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Search results 2301 to 2400 out of 2733 for C6

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:1927951
Assay Type: RNA in situ
Annotation Date: 2001-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1937619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:1928658
Age: embryonic day 11.5
Image: 8. O., P.
Note: Expression is detected in the vertebrae from thoracic 11 up to the boundary between cervical vertebrae 1 and 2 for 2 of 4 specimens. The boundary is between C2/3 for two other specimens. Data posterior to C5 is summarized in Fig. 9.
Specimen Label: 8. O., P.
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190549
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Hoxb5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190549
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Hoxb5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190549
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Hoxb5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190549
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Hoxb5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190549
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Hoxb5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190549
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Hoxb5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6175006
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190549
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Hoxb5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:1927951
Assay Type: RNA in situ
Annotation Date: 2001-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1933719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:1928658
Age: embryonic day 11.5
Image: 8. M., N.
Note: Expression is detected in the vertebrae from thoracic 11 up to the boundary between cervical vertebrae 1 and 2. Data posterior to C5 is summarized in Fig. 9.
Specimen Label: 8. M., N.
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1927951
Assay Type: RNA in situ
Annotation Date: 2001-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1933719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:1928658
Age: embryonic day 11.5
Image: 8. O., P.
Note: Expression is detected in the vertebrae from thoracic 11 up to the boundary between cervical vertebrae 1 and 2 for 2 of 4 specimens. The boundary is between C2/3 for two other specimens. Data posterior to C5 is summarized in Fig. 9.
Specimen Label: 8. O., P.
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:12545
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2778224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6448965
Age: embryonic day 16.0
Image: 8C/D/E
Note: Expressed predominantly in the epithelial cells.
Specimen Label: 8C/D/E
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
Probe: MGI:12545
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1881228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6448965
Age: postnatal adult
Image: 9A/B
Note: Expressed in dispersed cells in the connective tissue.
Specimen Label: 9A/B
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:5484761
Assay Type: RNA in situ
Annotation Date: 2013-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1625515
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5484883
Age: embryonic day 9.5
Note: Expression is proximal and extends to where the liver will develop.
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6460027
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3704926
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6460028
Age: embryonic day 18.0
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6460027
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6460028
Age: embryonic day 15.0
Note: Expression in ventral horns and area around central canal.
Specimen Label: 2B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6460027
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6460028
Age: embryonic day 18.0
Note: Authors report that intensity of expression changes from 15 to 18 days. Expression in ventral horns and area around central canal.
Specimen Label: 2C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6460027
Assay Type: Immunohistochemistry
Annotation Date: 2020-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3705026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6460028
Age: embryonic day 18.0
Note: Expression in motor regions of spinal cord. Intensity of expression varied in nuclei from one cell type to another.
Specimen Label: 2D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:12553
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3705413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:6448968
Age: embryonic day 8.5
Image: 1A/B
Specimen Label: 1A/B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:12553
Assay Type: RNA in situ
Annotation Date: 2020-08-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3705413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:6448968
Age: embryonic day 8.5
Image: 1D/E
Specimen Label: 1D/E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:256280
Assay Type: RNA in situ
Annotation Date: 2019-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3806722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6381375
Age: embryonic day 14.5
Image: 1C43
Specimen Label: 1C43
Detected: true
Specimen Num: 1
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Publication
1939212 | J:11536
First Author: Liu YH
Year: 1991
Journal: J Biol Chem
Title: Characterization of estrogen-responsive mouse lactoferrin promoter.
Volume: 266
Issue: 32
Pages: 21880-5
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Publication
8376406 | J:14683
First Author: Jiang H
Year: 1993
Journal: J Biol Chem
Title: Organization, sequence, and expression of the murine S100 beta gene. Transcriptional regulation by cell type-specific cis-acting regulatory elements.
Volume: 268
Issue: 27
Pages: 20502-11
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Publication
8733591 | J:36948
First Author: Schachter JB
Year: 1996
Journal: Br J Pharmacol
Title: Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.
Volume: 118
Issue: 1
Pages: 167-73
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Publication
9398466 | J:44422
First Author: Ishiyama T
Year: 1997
Journal: Exp Neurol
Title: Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.
Volume: 148
Issue: 1
Pages: 247-55
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Publication
34721260 | J:312684
 
First Author: Gata-Garcia A
Year: 2021
Journal: Front Neurol
Title: Contributions of Sex Chromosomes and Gonadal Hormones to the Male Bias in a Maternal Antibody-Induced Model of Autism Spectrum Disorder.
Volume: 12
Pages: 721108
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Publication
15313569 | J:121749
 
First Author: Fu Y
Year: 2004
Journal: Methods Enzymol
Title: RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.
Volume: 389
Pages: 229-43
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Publication
24716865 | J:214683
First Author: Okuda H
Year: 2014
Journal: J Neurochem
Title: OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex.
Volume: 130
Issue: 5
Pages: 612-25
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Publication
17868307 | J:299316
First Author: González MI
Year: 2007
Journal: J Neurochem
Title: Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1.
Volume: 103
Issue: 5
Pages: 1917-31
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Publication
12230553 | J:79155
First Author: Choi IY
Year: 2002
Journal: Eur J Biochem
Title: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism.
Volume: 269
Issue: 18
Pages: 4418-26
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Publication
16944923 | J:117470
First Author: Chen VC
Year: 2006
Journal: J Proteome Res
Title: Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins.
Volume: 5
Issue: 9
Pages: 2123-34
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Publication
2607149 | J:24637
First Author: Ong GL
Year: 1989
Journal: J Immunol Methods
Title: Mouse strains with typical mammalian levels of complement activity.
Volume: 125
Issue: 1-2
Pages: 147-58
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Publication
8563021 | J:28972
First Author: Charité J
Year: 1995
Journal: Dev Dyn
Title: Specification of multiple vertebral identities by ectopically expressed Hoxb-8.
Volume: 204
Issue: 1
Pages: 13-21
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Publication
9050867 | J:39011
First Author: Copertino DW
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Multiple promoter elements differentially regulate the expression of the mouse tenascin gene.
Volume: 94
Issue: 5
Pages: 1846-51
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Publication
9278390 | J:42743
First Author: Arystarkhova E
Year: 1997
Journal: J Biol Chem
Title: Tissue-specific expression of the Na,K-ATPase beta3 subunit. The presence of beta3 in lung and liver addresses the problem of the missing subunit.
Volume: 272
Issue: 36
Pages: 22405-8
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Publication
9323458 | J:43529
First Author: Wilson CD
Year: 1997
Journal: Dev Neurosci
Title: Expression of the brain creatine kinase gene is low in neuroblastoma cell lines.
Volume: 19
Issue: 5
Pages: 375-83
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Publication
9445394 | J:45635
 
First Author: Katayama K
Year: 1998
Journal: Biochem J
Title: Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver.
Volume: 329 ( Pt 3)
Pages: 647-52
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Publication
9754931 | J:52649
First Author: Bojic U
Year: 1998
Journal: Eur J Pharmacol
Title: Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.
Volume: 354
Issue: 2-3
Pages: 289-99
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Publication
10419054 | J:56573
First Author: Berenstein M
Year: 1999
Journal: Cancer Gene Ther
Title: Different efficacy of in vivo herpes simplex virus thymidine kinase gene transduction and ganciclovir treatment on the inhibition of tumor growth of murine and human melanoma cells and rat glioblastoma cells.
Volume: 6
Issue: 4
Pages: 358-66
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Publication
15051476 | J:89496
First Author: Tombran-Tink J
Year: 2004
Journal: Exp Eye Res
Title: Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells.
Volume: 78
Issue: 5
Pages: 945-55
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Publication
27036853 | J:252212
 
First Author: Contreras CJ
Year: 2016
Journal: Arch Biochem Biophys
Title: Incorporation of phosphate into glycogen by glycogen synthase.
Volume: 597
Pages: 21-9
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Protein
A0A338P687
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Protein
Q9D3I7
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Protein
Q8BKM6
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
A0A338P6T8
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Protein
Q3U6R8
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
A0A0N4SUY8
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
A0A3B2WCW8
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
A0A3B2WCF8
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Publication
20681989 | -
First Author: Nakai H
Year: 2010
Journal: FEBS J
Title: Aspergillus nidulans alpha-galactosidase of glycoside hydrolase family 36 catalyses the formation of alpha-galacto-oligosaccharides by transglycosylation.
Volume: 277
Issue: 17
Pages: 3538-51
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Publication
12123797 | -
First Author: Rigden DJ
Year: 2002
Journal: FEBS Lett
Title: Iterative database searches demonstrate that glycoside hydrolase families 27, 31, 36 and 66 share a common evolutionary origin with family 13.
Volume: 523
Issue: 1-3
Pages: 17-22
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Publication
21931163 | -
First Author: Bruel L
Year: 2011
Journal: J Biol Chem
Title: α-Galactosidase/sucrose kinase (AgaSK), a novel bifunctional enzyme from the human microbiome coupling galactosidase and kinase activities.
Volume: 286
Issue: 47
Pages: 40814-23
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Publication
7593276 | -
 
