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Search results 2301 to 2400 out of 2452 for Brca1

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Type Details Score
Protein Domain
IPR015525 | BRCA2
Type: Family
Description: The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor involved in double-strand break repair and/or homologous recombination []. BRCA2 gene expression is regulated in a cell-cycle dependent manner and peak expression of BRCA2 mRNA occurring in S phase, suggesting BRCA2 may participate in regulating cell proliferation. BRCA2, and related protein BRCA1, have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. BRCA2 has a number of 39 amino acid repeats []that are critical for binding to RAD51 (a key protein in DNA recombinational repair) and resistance to methyl methanesulphonate treatment [, , ]. There are eight repeats in BRCA2 designated as BRC1 to BRC8. BRC1, BRC2, BRC3, BRC4, BRC7, and BRC8 have high sequence identity and bind to Rad51, whereas BRC5 and BRC6 are less well conserved and are unable to bind Rad51 []. It has been suggested that BRCA2 plays a role in positioning Rad51 at the site of DNA repair or in removing Rad51 from DNA once repair has been completed.Mutations in BRCA1 and BRCA2 have been linked to an elevated risk of young onset breast cancer and confer a high risk of the disease through a dominantly inherited fashion []. BRCA2 mutations are typically microdeletions.Homologues exist in plants: the BRCA2A and BRCA2B proteins from Arabidopsis thalianaare required for repair of breaks in double-stranded DNA and homologous recombination and in the prophase stage of meiosis are required for formation of RAD51 and DMC1 foci in males [].
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Protein
Q5PSV9
Organism: Mus musculus/domesticus
Length: 1707  
Fragment?: false
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Protein
Q91VL8
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
P70399
Organism: Mus musculus/domesticus
Length: 1969  
Fragment?: false
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Protein
Q8R3P9
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
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Protein
Q8C0U1
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
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Protein
E9QK89
Organism: Mus musculus/domesticus
Length: 1708  
Fragment?: false
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Protein
Q3V1P7
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: true
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Protein
A0A5H1ZRL7
Organism: Mus musculus/domesticus
Length: 1919  
Fragment?: false
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Protein
Q8BZ87
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: true
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Protein
Q8C9Y7
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
17062627 | J:137511
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
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Protein
O70445
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
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Protein
Q3ULG2
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
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Publication
21079677 | J:167522
First Author: Shin YH
Year: 2010
Journal: PLoS Genet
Title: Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.
Volume: 6
Issue: 11
Pages: e1001190
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Publication
28945226 | J:257859
First Author: Bian X
Year: 2018
Journal: Oncogene
Title: PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy.
Volume: 37
Issue: 3
Pages: 341-351
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Publication
25556150 | J:219814
First Author: Bopp A
Year: 2015
Journal: Carcinogenesis
Title: Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.
Volume: 36
Issue: 3
Pages: 378-89
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Publication
28420963 | J:287461
 
First Author: Noristani HN
Year: 2017
Journal: Front Mol Neurosci
Title: RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury.
Volume: 10
Pages: 90
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Publication
33106234 | J:300342
 
First Author: Wang X
Year: 2020
Journal: Dis Model Mech
Title: Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites.
Volume: 13
Issue: 12
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Publication
25421723 | J:217471
First Author: Dabydeen SA
Year: 2015
Journal: Carcinogenesis
Title: Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.
Volume: 36
Issue: 1
Pages: 122-32
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Publication
32863939 | J:313352
First Author: Du L
Year: 2020
Journal: Theranostics
Title: Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells.
Volume: 10
Issue: 21
Pages: 9458-9476
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Publication
24278285 | J:208175
First Author: Helmer RA
Year: 2013
Journal: PLoS One
Title: Helicase-like transcription factor (Hltf) regulates G2/M transition, Wt1/Gata4/Hif-1a cardiac transcription networks, and collagen biogenesis.
Volume: 8
Issue: 11
Pages: e80461
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Publication
11016617 | J:64778
First Author: Hilakivi-Clarke L
Year: 2000
Journal: Cancer Res
Title: Estrogens, BRCA1, and breast cancer.
Volume: 60
Issue: 18
Pages: 4993-5001
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Publication
8972912 | J:37615
First Author: Zhang X
Year: 1996
Journal: Gene
Title: Cloning and sequencing of a copper-containing, topa quinone-containing monoamine oxidase from human placenta.
Volume: 179
Issue: 2
Pages: 279-86
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Publication
9461464 | J:46219
First Author: Shen MR
Year: 1998
Journal: Nucleic Acids Res
Title: Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair.
Volume: 26
Issue: 4
Pages: 1032-7
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Publication
25889730 | J:316502
 
First Author: Apostoli AJ
Year: 2015
Journal: Mol Cancer
Title: Opposing roles for mammary epithelial-specific PPARγ signaling and activation during breast tumour progression.
Volume: 14
Pages: 85
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Protein
Q7TSG2
Organism: Mus musculus/domesticus
Length: 960  
Fragment?: false
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Protein
Q07139
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
P35601
Organism: Mus musculus/domesticus
Length: 1131  
Fragment?: false
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Protein
Q5U4B1
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
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Protein
Q3U0S4
Organism: Mus musculus/domesticus
Length: 960  
Fragment?: false
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Protein
A0A2X0SFE3
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: true
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Protein
A0A0N5E9G7
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
G3UWX1
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Protein
G3X8Z6
Organism: Mus musculus/domesticus
Length: 1131  
Fragment?: false
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Protein
Q8C3R1
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
Q3U0P1
Organism: Mus musculus/domesticus
Length: 1104  
Fragment?: false
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Protein
Q3TT38
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
B2KF54
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
B2KF52
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q80VS5
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: true
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Protein
A0A3B2W3Q3
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
E9QLK3
Organism: Mus musculus/domesticus
Length: 867  
Fragment?: false
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Protein
A0A3B2WCT9
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
A0A3B2W3W9
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Publication
8673099 | -
First Author: Bork P
Year: 1996
Journal: Nat Genet
Title: Internal repeats in the BRCA2 protein sequence.
Volume: 13
Issue: 1
Pages: 22-3
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Publication
9405383 | -
First Author: Wong AK
Year: 1997
Journal: J Biol Chem
Title: RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Volume: 272
Issue: 51
Pages: 31941-4
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Publication
9560268 | -
First Author: Chen PL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Volume: 95
Issue: 9
Pages: 5287-92
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Publication
9811893 | -
First Author: Marmorstein LY
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The BRCA2 gene product functionally interacts with p53 and RAD51.
Volume: 95
Issue: 23
Pages: 13869-74
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Publication
10551859 | -
First Author: Chen CF
Year: 1999
Journal: J Biol Chem
Title: Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Volume: 274
Issue: 46
Pages: 32931-5
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Publication
11702069 | -
First Author: Sibanda BL
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of an Xrcc4-DNA ligase IV complex.
Volume: 8
Issue: 12
Pages: 1015-9
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Protein
Q8VDP4
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Protein
Q9QZ41
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
B2RS44
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Protein
E9PYK3
Organism: Mus musculus/domesticus
Length: 1969  
Fragment?: false
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Protein
P11103
Organism: Mus musculus/domesticus
Length: 1013  
Fragment?: false
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Protein
Q920Q2
Organism: Mus musculus/domesticus
Length: 1249  
Fragment?: false
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Protein
Q921K2
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3U0I5
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
Q3U868
Organism: Mus musculus/domesticus
Length: 973  
Fragment?: true
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Protein
Q3TM68
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3TX36
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3TIV3
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3TF18
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3UJ03
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Protein
Q3UMS5
Organism: Mus musculus/domesticus
Length: 690  
Fragment?: true
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Protein
Q922Y1
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Protein
P09838
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q9QXE2
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
Q9JIW4
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Protein
Q924W4
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Protein
Q5NCI3
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q7TN90
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: false
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Protein
Q3UZ80
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q8CH18
Organism: Mus musculus/domesticus
Length: 1146  
Fragment?: false
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Protein
A0A087WPK5
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
Q8BTF7
Organism: Mus musculus/domesticus
Length: 911  
Fragment?: false
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Protein
Q3UZD0
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Protein
Q3TN53
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: true
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Protein
A2AMG5
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: true
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Protein
Q8BTF5
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Publication
12442171 | -
First Author: Pellegrini L
Year: 2002
Journal: Nature
Title: Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Volume: 420
Issue: 6913
Pages: 287-93
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Publication
12646216 | -
First Author: Hatakeyama S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: U-box proteins as a new family of ubiquitin ligases.
Volume: 302
Issue: 4
Pages: 635-45
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Publication
15564047 | -
First Author: Ross CA
Year: 2004
Journal: Trends Cell Biol
Title: The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.
Volume: 14
Issue: 12
Pages: 703-11
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Protein
P97929
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
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Protein
Q9R207
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q6PB43
Organism: Mus musculus/domesticus
Length: 1180  
Fragment?: false
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Protein
Q8VHD0
Organism: Mus musculus/domesticus
Length: 3329  
Fragment?: false
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Protein
P97386
Organism: Mus musculus/domesticus
Length: 1015  
Fragment?: false
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Protein
Q80ZH7
Organism: Mus musculus/domesticus
Length: 1012  
Fragment?: false
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Protein
Q3UC82
Organism: Mus musculus/domesticus
Length: 1011  
Fragment?: false
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Protein
Q3U1F0
Organism: Mus musculus/domesticus
Length: 1011  
Fragment?: false
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Protein
K4DI59
Organism: Mus musculus/domesticus
Length: 1016  
Fragment?: false
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Protein
P35689
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Protein
Q6PDG5
Organism: Mus musculus/domesticus
Length: 1213  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom