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Search results 2201 to 2300 out of 2368 for Tpr

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Protein
O35685
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
Q8K2C9
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
Q9JLN9
Organism: Mus musculus/domesticus
Length: 2549  
Fragment?: false
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Protein
Q6PAL0
Organism: Mus musculus/domesticus
Length: 825  
Fragment?: false
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Protein
Q7TMX5
Organism: Mus musculus/domesticus
Length: 569  
Fragment?: false
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Protein
Q8R1N4
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q9CQ48
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
D3YZ08
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
B0FTY3
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q8C5Z6
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
A0A0U1RQ34
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
G3UYL4
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
Q8CFD2
Organism: Mus musculus/domesticus
Length: 25  
Fragment?: true
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Publication
10470031 | -
First Author: Siderovski DP
Year: 1999
Journal: Trends Biochem Sci
Title: The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor.
Volume: 24
Issue: 9
Pages: 340-1
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Publication
11121039 | -
First Author: De Vries L
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
Volume: 97
Issue: 26
Pages: 14364-9
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Publication
11024022 | -
First Author: Natochin M
Year: 2000
Journal: J Biol Chem
Title: AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin.
Volume: 275
Issue: 52
Pages: 40981-5
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Publication
11976690 | -
First Author: Kimple RJ
Year: 2002
Journal: Nature
Title: Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Volume: 416
Issue: 6883
Pages: 878-81
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Publication
10571178 | -
First Author: Shirasu K
Year: 1999
Journal: Cell
Title: A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
Volume: 99
Issue: 4
Pages: 355-66
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Publication
9573178 | -
First Author: Lee SH
Year: 1998
Journal: J Bacteriol
Title: Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection.
Volume: 180
Issue: 9
Pages: 2298-305
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Publication
12107127 | -
First Author: Tischler AD
Year: 2002
Journal: J Bacteriol
Title: The Vibrio cholerae vieSAB locus encodes a pathway contributing to cholera toxin production.
Volume: 184
Issue: 15
Pages: 4104-13
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Publication
20130089 | -
First Author: Ram?n NM
Year: 2010
Journal: Mol Biol Cell
Title: Interdependence of the peroxisome-targeting receptors in Arabidopsis thaliana: PEX7 facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes.
Volume: 21
Issue: 7
Pages: 1263-71
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Publication
15548601 | -
First Author: Woodward AW
Year: 2005
Journal: Mol Biol Cell
Title: The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5.
Volume: 16
Issue: 2
Pages: 573-83
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Publication
33677542 | -
First Author: Dubey AP
Year: 2021
Journal: Nucleic Acids Res
Title: Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10.
Volume: 49
Issue: 6
Pages: 3557-3572
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Protein Domain
IPR014460 | Sig_transdc_resp-reg_VieB
Type: Family
Description: Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents VieB-type response regulators. In Vibrio, it is part of a signal transduction pathway involved in cholera toxin production [, ].Response regulators of the microbial two-component signal transduction systems typically consist of an N-terminal CheY-like receiver (phosphoacceptor) domain and a C-terminal output (usually DNA-binding) domain. In response to an environmental stimulus, a phosphoryl group is transferred from the His residue of sensor histidine kinase to an Asp residue in the CheY-like receiver domain of the cognate response regulator [, , ]. Phosphorylation of the receiver domain induces conformational changes that activate an associated output domain, which in turn triggers the response. Phosphorylation-induced conformational changes in response regulator molecules have been demonstrated in direct structural studies [].The output domain found in this group is so far unique. In part, it contains a divergent version of TPR repeats.
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Protein Domain
IPR003109 | GoLoco_motif
Type: Conserved_site
Description: In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) are coupled to membrane-associated heterotrimers comprising a GTP-hydrolysing subunit G-alpha and a G-beta/G-gamma dimer. The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. When the ligand is associated to the receptor, GDP is displaced from G-alpha and GTP is bound. GTP/G-alpha complex dissociates from the trimer and associates to an effector until the intrinsic GTPase activity of G-alpha returns the protein to GDP bound form. Reassociation of GDP bound G-alpha with G-beta/G-gamma dimer terminates the signal. Several mechanisms regulate the signal output at different stage of the G-protein cascade. Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis (see ), and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation. The GoLoco or G-protein regulatory (GPR) motif found in various G-protein regulators [, ]acts as a GDI on G-alpha(i) [, ].The crystal structure of the GoLoco motif in complex with G-alpha(i) has been solved []. It consists of three small �� helices. The highly conserved Asp-Gln-Arg triad within the GoLoco motif participates directly in GDP binding by extending the arginine side chain into the nucleotide binding pocket, highly reminiscent of the catalytic arginine finger employed in GTPase-activating protein (see ). This addition of an arginine in the binding pocket affects the interaction of GDP with G-alpha and therefore is certainly important for the GoLoco GDI activity [].Some proteins known to contain a GoLoco motif are listed below:Mammalian regulators of G-protein signalling 12 and 14 (RGS12 and RGS14), multifaceted signal transduction regulators.Loco, the drosophila RGS12 homologue.Mammalian Purkinje-cell protein-2 (Pcp2). It may function as a cell-type specific modulator for G protein-mediated cell signalling. It is uniquely expressed in cerebellar Purkinje cells and in retinal bipolar neurons.Eukaryotic Rap1GAP. A GTPase activator for the nuclear ras-related regulatory protein RAP-1A.Drosophila protein Rapsynoid (also known as Partner of Inscuteable, Pins) and its mammalian homologues AGS3 and LGN. They form a G-protein regulator family that also contains TPR repeats.
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Publication
26123589 | J:236513
 
First Author: Kirschner LS
Year: 2016
Journal: Mol Cell Endocrinol
Title: Mouse models of thyroid cancer: A 2015 update.
Volume: 421
Pages: 18-27
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Protein
A6H8H2
Organism: Mus musculus/domesticus
Length: 1906  
Fragment?: false
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Protein
Q3U1Y4
Organism: Mus musculus/domesticus
Length: 1499  
Fragment?: false
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Protein
E9Q8V6
Organism: Mus musculus/domesticus
Length: 1869  
Fragment?: false
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Protein
A0A0R4J172
Organism: Mus musculus/domesticus
Length: 1510  
Fragment?: false
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Protein
B9EKY0
Organism: Mus musculus/domesticus
Length: 1354  
Fragment?: false
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Protein
E9Q449
Organism: Mus musculus/domesticus
Length: 1615  
Fragment?: false
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Publication
22569362 | J:294074
 
First Author: L?pez-Dom?nech G
Year: 2012
Journal: Nat Commun
Title: The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
Volume: 3
Pages: 814
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Publication
22921120 | J:187364
First Author: Pilli M
Year: 2012
Journal: Immunity
Title: TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.
Volume: 37
Issue: 2
Pages: 223-34
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Protein
O35099
Organism: Mus musculus/domesticus
Length: 1380  
Fragment?: false
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Protein
Q9D1P4
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Protein
Q9R000
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q9WTR2
Organism: Mus musculus/domesticus
Length: 1291  
Fragment?: false
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Protein
A2AQW0
Organism: Mus musculus/domesticus
Length: 1331  
Fragment?: false
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Protein
Q3TLI0
Organism: Mus musculus/domesticus
Length: 1258  
Fragment?: false
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Protein
Q9JMG1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Protein
B2RXC1
Organism: Mus musculus/domesticus
Length: 1133  
Fragment?: false
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Protein
A0A0A0MQ82
Organism: Mus musculus/domesticus
Length: 1291  
Fragment?: false
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Protein
E9PWG9
Organism: Mus musculus/domesticus
Length: 1372  
Fragment?: false
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Protein
Q14AY4
Organism: Mus musculus/domesticus
Length: 1372  
Fragment?: false
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Protein
Q3UQZ5
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
A0A0A6YY29
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
F6WQJ9
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
Q8BSQ6
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
Q9CUL7
Organism: Mus musculus/domesticus
Length: 452  
Fragment?: true
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Publication
11119645 | -
First Author: Pei J
Year: 2001
Journal: Proteins
Title: GGDEF domain is homologous to adenylyl cyclase.
Volume: 42
Issue: 2
Pages: 210-6
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Publication
11682196 | -
First Author: Ausmees N
Year: 2001
Journal: FEMS Microbiol Lett
Title: Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity.
