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Search results 2201 to 2300 out of 3113 for Rac1

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Type Details Score
Publication
26923603 | J:234358
First Author: Goel HL
Year: 2016
Journal: Cell Rep
Title: P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Volume: 14
Issue: 9
Pages: 2193-2208
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Publication
27489999 | J:235617
First Author: Xiang X
Year: 2016
Journal: FEBS Lett
Title: Arhgef1 negatively regulates neurite outgrowth through activation of RhoA signaling pathways.
Volume: 590
Issue: 17
Pages: 2940-55
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Publication
28912124 | J:249300
First Author: Böttcher RT
Year: 2017
Journal: J Cell Biol
Title: Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
Volume: 216
Issue: 11
Pages: 3785-3798
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Publication
28212753 | J:253022
First Author: Hartwig T
Year: 2017
Journal: Mol Cell
Title: The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.
Volume: 65
Issue: 4
Pages: 730-742.e5
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Publication
27040307 | J:248866
 
First Author: Varshney P
Year: 2016
Journal: Mol Cell Endocrinol
Title: P21-activated kinase 2 (PAK2) regulates glucose uptake and insulin sensitivity in neuronal cells.
Volume: 429
Pages: 50-61
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Publication
29396460 | J:257969
First Author: Wang J
Year: 2018
Journal: Nat Commun
Title: Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice.
Volume: 9
Issue: 1
Pages: 477
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Publication
20978238 | J:259315
First Author: Tian D
Year: 2010
Journal: Sci Signal
Title: Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.
Volume: 3
Issue: 145
Pages: ra77
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Publication
29791847 | J:271192
First Author: Tsuchiya M
Year: 2018
Journal: Cell Rep
Title: Neutrophils Provide a Favorable IL-1-Mediated Immunometabolic Niche that Primes GLUT4 Translocation and Performance in Skeletal Muscles.
Volume: 23
Issue: 8
Pages: 2354-2364
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Publication
31216465 | J:288424
First Author: Marcar L
Year: 2019
Journal: Cell Rep
Title: Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity.
Volume: 27
Issue: 12
Pages: 3422-3432.e4
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Publication
33397922 | J:300957
First Author: Pickering KA
Year: 2021
Journal: Nat Commun
Title: A RAC-GEF network critical for early intestinal tumourigenesis.
Volume: 12
Issue: 1
Pages: 56
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Publication
31644919 | J:300701
First Author: Laufer JM
Year: 2019
Journal: Cell Rep
Title: Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation.
Volume: 29
Issue: 4
Pages: 995-1009.e6
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Publication
31801077 | J:300864
First Author: Chu JF
Year: 2019
Journal: Cell Rep
Title: TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1.
Volume: 29
Issue: 10
Pages: 3118-3133.e6
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Publication
33958758 | J:307303
First Author: Park S
Year: 2021
Journal: Nat Cell Biol
Title: Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis.
Volume: 23
Issue: 5
Pages: 476-484
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Publication
26498519 | J:318352
First Author: Wurtzel JG
Year: 2015
Journal: Biochem Biophys Res Commun
Title: RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Volume: 467
Issue: 4
Pages: 785-91
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Publication
36823181 | J:360949
First Author: Zhu H
Year: 2023
Journal: Commun Biol
Title: RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Volume: 6
Issue: 1
Pages: 214
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Protein
B1AUC7
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: false
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Protein
O54834
Organism: Mus musculus/domesticus
Length: 987  
Fragment?: false
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Protein
A0A2X0U4H9
Organism: Mus musculus/domesticus
Length: 976  
Fragment?: true
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Protein
Z4YJK0
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
G3UZI7
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Publication
11780146 | -
First Author: Zhao X
Year: 2002
Journal: Nat Struct Biol
Title: Structure of the Bcr-Abl oncoprotein oligomerization domain.
Volume: 9
Issue: 2
Pages: 117-20
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Publication
17090304 | -
 
First Author: Zheng X
Year: 2006
Journal: BMC Cancer
Title: BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.
Volume: 6
Pages: 262
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Publication
15302586 | -
First Author: Laurent CE
Year: 2004
Journal: Exp Cell Res
Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Volume: 299
Issue: 1
Pages: 188-98
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Publication
11696321 | J:196124
First Author: Krugmann S
Year: 2001
Journal: Curr Biol
Title: Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.
Volume: 11
Issue: 21
Pages: 1645-55
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Publication
19913105 | -
First Author: Ahmed S
Year: 2010
Journal: Semin Cell Dev Biol
Title: I-BAR domains, IRSp53 and filopodium formation.
Volume: 21
Issue: 4
Pages: 350-6
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Publication
23740402 | -
First Author: Ferrari I
Year: 2012
Journal: Commun Integr Biol
Title: LIN7-IRSp53: A novel pathway for filopodia and neurite formation?
Volume: 5
Issue: 6
Pages: 631-3
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Publication
23055941 | J:193640
First Author: Lo JC
Year: 2012
Journal: PLoS Genet
Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Volume: 8
Issue: 10
Pages: e1002969
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Protein Coding Gene
MGI:95602 | Fyn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98923 | Vav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106211 | Cdc42
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339975 | Pak1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96610 | Itgb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P60766
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
P09055
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: false
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Protein
O88643
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
P39688
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
P27870
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3U261
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
Q8CG12
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
14752106 | -
First Author: Yamagishi A
Year: 2004
Journal: J Biol Chem
Title: A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.
Volume: 279
Issue: 15
Pages: 14929-36
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Publication
14980512 | -
First Author: Koh JT
Year: 2004
Journal: Exp Cell Res
Title: Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin.
Volume: 294
Issue: 1
Pages: 172-84
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Publication
17497115 | -
First Author: Machesky LM
Year: 2007
Journal: J Mol Med (Berl)
Title: MIM: a multifunctional scaffold protein.
Volume: 85
Issue: 6
Pages: 569-76
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Publication
17371834 | -
First Author: Mattila PK
Year: 2007
Journal: J Cell Biol
Title: Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.
Volume: 176
Issue: 7
Pages: 953-64
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Publication
19286134 | -
First Author: Weiss SM
Year: 2009
Journal: Cell Host Microbe
Title: IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.
Volume: 5
Issue: 3
Pages: 244-58
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Publication
31225512 | -
First Author: Keller L
Year: 2019
Journal: Cell Stress
Title: Biology and clinical relevance of EpCAM.
Volume: 3
Issue: 6
Pages: 165-180
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Publication
22819673 | J:190580
First Author: Lei Z
Year: 2012
Journal: Dev Biol
Title: EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.
Volume: 371
Issue: 2
Pages: 136-45
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Publication
20651236 | -
First Author: Nakatsukasa M
Year: 2010
Journal: Am J Pathol
Title: Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Volume: 177
Issue: 3
Pages: 1344-55
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Publication
18281513 | -
First Author: Wang J
Year: 2008
Journal: Mol Cancer Ther
Title: Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers.
Volume: 7
Issue: 2
Pages: 280-5
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Publication
31177095 | -
First Author: Mori Y
Year: 2019
Journal: J Biol Chem
Title: Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility.
Volume: 294
Issue: 30
Pages: 11513-11524
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Publication
30628064 | -
First Author: Yahyazadeh Mashhadi SM
Year: 2019
Journal: J Cell Physiol
Title: Shedding light on the EpCAM: An overview.
Volume: 234
Issue: 8
Pages: 12569-12580
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Publication
23536555 | -
First Author: Trerotola M
Year: 2013
Journal: Cancer Res
Title: Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.
Volume: 73
Issue: 10
Pages: 3155-67
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Protein Domain
IPR043406 | EPCAM/Trop-2
Type: Family
Description: This entry includes transmembrane glycoprotein EpCAM (epithelial cell adhesion molecule, also known as Trop-1) and Trop-2 (also known as tumor-associated calcium signal transducer 2, TACSTD2). They belong to the tumour-associated calcium signal transducer (TACSTD) family. They have been reported to directly interact with claudin-1 and claudin-7 [, , ]. EpCAM mediates homotypic cell contacts in epithelia tissues and regulates cell proliferation and cancer stemness. It has been used as a diagnostic marker for circulating tumour cells (CTCs) in the blood []. EpCAM has been shown to contribute to formation of intestinal barrier by recruiting claudins to cell-cell junctions []. Mutations in the EpCAM gene lead to congenital tufting enteropathy, severe intestinal epithelium homeostasis disorders, and Lynch syndrome []. Trop-2 is highly expressed in a variety of epithelial cancer cells. It has been identified as an oncogene leading to invasiveness and tumorigenesis []. It has been shown to regulate integrin-dependent signalling for cell-substrate adhesion and cell migration. It also modulates Rac1 GTPase activity and induces activation of PAK4 [].
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Protein Domain
IPR006816 | ELMO_dom
Type: Domain
Description: This entry represents the ELMO (EnguLfment and Cell MOtility) domain, which is found in a number of eukaryotic proteins involved in the cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility, including CED-12, ELMO-1 and ELMO-2. ELMO-1 and ELMO-2 are components of signalling pathways that regulate phagocytosis and cell migration and are mammalian orthologues of the Caenorhabditis elegans gene, ced-12 that is required for the engulfment of dying cells and cell migration. ELMO-1/2 act in association with DOCK1 and CRK. ELMO-1/2 interact with the SH3-domain of DOCK1 via an SH3-binding site to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. ELMO-1/2 could be part of a complex with DOCK1 and Rac1 that could be required to activate Rac Rho small GTPases. Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [].
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Protein Domain
IPR036481 | Bcr-Abl_oncoprot_oligo_sf
Type: Homologous_superfamily
Description: This entry represents the oligomerisation domain of the breakpoint cluster region oncoprotein Bcr, and the Bcr/Abl (Abelson-leukemia-virus) fusion protein created by a reciprocal (9;22) fusion []. Brc displays serine/threonine protein kinase activity (), acting as a GTPase-activating protein for RAC1 and CDC42. Brc promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them []. The Bcr/Abl fusion protein loses some of the regulatory function of Bcr with regards to small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells [].The Bcr, Bcr/Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [].
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Protein Domain
IPR046770 | DOCKER_Lobe_B
Type: Domain
Description: This entry represents a conserved region within a number of eukaryotic dedicator of cytokinesis proteins (DOCK), which are guanine nucleotide exchange factors (GEFs) [, , ], that activate some small GTPases by exchanging bound GDP for free GTP such as Rac. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis []. These proteins have a DOCK-homology region 1 (DHR-1, also known as DOCK-type C2 domain) at the N-terminal and a DHR-2 (also known as DOCKER domain) at the C-terminal. The DOCKER domain () is a GEF catalytic domain organised into three lobes, A, B and C, with the Rho-family binding site and catalytic centre generated entirely from lobes B and C. This entry represents Lobe B, which adopts an unusual architecture of two antiparallel beta sheets disposed in a loosely packed orthogonal arrangement. This lobe changes its position relative to lobe C and the bound GTPase, which suggests that lobe B distinguishes between the switch 1 conformations of the small GTPases Rac1 and Cdc42 [, ].
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Protein Domain
IPR030128 | IRSp53
Type: Family
Description: IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Protein Domain
IPR015123 | Bcr-Abl_oncoprot_oligo
Type: Domain
Description: This entry represents the oligomerisation domain of the breakpoint cluster region oncoprotein Bcr, and the Bcr/Abl (Abelson-leukemia-virus) fusion protein created by a reciprocal (9;22) fusion []. Brc displays serine/threonine protein kinase activity (), acting as a GTPase-activating protein for RAC1 and CDC42. Brc promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them []. The Bcr/Abl fusion protein loses some of the regulatory function of Bcr with regards to small Rho-like GTPases with negative consequences on cell motility, in particular on the capacity to adhere to endothelial cells [].The Bcr, Bcr/Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [].
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Protein Domain
IPR035594 | Irsp53_SH3
Type: Domain
Description: This entry represents the SH3 domain of IRSp53. The SH3 domain of IRSp53 has been shown to bind the proline-rich C terminus of EspFu (E. coli secreted protein F-like from prophage U) [].IRSp53, also known as IRS-58 or BAIAP2 (brain-specific angiogenesis inhibitor 1-associated protein 2), is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [].IRSp53 is an adaptor protein that acts at the membrane-actin interface, coupling membrane deformation with F-actin polymerisation []. It is involved in the formation of filopodia and lamellipodia in cultured mesenchymal cells and contributes to assembly/maintenance of tight junctions in cultured epithelial cells []. IRSp53 contains an N-terminal I-BAR domain, followed by a partial CRIB domain and a SH3 domain. It binds to small GTPase Cdc42, Rac1 and WAVE1 []. IRSp53 binds Rac through its I-BAR domain and to WAVE through its SH3 domain, and thus contributes to membrane ruffling []. Its SH3 domain also interacts with other regulators of actin dynamics, such as WAVE2, Mena, mDia1, Dynamin1, Eps8 and N-WASP [].
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Protein Domain
IPR013606 | I-BAR_dom
Type: Domain
Description: The I-BAR domain (also known as IMD domain, IRSp53 and MIM homology domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminal in the IRSp53 (insulin receptor tyrosine kinase substrate p53) and in the evolutionarily related IRSp53/MIM family. The BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [, ]. The I-BAR domain containing proteins include: Vertebrate MIM (missing in metastasis), an actin-binding scaffold protein that may be involved in cancer metastasis.Vertebrate ABBA, a MIM-related protein.Vertebrate insulin receptor tyrosine kinase substrate p53 (IRSp53), a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2) to induce lamellipodia or Cdc42 with Mena to induce filopodia [].Vertebrate IRTKS.Vertebrate Pinkbar.Drosophila melanogaster (Fruit fly) CG32082-PA.Caenorhabditis elegans M04F3.5 protein.The vertebrate I-BAR family is divided into two major groups: the IRSp53/IRTKS/Pinkbar subfamily and the MIM/ABBA subfamily. The putative invertebrate homologues are positioned between them. The IRSp53/IRTKS/Pinkbar subfamily members contain a SH3 domain, and the MIM/ABBA subfamily proteins contain a WH2 (WASP-homology 2) domain. The vertebrate SH3-containing subfamily is further divided into three groups according to the presence or absence of the WWB and the half-CRIB motif [, ]. The BAR domain binds phosphoinositide-rich vesicles with high affinity and does not display strong actin filament binding/bundling activity [, ].
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Protein Coding Gene
MGP_CAROLIEiJ_G0020942 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023023 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_103306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022852 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016647 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021848 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15014044 | J:89010
First Author: Paffenholz R
Year: 2004
Journal: Genes Dev
Title: Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.
Volume: 18
Issue: 5
Pages: 486-91
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Publication
7999144 | J:18555
First Author: Habets GG
Year: 1994
Journal: Cell
Title: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
Volume: 77
Issue: 4
Pages: 537-49
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Publication
12075356 | J:77148
First Author: Malliri A
Year: 2002
Journal: Nature
Title: Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
Volume: 417
Issue: 6891
Pages: 867-71
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Publication
22710731 | J:316670
First Author: Ellenbroek SI
Year: 2012
Journal: Small GTPases
Title: The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network.
Volume: 3
Issue: 1
Pages: 4-14
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Publication
16757331 | J:115039
 
First Author: Strumane K
Year: 2006
Journal: Methods Enzymol
Title: The Rac activator Tiam1 and Ras-induced oncogenesis.
Volume: 407
Pages: 269-81
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Publication
16186252 | J:102631
First Author: Mertens AE
Year: 2005
Journal: J Cell Biol
Title: The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
Volume: 170
Issue: 7
Pages: 1029-37
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Publication
19139083 | J:149331
First Author: Gérard A
Year: 2009
Journal: Blood
Title: The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.
Volume: 113
Issue: 24
Pages: 6138-47
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Publication
18349077 | J:139599
First Author: Rygiel TP
Year: 2008
Journal: J Cell Sci
Title: The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation.
Volume: 121
Issue: Pt 8
Pages: 1183-92
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Publication
22661025 | J:188067
First Author: Yoo S
Year: 2012
Journal: Mol Cells
Title: A gene trap knockout of the Tiam-1 protein results in malformation of the early embryonic brain.
Volume: 34
Issue: 1
Pages: 103-8
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Publication
12134164 | J:78463
First Author: Lambert JM
Year: 2002
Journal: Nat Cell Biol
Title: Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Volume: 4
Issue: 8
Pages: 621-5
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Publication
23103911 | J:194001
First Author: Mack NA
Year: 2012
Journal: Nat Cell Biol
Title: β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.
Volume: 14
Issue: 11
Pages: 1169-80
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Publication
25926441 | J:222968
First Author: Ma HL
Year: 2015
Journal: Biol Reprod
Title: Inhibition of Endometrial Tiam1/Rac1 Signals Induced by miR-22 Up-Regulation Leads to the Failure of Embryo Implantation During the Implantation Window in Pregnant Mice.
Volume: 92
Issue: 6
Pages: 152
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Publication
33328293 | J:301715
First Author: Cheng J
Year: 2021
Journal: J Neurosci
Title: The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions.
Volume: 41
Issue: 6
Pages: 1191-1206
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GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Liver
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Stomach
Detected: true
Specimen Num: 6
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Muscle
Detected: false
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Lung
Detected: false
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2665891
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2666051
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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