First Author: Way M
Year: 1995
Journal: J Cell Sci
Title: beta-Scruin, a homologue of the actin crosslinking protein scruin, is localized to the acrosomal vesicle of Limulus sperm.
Volume: 108 ( Pt 10)
Pages: 3155-62
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Publication
8126718 | -
First Author: Bork P
Year: 1994
Journal: J Mol Biol
Title: Drosophila kelch motif is derived from a common enzyme fold.
Volume: 236
Issue: 5
Pages: 1277-82
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Publication
19913487 | -
First Author: Oda S
Year: 2009
Journal: Structure
Title: Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.
Volume: 17
Issue: 11
Pages: 1528-37
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Publication
22194685 | -
First Author: Maluquer de Motes C
Year: 2011
Journal: PLoS Pathog
Title: Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Volume: 7
Issue: 12
Pages: e1002430
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Publication
29748387 | -
First Author: Tang Q
Year: 2018
Journal: J Biol Chem
Title: Mechanism of vaccinia viral protein B14-mediated inhibition of IκB kinase β activation.
Volume: 293
Issue: 26
Pages: 10344-10352
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Publication
17872444 | -
First Author: Hadders MA
Year: 2007
Journal: Science
Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.
Volume: 317
Issue: 5844
Pages: 1552-4
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Publication
16900325 | -
First Author: Noutoshi Y
Year: 2006
Journal: Plant Mol Biol
Title: Loss of Necrotic Spotted Lesions 1 associates with cell death and defense responses in Arabidopsis thaliana.
Volume: 62
Issue: 1-2
Pages: 29-42
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Publication
18440555 | -
First Author: Slade DJ
Year: 2008
Journal: J Mol Biol
Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.
Volume: 379
Issue: 2
Pages: 331-42
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Publication
15659064 | -
First Author: Ishino T
Year: 2005
Journal: Cell Microbiol
Title: A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection.
Volume: 7
Issue: 2
Pages: 199-208
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Publication
17368498 | -
First Author: Satoh H
Year: 2007
Journal: Toxicon
Title: Characterization of PsTX-60B, a new membrane-attack complex/perforin (MACPF) family toxin, from the venomous sea anemone Phyllodiscus semoni.
Volume: 49
Issue: 8
Pages: 1208-10
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Publication
15799997 | -
First Author: Morita-Yamamuro C
Year: 2005
Journal: Plant Cell Physiol
Title: The Arabidopsis gene CAD1 controls programmed cell death in the plant immune system and encodes a protein containing a MACPF domain.
Volume: 46
Issue: 6
Pages: 902-12
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Publication
10608922 | -
First Author: Ponting CP
Year: 1999
Journal: Curr Biol
Title: Chlamydial homologues of the MACPF (MAC/perforin) domain.
Volume: 9
Issue: 24
Pages: R911-3
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Publication
22172915 | -
First Author: Ruszczycky MW
Year: 2012
Journal: Biochim Biophys Acta
Title: Radical SAM enzymes in the biosynthesis of sugar-containing natural products.
Volume: 1824
Issue: 11
Pages: 1231-44
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Publication
15327949 | -
First Author: Sulzenbacher G
Year: 2004
Journal: J Mol Biol
Title: Crystal structure of E.coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme.
Volume: 342
Issue: 2
Pages: 489-502
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Publication
20924577 | -
First Author: Jarboe LR
Year: 2011
Journal: Appl Microbiol Biotechnol
Title: YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.
Volume: 89
Issue: 2
Pages: 249-57
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Publication
19383697 | -
First Author: Liu X
Year: 2009
Journal: Microbiology (Reading)
Title: Two novel metal-independent long-chain alkyl alcohol dehydrogenases from Geobacillus thermodenitrificans NG80-2.
Volume: 155
Issue: Pt 6
Pages: 2078-2085
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Protein Domain
IPR006652 | Kelch_1
Type: Repeat
Description: Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified []. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed β-propeller. The motif is also found in mouse protein MIPP []and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha- and beta-scruin [, ], and in galactose oxidase from the fungus Dactylium dendroides [, ]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded antiparallel β-sheet motif that forms the repeat unit in a super-barrel structural fold [].The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila []. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [].This entry represents a type of kelch sequence motif that comprises one β-sheet blade.
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Protein Domain
IPR002252 | Glyco_hydro_36
Type: Family
Description: O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.Glycoside hydrolase family 36 () occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-galactosidase, alpha-N-acetylgalactosaminidase, stachyose synthase, and raffinose synthase [, ]. All GH36 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein. GH36 members are retaining enzymes that cleave their substrates via an acid/base-catalyzed, double-displacement mechanism involving a covalent glycosyl-enzyme intermediate []. Two aspartic acid residues have been identified as the catalytic nucleophile and the acid/base, respectively.Proteins in this entry also include AgaSK, a bifunctional protein that contains two domains: one closely related to alpha-galactosidases from glycoside hydrolase family GH36 and the other containing a nucleotide-binding motif. It can hydrolyze melibiose and raffinose to galactose and either glucose or sucrose, respectively, and can specifically phosphorylate sucrose on the C6 position of glucose in the presence of ATP [].
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Protein Domain
IPR044731 | BDH-like
Type: Family
Description: Butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway, in which it catalyses the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidised in the process. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Members in this family use divalent ions, preferentially iron or zinc []. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3 [, ]. The active site of YqhD contains a zinc atom, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.This entry also includes Long-chain-alcohol dehydrogenase 2 from Geobacillus thermodenitrificans which is able to oxidise a broad range of alkyl alcohols from methanol to 1-triacontanol (C1 to C30), whose best substrate is 1-octanol. In contrast to other members of the family, it apparently does not use iron or other metals as cofactor [].
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Protein Domain
IPR015915 | Kelch-typ_b-propeller
Type: Homologous_superfamily
Description: Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified []. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed β-propeller. The motif is also found in mouse protein MIPP []and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha- and beta-scruin [, ], and in galactose oxidase from the fungus Dactylium dendroides [, ]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded antiparallel β-sheet motif that forms the repeat unit in a super-barrel structural fold [].The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila []. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [].This entry represents the 6-bladed Kelch β-propeller, which consists of six 4-stranded β-sheet motifs (or six Kelch repeats).
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Protein Domain
IPR011043 | Gal_Oxase/kelch_b-propeller
Type: Homologous_superfamily
Description: This entry represents a β-propeller domain found in galactose oxidase and in Kelch repeat-containing proteins.The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila []. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [].Galactose oxidase () is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde []. The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation []. Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich, the central domain forms a seven 4-bladed β-propeller, and the C-terminal domain has an immunoglobulin-like fold.
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Protein Domain
IPR011498 | Kelch_2
Type: Repeat
Description: Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified []. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed β-propeller. The motif is also found in mouse protein MIPP []and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha- and beta-scruin [, ], and in galactose oxidase from the fungus Dactylium dendroides [, ]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded antiparallel β-sheet motif that forms the repeat unit in a super-barrel structural fold [].The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila []. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [].This entry represents a type of kelch sequence motif that comprises one β-sheet blade.
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Publication
18662545 | J:139297
First Author: Dasen JS
Year: 2008
Journal: Cell
Title: Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
Volume: 134
Issue: 2
Pages: 304-16
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Publication
28009287 | J:239303
First Author: Amin S
Year: 2016
Journal: Cell Rep
Title: Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Volume: 17
Issue: 12
Pages: 3165-3177
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Publication
34994686 | J:317827
   
First Author: Sawai A
Year: 2022
Journal: Elife
Title: PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
Volume: 11
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Publication
20826310 | J:166088
First Author: Jung H
Year: 2010
Journal: Neuron
Title: Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
Volume: 67
Issue: 5
Pages: 781-96
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Publication
21943603 | J:178550
First Author: Sabharwal P
Year: 2011
Journal: Neuron
Title: GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling.
Volume: 71
Issue: 6
Pages: 1058-70
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Protein
Q6DFY8
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
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Protein
Q920P3
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
A1L314
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3UX67
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
Q5RKV8
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
A0A0G2JEL8
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
A0A0U1RQ03
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Protein
B1AQT5
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Protein
A0A0A6YWU9
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
E9QN37
Organism: Mus musculus/domesticus
Length: 720  
Fragment?: false
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Protein
Q9JI82
Organism: Mus musculus/domesticus
Length: 752  
Fragment?: false
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Publication
21543324 | -
First Author: Guo B
Year: 2011
Journal: J Biol Chem
Title: Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase.
Volume: 286
Issue: 24
Pages: 21937-43
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Publication
8288554 | J:16424
First Author: Alam J
Year: 1994
Journal: J Biol Chem
Title: Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals.
Volume: 269
Issue: 2
Pages: 1001-9
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Protein
Q8VDR7
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Protein
Q3TMF9
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
Q9D0D1
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Publication
7844540 | -
 
First Author: Wisler GC
Year: 1995
Journal: J Gen Virol
Title: Characterization of the P1 protein and coding region of the zucchini yellow mosaic virus.
Volume: 76 ( Pt 1)
Pages: 37-45
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Publication
1529535 | -
First Author: Verchot J
Year: 1992
Journal: Virology
Title: Mutational analysis of the tobacco etch potyviral 35-kDa proteinase: identification of essential residues and requirements for autoproteolysis.
Volume: 190
Issue: 1
Pages: 298-306
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Publication
32984814 | -
 
First Author: Pasin F
Year: 2020
Journal: Plant Commun
Title: Abscisic Acid Connects Phytohormone Signaling with RNA Metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self-Controlled RNA Virus.
Volume: 1
Issue: 5
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Publication
11698678 | -
First Author: Firbank SJ
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the precursor of galactose oxidase: an unusual self-processing enzyme.
Volume: 98
Issue: 23
Pages: 12932-7
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Publication
12418174 | -
 
First Author: Whittaker JW
Year: 2002
Journal: Adv Protein Chem
Title: Galactose oxidase.
Volume: 60
Pages: 1-49
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Publication
17717151 | -
First Author: Rosado CJ
Year: 2007
Journal: Science
Title: A common fold mediates vertebrate defense and bacterial attack.
Volume: 317
Issue: 5844
Pages: 1548-51
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