Volume: 204
Issue: 1
Pages: 163-7
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Publication
14562095 | -
First Author: Huh WK
Year: 2003
Journal: Nature
Title: Global analysis of protein localization in budding yeast.
Volume: 425
Issue: 6959
Pages: 686-91
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Publication
21525244 | -
First Author: Scrivens PJ
Year: 2011
Journal: Mol Biol Cell
Title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
Volume: 22
Issue: 12
Pages: 2083-93
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Publication
16000385 | -
First Author: Sadler KC
Year: 2005
Journal: Development
Title: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.
Volume: 132
Issue: 15
Pages: 3561-72
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Publication
9335584 | -
First Author: Lussier M
Year: 1997
Journal: Genetics
Title: Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.
Volume: 147
Issue: 2
Pages: 435-50
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Publication
29017571 | -
First Author: Bhattacharjee S
Year: 2017
Journal: Cell Commun Signal
Title: DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.
Volume: 15
Issue: 1
Pages: 41
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Protein
A2ALS5
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
P56565
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q9CWU0
Organism: Mus musculus/domesticus
Length: 1215  
Fragment?: false
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Protein
Q9CXW3
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
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Protein
A0A0A6YX17
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
Q91V77
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
A2A4P3
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
A2A4P4
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: false
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Protein
F6R0J2
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q69ZK3
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: true
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Protein
Q9D3M4
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
A2ALS4
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
E0CYD5
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q8BRP0
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Protein
S4R282
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Publication
37889040 | -
First Author: Nicastro GG
Year: 2023
Journal: Nucleic Acids Res
Title: Functionally comparable but evolutionarily distinct nucleotide-targeting?effectors help identify conserved paradigms across diverse immune systems.
Volume: 51
Issue: 21
Pages: 11479-11503
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Publication
37042948 | J:340074
First Author: Wu J
Year: 2023
Journal: Blood Adv
Title: EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.
Volume: 7
Issue: 14
Pages: 3382-3394
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Publication
28781166 | -
First Author: Bertram K
Year: 2017
Journal: Cell
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Volume: 170
Issue: 4
Pages: 701-713.e11
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Protein
O35385
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
Q8VBV4
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
Q8BU03
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: false
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Protein
Q2M1K2
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: false
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Protein
Q8R538
Organism: Mus musculus/domesticus
Length: 919  
Fragment?: false
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Protein
F6ZLN8
Organism: Mus musculus/domesticus
Length: 964  
Fragment?: true
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Protein
Q8CIG5
Organism: Mus musculus/domesticus
Length: 958  
Fragment?: false
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Publication
10606204 | -
First Author: Ponting CP
Year: 1999
Journal: J Mol Med (Berl)
Title: Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins.
Volume: 77
Issue: 10
Pages: 695-8
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Publication
15590835 | -
First Author: Bernstein KA
Year: 2004
Journal: Eukaryot Cell
Title: The small-subunit processome is a ribosome assembly intermediate.
Volume: 3
Issue: 6
Pages: 1619-26
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Publication
20972447 | -
First Author: Yip CK
Year: 2010
Journal: Nat Struct Mol Biol
Title: Molecular architecture of the TRAPPII complex and implications for vesicle tethering.
Volume: 17
Issue: 11
Pages: 1298-304
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Publication
23078654 | -
First Author: Zou S
Year: 2013
Journal: Traffic
Title: Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.
Volume: 14
Issue: 2
Pages: 233-46
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Publication
37410820 | -
First Author: Liu S
Year: 2023
Journal: Science
Title: Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing.
Volume: 381
Issue: 6653
Pages: eadg4725
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Protein
O35655
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
Q3TDX8
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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Protein
Q8BJA3
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q0P5W1
Organism: Mus musculus/domesticus
Length: 1427  
Fragment?: false
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Protein
Q3UKJ7
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Protein
Q9JIL5
Organism: Mus musculus/domesticus
Length: 1547  
Fragment?: false
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Protein
H3BK13
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
H3BK67
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
H3BKF8
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: true
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Protein
H3BKM3
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
H3BL55
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
H3BJ31
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: true
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Publication
7854424 | -
First Author: Stebbins CE
Year: 1995
Journal: Nature
Title: Crystal structure of the GreA transcript cleavage factor from Escherichia coli.
Volume: 373
Issue: 6515
Pages: 636-40
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom