting protein 1 (PTIP or Swift) and chromatin modification-related protein eaf1 (from Aspergillus fumigatus). PTIP is involved in the DNA damage response and is an adaptor protein for the ATM/ATR kinases. PTIP contains five BRCT domains with which it interacts with the activation domain of the transcription factor Pax2 []. Knockout of PTIP prevent ubiquitination of proliferating cell nuclear antigen (PCNA), and monoubiquitination of PCNA enables translesion synthesis by specialized DNA polymerases to replicate damaged DNA []. Cells without PTIP are unable to progress through mitosis []. PTIP is a component of the MLL2/MLL3 complex [], but a PTIP-PA1 subcomplex functions independently of the MLL3/MLL4 complex to mediate transcription during class switch recombination, important for generating antibody diversity []. In Saccharomyces cerevisiae, EAF1 is a component of the NuA4 histone acetyltransferase complex involved in acetylation of nucleosomal histone H4 and H2A [].
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Protein Coding Gene
MGI:97891 | Rfc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443370 | Chtf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8001157 | -
First Author: Krishna TS
Year: 1994
Journal: Cell
Title: Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA.
Volume: 79
Issue: 7
Pages: 1233-43
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Publication
17576694 | J:150999
First Author: Schermelleh L
Year: 2007
Journal: Nucleic Acids Res
Title: Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation.
Volume: 35
Issue: 13
Pages: 4301-12
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Publication
15899793 | J:98544
First Author: Hsu SH
Year: 2005
Journal: Cancer Res
Title: bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.
Volume: 65
Issue: 10
Pages: 4041-50
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Publication
22387026 | J:184478
First Author: Yu Y
Year: 2012
Journal: Mol Cell
Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.
Volume: 46
Issue: 1
Pages: 7-17
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Publication
22036607 | J:224731
First Author: Liu T
Year: 2012
Journal: DNA Repair (Amst)
Title: RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
Volume: 11
Issue: 2
Pages: 131-8
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Publication
1741293 | J:40005
First Author: Gai XX
Year: 1992
Journal: Nucleic Acids Res
Title: Unusual DNA binding characteristics of an in vitro translation product of the CCAAT binding protein mYB-1.
Volume: 20
Issue: 3
Pages: 601-6
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Publication
25620558 | J:219962
First Author: Sarek G
Year: 2015
Journal: Mol Cell
Title: TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
Volume: 57
Issue: 4
Pages: 622-35
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Publication
30576655 | J:269019
First Author: Lim KS
Year: 2018
Journal: Mol Cell
Title: USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Volume: 72
Issue: 6
Pages: 925-941.e4
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Publication
29533773 | J:263866
First Author: Kim MJ
Year: 2018
Journal: Dev Cell
Title: PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.
Volume: 44
Issue: 5
Pages: 582-596.e4
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Publication
15234348 | J:109747
First Author: Menu dit Huart L
Year: 2004
Journal: Mol Cell Neurosci
Title: DNA repair in the degenerating mouse retina.
Volume: 26
Issue: 3
Pages: 441-9
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Publication
16177983 | J:104410
First Author: Wang YL
Year: 2006
Journal: Mol Reprod Dev
Title: Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice.
Volume: 73
Issue: 1
Pages: 40-9
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Publication
11159909 | J:67389
First Author: Wagner M
Year: 2001
Journal: Genes Dev
Title: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.
Volume: 15
Issue: 3
Pages: 286-93
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Publication
17183066 | J:121075
First Author: Kim I
Year: 2007
Journal: Carcinogenesis
Title: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.
Volume: 28
Issue: 5
Pages: 940-6
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Publication
19171122 | J:146133
First Author: Koch KS
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Targeted deletion of hepatocyte Ikkbeta confers growth advantages.
Volume: 380
Issue: 2
Pages: 349-54
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Publication
23159736 | J:194097
First Author: Piatkov KI
Year: 2012
Journal: Mol Cell
Title: The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Volume: 48
Issue: 6
Pages: 926-33
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Publication
24210823 | J:205527
First Author: Békés M
Year: 2013
Journal: Cell Rep
Title: DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.
Volume: 5
Issue: 3
Pages: 826-38
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Publication
18559501 | J:138901
First Author: Larsen E
Year: 2008
Journal: Cancer Res
Title: Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.
Volume: 68
Issue: 12
Pages: 4571-9
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Publication
30217558 | J:269013
First Author: Bellelli R
Year: 2018
Journal: Mol Cell
Title: POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.
Volume: 72
Issue: 1
Pages: 112-126.e5
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Publication
11786919 | J:74392
First Author: Lu H
Year: 2002
Journal: Int J Mol Med
Title: Prevention of development of N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice.
Volume: 9
Issue: 2
Pages: 113-7
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Publication
7936657 | J:21336
First Author: Mosner J
Year: 1994
Journal: Oncogene
Title: p53 and mdm2 are expressed independently during cellular proliferation.
Volume: 9
Issue: 11
Pages: 3321-8
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Publication
7478594 | J:29657
First Author: Kearsey JM
Year: 1995
Journal: Oncogene
Title: Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.
Volume: 11
Issue: 9
Pages: 1675-83
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Publication
9535864 | J:46961
First Author: Kim K
Year: 1998
Journal: J Biol Chem
Title: Involvement of flap endonuclease 1 in base excision DNA repair.
Volume: 273
Issue: 15
Pages: 8842-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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